Mette Vesterhus, M.D. (UiB 1999), Ph.D. (UiB 2009), works as Full Professor at the University of Bergen and Senior Consulting Gastroenterologist & Hepatologist at Haraldsplass Deaconess Hospital in Bergen, Norway. With a particular focus on primary sclerosing cholangitis (PSC) and other autoimmune liver diseases, her main areas of interest are prognostic biomarkers and non-invasive assessment of liver fibrosis (including liver elastography), as well as clinical trials in autoimmune liver diseases. She is Group Leader of the Haraldsplass Liver Research Group and Clinical Group Bergen of the Norwegian PSC Research Center (NoPSC) and National PI for the Strategic Prospective Scandinavian PSC Biobank (ScandPSC).  Internationally, she is a Board Member of the International PSC Study Group as well as the UEG Meeting of Members.  

Academic article

• Hussain, Nasir; Ma, Christopher; Hirschfield, Gideon et al. (2024). Protocol for the development of a core outcome set for clinical trials in primary sclerosing cholangitis. (external link)
• De Muynck, Kevin; Heyerick, Lander; De Ponti, Federico F. et al. (2023). Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis. (external link)
• Wacker, Eike Matthias; Uellendahl-Werth, Florian; Bej, Saptarshi et al. (2023). Whole blood RNA sequencing identifies transcriptional differences between primary sclerosing cholangitis and ulcerative colitis. (external link)
• Lapitz, Ainhoa; Azkargorta, Mikel; Milkiewicz, Piotr et al. (2023). Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma. (external link)
• Braadland, Peder Rustøen; Bergquist, Annika; Kummen, Martin et al. (2023). Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation. (external link)
• Lazarus, Jeffrey V.; Mark, Henry E.; Allen, Alina M. et al. (2023). A global action agenda for turning the tide on fatty liver disease. (external link)
• Helgadottir, Holmfridur; Folvik, Geir; Vesterhus, Mette Nåmdal (2022). Improvement of cholestatic episodes in patients with benign recurrent intrahepatic cholestasis (BRIC) treated with rifampicin. A long-term follow-up. (external link)
• Singh, Yashbir; Jons, William A.; Eaton, John E. et al. (2022). Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis. (external link)
• Bergquist, Annika; Weismüller, Tobias J.; Levy, Cynthia et al. (2022). Impact on follow-up strategies in patients with primary sclerosing cholangitis. (external link)
• Braadland, Peder Rustøen; Schneider, Kai Markus; Bergquist, Annika et al. (2022). Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis. (external link)
• Laursen, Tea Lund; Bossen, Lars; Pihl, Rasmus et al. (2022). Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4 (ITIH4) in Autoimmune Cholestatic Liver Diseases. (external link)
• Mjelle, Anders Batman; Mulabecirovic, Anesa; Olafsdottir, Edda Jonina et al. (2021). Controlled Attenuation Parameter in Healthy Individuals Aged 8-70 Years. (external link)
• Bossen, Lars; Vesterhus, Mette Nåmdal; Hov, Johannes Espolin Roksund et al. (2021). Circulating Macrophage Activation Markers Predict Transplant-Free Survival in Patients With Primary Sclerosing Cholangitis. (external link)
• Vesterhus, Mette; Nielsen, Mette Juul; Hov, Johannes Roksund et al. (2021). Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease. (external link)
• Dhillon, Amandeep Kaur; Rupp, Christian; Bergquist, Annika et al. (2021). Associations of neopterin and kynurenine–tryptophan ratio with survival in primary sclerosing cholangitis. (external link)
• Fossdal, Guri; Mjelle, Anders Batman; Wiencke, Kristine et al. (2021). Fluctuating biomarkers in primary sclerosing cholangitis: A longitudinal comparison of alkaline phosphatase, liver stiffness, and ELF. (external link)
• Mousa, Omar Y; Juran, Brian D; McCauley, Bryan M. et al. (2020). Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation. (external link)
• Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C. et al. (2020). Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis. (external link)
• Taraldsen, Victoria Resvik; Tomasgard, Sunneva; Rudlang, Margrethe Thune et al. (2020). Point shear wave elastography and the effect of physical exercise, alcohol consumption, and respiration in healthy adults. (external link)
• Mjelle, Anders Batman; Mulabecirovic, Anesa; Havre, Roald Flesland et al. (2020). Liver elastography in healthy children using three different systems - how many measurements are necessary?. (external link)
• Mjelle, Anders Batman; Fossdal, Guri; Gilja, Odd Helge et al. (2020). Liver Elastography in Primary Sclerosing Cholangitis Patients Using Three Different Scanner Systems. (external link)
• Hedin, Charlotte Rose Hawkey; Sado, Gina; Ndegwa, Nelson et al. (2020). Effects of Tumor Necrosis Factor Antagonists in Patients With Primary Sclerosing Cholangitis. (external link)
• Mjelle, Anders Batman; Mulabecirovic, Anesa; Havre, Roald Flesland et al. (2019). Normal Liver Stiffness Values in Children: A Comparison of Three Different Elastography Methods. (external link)
• Dhillon, Amandeep Kaur; Kremer, Andreas E.; Kummen, Martin et al. (2019). Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis. (external link)
• Dhillon, Amandeep Kaur; Kummen, Martin; Trøseid, Marius et al. (2019). Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis. (external link)
• Saffioti, Francesca; Roccarina, Davide; Vesterhus, Mette et al. (2019). Cholangiocarcinoma is associated with a raised enhanced liver fibrosis score independent of primary sclerosing cholangitis. (external link)
• Nielsen, MJ; Thorburn, Douglas; Leeming, DJ et al. (2018). Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis. (external link)
• Goode, EC; Clark, AB; Melis, GM et al. (2018). Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System. (external link)
• Eaton, JE; Vesterhus, Mette; McCauley, Bryan M. et al. (2018). Primary sclerosing cholangitis risk estimate tool (PREsTo) predicts outcomes of the disease: A derivation and validation study using machine learning. (external link)
• Zenouzi, Roman; Liwinski, T; Yamamura, J et al. (2018). Follow-up magnetic resonance imaging/3D-magnetic resonance cholangiopancreatography in patients with primary sclerosing cholangitis: challenging for experts to interpret. (external link)
• Mulabecirovic, Anesa; Mjelle, Anders Batman; Gilja, Odd Helge et al. (2018). Liver elasticity in healthy individuals by two novel shear-wave elastography systems-Comparison by age, gender, BMI and number of measurements. (external link)
• de Vries, Elisabeth M.G.; Färkkilä, Martti; Milkiewicz, Piotr et al. (2017). Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study. (external link)
• Hov, Johannes Espolin Roksund; Boberg, Kirsten Muri; Taraldsrud, Eli et al. (2017). Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis. (external link)
• Vesterhus, Mette; Holm, Anders; Hov, Johannes Espolin Roksund et al. (2017). Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. (external link)
• Jendrek, Sebastian Torben; Gotthardt, Daniel; Nitzsche, Thomas et al. (2017). Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis. (external link)
• Bende, Felix; Mulabecirovic, Anesa; Popescu, Alina et al. (2017). Assessing liver stiffness by 2-D shear wave elastography in a healthy cohort. (external link)
• Mulabecirovic, Anesa; Mjelle, Anders Batman; Gilja, Odd Helge et al. (2017). Repeatability of shear wave elastography in liver fibrosis phantoms—Evaluation of five different systems. (external link)
• Trivedi, PJ; Tickle, J; Vesterhus, Mette et al. (2017). Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner. (external link)
• Zweers, Serge J.; Shiryaev, Alexey; Komuta, Mina et al. (2016). Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis. (external link)
• Kummen, Martin; Vesterhus, Mette; Trøseid, Marius et al. (2016). Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function. (external link)
• Kummen, Martin; Holm, Kristian; Anmarkrud, Jarl Andreas et al. (2016). The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls. (external link)
• Vesterhus, Mette; Melum, Espen (2016). Prognostic biomarkers and surrogate end points in PSC.. (external link)
• Mjelle, Anders Batman; Mulabecirovic, Anesa; Hausken, Trygve et al. (2016). Ultrasound and point shear wave elastography in livers of patients with primary sclerosing cholangitis. (external link)
• Mulabecirovic, Anesa; Vesterhus, Mette; Gilja, Odd Helge et al. (2016). In vitro comparison of five different elastography systems for clinical applications, using strain and shear wave technology. (external link)
• Mulabecirovic, Anesa; Mjelle, Anders Batman; Vesterhus, Mette et al. (2016). In Vitro Comparison of Five Different Elastography Systems for Clinical Applications, Using Strain and Shear Wave Technology. (external link)
• Jørgensen, Silje Fjellgård; Trøseid, Marius; Kummen, Martin et al. (2016). Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation. (external link)
• Vesterhus, Mette; Hov, Johannes Espolin Roksund; Holm, Anders et al. (2015). Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis. (external link)
• Karlsen, Tom Hemming; Vesterhus, Mette; Boberg, Kirsten Muri (2014). Review article: Controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis. (external link)
• Ræder, Helge; McAllister, Fiona E.; Tjora, Erling et al. (2014). Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid. (external link)
• Ræder, Helge; Vesterhus, Mette; El Ouaamari, Abdelfattah et al. (2013). Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (Maturity-Onset Diabetes of the young). (external link)
• Haldorsen, Ingfrid S.; Ræder, Helge; Vesterhus, Mette et al. (2011). The role of pancreatic imaging in monogenic diabetes. (external link)
• Johansson, Bente Berg; Torsvik, Janniche; Bjørkhaug, Lise et al. (2011). Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE. (external link)
• Vesterhus, Mette; Ræder, Helge; Kurpad, Amarnath J et al. (2010). Pancreatic Function in Carboxyl-Ester Lipase Knockout Mice. (external link)
• Vesterhus, Mette; Haldorsen, Ingfrid Salvesen; Ræder, Helge et al. (2008). Reduced pancreatic volume in hepatocyte nuclear factor 1A-maturity-onset diabetes of the young. (external link)
• Vesterhus, Mette; Ræder, Helge; Aurlien, Harald et al. (2008). Neurological features and enzyme therapy in patients with endocrine and exocrine pancreas dysfunction due to CEL mutations. (external link)
• Vesterhus, Mette; Ræder, Helge; Johansson, Stefan et al. (2008). Pancreatic Exocrine Dysfunction in Maturity-Onset Diabetes of the Young Type 3. (external link)
• Haldorsen, Ingfrid Salvesen; Vesterhus, Mette; Ræder, Helge et al. (2008). Lack of pancreatic body and tail in HNF1B mutation carriers. (external link)

Article in business/trade/industry journal

• Helgadottir, Holmfridur; Folseraas, Trine; Kemmerich, Gunter et al. (2023). Primær skleroserende kolangitt. (external link)
• Ness-Jensen, Eivind; Seip, Birgitte Karen Berggreen; Vesterhus, Mette (2020). Prioriteringsråd for fordøyelsessykdommer under korona-pandemien. (external link)

Letter to the editor

• Haukeland, John Willy; Vesterhus, Mette Nåmdal; Jørgensen, Kristin Kaasen et al. (2023). FIB-4-testen som beslutningsverktøy. (external link)
• Lohse, Ansgar W.; Sebode, Marcial; Vesterhus, Mette Nåmdal (2021). Reply to: "Both tacrolimus and mycophenylate mophetil should be considered second-line therapy for autoimmune hepatitis". (external link)

Academic literature review

• Helgadottir, Holmfridur; Vesterhus, Mette Nåmdal (2023). Noninvasive evaluation of fibrosis in adult biliary diseases. (external link)
• Vesterhus, Mette Nåmdal; Wiencke, Kristine; Haukeland, John Willy et al. (2021). Klinisk oversiktsartikkel: Diagnostikk og behandling av autoimmun hepatitt. (external link)
• Lazarus, Jeffrey V.; Mark, Henry E.; Anstee, Quentin M. et al. (2021). Advancing the global public health agenda for NAFLD: a consensus statement. (external link)
• Vesterhus, Mette; Karlsen, Tom Hemming (2020). Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities. (external link)
• Lohse, Ansgar W.; Sebode, Marcial; Jørgensen, Marianne H. et al. (2020). Second-line and third-line therapy for autoimmune hepatitis: A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group. (external link)
• Karlsen, Tom Hemming; Folseraas, Trine; Thorburn, Douglas et al. (2017). Primary sclerosing cholangitis - a comprehensive review. (external link)
• Haldorsen, Ingfrid S.; Ræder, Helge; Vesterhus, Mette et al. (2012). The role of pancreatic imaging in monogenic diabetes mellitus. (external link)

Feature article

• Vesterhus, Mette Nåmdal; Jørgensen, Kristin Kaasen; Frigstad, Svein Oskar et al. (2022). Vi trenger en ny strategi for leversykdom. (external link)

Editorial

• Vesterhus, Mette Nåmdal (2022). Gode TIPS ved alvorlig leversykdom. (external link)

Lecture

• Vesterhus, Mette Nåmdal (2021). ELF Test in PSC - should we start using it?. (external link)
• Vesterhus, Mette Nåmdal (2021). ULTRASOUND EVALUATION OF PSC. (external link)
• Vesterhus, Mette Nåmdal (2021). Juvenile PSC/ASC: The adult side.. (external link)
• Vesterhus, Mette Nåmdal (2021). PSC - What is that disease exactly?. (external link)
• Vesterhus, Mette Nåmdal (2021). 2.linjebehandling ved PBC og AIH. (external link)
• Mulabecirovic, Anesa; Vesterhus, Mette; Gilja, Odd Helge et al. (2017). Ultralyd Elastografi. (external link)
• Mulabecirovic, Anesa; Mjelle, Anders Batman; Gilja, Odd Helge et al. (2017). Måling av vevsstivhet på fantomer med fire ulike «shear wave» elastografisystemer. (external link)

Poster

• Mortensen, Joachim Høg; Lunder, Aida Kapic; Manon-Jensen, Tina et al. (2020). P117 Biomarkers of extracellular matrix remodelling are associated with intestinal fibrosis assessed by magnetic resonance enterography and accumulated intestinal damage (Lémann index): the IBSEN study. (external link)
• Mulabecirovic, Anesa; Bende, Felix; Sporea, I et al. (2017). ASSESSING LIVER STIFFNESS USING 2D-SHEAR WAVE ELASTOGRAPHY IN A HEALTHY COHORT. (external link)
• Mulabecirovic, Anesa; Vesterhus, Mette; Gilja, Odd Helge et al. (2015). In vitro quantification and reproducibility of elasticity measurements using four different ultrasound scanners. (external link)
• Kummen, Martin; Vesterhus, Mette; Trøseid, Marius et al. (2015). MICROBIOTA-DEPENDENT MARKER TRIMETHYLAMINE-N-OXIDE (TMAO) IS ASSOCIATED WITH THE SEVERITY OF PRIMARY SCLEROSING CHOLANGITIS. (external link)
• Kummen, Martin; Vesterhus, Mette; Trøseid, Marius et al. (2015). P1174: Microbiota-dependent marker trimethylamine-N-oxide (TMAO) is associated with the severity of primary sclerosing cholangitis.. (external link)
• Mjelde, Anders Batman; Hausken, Trygve; Karlsen, Tom Hemming et al. (2015). Point shear wave elastography of the liver in primary sclerosing cholangitis.. (external link)

Academic lecture

• Mjelle, Anders Batman; Mulabecirovic, Anesa; Hausken, Trygve et al. (2016). Elastography of the Liver in Primary Sclerosing Cholangitis. (external link)
• Mulabecirovic, Anesa; Mjelle, Anders Batman; Havre, Roald Flesland et al. (2016). Quantification of tissue elasticity in vitro using three clinical shear wave elastography platforms on liver fibrosis phantoms. (external link)
• Mulabecirovic, Anesa; Vesterhus, Mette; Gilja, Odd Helge et al. (2015). In vitro quantification and reproducibility of elasticity measurements using five different elastography systems. (external link)
• Kummen, Martin; Holm, Kristian; Anmarkrud, Jarl Andreas et al. (2015). O082 : THE GUT MICROBIOTA IN PRIMARY SCLEROSING CHOLANGITIS DIFFERS FROM THAT OF HEALTHY CONTROLS AND ULCERATIVE COLITIS PATIENTS WITHOUT BILIARY DISEASE. (external link)

Abstract

• Havre, Roald Flesland; Mulabecirovic, Anesa; Vesterhus, Mette et al. (2015). Elasticity Mearsurements Using Four Different Ultrasound Scanners. (external link)
• Vesterhus, Mette; Johansson, Stefan; Ræder, Helge et al. (2007). Pancreatic exocrine deficiency is common in MODY 3. (external link)

Academic chapter/article/Conference paper

• Mjelde, Anders Batman; Hausken, Trygve; Karlsen, Tom Hemming et al. (2015). Point shear wave elastography of the liver in primary sclerosing cholangitis.. (external link)

Doctoral dissertation

• Vesterhus, Mette (2009). Monogenic diabetes and pancreatic exocrine dysfunction in mouse and man. (external link)

See a complete overview of publications in Cristin.