I am Professor at the Department of Biomedicine, University of Bergen, Norway and PI in the Metabolism and Cancer group. Our research aims to understand molecular interactions at the atomic level and the nuanced relationships between structure, dynamics and function of biomolecules. We develop and apply computational methods to simulate molecular motions, complementing experimental observations. Through collaboration with groups that develop the Amber software package for molecular simulations, we have developed the Amber force field to simulate molecular interactions of lipid complexes. With the Amber lipid force field, we are currently able to simulate complex molecular systems of any composition. We apply these methods to understand the function of large molecular systems based on intermolecular forces and inherent dynamics. Our force field development is also relevant to methods for virtual screening of compound databases against any macromolecular target and integrates well with the experimental screening of small compounds at the Department of Biomedicine. I am cofounder and shareholder of the company Pluvia Pharma AS, a startup biotech company in Bergen that seeks to develop small molecule pharmacological chaperones with potential to correct protein misfolding diseases.

I am member of the Program Commitee for medical education at UiB and responsible for the second semester of medical school. I teach subjects in biochemistry and cell biology for pharmacy, dentistry, and medical students and am also involved in teaching structural biology as part of master's and PhD courses at the Department of Biomedicine. I offer master's projects for students in pharmacy, nanoscience, biomedicine, and medical technology, as well as projects for the research program in medicine. Through the Federation of European Biochemical Societies (FEBS), I am involved in the development of biochemistry education and participate in FEBS forums as the Norwegian ambassador for biochemistry education.

When not teaching biochemistry I am very passionate about skiing and am part of the educational board of Snowsports Norway where I am involved in education and international certification of snowsport instructors.

Poster

• Støve, Svein Isungset; Skjevik, Åge Aleksander; Teigen, Knut et al. (2022). High-throughput screening for VMAT2 activity modulators. (external link)
• Skjevik, Åge Aleksander; Støve, Svein Isungset; Teigen, Knut et al. (2020). Identification of VMAT2 inhibitory compounds. (external link)
• Støve, Svein Isungset; Skjevik, Åge Aleksander; Teigen, Knut et al. (2020). Searching for new inhibitors of vesicular monoamine transporter 2 by differential scanning fluorimetry. (external link)
• Olsson, Elaine; Martinez, Aurora; Teigen, Knut et al. (2010). Dioxygen Binding and Formation of the Hydroxylating FeIV=O Intermediate in Aromatic Amino Acid Hydroxylases. (external link)
• Skjevik, Åge Aleksander; Lygre, Henning; Teigen, Knut (2010). Can intramolecular hydrogen bonding in articaine be related to superior bone tissue penetration? A molecular dynamics study. (external link)
• Skjevik, Åge Aleksander; Lygre, Henning; Teigen, Knut (2009). Molecular dynamics simulation: Interaction between the local anaesthetic articaine and membrane models. (external link)
• Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut et al. (2009). Catalytic cycle of phenylalanine hydroxylase. (external link)
• Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut et al. (2009). Catalytic cycle of phenylalanine hydroxylase. (external link)
• Pedersen, Ida Benedikte; Skjevik, Åge Aleksander; Lygre, Henning et al. (2008). Drug-membrane interactions. An explanation for the anti-inflammatory effect of local anesthetics?. (external link)
• Skjevik, Åge Aleksander; Pedersen, Ida Benedikte; Lygre, Henning et al. (2008). Interactions between the local anesthetic articaine and membranes: A theoretical and experiemntal study. (external link)
• Skjevik, Åge Aleksander; Lygre, Henning; Teigen, Knut (2008). Interaction of a local anaesthetic with lipid membranes studied by computer modelling. (external link)

Academic article

• Støve, Svein Isungset; Skjevik, Åge Aleksander; Teigen, Knut et al. (2022). Inhibition of VMAT2 by β2-adrenergic agonists, antagonists, and the atypical antipsychotic ziprasidone. (external link)
• Bueno-Carrasco, María Teresa; Cuellar, Jorge; Flydal, Marte Innselset et al. (2022). Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. (external link)
• Zhang, Aidan; Teigen, Knut; Kouznetsova, Valentina L. et al. (2022). Modeling of mutant superoxide dismutase 1 octamers with cross-linked disulfide bonds. (external link)
• Betari, Nibal; Teigen, Knut; Sahlholm, Kristoffer et al. (2021). Synthetic corticosteroids as tryptophan hydroxylase stabilizers. (external link)
• Dobrovolska, Olena; Strømland, Øyvind; Handegård, Ørjan Sele et al. (2021). Investigating the Disordered and Membrane-Active Peptide A-Cage-C Using Conformational Ensembles. (external link)
• Pedersen, Line; Panahandeh, Pouda; Siraji, Muntequa Ishtiaq et al. (2020). Golgi-Localized PAQR4 Mediates Antiapoptotic Ceramidase Activity in Breast Cancer. (external link)
• Flydal, Marte Innselset; Kråkenes, Trond-André; Tai, Mary Dayne Sia et al. (2020). Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase. (external link)
• Betari, Nibal; Sahlholm, Kristoffer; Morató, Xavier et al. (2020). Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole—In Vitro and In Vivo Investigations. (external link)
• Dobrovolska, Olena; Brilkov, Maxim; Madeleine, Noëlly et al. (2020). The Arabidopsis (ASHH2) CW domain binds monomethylated K4 of the histone H3 tail through conformational selection. (external link)
• Betari, Nibal; Sahlholm, Kristoffer; Ishizuka, Yuta et al. (2020). Discovery and biological characterization of a novel scaffold for potent inhibitors of peripheral serotonin synthesis. (external link)
• Humisto, Anu; Jokela, Jouni; Teigen, Knut et al. (2019). Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes. (external link)
• Holtan, Josephine Prener; Teigen, Knut; Aukrust, Ingvild et al. (2019). Dominant ARL3-related retinitis pigmentosa. (external link)
• Kouznetsova, Valentina L.; Hu, Hannah; Teigen, Knut et al. (2017). Cripto stabilizes GRP78 on the cell membrane. (external link)
• Leandro, João; Stokka, Anne Jorunn; Teigen, Knut et al. (2017). Substituting Tyr138 in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation. (external link)
• Skjevik, Åge Aleksander; Madej, Benjamin D.; Dickson, Callum J. et al. (2016). Simulation of lipid bilayer self-assembly using all-atom lipid force fields. (external link)
• Skjevik, Åge Aleksander; Madej, Benjamin D.; Dickson, Callum J. et al. (2015). All-atom lipid bilayer self-assembly with the AMBER and CHARMM lipid force fields. (external link)
• Hole, Magnus; Underhaug, Jarl; Diez, Hector et al. (2015). Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms. (external link)
• Winge, Ingeborg; Teigen, Knut; Fossbakk, Agnete et al. (2015). Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression. (external link)
• Herfindal, Lars; Krakstad, Camilla; Myhren, Lene Elisabeth et al. (2014). Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3. (external link)
• Skjevik, Åge Aleksander; Mileni, Mauro; Baumann, Anne et al. (2014). The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes. (external link)
• Dickson, Callum J.; Madej, Benjamin D.; Skjevik, Åge Aleksander et al. (2014). Lipid14: The amber lipid force field. (external link)
• Lindstad, Rune I.; Teigen, Knut; Skjeldal, Lars (2013). Inhibition of sorbitol dehydrogenase by nucleosides and nucleotides. (external link)
• Martin, Ianire; Underhaug, Jarl; Celaya, Garbiñe et al. (2013). Screening and evaluation of small organic molecules as ClpB inhibitors and potential antimicrobials. (external link)
• Myhren, Lene Elisabeth; Nygaard, Gyrid; Gausdal, Gro et al. (2013). Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. (external link)
• Skjevik, Åge Aleksander; Madej, Benjamin D.; Walker, Ross C. et al. (2012). LIPID11: A modular framework for lipid simulations using amber. (external link)
• Skjevik, Åge Aleksander; Haug, Bengt Erik; Lygre, Henning et al. (2011). Intramolecular hydrogen bonding in articaine can be related to superior bone tissue penetration: A molecular dynamics study. (external link)
• Molnes, Janne; Teigen, Knut; Aukrust, Ingvild et al. (2011). Binding of ATP at the active site of human pancreatic glucokinase - nucleotide-induced conformational changes with possible implications for its kinetic cooperativity. (external link)
• Skjærven, Lars; Grant, Barry; Muga, Arturo et al. (2011). Conformational sampling and nucleotide-dependent transitions of the GroEL subunit probed by unbiased molecular dynamics simulations. (external link)
• Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut et al. (2011). Formation of the Iron-Oxo Hydroxylating Species in the Catalytic Cycle of Aromatic Amino Acid Hydroxylases. (external link)
• Dao, Khanh Kim; Pey, Angel L.; Gjerde, Anja Underhaug et al. (2011). The regulatory subunit of PKA-I remains partially structured and undergoes beta-aggregation upon thermal denaturation. (external link)
• Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut et al. (2011). Substrate Hydroxylation by the Oxido-Iron Intermediate in Aromatic Amino Acid Hydroxylases: A DFT Mechanistic Study. (external link)
• Flydal, Marte Innselset; Mohn, Tonje Cecilie; Pey, Rodroguez Angel Luis et al. (2010). Superstoichiometric binding of L-Phe to phenylalanine hydroxylase from Caenorhabditis elegans: evolutionary implications. (external link)
• Siltberg-Liberles, Jessica; Flydal, Marte Innselset; Teigen, Knut et al. (2009). Evolution of regulation, structure and function in phenylalanine hydroxylase. (external link)
• Skjevik, Åge Aleksander; Teigen, Knut; Martinez, Aurora (2009). Overview of computational methods employed in early-stage drug discovery. (external link)
• Hodneland, Erlend; Teigen, Knut (2007). A simple method to calculate the accessible volume of protein-bound ligands: Application for ligand selectivity. (external link)
• Pey, Angel; Martinez, Aurora; Charubala, Ramamurthy et al. (2006). Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo. (external link)
• Dao, Khanh Kim; Teigen, Knut; Kopperud, Reidun Kristin et al. (2006). Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition. (external link)
• Teigen, Knut; Jensen, Vidar Remi; Martinez, Aurora (2005). The reaction mechanism of phenylalanine hydroxylase. A question of coordination. (external link)
• Pey, Angel; Thorolfsson, Matthias; Teigen, Knut et al. (2004). Thermodynamic characterization of the binding of tetrahydropterins to phenylalanine hydroxylase . (external link)
• Teigen, Knut; Dao, Khanh Kim; Mckinney, Jeffrey Alan et al. (2004). Tetrahydrobiopterin binding to aromatic amino acid hydroxylases. Ligand recognition and specificity. (external link)
• Miranda, Frederico F.; Thorolfsson, Matthias; Teigen, Knut et al. (2004). Structural and stability effects of phosphorylation � Localized structural changes in phenylalanine hydroxylase. (external link)
• Teigen, Knut; Frøystein, Nils Åge; Martinez, Aurora (1999). The structural Basis of the Recognition of Phenylalanine and Pterine Cofactors by Phenylalanine Hydroxylase. Implications for the Catalytic Mechanism. (external link)
• Teigen, Knut; Frøystein, Nils Åge; Martinez, Aurora (1999). The structural basis of the recognition of phenylalanine and pterin cofactors by phenylalanine hydroxylase. Implications for the catalytic mechanism. (external link)

Academic literature review

• Hole, Magnus; Jorge Finnigan, Ana; Underhaug, Jarl et al. (2016). Pharmacological chaperones that protect Tetrahydrobiopterin dependent aromatic amino acid hydroxylases through different mechanisms. (external link)
• Olsson, Elaine; Teigen, Knut; Martinez, Aurora et al. (2010). The aromatic amino acid hydroxylase mechanism: A perspective from computational chemistry. (external link)
• Martinez, Aurora; Calvo, Ana C; Teigen, Knut et al. (2009). Rescuing proteins of low kinetic stability by chaperones and natural ligands; phenylketonuria, a case study. (external link)
• Teigen, Knut; Mckinney, Jeffrey Alan; Haavik, Jan et al. (2007). Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. (external link)

Errata

• Hole, Magnus; Underhaug, Jarl; Diez, Hector et al. (2016). Erratum: Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms (Biochimica et Biophysica Acta - Proteins and Proteomics (2015) 1854:9 (1078-1089) DOI: 10.1016/j.bbapap.2015.04.030). (external link)

Masters thesis

• Hjelmdal, Ellen Hovind; Teigen, Knut; Martinez, Aurora (2016). Characterization of prevalent phenylketonuria mutations Effect of potential pharmacological chaperones . (external link)
• Skogheim, Elise; Teigen, Knut; Kleppe, Rune (2015). Identification of small molecular modulators of 14-3-3 functions. A virtual screening approach with experimental validation. (external link)
• Akerholdt, Monica Hallem; Teigen, Knut; Kleppe, Rune (2015). Discovery of small-molecular disruptors of protein-protein inteactions A virtual screening approach applied to 14-3-3¿ and tyrosine hydroxylase. (external link)
• Harris, Gerd Marie Eskerud; Teigen, Knut; Martinez, Aurora (2014). Identification of pharmacological chaperones for Phenylalanine Hydroxylase A virtual screening approach to discover novel drug candidates for treatment of phenylketonuria. (external link)
• Berg, Rikke Landsvik; Teigen, Knut; Haavik, Jan (2014). IDENTIFICATION OF INHIBITORS OF TRYPTOPHAN HYDROXYLASE 1. (external link)
• Hole, Magnus; Teigen, Knut; Martinez, Aurora (2012). SEARCH AND ANALYSIS OF COMPOUNDS THAT STABILIZE TYROSINE HYDROXYLASE - IDENTIFICATION OF PHARMACOLOGICAL CHAPERONES. (external link)
• Bezem, Maria Teresa; Martinez, Aurora; Teigen, Knut (2012). Stabilisation of Tyrosine Hydroxylase in Nanoparticles for Enzyme Replacement Therapy. (external link)
• Aardal, Marit Elisabet; Teigen, Knut; Meier, Sonnich et al. (2011). Interactions between polychlorinated biphenyls (PCBs) and a phospholipid bilayer: A molecular dynamics study. (external link)
• Skjevik, Åge Aleksander; Teigen, Knut; Gjerde, Anja Underhaug et al. (2008). INTERACTION OF A LOCAL ANAESTHETIC WITH MEMBRANE LIPIDS STUDIED COMPUTER MODELLING. (external link)
• Pedersen, Ida Benedikte; Teigen, Knut; Gjerde, Anja Underhaug et al. (2008). BIOLOGICAL TARGETS OF LOCAL ANAESTHETICS – A MOLECULAR MODELLING STUDY. (external link)

Doctoral dissertation

• Hole, Magnus; Teigen, Knut (2015). A study of Structure-Function-Stability Relationships in Tyrosine Hydroxylase. (external link)
• Teigen, Knut (2004). Structural and Functional Aspects of Pterin-Binding Enzymes - A Nuclear Magnetic Resonance Spectroscopy and Molecular Modeling Study. (external link)

Academic chapter/article/Conference paper

• Skjærven, Lars; Teigen, Knut; Martinez, Aurora (2014). Structure–Function Relationships in the Aromatic Amino Acid Hydroxylases Enzyme Family: Evolutionary Insights. (external link)
• Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut et al. (2010). The aromatic amino acid hydroxylase mechanism: a perspective from computational chemistry. (external link)

Abstract

• Walker, Ross C.; Skjevik, Åge Aleksander; Teigen, Knut (2012). Developing a comprehensive modular phospholipid force field for AMBER. (external link)
• Madej, Benjamin D.; Skjevik, Age; Teigen, Knut et al. (2012). AMBER-Lipid 11: A new modular lipid force field for molecular dynamics. (external link)

Short communication

• Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut et al. (2010). Water dissociation and dioxygen binding in phenylalanine hydroxylase. (external link)

Academic lecture

• Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut et al. (2009). Dioxygen in aromatic amino acid hydroxylases. (external link)
• Teigen, Knut; Frøystein, Nils Åge; Martínez, Aurora (1998). NMR study on the conformation of L-phenylalanine and dihydrobiopterin bound to wild-type and mutant forms of recombinant human phenylalanine hydroxylase. (external link)

See a complete overview of publications in Cristin.