Academic literature review

• Bagordo, Domenico; Rossi, Gian Paolo; Delles, Christian et al. (2024). Tangram of Sodium and Fluid Balance. (external link)
• Miyauchi, Hidetaka; Geisberger, Sabrina; Luft, Friedrich C. et al. (2024). Sodium as an Important Regulator of Immunometabolism. (external link)
• Berggreen, Ellen; Wiig, Helge; Virtej, Anca (2020). Fluid transport from the dental pulp revisited. (external link)
• Wiig, Helge; Luft, FC; Titze, Jens M. (2017). The interstitium conducts extrarenal storage of sodium and represents a third compartment essential for extracellular volume and blood pressure homeostasis. (external link)
• Wagner, Marek; Wiig, Helge (2015). Tumor interstitial fluid formation, characterization, and clinical implications. (external link)
• Berggreen, Ellen; Wiig, Helge (2014). Lymphatic function and responses in periodontal disease. (external link)
• Haslene-Hox, Hanne; Tenstad, Olav; Wiig, Helge (2013). Interstitial fluid-A reflection of the tumor cell microenvironment and secretome. (external link)
• Gjertsen, Bjørn Tore; Wiig, Helge (2012). Investigation of therapy resistance mechanisms in myeloid leukemia by protein profiling of bone marrow extracellular fluid. (external link)
• Wiig, Helge; Swartz, Melody A. (2012). Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. (external link)
• Wiig, Helge (2011). Pathophysiology of tissue fluid accumulation in inflammation. (external link)
• Popova, Svetlana; Lundgren-Äkerlund, Evy; Wiig, Helge et al. (2007). Physiology and pathology of collagen receptors. (external link)
• Wiig, Helge; Gyenge, Christina; Tenstad, Olav (2004). The contribution of sterical and electrostatical factors on distribution of macromolecules in the interstitial space. (external link)

Academic article

• Øien, Alf H.; Tenstad, Olav; Wiig, Helge (2024). Models of Hydration Dependent Lymphatic Opening, Interstitial Fluid Flows and Ambipolar Diffusion. (external link)
• Virtej, Anca; Marti, Larissa Alexandrina von; Wagner, Marek et al. (2024). Contribution of initial lymphatics to oral wound healing after tooth extraction. (external link)
• Steinskog, Eli Sihn Samdal; Finne, Kenneth; Enger, Marianne et al. (2023). Isolation of lymph shows dysregulation of STAT3 and CREB pathways in the spleen and liver during leukemia development in a rat model. (external link)
• Samuelsson, Anne-Maj; Bartolomaeus, Theda Ulrike Patricia; Anandakumar, Harithaa et al. (2023). VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats. (external link)
• Thowsen, Irene Matre; Karlsen, Tine Veronica; Nikpey, Elham et al. (2022). Na+ is shifted from the extracellular to the intracellular compartment and is not inactivated by glycosaminoglycans during high salt conditions in rats. (external link)
• Thowsen, Irene Matre; Reikvam, Tore; Skogstrand, Trude et al. (2022). Genetic engineering of lymphangiogenesis in skin does not affect blood pressure in mouse models of salt-sensitive hypertension. (external link)
• Eigenmann, Miro Julian; Karlsen, Tine Veronica; Wagner, Marek et al. (2021). Pharmacokinetics and pharmacodynamics of t-cell bispecifics in the tumour interstitial fluid. (external link)
• Mullins, Linda; Ivy, Jessica; Ward, Mairi et al. (2021). Abnormal neonatal sodium handling in skin precedes hypertension in the SAME rat. (external link)
• Maifeld, Andras; Wild, Johannes; Karlsen, Tine Veronica et al. (2021). Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity. (external link)
• Avery, Ellen G.; Bartolomaeus, Hendrik; Maifeld, Andras et al. (2021). The Gut Microbiome in Hypertension: Recent Advances and Future Perspectives. (external link)
• Virtej, Anca; Tenstad, Olav; Wiig, Helge et al. (2020). Interstitial fluid drainage from rat apical area takes place via vessels in the mandibular canal.. (external link)
• Nakano, Daisuke; Kitada, Kento; Wan, Ningning et al. (2020). Lipopolysaccharide induces filtrate leakage from renal tubular lumina into the interstitial space via a proximal tubular Toll-like receptor 4–dependent pathway and limits sensitivity to fluid therapy in mice. (external link)
• Wiig, Helge (2020). Commentary: Trends in cardiovascular medicine From deep in the heart - An emerging role of cardiac lymphatics. (external link)
• Wagner, Marek; Steinskog, Eli Sihn Samdal; Wiig, Helge (2019). Blockade of Lymphangiogenesis Shapes Tumor-Promoting Adipose Tissue Inflammation. (external link)
• Huang, Li-Hao; Zinselmeyer, Bernd H.; Chang, Chih-Hao et al. (2019). Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis. (external link)
• Indrebø, Marianne Muller; Berg, Ansgar; Holmstrøm, Henrik et al. (2019). Fluid accumulation in the staged Fontan procedure: the impact of colloid osmotic pressures. (external link)
• Karlsen, Tine Veronica; Nikpey, Elham; Han, Jianhua et al. (2018). High-Salt Diet Causes Expansion of the Lymphatic Network and Increased Lymph Flow in Skin and Muscle of Rats. (external link)
• Øien, Alf Hartvig; Wiig, Helge (2018). Modeling In Vivo Interstitial Hydration-Pressure Relationships in Skin and Skeletal Muscle. (external link)
• Huang, Li-Hao; Zinselmeyer, Bernd H.; Chang, Chih-Hao et al. (2018). Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis. (external link)
• Guthe, Hans Jørgen; Nedrebø, Torbjørn; Damås, Jan Kristian et al. (2018). Transcapillary fluid flux and inflammatory response during neonatal therapeutic hypothermia: An open, longitudinal, observational study. (external link)
• Indrebø, Marianne Muller; Berg, Ansgar; Holmstrøm, Henrik et al. (2017). Fluid accumulation after closure of atrial septal defects: the role of colloid osmotic pressure. (external link)
• Kryvi, Harald; Rusten, Iselin; Fjelldal, Per Gunnar et al. (2017). The notochord in Atlantic salmon (Salmo salar L.) undergoes profound morphological and mechanical changes during development. (external link)
• Papadakou, Panagiota; Bletsa, Athanasia; Yassin, Mohammed Ahmed Alamin Yousif et al. (2017). Role of Hyperplasia of Gingival Lymphatics in Periodontal Inflammation. (external link)
• Karlsen, Tine Veronica; Reikvam, Tore; Tofteberg, Anne et al. (2017). Lymphangiogenesis Facilitates Initial Lymph Formation and Enhances the Dendritic Cell Mobilizing Chemokine CCL21 Without Affecting Migration. (external link)
• Eigenmann, Miro Julian; Karlsen, Tine Veronica; Krippendorff, Ben-Fillippo et al. (2017). Interstitial IgG antibody pharmacokinetics assessed by combined in vivo- and physiologically-based pharmacokinetic modelling approaches. (external link)
• Hinze, Christian; Ruffert, Janett; Walentin, Katharina et al. (2017). GRHL2 is required for collecting duct epithelial barrier function and renal osmoregulation. (external link)
• Esfahlan, Elham Nikpey; Karlsen, Tine Veronica; Rakova, Natalia et al. (2017). High-salt diet causes osmotic gradients and hyperosmolality in skin without affecting interstitial fluid and lymph. (external link)
• Øien, Alf Hartvig; Wiig, Helge (2016). Electrostatic, elastic and hydration-dependent interactions in dermis influencing volume exclusion and macromolecular transport. (external link)
• Lund, Amanda W.; Wagner, Marek; Fankhauser, Manuel et al. (2016). Lymphatic vessels regulate immune microenvironments in human and murine melanoma. (external link)
• Steinskog, Eli Sihn Samdal; Sagstad, Solfrid Johanne; Wagner, Marek et al. (2016). Impaired lymphatic function accelerates cancer growth. (external link)
• Bivol, Liliana Monica; Iversen, Bjarne Magnus; Hultström, Michael et al. (2016). Unilateral renal ischaemia in rats induces a rapid secretion of inflammatory markers to renal lymph and increased capillary permeability. (external link)
• Papadakou, Panagiota; Karlsen, Tine Veronica; Wiig, Helge et al. (2015). Determination of lymph flow in murine oral mucosa using depot clearance of near-infrared-labeled albumin. (external link)
• Guthe, Hans Jørgen Timm; Indrebø, Marianne Muller; Nedrebø, Torbjørn et al. (2015). Interstitial fluid colloid osmotic pressure in healthy children. (external link)
• Aspelund, Aeksanteri; Antila, Salli; Proulx, Steven et al. (2015). A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. (external link)
• Sagstad, Solfrid Johanne; Oveland, Eystein; Karlsen, Tine Veronica et al. (2015). Extracellular matrix composition affects rat skin distribution volume of plasma proteins with different size and charge. (external link)
• Haslene-Hox, Hanne; Oveland, Eystein; Woie, Kathrine et al. (2015). Distribution volume of macromolecules in human ovarian and endometrial cancers - effects of extracellular matrix structure. (external link)
• Wagner, Marek; Steinskog, Eli Sihn Samdal; Wiig, Helge (2015). Adipose tissue macrophages: the inflammatory link between obesity and cancer? Invited review. (external link)
• Haslene-Hox, Hanne; Madani, Amina; Berg, Kaja Christine Graue et al. (2014). Quantification of the concentration gradient of biomarkers between ovarian carcinoma interstitial fluid and blood. (external link)
• Ebah, Laonard M.; Wiig, Helge; Dawidowska, Idalia et al. (2013). Subcutaneous interstitial pressure and volume characteristics in renal impairment associated with edema. (external link)
• Helle, Frank; Karlsen, Tine Veronica; Tenstad, Olav et al. (2013). High-salt diet increases hormonal sensitivity in skin pre-capillary resistance vessels. (external link)
• Wiig, Helge; Schroeder, Agnes; Neuhofer, Wolfgang et al. (2013). Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. (external link)
• Berggreen, Ellen; Wiig, Helge (2013). Lymphangiogenesis and lymphatic function in periodontal disease. (external link)
• Wagner, Marek; Bjerkvig, Rolf; Wiig, Helge et al. (2013). Loss of adipocyte specification and necrosis augment tumor-associated inflammation. (external link)
• Haslene-Hox, Hanne; Oveland, Eystein; Woie, Kathrine et al. (2013). Increased WD-repeat containing protein 1 in interstitial fluid from ovarian carcinomas shown by comparative proteomic analysis of malignant and healthy gynecological tissue. (external link)
• Markhus, Carl Erik Nordvik; Karlsen, Tine Veronica; Wagner, Marek et al. (2013). Increased interstitial protein because of impaired lymph drainage does not induce fibrosis and inflammation in lymphedema. (external link)
• Øien, Alf Hartvig; Justad, Sigrid Ravnsborg; Tenstad, Olav et al. (2013). Effects of Hydration on Steric and Electric Charge-Induced Interstitial Volume Exclusion-a Model. (external link)
• Haslene-Hox, Hanne; Tenstad, Olav; Wiig, Helge (2013). Interstitial fluid-a reflection of the tumor cell microenvironment and secretome. (external link)
• Rosengren, Bert-Inge; Sagstad, Solfrid Johanne; Karlsen, Tine Veronica et al. (2013). Isolation of interstitial fluid and demonstration of local proinflammatory cytokine production and increased absorptive gradient in chronic peritoneal dialysis. (external link)
• Guthe, Hans Jørgen Timm; Nedrebø, Torbjørn; Tenstad, Olav et al. (2012). Effect of topical anaesthetics on interstitial colloid osmotic pressure in human subcutaneous tissue sampled by wick technique. (external link)
• Wagner, Marek; Bjerkvig, Rolf; Wiig, Helge et al. (2012). Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis. (external link)
• Mkonyi, Lilian Ephrem; Bletsa, Athanasia; Bolstad, Anne Isine et al. (2012). Gingival lymphatic drainage protects against porphyromonas gingivalis-induced bone loss in mice. (external link)
• Karlsen, Tine Veronica; McCormack, Emmet Martin; Mujic, Maja et al. (2012). Minimally invasive quantification of lymph flow in mice and rats by imaging depot clearance of near-infrared albumin. (external link)
• Oveland, Eystein; Karlsen, Tine Veronica; Haslene-Hox, Hanne et al. (2012). Proteomic Evaluation of Inflammatory Proteins in Rat Spleen Interstitial Fluid and Lymph during LPS-Induced Systemic Inflammation Reveals Increased Levels of ADAMST1. (external link)
• Haslene-Hox, Hanne; Oveland, Eystein; Berg, Kaja Christine Graue et al. (2011). A new method for isolation of interstitial fluid from human solid tumors applied to proteomic analysis of ovarian carcinoma tissue. (external link)
• Rutkowski, Joseph M.; Markhus, Carl Erik; Gyenge, Christina et al. (2010). Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema. (external link)
• Wiig, Helge; Keskin, D; Kalluri, Raghu (2010). Interaction between the extracellular matrix and lymphatics: consequences for lymphangiogenesis og lymphatic function. (external link)
• Curry, Fitz-Roy E.; Brekke, Cecilie; Karlsen, Tine Veronica et al. (2010). Atrial natriuretic peptide modulation of albumin clearance and contrast agent permeability in mouse skeletal muscle and skin: role in regulation of plasma volume. (external link)
• Mounzer, Rawad H; Svendsen, Øyvind Sverre; Baluk, Peter et al. (2010). Lymphotoxin-alpha contributes to lymphangiogenesis. (external link)
• Brekke, Hege Kristin; Oveland, Eystein; Kolmannskog, Odd et al. (2010). Isolation of interstitial fluid in skin during volume expansion: evaluation of a method in pigs. (external link)
• Mkonyi, Lilian Ephrem; Bletsa, Athanasia; Fristad, Inge et al. (2010). Importance of lymph vessels in transcapillary fluid balance in gingiva studied in a transgenic mouse model. (external link)
• Semaeva, Elvira; Tenstad, Olav; Skavland, Jørn et al. (2010). Access to the spleen microenvironment through lymph shows local cytokine production, increased cell flux, and altered signaling of immune cells during lipopolysaccharide-induced acute inflammation. (external link)
• Wiig, Helge; Tenstad, Olav; Iversen, Per Ole et al. (2010). Interstitial fluid: the overlooked component of the tumor microenvironment?. (external link)
• Iversen, Per Ole; Semaeva, Elvira; Sørensen, Dag R. et al. (2009). Dendritic cells loaded with tumor antigens and a dual immunostimulatory and anti-IL-10 specific siRNA can prime T lymphocytes against leukemic cells. (external link)
• Borge, Bengt Åge Sørby; Kalland, Karl-Henning; Olsen, Sue et al. (2009). Cytokines are produced locally by myocytes in rat skeletal muscle during endotoxemia. (external link)
• Svendsen, Øyvind Sverre; Barczyk, Malgorzata; Popova, Svetlana et al. (2009). The alpha 11 beta 1 integrin has a mechanistic role in control of interstitial fluid pressure and edema formation in inflammation. (external link)
• Hofmann, Matthias; McCormack, Emmet Martin; Mujic, Maja et al. (2009). Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumour model. (external link)
• Rehn, Tommy A.; Borge, Bengt Åge Sørby; Lunde, Per K. et al. (2009). Temporary fatigue and altered extracellular matrix in skeletal muscle during progression of heart failure in rats. (external link)
• Stuhr, Linda Elin Birkhaug; Moen, Ingrid; Nedrebø, Torbjørn et al. (2008). Peritumoral TNFalpha administration influences tumor stroma structure and physiology independently of growth in DMBA-induced mammary tumours. (external link)
• Stuhr, Linda Elin Birkhaug; Moen, Ingrid; Nedrebø, Torbjørn et al. (2008). Peritumoral TNF alpha administration influences tumour stroma structure and physiology independently of growth in DMBA-induced mammary tumours. (external link)
• Niclou, Simone P; Danzeisen, Claude; Eikesdal, Hans Petter et al. (2008). A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. (external link)
• Wiig, Helge; Gyenge, Christina; Iversen, Per Ole et al. (2008). The role of the extracellular matrix in tissue distribution of macromolecules in normal and pathological tissues: Potential therapeutic consequences. (external link)
• Semaeva, Elvira; Tenstad, Olav; Bletsa, Athanasia et al. (2008). Isolation of rat trachea interstitial fluid and demonstration of local cytokine production in lipopolysaccharide-induced systemic inflammation. (external link)
• Choi, Jaehwa; Credit, Kimberly; Henderson, Karla et al. (2006). Intraperitoneal immunotherapy for metastatic ovarian carcinoma: Resistance of intratumoral collagen to antibody penetration. (external link)
• Salnikov, Alexei V.; Heldin, Nils-Erik; Stuhr, Linda Elin Birkhaug et al. (2006). Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinoma. (external link)
• Bletsa, Athanasia; Berggreen, Ellen; Fristad, Inge et al. (2006). Cytokine signalling in rat pulp interstitial fluid and transcapillary fluid exchange during lipopolysaccharide-induced acute inflammation. (external link)
• Hofmann, Matthias; Guschel, Maike; Bernd, August et al. (2006). Lowering of tumor interstitial fluid pressure reduces tumor cell proliferation in a xenograft tumor model. (external link)
• Negrini, Daniela; Tenstad, Olav; Passi, Alberto et al. (2006). Differential degradation of matrix proteoglycans and edema development in rabbit lung. (external link)
• Karlsen, Tine Veronica; Alitalo, Kari; Karkkainen, Marika J. et al. (2006). Transcapillary fluid balance consequences of missing initial lymphatics studied in a mouse model of primary lymphoedema. (external link)
• Berggreen, Ellen; Wiig, Helge (2006). Lowering of interstitial fluid pressure in rat submandibular gland: a novel mechanism in saliva secretion. (external link)
• Wiig, Helge; Iversen, Per Ole (2005). Tumor necrosis factor alpha and adiponectin in bone marrow interstitial fluid from patients with acute myeloid leukemia inhibit normal hematopoiesis. (external link)
• Iversen, Per Ole; Wiig, Helge (2005). Tumor necrosis factor alpha and adiponectin in bone marrow interstitial fluid from patients with acute myeloid leukemia inhibit normal hematopoiesis. (external link)
• Wiig, Helge; Gyenge, Christina; Tenstad, Olav (2005). The interstitial distribution of macromolecules in rat tumours is influenced by the negatively charged matrix components. (external link)
• Wiig, Helge; Tenstad, Olav; Bert, Joel L. (2005). Effect of hydration on interstitial distribution of charged albumin in rat dermis in vitro. (external link)
• Nedrebø, Torbjørn; Reed, Rolf Kåre; Jonsson, Roland et al. (2004). Differential cytokine response in interstitial fluid in skin and serum during experimental inflammation in rats. (external link)
• Uutela, Marko; Wirzenius, Maria; Paavonen, Karri et al. (2004). PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. (external link)
• Wiig, Helge; Berggreen, Ellen; Borge, Bengt Åge Sørby et al. (2004). Demonstration of altered signaling responses in bone marrow extracellular fluid during increased hematopoiesis in rats using a centrifugation method. (external link)
• Markhus, Carl Erik; Wiig, Helge (2004). Isolation of interstitial fluid from skeletal muscle and subcutis in mice using a wick method. (external link)
• Rosengren, Bert Inge; Rippe, Bengt; Tenstad, Olav et al. (2004). Acute peritoneal dialysis in rats results in a marked reduction of interstitial colloid osmotic pressure. (external link)
• Uutela, Marko; Wirzenius, Maria; Paavonen, Karri et al. (2004). PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. (external link)
• Wright, David Michael; Wiig, Helge; Winlove, C P et al. (2003). Simultaneous measurement of interstitial fluid pressure and load in rat skin after strain application in vitro. (external link)
• Negrini, Daniela; Tenstad, Olav; Wiig, Helge (2003). Interstitial exclusion of albumin in rabbit lung during development of pulmonary oedema. (external link)
• Negrini, Daniela; Tenstad, Olav; Wiig, Helge (2003). Interstitial exclusion of albumin in rabbit lung measured with the continuous infusion method in combination with the wick technique. (external link)
• Wiig, Helge; Kolmannskog, Odd; Tenstad, Olav et al. (2003). Effect of charge on interstitial distribution of albumin in rat dermis in vitro. (external link)
• Stuhr, Linda EB; Reith, Alison; Lepsøe, Sigrid et al. (2003). Fluid pressure in human dermal fibroblast aggregates measured with micropipettes. (external link)
• Wiig, Helge; Aukland, Knut; Tenstad, Olav (2003). Isolation of interstitial fluid from rat mammary tumors by a centrifugation method. (external link)
• Wiig, Helge; Rubin, Kristofer; Reed, Rolf Kåre (2003). New and active role of the interstitium in control of interstitial fluid pressure: potential therapeutic consequences. (external link)
• Gyenge, Christina; Tenstad, Olav; Wiig, Helge (2003). In vivo determination of steric and electrostatic exclusion of albumin in rat skin and skeletal muscle. (external link)
• Berggreen, Ellen; Wiig, Helge; Heyeraas, Karin Johanne (2003). Blood flow and interstitial fluid pressure in the rat submandibular gland during changes in perfusion. (external link)
• Wright, David; Wiig, Helge; Winlove, Peter et al. (2003). Simultaneous measurement of interstitial fluid pressure and load in rat skin after strain application in vitro. (external link)
• Negrini, Daniela; Passi, Alberto; Bertin, Katia et al. (2001). Isolation of pulmonary interstitial fluid in rabbits by a modified wick technique. (external link)
• Wiig, Helge; Tenstad, Olav (2001). Interstitial exclusion of positively and negatively charged IgG in rat skin and muscle. (external link)
• Kajimura, Majumi; Wiig, Helge; Reed, Rolf Kåre et al. (2001). Interstitial fluid pressure surrounding rat mesenteric venules during changes in fluid filtration. (external link)
• Wiig, Helge; Lund, Tjøstolv (2001). Relationship between interstitial fluid volume and pressure (compliance) in hypothyroid rats. (external link)
• Aukland, Knut; Tenstad, Olav; Wiig, Helge (2001). Distribution spaces for hyaluronan and albumin in rat tail tendons. (external link)
• Tenstad, Olav; Heyeraas, Karin Johanne; Wiig, Helge et al. (2001). Drainage of plasma proteins from renal medullary interstitium in rats. (external link)
• Zhang, W. B.; Aukland, Knut; Lund, T. et al. (2000). Distribution of interstitial fluid pressure and fluid volumes in hind-limb skin of rats: relation to meridians?. (external link)
• Wiig, Helge; Reed, Rolf Kåre; Tenstad, Olav (2000). Interstitial fluid pressure, composition of interstitium, and interstitial exclusion of albumin in hypothyroid rats. (external link)
• Tanaka, Hideharu; Lund, T; Wiig, Helge et al. (1999). High dose vitamin-C counteracts the negative interstitial fluid hydrostatic pressure and early edema generation in thermally injured rats. (external link)
• Tanaka, Hideharu; Lund, Tjøstolv; Wiig, Helge et al. (1999). High dose Vitamin C counteracts the negative interstitial fluid hydrostatic pressure and early edema generation in thermally injured rats. (external link)
• Aukland, Knut; Reed, Rolf Kåre; Wiig, Helge (1997). The problem of gaining access to interstitial fluid. An attempt to rationalize a wicked discussion on wicks. (external link)
• Aukland, Knut; Wiig, Helge; Tenstad, Olav et al. (1997). Interstitial exclusion of macromolecules studied by graded centrifugation. (external link)
• Kvåle, R; Reed, RK; Wiig, Helge et al. (1996). Iontoforese - gammelt prinsipp - nye bruksområder. (external link)
• Reed, Rolf Kåre; Rubin, Kristofer; Wiig, Helge et al. (1992). Blockade of _b%b-Integrins in skin causes edema through lowering of interstitial fluid pressure. (external link)
• Wiig, Helge; Sibley, L.; Decarlo, M. et al. (1991). Sampling interstitial fluid from rat skeletal muscle by intermuscular wicks. (external link)

Academic chapter/article/Conference paper

• Wagner, Marek; Wiig, Helge (2022). Lymphatics in Malignant Tumors. (external link)
• Svendsen, Øyvind Sverre; Reed, Rolf K.; Wiig, Helge (2011). The interstitium and lymphatics have an important role in edema generation during sepsis. (external link)
• Reed, Rolf Kåre; Wiig, Helge; Lund, T. et al. (1992). Interstitial fluid pressure in control of interstitial fluid volume during normal conditions, injury and inflammation. (external link)
• Reed, Rolf Kåre; Wiig, Helge; Lund, T. et al. (1992). Interstitial fluid pressure in control of interstitial fluid volume during normal conditions, injury and inflammation. (external link)
• Aukland, K.; Heyeraas, Karin Johanne; Wiig, Helge (1991). Arterial resistance in rat tail and kidney. (external link)

Editorial

• Wiig, Helge (2021). As for blood vessels, the answer regarding lymphatics is often NO. (external link)
• Wiig, Helge (2018). Regulation of Fluid Volume From the Outside A Role of Glycosaminoglycans in the Skin Interstitium?. (external link)
• Robert, Thomas; Moktefi, Anissa; Wiig, Helge et al. (2013). Acute kidney failure with renal carcinomatous lymphangitis secondary to advanced colon cancer. (external link)
• Wiig, Helge (2008). Plasma protein charge: a majon determinant of fluid exchange. (external link)

Poster

• Virtej, Anca; Tenstad, Olav; Wiig, Helge et al. (2019). Protein-rich fluid dynamics from the periapical mandibular area in rats. (external link)
• Virtej, Anca; Tenstad, Olav; Wiig, Helge et al. (2018). Lymphatic transport route from the dental pulp. (external link)
• Rehn, Tommy Aune; Borge, BA; Lunde, Per Kristian et al. (2008). Temporary fatigue and altered extracellular matrix in skeletal muscle during progression of heart failure in rats. (external link)
• Rehn, Tommy Aune; Borge, BA; Lunde, Per Kristian et al. (2008). Temporary alterations in skeletal muscle extracellular matrix during progression of congestive heart failure in rats. (external link)
• Lunde, Per Kristian; Borge, BÅS; Stranda, Annicke et al. (2006). Contribution of skeletal muscle to cytokine production in heart failure. (external link)
• Berggreen, Ellen; Heyeraas, Karin Johanne; Wiig, Helge (2001). Blood flow and interstitial fluid pressure during changes in perfusion and after nervous stimulation in rat submandibular gland. (external link)
• Negrini, Daniela; Passi, Alberto; Bertin, Katia et al. (2000). Isolation of pulmonary interstitial fluid by a modified wick technique. (external link)

Doctoral dissertation

• Steinskog, Eli Sihn Samdal; Wiig, Helge; Tenstad, Olav et al. (2017). Role of the microenvironment and lymphatics in cancer development. (external link)
• Eigenmann, Miro Julian; Wiig, Helge (2017). Application of combined experimental and translational modeling approaches in early drug development. (external link)
• Esfahlan, Elham Nikpey; Wiig, Helge (2017). Role of the Extracellular Microenvironment and Lymphatics in Electrolyte and Blood Pressure Regulation. (external link)
• Sagstad, Solfrid Johanne; Wiig, Helge (2014). Role of the extracellular microenvironment and lymphatics in disease development and progression. (external link)
• Wiig, Helge (1986). Insterstitial fluid pressure and the relationship between interstitial fluid volume and pressure (compliance) in various organs and species. (external link)

Masters thesis

• Tofteberg, Anne; Wiig, Helge; Karlsen, Tine Veronica (2014). Interstitial Phenotype and Lymphatic Function in Mice Overexpressing Vascular Endothelial Growth Factor-C. (external link)
• Jonassen, Anne K.; Wiig, Helge; Boardman, Neoma Tove (2006). Evaluation of the effect of direct activation of p70s6 kinase on cell survival after ischemic-reperfusion. (external link)

Abstract

• Tenstad, Olav; Bivol, Liliana Monica; Iversen, Bjarne Magnus et al. (2013). Renal ischemia-reperfusion (I/R) injury induces a rapid activation of local inflammatory markers and causes increased peritubular permeability. (external link)
• Wiig, Helge; Karlsen, Tine Veronica; Tenstad, Olav et al. (2013). Increased interstitial osmolality in skin of rats on a high salt diet. (external link)
• Ebah, Leonard; Oveland, Eystein; Read, Ian et al. (2012). A LOOK BEYOND BLOOD IN THE UREMIC SYNDROME: COMPARATIVE ANALYSIS OF INTERSTITIAL FLUID AND PLASMA IN KIDNEY DISEASE. (external link)
• Ebah, Leonard; Nikam, Milin; Summers, Angela et al. (2012). PRESSURE-VOLUME RELATIONSHIPS IN THE INTERSTITIAL COMPARTMENT OF PATIENTS WITH RENAL DYSFUNCTION AND OEDEMA; CLINICAL CORRELATES AND IMPLICATIONS FOR VOLUME ASSESSMENT. (external link)
• Titze, Jens; Karlson, Tine; Boschmann, Micheal et al. (2011). Salt-sensitive hypertension is paralleled by sodium storage, interstitial hypertonicity, and increased interstitial fluid pressure in the skin. (external link)
• Mounzer, Rawad H; Bentley, Kris; Svendsen, Øyvind Sverre et al. (2011). LTalpha CONTRIBUTES TO LYMPHATIC VESSEL DEVELOPMENT AND FUNCTION. (external link)
• Brekke, Hege Kristin; Oveland, Eystein; Tenstad, Olav et al. (2010). ISOLATION AND IDENTIFICATION OF INFLAMMATORY SPECIFIC PROTEINS IN INTERSTITIAL FLUID IN SKIN DURING ACUTE OVERHYDRATION. (external link)
• Hofmann, Matthias; McCormack, Emmet Martin; Bernd, A et al. (2009). Intravenous application of serum albumin reduces the tumour interstitial fluid pressure and increases the absorption of therapeutics in a xenograft model. (external link)
• Iversen, Per Ole; Semaeva, Elvira; Sorensen, DR et al. (2009). A combined immunostimulatory and immunoinhibitory sirna with anti-leukemic properties in a rat model of acute myeloid leukemia. (external link)
• Rehn, Tommy Aune; Lunde, Per Kristian; Borge, BA et al. (2008). Contribution of skeletal muscle to cytokine production in heart failure. (external link)
• Hofmann, Matthias; McCormack, Emmet Martin; Wiig, Helge et al. (2008). Application of serum albumin lowers tumour interstitial fluid pressure and increases the uptake of macromolecules in a xenograft tumour model. (external link)
• Hofmann, Matthias; McCormack, Emmet Martin; Wiig, Helge et al. (2007). Enhanced colloid osmotic pressure facilitates the uptake of macromolecules in a xenograft tumour model. (external link)
• Hofmann, Matthias; McCormack, Emmet Martin; Wiig, Helge et al. (2007). Increased uptake of macromolecules in a xenograft tumour model is facilitated via enhanced colloid osmotic pressure. (external link)
• Rosengren, Bert-Inge; Gyenge, Christina; Olsen, Sue et al. (2006). Interstitial colloid osmotic pressures after chronic endothelial no production contributes to peritoneal dialysis. (external link)
• Semaeva, Elvira; Gjerde, Eli-Anne Birgitte; Tenstad, Olav et al. (2006). Isolation of interstitial fluid and identification inflammatory mediators in rat trachea. (external link)
• Hofmann, Matthias; Guschel, Maike; Salvesen, Gerd Signe et al. (2006). Increased colloid osmotic pressure enhances the uptake of macromolecules in a xenograft tumor model. (external link)
• Wiig, Helge; Gyenge, Christina; Tenstad, Olav (2005). Extracellular distribution of monoclonal antibodies and other macromolecules in tumors. (external link)
• Karlsen, Tine Veronica; Karkkainen, M; Alitalo, K et al. (2005). Fluid volume regulation parameters in a mouse model of primary lymphedema. (external link)
• Iversen, PO; Wiig, Helge (2005). Impaired hematopoiesis in acute myeloid leukemia is associated with elevated levels of tumor necrosis factor alpha and adiponectin in bone marrow, but not in plasma. (external link)

Academic lecture

• Wiig, Helge; Tenstad, Olav (2000). Exclusion of positively and negatively charged IgG in rat skin and muscle interstitium. (external link)
• Reed, Rolf Kåre; Rubin, Kristofer; Wiig, Helge et al. (1993). Blockade of _b%b-integrins in skin causes edema through lowering of interstitial fluid pressure, (Pif). (external link)

Report

• Hope, A; Lund, T; Elliot, D et al. (1994). Long term health effect of diving. (external link)

Non-fiction book

• Hope, A.; Lund, T.; Elliott, D. H. et al. (1994). Long term health effects of diving. (external link)
• Hope, T.; Lund, T.; Elliott, D. H. et al. (1994). Long Term Health Effects of Diving. (external link)

See a complete overview of publications in Cristin.