I am working as a researcher in Professor Stephanie Le Hellards lab, which focuses on the epigenetics of mental disorders. We are part of the Dr. Einar Martens Research Group for Biological Psychiatry and the Norwegian Center for Mental Disorders Research (NORMENT).

We are working on several project where we study the interaction between the environment and genetic background, and how this affect variations in gene regulation and expression.

Current projects include epigenetic effects of

• Cannabis usage
• Anti-psychotic drugs
• Alcohol
• Childhood trauma

An underestimated factor in most studies is sex. Several disorders display sex imbalances, which can be observed as differences in disease prevalence, onset or outcome. Sex differences are driven by the sex chromosomes and sex specific environment (incl. hormones). Understanding how sex differences impact the genetic architecture of complex disorders is something we are particularly interested in.

 

2024

• Tesfaye, Markos ; Spindola, Leticia Maria Nery; Stavrum, Anne-Kristin Støbakk et al. (2024). Sex effects on DNA methylation affect discovery in epigenome-wide association study of schizophrenia. (external link)
• Bakke, Laura Anne Wortinger; Stavrum, Anne-Kristin Støbakk; Shadrin, Alexey et al. (2024). Divergent epigenetic responses to perinatal asphyxia in severe mental disorders. (external link)

2023

• Villar, Jonelle Marie Dickow; Stavrum, Anne-Kristin Støbakk; Nery Spindola, Leticia Maria et al. (2023). Differences in white blood cell proportions between schizophrenia cases and controls are influenced by medication and variations in time of day. (external link)
• Hagen, Kristen; Solem, Stian; Stavrum, Anne-Kristin Støbakk et al. (2023). Changes in mental health symptoms from April (COVID-19 outbreak) to December 2020 in Norway: A two-wave study. (external link)
• Frid, Leila Marie; Kessler, Ute; Ousdal, Olga Therese et al. (2023). Neurobiological mechanisms of ECT and TMS treatment in depression: study protocol of a multimodal magnetic resonance investigation. (external link)

2022

• Løkhammer, Solveig; Stavrum, Anne-Kristin Støbakk; Polushina, Tatiana et al. (2022). An epigenetic association analysis of childhood trauma in psychosis reveals possible overlap with methylation changes associated with PTSD. (external link)

2021

• Hagen, Kristen; Solem, Stian; Stavrum, Anne-Kristin Støbakk et al. (2021). Mental health symptoms during the first months of the COVID-19 outbreak in Norway: A cross-sectional survey study. (external link)

2020

• Stavrum, Anne-Kristin; Szabo, Attila; Fernandes, Carla Patricia Duarte et al. (2020). Epigenetic Effects of THC and CBD in Neuronal Stem Cells. (external link)
• Szabo, Attila; Akkouh, Ibrahim; Ueland, Thor et al. (2020). Cannabis Use Is Associated With Increased Levels of Soluble gp130 in Schizophrenia but Not in Bipolar Disorder. (external link)

2018

• Jørgensen, Katarina Mariann; Mosleth, Ellen Færgestad; Liland, Kristian Hovde et al. (2018). Gene expression response in peripheral blood cells of petroleum workers exposed to sub-ppm benzene levels. (external link)

2017

• Schäuble, Sascha; Stavrum, Anne-Kristin; Bockwoldt, Mathias et al. (2017). SBMLmod: a Python-based web application and web service for efficient data integration and model simulation. (external link)

2016

• Heiland, Ines; Bockwoldt, Mathias; Puntervoll, Pål et al. (2016). Tissue specific models of Trp- and NAD-metabolism — insights into metabolic crosstalk.. (external link)
• Heiland, Ines; Bockwoldt, Mathias; Stavrum, Anne-Kristin et al. (2016). Tissue specific models of Tryptohan-metabolism — insights into metabolic crosstalk. (external link)

2015

• Bockwoldt, Mathias; Stavrum, Anne-Kristin; Gossmann, Toni I. et al. (2015). Dynamics of NAD-metabolism - everything but constant. (external link)

2014

• Kolesar, Ivan; Parulek, Julius; Viola, Ivan et al. (2014). Interactively illustrating polymerization using three-level model fusion. (external link)
• Le Muzic, Mathieu; Parulek, Julius; Stavrum, Anne-Kristin et al. (2014). Illustrative visualization of molecular reactions using omniscient intelligence and passive agents. (external link)
• Stavrum, Anne-Kristin (2014). A kinetic model of tryptofan metabolism - Developments towards accurate and scalable kinetic models. (external link)
• Heiland, Ines; Brandes, Susanne; Stavrum, Anne-Kristin et al. (2014). NAD-metabolism and the circadian clock -- Unraveling contradictions. (external link)
• Stavrum, Anne-Kristin; Heiland, Ines; Schuster, Stefan et al. (2014). Predicting pathological metabolic changes using a kinetic model of tryptophan metabolism. (external link)

2013

• Stavrum, Anne-Kristin; Heiland, Ines; Schuster, Stefan et al. (2013). Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data. (external link)
• Heiland, Ines; Brandes, Susanne; Stavrum, Anne-Kristin et al. (2013). NAD-metabolism and the circadian clock. (external link)
• Schäuble, Sascha; Stavrum, Anne-Kristin; Puntervoll, Pål et al. (2013). Effect of substrate competition in kinetic models of metabolic networks. (external link)

2012

• Stavrum, Ruth; Valvatne, Håvard; Stavrum, Anne-Kristin et al. (2012). Mycobacterium tuberculosis Mcel protein complex initiates rapid induction of transcription of genes involved in substrate trafficking. (external link)

2011

• Stavrum, Ruth; Stavrum, Anne-Kristin; Valvatne, Håvard et al. (2011). Modulation of transcriptional and inflammatory responses in murine macrophages by the mycobacterium tuberculosis mammalian cell entry (Mce) 1 complex. (external link)
• Søfteland, Liv Ingeborg Rosvoll; Petersen, Kjell; Stavrum, Anne-Kristin et al. (2011). Hepatic in vitro toxicity assessment of PBDE congeners BDE47, BDE153 and BDE154 in Atlantic salmon (Salmo salar L.). (external link)

2010

• Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Stavrum, Anne-Kristin et al. (2010). From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery. (external link)
• Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Stavrum, Anne-Kristin et al. (2010). From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery. (external link)
• Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Stavrum, Anne-Kristin et al. (2010). Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. (external link)

2009

• Trösse, Christiane; Waagbø, Rune; Breck, Olav et al. (2009). Genome-wide transcription analysis of histidine-related cataract in Atlantic salmon (Salmo salar L). (external link)
• Trösse, Christiane; Waagbø, Rune; Breck, Olav et al. (2009). Genome-wide transcription analysis of histidine-related cataract in Atlantic salmon (Salmo salar L). (external link)

2008

• Olsvik, Pål Asgeir; Lie, Kai Kristoffer; Mykkeltvedt, Eva et al. (2008). Pharmacokinetics and transcriptional effects of the anti-salmon lice drug emamectin benzoate in Atlantic salmon (Salmo salar L.). (external link)

2007

• Olsvik, Pål A.; Lie, Kai K; Stavrum, Anne-Kristin et al. (2007). Gene-expression profiling in gill and liver of zebrafish exposed to produced water. (external link)
• Hevrøy, Ernst Morten; Tonheim, Sigurd Kristian; Rønnestad, Ivar et al. (2007). Zebrafish as a genetic model for the nutritional impact on growth in fish. (external link)
• Hjelmervik, Trond Ove R.; Lindqvist, Anna-Karin B.; Petersen, Kjell et al. (2007). The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice. (external link)
• Håvik, Bjarte; Røkke, Håvard; Dagyte, Girstaute et al. (2007). Synaptic activity-induced global gene expression patterns in the dentate gyrus of adult behaving rats: Induction of immunity-linked genes. (external link)

2006

• Stavrum, Ruth M Støbakk; Valvatne, Håvard; Stavrum, Anne-Kristin et al. (2006). Dynamics of global macrophage expression responses to in vitro infection with wild-type and a hypervirulent mce1-mutant of M. tuberculosis. (external link)

See a complete overview of publications in Cristin.