I am a molecular biologist, with a PhD from University of Bergen on stem cell research and diabetes. My current research work focuses on identifying protein biomarkers and novel targets in aggressive breast cancer, with special emphasis on tumor cell plasticity and nerve involvement in the tumor microenvironment. To study the interaction between cancer cells and nerves, we use a combination of methods including mass spectrometry-based proteomics, imaging mass cytometry and cell models.

Academic article

• Kjølle, Silje; Finne, Kenneth; Birkeland, Even et al. (2023). Hypoxia induced responses are reflected in the stromal proteome of breast cancer. (external link)
• Berle, Magnus; Hestetun, Kjersti Elvestad; Vethe, Heidrun et al. (2022). Mapping Proteome Changes in Microsatellite Stable, Recurrent Colon Cancer Reveals a Significant Immune System Signature. (external link)
• Wik, Elisabeth; Aziz, Sura Mohammed; Vethe, Heidrun et al. (2022). Neurogenesis and angiogenesis are associated features of aggressive breast cancer . (external link)
• Okuyama, Tomoko; Shirakawa, Jun; Tajima, Kazuki et al. (2020). Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor. (external link)
• Legøy, Thomas Aga; Vethe, Heidrun; Abadpour, Shadab et al. (2020). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling . (external link)
• Ghila, Luiza; Bjørlykke, Yngvild; Legøy, Thomas Aga et al. (2020). Bioinformatic analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4α mutation. (external link)
• Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Salim, Zaidon et al. (2020). In vivo environment swiftly restricts human pancreatic progenitors toward mono-hormonal identity via a HNF1A/HNF4A mechanism. (external link)
• Gupta, Manoj K.; Vethe, Heidrun; Softic, Samir et al. (2020). Leptin receptor signaling regulates protein synthesis pathways and neuronal differentiation in pluripotent stem cells. (external link)
• Legøy, Thomas Aga; Ghila, Luiza; Vethe, Heidrun et al. (2019). In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. (external link)
• Loo, Larry Sai Weng; Vethe, Heidrun; Soetedjo, Andreas Alvin Purnomo et al. (2019). Dynamic proteome profiling of human pluripotent stem cell-derived pancreatic progenitors. (external link)
• Furuyama, Kenichiro; Chera, Simona; van Gurp, Leon et al. (2019). Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. (external link)
• Vethe, Heidrun; Legøy, Thomas Aga; Abadpour, Shadab et al. (2019). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. (external link)
• Bjørlykke, Yngvild; Søviknes, Anne Mette; Hoareau, Laurence et al. (2019). Reprogrammed cells display distinct proteomic signaturesAssociated with colony morphology variability. (external link)
• Vethe, Heidrun; Ghila, Luiza; Berle, Magnus et al. (2019). The effect of WnT pathway modulators on human iPSC-derived pancreatic beta cell maturation. (external link)
• Berle, Magnus; Ghila, Luiza; Vethe, Heidrun et al. (2018). Novel protein signatures suggest progression to muscular invasiveness in bladder cancer. (external link)
• Vethe, Heidrun; Bjørlykke, Yngvild; Ghila, Luiza et al. (2017). Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells. (external link)
• Finne, Kenneth; Marti, Hans-Peter; Leh, Sabine Maria et al. (2016). Proteomic Analysis of Minimally Damaged Renal Tubular Tissue from Two-Kidney-One-Clip Hypertensive Rats Demonstrates Extensive Changes Compared to Tissue from Controls. (external link)
• Vethe, Heidrun; Finne, Kenneth; Skogstrand, Trude et al. (2015). Distinct protein signature of hypertension-induced damage in the renal proteome of two-kidney-one-clip (2K1C) rat model. (external link)
• Kroksveen, Ann Cathrine; Jaffe, Jacob D.; Aasebø, Elise et al. (2015). Quantitative proteomics suggests decrease in the secretogranin-1 cerebrospinal fluid levels during the disease course of multiple sclerosis. (external link)
• Finne, Kenneth; Vethe, Heidrun; Skogstrand, Trude et al. (2014). Proteomic analysis of formalin-fixed paraffin-embedded glomeruli suggests depletion of glomerular filtration barrier proteins in two-kidney one-clip hypertensive rats. (external link)
• Bjørlykke, Yngvild; Vethe, Heidrun; Vaudel, Marc et al. (2014). Carboxyl-ester lipase maturity-onset diabetes of the young disease protein biomarkers in secretin-stimulated duodenal juice. (external link)
• Guldbrandsen, Astrid; Vethe, Heidrun; Farag, Yehia Mohamed Mokhtar et al. (2014). In-depth characterization of the cerebrospinal fluid (CSF) proteome displayed through the CSF proteome resource (CSF-PR). (external link)
• Kroksveen, Ann Cathrine; Aasebø, Elise; Vethe, Heidrun et al. (2013). Discovery and initial verification of differentially abundant proteins between multiple sclerosis patients and controls using iTRAQ and SID-SRM. (external link)

Academic chapter/article/Conference paper

• Vethe, Heidrun; Bjørnstad, Ole Vidhammer; Carrasco Fernandez, Manuel et al. (2022). Neurogenesis in the Tumor Microenvironment. (external link)

Abstract

• Finne, Kenneth; Skogstrand, Trude; Tenstad, Olav et al. (2013). Proteomic analysis of outer and juxtamedullary cortex of non-clipped kidneys in 2K1C hypertensive rats. (external link)

See a complete overview of publications in Cristin.