I am Kazi Asraful Alam, a molecular biologist, and a protein chemist, working as a postdoctoral researcher in the PRIME project, Horizon 2020 research program (https://prime-study.eu/) at the University of Bergen. My project involves studying ion channels, their function, and the genetic variant of these channels associated with neurodegenerative diseases using the Chemo-genomics approach. I have a wide range of experienced working on structure-based drug design, Chemoinformatics, Protein kinase, T cell biology, and Natural killer cells (NK).  I did my master's in Protein Science followed by a Ph.D. in structural studies of protein kinase inhibitor binding. 

Masters thesis

• Ashfaq, Aiza; Alam, Kazi Asraful; Haavik, Jan et al. (2023). Expression, Purification, and Small Molecule Binding to Cysteine Sulfinic Acid Decarboxylase. (external link)

Academic literature review

• Alam, Kazi Asraful; Svalastoga, Pernille; Martinez, Aurora et al. (2023). Potassium channels in behavioral brain disorders. Molecular mechanisms and therapeutic potential: A narrative review. (external link)

See a complete overview of publications in Cristin.

1. KA Alam, OA Gani, RA Engh - Journal of Molecular Recognition, 2021. Inhibitor binding to mutants of protein kinase A with GGGxxG and GxGxxA glycine‐rich loop motifs

2. BS Lauber, LA Hardegger, AK Asraful, BA Lund… - Chemistry–A European Journal, 2016. Addressing the glycine‐rich loop of protein kinases by a multi‐facetted interaction network: inhibition of PKA and a PKB mimic

3. T Ivan, E Enkvist, B Viira, GB Manoharan, G Raidaru… - Bioconjugate Chemistry, 2016. Bifunctional ligands for inhibition of tight-binding protein–protein interactions.

4. OA Gani, B Thakkar, D Narayanan, KA Alam… - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2015. Assessing protein kinase target similarity: Comparing sequence, structure, and cheminformatics approaches.

5.  Jonas A. Wik, Azazul Chowdhury;Shrikant Kolan;Nasser E. Bastani;Gaoyang Li;Kazi Alam;Franco Grimolizzi; Bjørn S. Skålhegg. Endogenous glutamine is rate-limiting for anti-CD3 and anti-CD28 induced CD4⁺ T-cell proliferation and glycolytic activity under hypoxia and normoxia. Biochem J (2022) 479 (11): 1221–1235. https://doi.org/10.1042/BCJ20220144

6. Alam, Kazi Asraful; Svalastoga, Pernille; Martinez, Aurora; Glennon, Jeffrey Colm; Haavik, Jan. (2023). Potassium channels in behavioral brain disorders. Molecular mechanisms and therapeutic potential: A narrative review. Neuroscience and Biobehavioral Reviews. https://www.sciencedirect.com/science/article/pii/S0149763423002701.

 

Structural and functional studies  of Ion Channel

Neurodegenerative Diseases