The group's research is focused on the disease acute myeloid leukemia (AML). Performs biobanking, cell culture, BioPlex analyses, flow cytometry, prolif.assay, lab training of PhD candidates

Academic article

• Brattås, Marte Karen; Görtler, Franziska Stilla Maria; Johansen, Silje et al. (2025). Gene Expression Profiling in Acute Myeloid Leukemia Patient Subgroups With High and Low Sensitivity Toward SYK Inhibitors. (external link)
• Lellahi, Seyed Mohammad; Azeem, Waqas; Hua, Yaping et al. (2023). GM-CSF, Flt3-L and IL-4 affect viability and function of conventional dendritic cell types 1 and 2. (external link)
• Bartaula-Brevik, Sushma; Leitch, Calum; Valladares, Maria del Carmen Hernandez et al. (2023). Vacuolar ATPase Is a Possible Therapeutic Target in Acute Myeloid Leukemia: Focus on Patient Heterogeneity and Treatment Toxicity. (external link)
• Hemsing, Anette Lodvir; Rye, Kristin Paulsen; Hatfield, Kimberley Joanne et al. (2022). NPM1-mutated patient-derived AML cells are more vulnerable to rac1 inhibition. (external link)
• Brattås, Marte Karen; Hemsing, Anette Lodvir; Rye, Kristin Paulsen et al. (2022). Heterogeneity of patient-derived acute myeloid leukemia cells subjected to SYK in vitro inhibition. (external link)
• Nepstad, Ina; Hatfield, Kimberley Joanne; Grønningsæter, Ida Sofie et al. (2019). Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells.. (external link)
• Melve, Guro Kristin; Ersvær, Elisabeth; Rye, Kristin Paulsen et al. (2018). The healthy donor profile of immunoregulatory soluble mediators is altered by stem cell mobilization and apheresis. (external link)
• Brenner, Annette; Tvedt, Tor Henrik Anderson; Nepstad, Ina et al. (2017). Patients with acute myeloid leukemia can be subclassified based on the constitutive cytokine release of the leukemic cells; the possible clinical relevance and the importance of cellular iron metabolism. (external link)
• Hanevik, Kurt; Kristoffersen, Einar Klæboe; Mørch, Kristine et al. (2017). Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome. (external link)
• Brenner, Annette; Reikvam, Håkon; Rye, Kristin Paulsen et al. (2017). CDC25 inhibition in acute myeloid leukemia - A study of patient heterogeneity and the effects of different inhibitors. (external link)
• Tvedt, Tor Henrik Anderson; Lie, Stein Atle; Reikvam, Håkon et al. (2016). Pretransplant levels of CRP and interleukin-6 family cytokines; effects on outcome after allogeneic stem cell transplantation. (external link)
• Kittang, Astrid Marta Olsnes; Kordasti, Shahram; Sand, Kristoffer et al. (2016). Expansion of myeloid derived suppressor cells correlates with number of T regulatory cells and disease progression in myelodysplastic syndrome. (external link)
• Kittang, Astrid Marta Olsnes; Sand, Kristoffer; Brenner, Annette et al. (2016). The systemic profile of soluble immune mediators in patients with myelodysplastic syndromes. (external link)
• Tvedt, Tor Henrik Anderson; Rye, Kristin Paulsen; Reikvam, Håkon et al. (2015). The importance of sample collection when using single cytokine levels and systemic cytokine profiles as biomarkers - a comparative study of serum versus plasma samples. (external link)
• Sand, Kristoffer; Rye, Kristin Paulsen; Mannsåker, Bård et al. (2013). Expression patterns of chemokine receptors on circulating T cells from myelodysplastic syndrome patients. (external link)
• Liseth, Knut; Sjo, Malvin; Paulsen, Kristin et al. (2010). Early pre-engraftment, functional, in vitro responsiveness of T lymphocytes in allotransplanted, acute leukemia patients: proliferation and release of a broad profile of cytokines, possibly predictive of graft-versus-host disease. (external link)
• Olsnes, Astrid Marta; Ersvær, Elisabeth; Ryningen, Anita et al. (2009). The protein kinase C agonist PEP005 increases NF-kB expression, induces differentiation and increases constitutive chemokine release by primary acute myeloid leukaemia cells. (external link)
• Ryningen, Anita; Stapnes, Camilla I; Paulsen, Kristin et al. (2008). In vivo biological effects of ATRA in the treatment of AML. (external link)
• Wendelbo, Øystein; Nesthus, Ingerid; Sjo, Malvin et al. (2004). Functional characterization of T lymphocytes derived from patients with acute myelogenous leukemia and chemotherapy-induced leukopenia. (external link)
• Bruserud, Øystein; Wendelbo, Øystein; Paulsen, Kristin (2004). Lipoteichoic acid derived from Enterococcus faecalis modulates the functional characteristics of both normal peripheral blood leukocytes and native human acute myelogenous leukemia blasts. (external link)

See a complete overview of publications in Cristin.