Andreas Frøslev Mathisen

Position

Research Technician, Chera lab

Affiliation

Work

Our research is directed at how cell death features (type, timing, extent) govern the type of regenerative strategy employed by a biological system.

We primarily use the murine pancreas as a model system, due to the wide-range of genetic tools available for this organ and its demonstrated cell plasticity potential. Besides employing classical systems of rapid cell-ablation (RIP-DTR, chemical ablation), we developed novel transgenic models of progressive β-cell decay (financed by Excellence Project for Young Investigators of Novo Nordisk Foundation). By coupling the diverse β-cell ablation configurations with genetic cell tracing, timed conditional gene expression and diverse omics assays, we study the dynamical molecular fingerprint of β-cell death and the regenerative response employed, with focus on β-cell self-renewal potential (financed by FRIPRO Young Research Talent grant – Research Council of Norway).

Publications
2024
2023
2022
2021
2020
2019

See a complete overview of publications in Cristin.