Lab website

Center for Cancer Biomarkers website

Academic article

• Grøndal, Sturla Magnus; Tutusaus, Anna; Boix, Loreto et al. (2024). Dynamic changes in immune cell populations by AXL kinase targeting diminish liver inflammation and fibrosis in experimental MASH. (external link)
• Marquez-Palencia, Mauricio; Reza Herrera, Luis; Parida, Pravat Kumar et al. (2024). AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer. (external link)
• Rayford, Austin James; Gärtner, Fabian; Ramnefjell, Maria Paula et al. (2024). AXL expression reflects tumor-immune cell dynamics impacting outcome in non-small cell lung cancer patients treated with immune checkpoint inhibitor monotherapy. (external link)
• Tenstad, Olav; Christakou, Eleni; Hodneland Nilsson, Linn et al. (2024). In vivo turnover and biodistribution of soluble AXL: implications for biomarker development. (external link)
• Knutsen, Erik; Sajib, Saikat Das; Fiskaa, Tonje et al. (2023). Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes. (external link)
• Lotsberg, Maria Lie; Røsland, Gro Vatne; Rayford, Austin James et al. (2022). Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models. (external link)
• Larrieu, Claire M.; Storevik, Simon Humberto; Guyon, Joris et al. (2022). Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development. (external link)
• Liu, Xiaozheng; Rulina, Anastasiia; Choi, Man Hung et al. (2022). C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer. (external link)
• Ekanger, Camilla Tvedt; Zhou, Fan; Bohan, Dana et al. (2022). Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 respiratory virus. (external link)
• Engelsen, Agnete Svendsen Tenfjord; Lotsberg, Maria Lie; Khouzam, Raefa Abou et al. (2022). Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition. (external link)
• Li, Huiyu; Liu, Zhida; Liu, Longchao et al. (2022). AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1⁺ CD8 T cells. (external link)
• Dyrstad, Sissel Elisabeth; Lotsberg, Maria Lie; Tan, Tuan Zea et al. (2021). Blocking aerobic glycolysis by targeting pyruvate dehydrogenase kinase in combination with EGFR TKI and ionizing radiation increases therapeutic effect in non-small cell lung cancer cells. (external link)
• Hoel, August; Osman, Tarig; Hoel, Fredrik et al. (2021). Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model. (external link)
• Wogsland, Cara Ellen; Lien, Hilde Eide; Pedersen, Line et al. (2021). High-dimensional immunotyping of tumors grown in obese and non-obese mice. (external link)
• Chen, Tony Jialiang; Mydel, Piotr Mateusz; Benedyk-Machaczka, Małgorzata et al. (2021). AXL targeting by a specific small molecule or monoclonal antibody inhibits renal cell carcinoma progression in an orthotopic mice model. (external link)
• Beitzen-Heineke, Antonia; Berenbrok, Nikolaus; Lorens, James Bradley (2021). AXL Inhibition Represents a Novel Therapeutic Approach in BCR-ABL Negative Myeloproliferative Neoplasms. (external link)
• Bohan, Dana; Van Ert, Hanora; Ruggio, Natalie et al. (2021). Phosphatidylserine receptors enhance SARS-CoV-2 infection. (external link)
• Terry, Stéphane; Dalban, Cécile; Rioux-Leclerq, Nathalie et al. (2021). Association of AXL and PD-L1 Expression with Clinical Outcomes in Patients with Advanced Renal Cell Carcinoma Treated with PD-1 Blockade. (external link)
• Du, Wenting; Phinney, Natalie Z.; Huang, Huocong et al. (2021). AXL is a key factor for cell plasticity and promotes metastasis in Pancreatic cancer. (external link)
• Engelsen, Agnete ; Wnuk-Lipinska, Katarzyna; Bougnaud, Sébastien et al. (2020). AXL is a driver of stemness in normal mammary gland and breast cancer. (external link)
• Bae, Cheong A; Ham, In-Hye; Oh, Hye Jeong et al. (2020). Inhibiting the GAS6/AXL axis suppresses tumor progression by blocking the interaction between cancer-associated fibroblasts and cancer cells in gastric carcinoma. (external link)
• Lotsberg, Maria Lie; Wnuk-Lipinska, Katarzyna; Terry, Stéphane et al. (2020). AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells. (external link)
• Terry, Stéphane; Abdou, Abderemane; Svendsen, Agnete et al. (2019). AXL targeting overcomes human lung cancer cell resistance to NK- And CTL-mediated cytotoxicity. (external link)
• Tutusaus, Anna; de Gregorio, Estefanía; Cucarull, Blanca et al. (2019). A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target. (external link)
• Røsland, Gro Vatne; Dyrstad, Sissel Elisabeth; Tusubira, Deusdedit et al. (2019). Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC.. (external link)
• Landolt, Lea Zoe; Furriol, Jessica; Babickova, Janka et al. (2019). AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction. (external link)
• Sharma, Sunita; Xue, Ying; Xing, Zhe et al. (2019). Adenoviral mediated mono delivery of BMP2 is superior to the combined delivery of BMP2 and VEGFA in bone regeneration in a critical-sized rat calvarial bone defect. (external link)
• Bozickovic, Olivera; Skartveit, Linn; Svendsen, Agnete et al. (2018). A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells. (external link)
• Poirier, Marion; Awale, Mahendra; Roelli, Matthias A. et al. (2018). Identifying Lysophosphatidic Acid Acyltransferase β (LPAAT‐β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2. (external link)
• Jokela, Tiina; Svendsen, Agnete; Rybicka, Agata et al. (2018). Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance. (external link)
• Pelissier, Fanny; Schapiro, Dennis; Chang, Hang et al. (2018). High-Dimensional Phenotyping Identifies Age-Emergent Cells in Human Mammary Epithelia. (external link)
• Ludwig, Kathleen F.; Du, Wenting; Sorelle, Noah B. et al. (2017). Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer. (external link)
• Haaland, Gry Sandvik; Falk, Ragnhild Sørum; Straume, Oddbjørn et al. (2017). Association of Warfarin Use With Lower Overall Cancer Incidence Among Patients Older Than 50 Years. (external link)
• Ertsås, Henriette Christie; Nolan, Garry P.; LaBarge, Mark A. et al. (2017). Microsphere cytometry to interrogate microenvironment-dependent cell signaling. (external link)
• Terry, Stéphane; Buart, Stéphanie; Tan, Tuan Zea et al. (2017). Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity. (external link)
• Landolt, Lea Zoe; Eikrem, Øystein Solberg; Strauss, Philipp et al. (2017). Clear cell renal cell carcinoma is linked to epithelial-to-mesenchymal transition and to fibrosis. (external link)
• Ellensen, Vegard Skalstad; Abrahamsen, Iren; Lorens, James et al. (2016). Heparin Inhibits Proliferation and Migration of Patient-Derived Vascular Cells Only at Non-physiological Concentrations Due to Antagonistic Pathways. (external link)
• Hellesøy, Monica; Lorens, James (2015). Cellular context-mediated Akt dynamics regulates MAP kinase signaling thresholds during angiogenesis. (external link)
• Kirane, Amanda; Ludwig, Kathleen F.; Sorrelle, Noah et al. (2015). Warfarin blocks Gas6-mediated Axl activation required for pancreatic cancer epithelial plasticity and metastasis. (external link)
• Virtakoivu, Reetta; Mai, Anja; Mattila, Elina et al. (2015). Vimentin-ERK signaling uncouples slug gene regulatory function. (external link)
• Ocal, Ozhan; Pashkov, Victor; Kollipara, Rahul K. et al. (2015). A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics. (external link)
• Lorens, James (2015). The immortality two-step. (external link)
• Hodneland, Linn I.; Pettersen, Ina Katrine Nitschke; Nikolaisen, Julie et al. (2015). A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology. (external link)
• Hellesøy, Monica; Blois, Anna; Tiron, Crina Elena et al. (2014). Akt1 activity regulates vessel maturation in a tissue engineering model of angiogenesis. (external link)
• Ellensen, Vegard Skalstad; Abrahamsen, Iren; Lorens, James et al. (2014). Effects of enoxaparin and dalteparin on proliferation and migration of patient-derived vascular smooth muscle cells . (external link)
• Nikolaisen, Julie; Hodneland, Linn I.; Pettersen, Ina Katrine Nitschke et al. (2014). Automated quantification and integrative analysis of 2D and 3D mitochondrial shape and network properties. (external link)
• Ellensen, Vegard Skalstad; Abrahamsen, Iren; Lorens, James et al. (2014). Auswirkungen von enoxaparin und dalteparin auf die proliferation und migration humaner vaskulärer glatter muskelzellen aus einem patientenkollektiv. (external link)
• Pelissier, Fanny; Garbe, James C.; Ananthanarayanan, Badriprasad et al. (2014). Age-Related Dysfunction in Mechanotransduction Impairs Differentiation of Human Mammary Epithelial Progenitors. (external link)
• Pedersen, Torbjørn Østvik; Blois, Anna; Xue, Ying et al. (2014). Mesenchymal stem cells induce endothelial cell quiescence and promote capillary formation. (external link)
• Micklem, David Robert; Blø, Magnus; Bergström, Petra et al. (2014). Flow cytometry-based functional selection of RNA interference triggers for efficient epi-allelic analysis of therapeutic targets. (external link)
• Kvestad, Hilde; Evensen, Lasse; Lorens, James et al. (2014). In Vitro Characterization of Valproic Acid, ATRA, and Cytarabine Used for Disease-Stabilization in Human Acute Myeloid Leukemia: Antiproliferative Effects of Drugs on Endothelial and Osteoblastic Cells and Altered Release of Angioregulatory Mediators by Endothelial Cells.. (external link)
• Evensen, Lasse; Odlo, Kristin; Micklem, David Robert et al. (2013). Contextual compound screening for improved therapeutic discovery. (external link)
• Abrahamsen, Iren; Lorens, James (2013). Evaluating extracellular matrix influence on adherent cell signaling by cold trypsin phosphorylation-specific flow cytometry. (external link)
• Ben-Batalla, Isabel; Schultze, Alexander; Wroblewski, Mark et al. (2013). Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma. (external link)
• Pedersen, Torbjørn Østvik; Blois, Anna; Xing, Zhe et al. (2013). Endothelial microvascular networks affect gene-expression profiles and osteogenic potential of tissue-engineered constructs. (external link)
• Olsen, Jan Roger; Øyan, Anne Margrete; Rostad, Kari et al. (2013). p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. (external link)
• Raddum, Aase Merethe; Evensen, Lasse; Hollås, Hanne et al. (2013). Domains I and IV of annexin A2 affect the formation and integrity of in vitro capillary-like networks. (external link)
• McCormack, Emmet ; Silden, Elisabeth; West, Richard M. et al. (2013). Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer. (external link)
• McCormack, Emmet Martin; Haaland, Ingvild; Venås, Gurid et al. (2012). Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia. (external link)
• Sapkota, Dipak; Costea, Daniela Elena; Blø, Magnus et al. (2012). S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest. (external link)
• Oveland, Eystein; Wergeland, Line; Hovland, Randi et al. (2012). Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines. (external link)
• Pedersen, Torbjørn; Blois, Anna; Xue, Ying et al. (2012). Osteogenic stimulatory conditions enhance growth and maturation of endothelial cell microvascular networks in culture with mesenchymal stem cells. (external link)
• Radi, Marco; Evensen, Lasse; Dreassi, Elena et al. (2012). A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation. (external link)
• Hatfield, Kimberley Joanne; Evensen, Lasse; Reikvam, Håkon et al. (2012). Soluble mediators released by acute myeloid leukemia cells increase capillary-like networks. (external link)
• Christodoulou, Michael S; Zunino, Franco; Zuco, Valentina et al. (2012). Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation. (external link)
• Vuoriluoto, Karoliina; Haugen, Hallvard; Kiviluoto, Santeri et al. (2011). Vimentin regulates EMT induction by Slug and oncogenic H-ras and migration by governing Axl expression in breast cancer. (external link)
• Hegen, Anja; Blois, Anna; Tiron, Crina Elena et al. (2011). Efficient in vivo vascularization of tissue-engineering scaffolds. (external link)
• Napolitano, Carmela; Natoni, Alessandro; Santocanale, Corrado et al. (2011). Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation. (external link)
• Wang, Jian; Daphu, Inderjit Kaur; Pedersen, Paal-Henning et al. (2011). A novel brain metastases model developed in immunodeficient rats closely mimics the growth of metastatic brain tumours in patients. (external link)
• Riva, Elena; Comi, Daniella; Borrelli, Stella et al. (2010). Synthesis and biological evaluation of new camptothecin derivatives obtained by modification of position 20. (external link)
• Napolitano, Carmela; Natoni, Alessandro; Santocanale, Corrado et al. (2010). Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcyclic acid lactone series and biological evaluation. (external link)
• Gjerdrum, Christine; Tiron, Crina Elena; Høiby, Torill et al. (2010). Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. (external link)
• Evensen, Lasse; Micklem, David Robert; Link, Wolfgang et al. (2010). A novel imaging-based high-throughput screening approach to anti-angiogenic drug discovery. (external link)
• Evensen, Lasse; Micklem, David Robert; Link, W et al. (2009). A novel imaging-based high-throughput screening approach to anti-angiogenic drug discovery. (external link)
• Parlati, Francesco; Lee, Susan J.; Aujay, Monette et al. (2009). Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. (external link)
• Evensen, Lasse; Micklem, David Robert; Blois, Anna et al. (2009). Mural cell associated VEGF is required for organotypic vessel formation. (external link)
• Blø, Magnus; Micklem, David Robert; Lorens, James (2008). Enhanced gene expression from retroviral vectors. (external link)
• Blø, Magnus; Bogenberger, Jakob M.; Swift, Susan E. et al. (2007). Expanding the spectrum of genetic elements transferable by retroviral vectors. (external link)
• McCormack, Emmet Martin; Micklem, David Robert; Pindard, Lars Erik et al. (2007). In vivo optical Imaging of acute myeloid leukemia by green fluorescent protein: Time-domain autofluorescence decoupling, fluorophore quantification, and localization. (external link)
• Bjørndal, Bodil; Myklebust, Line Merethe; Rosendal, Ken Roger et al. (2007). RACK1 regulates Ki-Ras-mediated signaling and morphological transformation of NIH 3T3 cells. (external link)
• Stapnes, Camilla I; Døskeland, Anne Paulus; Hatfield, Kimberley Joanne et al. (2007). The proteasome inhibitors bortezomib and PR-171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells. (external link)
• Blø, Magnus; Micklem, David Robert; Lorens, James (2007). Target discovery using retroviruses. (external link)
• Hitoshi, Y; Demo, SD; Masuda, E et al. (2004). Isolation of Genetic Effectors using the Tetracycline-Regulatable System. (external link)
• Lorens, James; Pearsall, DM; Swift, SE et al. (2004). Stable, stoichiometric delivery of diverse protein functions. (external link)
• Oppen-Berntsen, Dag Oskar; Arukwe, Augustine; Yadetie, Fekadu et al. (1999). Salmon eggshell protein expression: A marker for environmental estrogens. (external link)
• Oppen-Berntsen, Dag Oscar; Arukwe, Augustine; Yadetie, Fekadu et al. (1999). Salmon Eggshell Protein Expression: A Marker for Environmental Estrogens.. (external link)
• Amirthalingam, K.; Lorens, James; Sætre, B. O. et al. (1995). Embryonic expression and DNA-binding properties of zebrafish pax-6. (external link)
• Lorens, James; Nerland, Audun H.; Aasland, Rein et al. (1993). Expression of growth hormone genes in Atlantic salmon. (external link)
• Male, Rune; Lorens, James; Nerland, Audun H. et al. (1993). Biotechnology in Aquaculture, with Special Reference to Transgenic Salmon. (external link)
• Male, Rune; Nerland, Audun H.; Lorens, James et al. (1992). The complete nucleotide sequence of the Atlantic salmon growth hormone I gene. (external link)

Masters thesis

• Guttormsen, Maren Sofie Faldalen; Engelsen, Agnete ; Lorens, James et al. (2023). Predictive Biomarkers Beyond Next Generation Sequencing: Functional Testing of Homologous Recombination Repair Deficiency Status in Patient-Derived Tissue Cultures. (external link)
• Rayford, Austin James; Lorens, James; Svendsen, Agnete (2019). The Role of Axl in Cancer and Stem Cell Plasticity: in vivo Lineage Tracing and Imaging Mass Cytometry Analysis. (external link)
• Siraji, Muntequa Ishtiaq; Aarsaether, Niels; Lorens, James (2018). Investigating the role of vitamin K in Axl-mediated melanoma progression and chemotherapeutic resistance. (external link)
• Dhakal, Sushil; Lorens, James; Aarsaether, Niels (2017). Axl Inhibition Enhances Sensitivity of BRAF Mutant Melanoma Cells to Vemurafenib. (external link)
• Kang, Jing; Aarsaether, Niels; Lorens, James (2015). The role of Axl in melanoma metastasis. (external link)
• Lie, Maria Kolnes; Lorens, James (2013). In vitro phenotypic patterning of vascular cells by nano- and micro-design of the matrix substatum. (external link)
• Dyrstad, Sissel Elisabeth; Tronstad, Karl Johan; Lorens, James (2013). Metabolic reprogramming in Slug and Twist overexpressing MCF10A cells. (external link)
• Manandar, Dina; Tronstad, Karl Johan; Lorens, James (2012). A study of mitochondrial function, ROS and signaling in Twist overexpressing cells. (external link)
• Håvardstun, Agathe; Aarsaether, Niels; Lorens, James (2010). Effekten av arakidonsyremetabolitten prostaglandin E2 (PGE2) på humane endotelceller. (external link)
• Hellesøy, Monica; Lorens, James (2008). Assessing Blood Vessel Formation and Maturation in Tissue Engineering Implants -The Role of Akt Kinase. (external link)
• Witsø, Solveig Lund; Lorens, James; Aarsaether, Niels (2008). The disruption of VEGF signalling by the inhibition of delta 5- fatty acid desaturase (dFADS) in HUVECs. (external link)
• Heggland, Ragnhild; Aarsaether, Niels; Lorens, James (2006). Knockdown of p110β subunit of phosphatidylinositol 3-kinase in human umbilical vein endothelial cells with small interfering RNA. (external link)

Academic literature review

• Lotsberg, Maria Lie; Rayford, Austin James; Thiery, Jean Paul et al. (2020). Decoding cancer’s camouflage: epithelial-mesenchymal plasticity in resistance to immune checkpoint blockade. (external link)
• Ferreira, Bibiana I.; Lie, Maria Kolnes; Svendsen, Agnete et al. (2017). Adaptive mechanisms of resistance to anti-neoplastic agents. (external link)
• LaBarge, Mark A.; Parvin, Bahram; Lorens, James (2014). Molecular deconstruction, detection, and computational prediction of microenvironment-modulated cellular responses to cancer therapeutics. (external link)
• Evensen, Lasse; Link, Wolfgang; Lorens, James (2010). Image-based high-throughput screening for anti-angiogenic drug discovery. (external link)
• Zanella, Fabian; Lorens, James; Link, Wolfgang (2010). High content screening: seeing is believing. (external link)
• Micklem, David Robert; Lorens, James (2007). RNAi screening for therapeutic targets in human malignancies. (external link)
• Skaftnesmo, Kai Ove; Prestegarden, Lars; Micklem, David Robert et al. (2007). MicroRNAs in tumorigenesis. (external link)

Editorial

• Chouaib, Salem; Lorens, James (2020). Editorial: Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy. (external link)

Academic chapter/article/Conference paper

• Lotsberg, Maria Lie; Chen, Ying Yi; Dhakal, Sushil et al. (2020). Autophagy mediated danger signaling regulates tumor immunosurveillance and may potentiate the effects of anti-cancer immunotherapy through increased adjuvanticity. (external link)
• Davidsen, Kjersti; Haaland, Gry Sandvik; Lie, Maria Kolnes et al. (2017). The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance. (external link)
• Evensen, Lasse; Link, Wolfgang; Lorens, James (2013). Image-based high-throughput screening for inhibitors of angiogenesis. (external link)
• Mora-Blanco, Lorena E.; Lorens, James; LaBarge, Mark A. (2013). The Tumor Microenvironment as a Transient Niche: A Modulator of Epigenetic States and Stem Cell Funct. (external link)
• Gjertsen, Bjørn Tore; Lorens, James (2008). Comprehensive Analysis of Gene Function: RNA interference and Chemical Genomics. (external link)
• Lossius, Ivar; Kryvi, Harald; Lorens, James et al. (1993). Cloning and characterization of growth regulating genes from Atlantic salmon: A strategy for increasing growth rate by microinjection of a modified growth hormone gene into fertilized salmon eggs. (external link)

Doctoral dissertation

• Lotsberg, Maria Lie; Lorens, James (2019). The role of AXL and the microenvironment in cancer cell plasticity and therapy responses. A study in non-small cell lung cancer models. (external link)
• Davidsen, Kjersti; Lorens, James (2019). The receptor tyrosine kinase AXL in tumor phenotypic plasticity and acquired resistance to cancer targeted- and immunotherapy. (external link)
• Ertsås, Henriette Christie; Lorens, James; LaBarge, Mark A. et al. (2018). The effects of ageing on microenvironment-contextual epithelial cell signalling . (external link)
• Hinz, Stefan; Lorens, James; Brekken, Rolf A. et al. (2017). Mechanisms of AXL Mediated Cell Plasticity and Drug Resistance . (external link)
• Haaland, Gry Sandvik; Lorens, James (2017). Investigations of the cancer therapeutic and protective effects of warfarin-mediated inhibition of the receptor tyrosine kinase AXL. (external link)
• Pelissier, Fanny; Lorens, James (2016). The Role of Age in Cellular Responses to Microenvironmental Cues as a Breast Cancer Susceptibility Factor. (external link)
• Wnuk-Lipinska, Katarzyna; Lorens, James (2015). The role of Axl signaling in phenotypic plasticity in normal and neoplastic epithelial cells. (external link)
• Lorens, James (1993). Molecular studies on the gene structure and expression of Atlantic salmon growth hormone. (dr.scient). (external link)

Letter to the editor

• Haaland, Gry Sandvik; Falk, Ragnhild Sørum; Lorens, James (2018). In reply. (external link)

Abstract

• Schuster, Cornelia; Gausdal, Gro; Gjertsen, Bjørn Tore et al. (2018). Update on the randomised phase Ib/II study of the selective small molecule AXL inhibitor bemcentinib (BGB324) in combination with either dabrafenib/trametinib or pembrolizumab in patients with metastatic melanoma. (external link)
• Ben Batalla, I; Schultze, A; Wroblewski, Mark et al. (2013). Axl, a therapeutic target in AML mediates stroma-induced chemoresistance. (external link)
• Kirane, Amanda R.; Dellinger, Michael T.; Toombs, Jason E. et al. (2013). Warfarin blocks Gas6-mediated Axl activation required for pancreatic tumor EMT and metastasis. (external link)
• Tiron, Crina Elena; Gjerdrum, Christine; Høiby, Torill et al. (2011). Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. (external link)
• Parlati, F; Lee, S; Aujay, M et al. (2009). CARFILZOMIB: A SELECTIVE INHIBITOR OF THE CHYMOTRYPSIN-LIKE ACTIVITY OF THE CONSTITUTIVE PROTESOME AND IMMUNOPROTEASOME HAS ANTI-TUMOR ACTIVITY ON MULTIPLE MYELOMA, LYMPHOMA AND LEUKEMIA CELLS WITH MINIMAL EFFECTS ON NORMAL CELLS. (external link)
• Gjerdrum, Christine; Tiron, Crina Elena; Haugen, Hallvard et al. (2009). The receptor tyrosine kinase Axl controls breast carcinoma cell invasiveness and tumor formation by regulating E-cadherin. (external link)
• Myklebust, Line Merethe; Bjørndal, Bodil; Rosendal, Ken Roger et al. (2008). The scaffold protein RACK1 regulates Ki-Ras-mediated signaling and morphological transformation of NIH 3T3 cells. (external link)
• Parlati, Francesco; Aujay, Monette; Bedringaas, Siv Lise et al. (2007). Anti-tumor activity of immunoproteasome selective inhibitors. (external link)

Errata

• Hodneland Nilsson, Linn Iren; Pettersen, Ina Katrine Nitschke; Nikolaisen, Julie et al. (2016). Corrigendum: A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology.. (external link)

Poster

• Pedersen, Torbjørn Østvik; Blois, Anna; Xing, Zhe et al. (2013). Endothelial Microvascular Networks Influence Gene Expression Profiles in MSCs. (external link)
• Pedersen, Torbjørn; Blois, Anna; Xue, Ying et al. (2012). Osteogenic conditions stimulate microvascular networks – establishing culture conditions for stem cell based reconstruction of bone defects. (external link)
• Xing, Zhe; Xue, Ying; Ibrahim, Salah Osman et al. (2008). Co-culuture of endothelial cells and mesenchymal stem cells on 3D scaffolds. (external link)
• Silden, Elisabeth; McCormack, Emmet Martin; Micklem, David Robert et al. (2007). Development of a near infrared reporter system for in vivo imaging. (external link)
• Parlati, F; Aujay, M; Bedringaas, Siv Lise et al. (2007). Anti-Tumor Activity of Immunoproteasome Selective Inhibitors. (external link)

Academic lecture

• Pedersen, Torbjørn Østvik; Blois, Anna; Xue, Ying et al. (2013). Prevascularization of tissue-engineered constructs with endothelial and mesenchymal stem cells. (external link)

See a complete overview of publications in Cristin.

A full bibliography is available here. 

Prof. Lorens completed undergraduate studies at Carleton College (USA) and University of Bergen (UiB), and graduate studies in chemistry (MS) and molecular biology (PhD) at UiB in 1993. He did postdoctoral work with Prof. Garry Nolan at Stanford University studying tumor and immune cell apoptosis mechanisms, before joining Rigel Pharmaceuticals in 1997. As one of the first scientists at Rigel, Prof. Lorens led technology development and was later Director of Oncology R&D. He returned to UiB as a Professor in the Medical Faculty, starting his academic laboratory in the Dept. Biomedicine in 2004 to focus on cancer research. Prof. Lorens is a principal investigator at the Center for Cancer Biomarkers, Norwegian Center of Excellence. He founded BerGenBio AS in 2008 to facilitate clinical translation of his group’s pioneering research on the Axl receptor tyrosine kinase. He continues to serve as Chief Scientific Officer. BerGenBio’s Axl inhibitor (BGB324) is currently in Phase I/II clinical trials to treat cancer.

In addition to his university research, teaching and supervisory activities, Prof. Lorens serves on the Editorial Board of Cancer Research and is an Affiliate at Lawrence Berkeley National Laboratory (USA). He has held several research administration and scientific advisory positions, including a current appointment to the board of the Research Council Division of Innovation. He has received several awards recognizing his achievements in innovation and holds several patents. A full bibliography is available here.