Vaults are large ribonucleoprotein complexes (13 MDa) found in most eukaryotic organisms. The mammalian vault complex consists of three proteins; the major vault protein (MVP), telomerase-associated protein 1 (TEP1), and vault poly(ADP-ribose) polymerase, as well as small untranslated vault RNAs. The functional role of the vault complex is still poorly understood. However, it has been hypothesized to be involved in various cellular processes such as cell signaling, transport, multidrug resistance, and immune response. The PhD project aims to functionally characterize the vault complex using the salmon louse (Lepeophtheirus salmonis) as a model.

MOL300-Practical Biochemistry and Molecular Biology

MOL221-Experimental Molecular Biology I

Article in business/trade/industry journal

• Slinning, Malene Skuseth; Nthiga, Thaddaeus Mutugi; Eichner, Christiane et al. (2024). Major vault protein is partof an extracellular cement materialin the Atlantic salmon louse(Lepeophtheirus salmonis). (external link)

Academic article

• Papdine Morovicz, Andrea; Mazloumi Gavgani, Fatemeh; Jacobsen, Rhian Gaenor et al. (2022). Phosphoinositide 3-kinase signalling in the nucleolus. (external link)
• Gavgani, Fatemeh Mazloumi; Slinning, Malene Skuseth; Morovicz, Andrea Papdine et al. (2021). Nuclear Phosphatidylinositol 3,4,5-Trisphosphate Interactome Uncovers an Enrichment in Nucleolar Proteins. (external link)

Academic literature review

• Morovicz, Andrea Papdine; Gavgani, Fatemeh Mazloumi; Jacobsen, Rhian Gaenor et al. (2021). Phosphoinositide 3-kinase signalling in the nucleolus. (external link)

See a complete overview of publications in Cristin.

LiceVault- Implementing a model organism for studying vault function and application as smart adjuvant for fish vaccination.