Selina Cannon Homaei

Position

PhD Candidate

Belonging

Department of Biomedicine The Department of Biomedicine

Research groups

Research

The main focus of my PhD is Glutamate Decarboxylase Like 1 (GADL1) and the consequences of reduced or non-existent enzyme function. Our findings show that GADL1 participates in the decarboxylation of aspartate to β-alanine; thus, influencing the levels of the dipeptide carnosine (β-alanyl-L-histidine) in our GADL1 mouse model. Many are familiar with β-alanine and carnosine as sports supplements, as carnosine can delay lactic acid production during high-intensity interval training (HIIT) due to its pH-buffering capabilities. Although the functional output of these supplements is debated, other studies also show that carnosine can function as an antioxidant and neuromodulator, possibly affecting the development of e.g. neurodegenerative diseases such as Alzheimer’s or Parkinson’s disease.

I primarily work on the GADL1 mouse model using techniques such as behaviour analysis, western blotting, metabolomics (LC-MS, HPLC, 1H-NMR) and transcriptomics (RNA sequencing), and R-analysis.

Previously, I was involved in a project on ADHD and neurometabolic disorders. 

Teaching

@ the University of Bergen

  • Biochemistry (FARM150) 

    • Lab-assistant: enzyme kinetics

  • The first year of medicine- and odontology (MEDOD1, MEDOD2)

    • Lab-assistant: enzyme kinetics, carbohydrates, diffusion and osmosis, DNA lab

 

Publications
Projects