I am a Senior Engineer for the core facility in Biostatistics and Data Analysis (BIOS), Department of Global Public Health and Primary Care (IGS). My expertise spans biostatistics, pharmacoepidemiology, causal inference, and advanced statistical modelling, with a strong foundation in applied mathematics, and dynamical systems.

Professional Experience:

Senior Engineer (2025– )
Biostatistics and Data Analysis, Department of Global Public Health and Primary Care, Bergen, Norway

Senior Advisor (2024–2025 )
Statistics Section, Directorate of Fisheries, Bergen, Norway
 

Adviser / Administrative Coordinator (2024)
NORBIS – National Research School in Bioinformatics, Biostatistics and Systems Biology, University of Bergen

Postdoctoral Research Fellow (2019–2024)
Computational Biology Unit, Department of Informatics, University of Bergen
Fields: Applied Mathematics, Statistics, Systems Biology

Education:

PhD in Biostatistics and Pharmacoepidemiology (2016–2019)
PharmaSafe, School of Pharmacy, University of Oslo, Norway
Thesis: Thyroid hormone replacement therapy during pregnancy – Quantifying medication patterns
and associated outcomes in the offspring

MSc in Mathematics in Bioscience (2016)
Technical University of Munich, Germany

BSc in Mathematics (2013)
Technical University of Munich, Germany

International Experience:

• Visiting Scientist, Cornell University, USA (2, months, 2019)
• Visiting Research Fellow, Cornell University, USA (6 months, 2018)
• Erasmus Scholar, Université Paul Sabatier Toulouse III, France (6 months, 2014–2015)

UiB-webpage: The pulse of marine food chain models

Interview (in Norwegian): Takker fastelavnsris for ny kunnskap om svangerskap og trygg medisinbruk

Teaching Experience*

Discrete Structures (MNF130)
Main course instructor — Spring 2024
Approximately 300 students
Department of Informatics, University of Bergen

Computational Systems Biology (BINF305)
Main course instructor — Autumn 2021 and 2022
5–7 students
Department of Informatics, University of Bergen

Parameter Estimation in Systems Biology (NORBIS PhD Summer School)
Assisted lecture design and teaching — 2021

M.Sc. Theses, Department of Mathematical Sciences
External examiner

• University of Agder, Norway — Two theses, Summer 2022

Course Exams, Department of Mathematical Sciences
External examiner

• NTNU (Norwegian University of Science and Technology), 2023–2024

 

*In 2023, I completed the the University of Bergen's Program for University Pedagogy (UPED)

Academic article

• Ryu, Hwayeon; Röblitz, Susanna; Larripa, Kamila et al. (2025). Modeling bistable dynamics arising from macrophage–tumor interactions in the tumor microenvironment. (external link)
• Yousefian, Maryam; Frank, Anna-Simone Josefine; Weber, Marcus et al. (2025). Efficient construction of Markov state models for stochastic gene regulatory networks by domain decomposition. (external link)
• Schaarschmidt, Ute Alexandra; Frank, Anna-Simone Josefine; Subbey, Samuel (2025). Equivalence of Stock-Recruitment Functions and Parent-Progeny Relationships in Discrete-Time Multi-Stage Models. (external link)
• Yousefian, Maryam; Tonello, Elisa; Frank, Anna-Simone Josefine et al. (2024). Uncovering dynamic structures within cyclic attractors of asynchronous Boolean networks with spectral clustering. (external link)
• Frank, Anna-Simone Josefine; Sikorski, Alexander; Röblitz, Susanna (2024). Spectral clustering of Markov chain transition matrices with complex eigenvalues. (external link)
• Yousefian, Maryam; Frank, Anna-Simone Josefine; Weber, Marcus et al. (2023). Efficient construction of Markov state models for stochastic gene regulatory networks by domain decomposition. (external link)
• Frank, Anna-Simone Josefine; Larripa, Kamila; Ryu, Hwayeon et al. (2023). Macrophage phenotype transitions in a stochastic gene-regulatory network model. (external link)
• Frank, Anna-Simone Josefine; Sikorski, Alexander; Röblitz, Susanna (2022). Spectral clustering of Markov chain transition matrices with complex eigenvalues. (external link)
• Frank, Anna-Simone Josefine; Larripa, Kamila; Ryu, Hwayeon et al. (2022). Macrophage phenotype transitions in a stochastic gene-regulatory network model. (external link)
• Frank, Anna-Simone Josefine; Subbey, S.; Kobras, Melanie et al. (2021). Population dynamic regulators in an empirical predator-prey system. (external link)
• Frank, Anna-Simone Josefine; Subbey, Samuel; Kobras, Melanie (2020). Crowding Effects in an Empirical Predator-Prey System. (external link)
• Broek, Sophie van den; Lupattelli, Angela; Frank, Anna-Simone et al. (2020). Thyroid hormone replacement therapy in pregnancy and motor function, communication skills, and behavior of preschool children: The Norwegian Mother, Father, and Child Cohort Study. (external link)
• Frank, Anna-Simone; Larripa, Kamila; Ryu, Hwayeon et al. (2020). Bifurcation and sensitivity analysis reveal key drivers of multistability in a model of macrophage polarization. (external link)
• Frank, Anna-Simone; Matteson, David S.; Solvang, Hiroko Kato et al. (2020). Extending balance assessment for the generalized propensity score under multiple imputation. (external link)
• Frank, Anna-Simone; Lupattelli, Angela; Matteson, David S. et al. (2019). Thyroid hormone replacement therapy patterns in pregnant women and perinatal outcomes in the offspring. (external link)
• Frank, Anna-Simone; Lupattelli, Angela; Brandlistuen, Ragnhild Eek et al. (2019). Maternal thyroid hormone replacement therapy exposure and language and communication skills of offspring at 8 years of age. (external link)
• Frank, Anna-Simone Josefine; Lupattelli, Angela; Matteson, David S. et al. (2018). Maternal use of thyroid hormone replacement therapy before, during, and after pregnancy: agreement between self-report and prescription records and group-based trajectory modeling of prescription patterns. (external link)
• Frank, Anna-Simone Josefine; Subbey, Sam (2018). Predictability of marine population trajectories affected by birth and harvest pulses. (external link)
• Frank, Anna-Simone Josefine; Lupattelli, Angela; Nordeng, Hedvig Marie Egeland (2018). Risk factors for discontinuation of thyroid hormone replacement therapy in early pregnancy: A study from the Norwegian Mother and Child Cohort Study and the Medical Birth Registry of Norway. (external link)
• Subbey, Sam; Solvang, Hiroko Kato; Frank, Anna-Simone Josefine (2018). Causal Drivers of Barents Sea Capelin (Mallotus villosus) Population Dynamics on Different Time Scales. (external link)
• Frank, Anna-Simone Josefine (2017). Predictability of Marine Population Trajectories–the effect of delays and resource availability. (external link)
• Frank, Anna-Simone Josefine; Subbey, Sam (2017). Combined effect of birth and harvest impulses on dynamics of a single-species marine population. (external link)

Academic literature review

• Frank, Anna-Simone Josefine; Pinke, Andrea; Read, Elizabeth et al. (2025). Exploring multistability in marine ecosystems: Insights from food web model dynamics. (external link)

Academic lecture

• Frank, Anna-Simone Josefine (2022). What is Optimization? -- Application to macrophage polarization data. (external link)
• Frank, Anna-Simone Josefine (2022). Uncovering macrophage phenotype switches using a stochastic modeling approach. (external link)
• Frank, Anna-Simone Josefine (2022). Mathematics as an Instrument to New Biological Insights – Two Examples of the Barents Sea Capelin. (external link)
• Frank, Anna-Simone Josefine (2018). Maternal use of thyroid hormone replacement therapy at the time of pregnancy: group-based trajectory modeling of adherence and agreement between self-reporting and prescription records. (external link)
• Frank, Anna-Simone Josefine (2018). Quantifying agreement and adherence patterns using different data sources. (external link)
• Subbey, Sam; Frank, Anna-Simone Josefine; Planque, Benjamin (2017). The (Un)Predictability of Population Dynamic Trajectories. (external link)
• Frank, Anna-Simone Josefine; Lupattelli, Angela; Røysland, Kjetil et al. (2017). Risk factors for discontinuation of hypothyroid medication in early pregnancy -- a study from the Norwegian Mother and Child Cohort Study and the Medical Birth Registry of Norway. (external link)
• Frank, Anna-Simone Josefine; Subbey, Sam (2017). Predictability of Marine Population Trajectories under the Effect of Birth and Harvest Pulses. (external link)
• Frank, Anna-Simone Josefine; Subbey, Sam (2016). The Predictability and Prediction Horizon of Population Dynamic Trajectories (CM Code–1:240).. (external link)
• Frank, Anna-Simone Josefine (2016). Predictability of Marine Population Trajectories--the effect of delays and Resource availability. (external link)
• Solvang, Hiroko Kato; Subbey, Sam; Frank, Anna-Simone Josefine (2016). Deriving Causal Drivers of Population Dynamics on Different Time Scales (CM Code–1:242). (external link)
• Frank, Anna-Simone Josefine (2016). Predictability of Marine Population Trajectories under the Effect of Birth and Harvest Pulses. (external link)
• Frank, Anna-Simone Josefine (2016). The Effect of Resource Dynamics on Marine Population Trajectories and Stability. (external link)
• Frank, Anna-Simone Josefine; Subbey, Sam (2015). Numerical Study of a System of Delay Differential Equations With Impulses. (external link)
• Frank, Anna-Simone Josefine; Subbey, Sam; Solvang, Hiroko Kato (2014). Correlations, Causalities, and the Prediction of Fisheries Time Series. (external link)

Interview

• Frank, Anna-Simone (2019). No link between maternal thyroid HT and children’s language, communication skills. (external link)
• Frank, Anna-Simone (2019). Takker fastelavnsris for ny kunnskap om svangerskap og trygg medisinbruk. (external link)

Lecture

• Frank, Anna-Simone Josefine (2019). Missingness in longitudinal data: Statistical methods for handling drop-outs. (external link)
• Frank, Anna-Simone Josefine (2016). Presentation titel: Hypothyroidism and -medication during pregnancy. (external link)

Doctoral dissertation

• Frank, Anna-Simone Josefine (2019). Thyroid hormone replacement therapy during pregnancy – Quantifying medication patterns and associated outcomes in the offspring. (external link)

Poster

• Frank, Anna-Simone Josefine; Lupattelli, Angela; Matteson, David S. et al. (2018). Maternal Use of Thyroid Hormone Replacement Therapy: Group-Based Trajectory Modeling of Adherence and Agreement Between Self-Reporting and Prescription Records During Pregnancy. (external link)
• Frank, Anna-Simone Josefine; Lupattelli, Angela; Røysland, Kjetil et al. (2017). Patterns and Predictors of Hypothyroid Medication Use in Relation to Pregnancy: A Drug Utilization Study. (external link)
• Frank, Anna-Simone Josefine; Lupattelli, Angela; Røysland, Kjetil et al. (2017). PATTERNS AND PREDICTORS OF HYPOTHYROID MEDICATION USE IN RELATION TO PREGNANCY: A DRUG UTILIZATION STUDY. (external link)

Report

• Frank, Anna-Simone Josefine (2016). The Effect of Resource Dynamics on Marine Population Trajectories and Stability. (external link)
• Frank, Anna-Simone Josefine (2016). Predictability of Marine Population Trajectories under the Effect of Birth and Harvest Pulses. (external link)
• Frank, Anna-Simone Josefine (2016). Predictability of Marine Population Trajectories--the effect of delays and resource availability. (external link)

Masters thesis

• Frank, Anna-Simone Josefine (2016). Regulatory Factors on the Dynamics of a System of Delayed Differential Equations. (external link)

See a complete overview of publications in Cristin.

Ongoing projects:

Multiple States and Transition Paths in Marine Ecosystems (SQuaRE, American Institute of Mathematics (AIM), Caltech)

Role: PI

 

Past projects:

A mathematical model of macrophage differentiation in the tumor microenvironment (SQuaRE, American Institute of Mathematics (AIM), Caltech)

Role: Participant (PostDoc)

Svangerskapsutfall og nevroutvikling hos barn av mødre med hypotyrose i svangerskapet

Role: Participant (Ph.D. student)