Dendritic cell biology with special emphasis on aspects that enable their use in immunotherapeutic strategies, both for cancer and autoimmune diseases.

Single cell network profiling to stratify patients and develop new treatment strategies.

 

Member of the organizing committee for the annual "Day of Immunology" (29.4.)

• Immunology MED3 (third semester medical studies)
• FARM270 (Pharmaceutical microbiology and immunology)
• MEDMET901 Ethics and health research

 

 

Poster

• Meeren, Aina van der; Appel, Silke; Lied, Gülen Arslan et al. (2024). Mapping of the duodenal mucosal microenvironment in iriitabel bowel syndrome with imaging mass cytometry. (external link)
• Meeren, Aina van der; Appel, Silke; Lied, Gülen Arslan et al. (2023). Diagnostic gut biomarkers with imaging mass cytometry in irritable bowel syndrome. (external link)
• Van Der Meeren, Aina; Appel, Silke; Lied, Gülen Arslan et al. (2023). Bergen BrainGut study: diagnostic gut biomarkers in irritable bowel syndrome with imaging mass cytometry. (external link)
• Haldorsen, Karstein; Appel, Silke; Bruland, Ove et al. (2009). Fc receptor IIA, IIIA and IIIB single nucleotide polymorphisms and Fc receptor IIIB copy number variation: No association with primary Sjögren’s syndrome. (external link)
• Vogelsang, Petra; Brun, Johan G; Jonsson, Roland et al. (2009). Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjögren's syndrome. (external link)
• Vogelsang, Petra; Lier, GS; Brun, Johan G et al. (2009). Dendritic cells from patients with primary Sjögren's syndrome have slightly enhanced endocytic capacity. (external link)
• Nordmark, Gunnel; Kristjansdottir, Gudlaug; Appel, Silke et al. (2009). Association of C8orf13-BLK and TNFSF4 Gene Variants with Primary Sjögren's Syndrome. (external link)

Letter to the editor

• Petrovic, Aleksandra; Ten Bergen, Lisa Lynn; Solberg, Silje Michelsen et al. (2023). Biological treatment in severe psoriasis: Influence on peripheral blood dendritic cells. (external link)

Academic article

• Petrovic, Aleksandra; Bueide, Ingvild Øye; Tveit, Kåre Steinar et al. (2023). Herring roe oil in treatment of psoriasis – influence on immune cells and cytokine network. (external link)
• Lundtoft, Christian; Pucholt, Pascal; Martin, Myriam et al. (2022). Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases. (external link)
• Sarkar, Irene; Davies, Richard Allan; Aarebrot, Anders Krogh et al. (2022). Aberrant signaling of immune cells in Sjögren's syndrome patient subgroups upon interferon stimulation. (external link)
• Trutschel, Diana; Bost, Pierre; Mariette, Xavier et al. (2022). Variability of Primary Sjögren's Syndrome Is Driven by Interferon α and Interferon α Blood Levels Are Associated With the Class II HLA–DQ Locus. (external link)
• Keindl, Magdalena; Davies, Richard Allan; Bergum, Brith et al. (2022). Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome. (external link)
• Azeem, Waqas; Bakke, Ragnhild Maukon; Gabriel, Benjamin et al. (2021). Evaluation of β-catenin inhibition of axitinib and nitazoxanide in human monocyte-derived dendritic cells. (external link)
• Bharaj, Tamandeep Kaur; Aqrawi, Lara A.; Fromreide, Siren et al. (2021). Inflammatory Stratification in Primary Sjögren’s Syndrome Reveals Novel Immune Cell Alterations in Patients’ Minor Salivary Glands. (external link)
• Keindl, Magdalena; Fedotkina, Olena; du Plessis, Elsa et al. (2020). Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms. (external link)
• Solberg, Silje Michelsen; Aarebrot, Anders K.; Sarkar, Irene et al. (2020). Mass cytometry analysis of blood immune cells from psoriasis patients on biological therapy. (external link)
• Azeem, Waqas; Bakke, Ragnhild Maukon; Appel, Silke et al. (2020). Dual pro- and anti-inflammatory features of monocyte-derived dendritic cells. (external link)
• Davies, Richard Allan; Sarkar, Irene; Hammenfors, Daniel et al. (2019). Single cell based phosphorylation profiling identifies alterations in toll-like receptor 7 and 9 signaling in patients with primary sjogren's syndrome. (external link)
• Sauter, Alexander; Yi, Dag Heiro; Li, Yayan et al. (2019). The Culture Dish Surface Influences the Phenotype and Cytokine Production of Human Monocyte-Derived Dendritic Cells. (external link)
• Aarebrot, Anders Krogh; Solberg, Silje Michelsen; Davies, Richard Allan et al. (2018). Phosphorylation of intracellular signaling molecules in peripheral blood cells from psoriasis patients on originator or biosimilar infliximab. (external link)
• Davies, Richard Allan; Hammenfors, Daniel; Bergum, Brith et al. (2018). Aberrant cell signalling in PBMCs upon IFN-? stimulation in primary Sjogren's syndrome patients associates with type I interferon signature. (external link)
• Yi, Dag Heiro; Stetter, Nadine; Jakobsen, Kjerstin et al. (2018). 3-Day monocyte-derived dendritic cells stimulated with a combination of OK432, TLR7/8 ligand, and prostaglandin E2 are a promising alternative for cancer immunotherapy. (external link)
• Fuchs, Anke; Gliwiński, Mateusz; Grageda, Nathali et al. (2018). Minimum information about T regulatory cells: A step toward reproducibility and standardization. (external link)
• Solberg, Silje Michelsen; Sandvik, Lene Frøyen; Eidsheim, Marianne et al. (2018). Serum cytokine measurements and biological therapy of psoriasis - Prospects for personalized treatment?. (external link)
• Davies, Richard Allan; Hammenfors, Daniel; Bergum, Brith et al. (2017). Patients with primary Sjögren's syndrome have alterations in absolute quantities of specific peripheral leucocyte populations. (external link)
• Karlsen, Marie; Jakobsen, Kjerstin; Jonsson, Roland et al. (2017). Expression of Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Patients with Primary Sjogren's Syndrome. (external link)
• Lord, Phillip; Spiering, Rachel; Aguillon, Juan C. et al. (2016). Minimum information about tolerogenic antigen-presenting cells (MITAP): A first step towards reproducibility and standardisation of cellular therapies. (external link)
• Davies, Richard Allan; Vogelsang, Petra; Jonsson, Roland et al. (2016). An optimized multiplex flow cytometry protocol for the analysis of intracellular signaling in peripheral blood mononuclear cells. (external link)
• Sauter, Alexander; Mc Duffie, Yvonne; Böhm, Heike et al. (2015). Surface-mediated priming during in vitro generation of monocyte-derived dendritic cells. (external link)
• Karlsen, Marie; Hansen, Torbjørn; Nordal, Hilde Haugedal et al. (2015). Expression of toll-like receptor -7 and -9 in B cell subsets from patients with primary Sjögren's syndrome. (external link)
• Karlsen, Marie; Jonsson, Roland; Brun, Johan G et al. (2015). TLR-7 and -9 Stimulation of Peripheral Blood B Cells Indicate Altered TLR Signalling in Primary Sjögren's Syndrome Patients by Increased Secretion of Cytokines. (external link)
• Sandvik, Lene Frøyen; Skarstein, Kathrine; Krynitz, Britta et al. (2015). Peritumoral dermis of squamous cell carcinomas in renal transplant recipients contains less CD11c+ myeloid dendritic cells and FoxP3+ T cells compared to immunocompetent controls. (external link)
• Sprater, Florian; Azeem, Waqas; Appel, Silke (2014). Activation of peroxisome proliferator-activated receptor gamma leads to upregulation of ESE-3 expression in human monocyte-derived dendritic cells. (external link)
• Sandvik, Lene Frøyen; Skarstein, Kathrine; Sviland, Lisbeth et al. (2014). CD11c+ dendritic cells rather than Langerhans cells are reduced in normal skin of immunosuppressed renal transplant recipients. (external link)
• Vogelsang, Petra; Karlsen, Marie; Brun, Johan G et al. (2014). Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren's syndrome. (external link)
• Sauter, Alexander; Richter, Gunther; Micoulet, Alexandre et al. (2013). Effective polyethylene glycol passivation for the inhibition of surface interactions of peripheral blood mononuclear cells and platelets. (external link)
• Volchenkov, Roman; Brun, Johan G; Jonsson, Roland et al. (2013). In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome. (external link)
• Sandvik, Lene Frøyen; Volchenkov, Roman; Jonsson, Roland et al. (2013). Characterization of monocyte-derived dendritic cells from immunosuppressed renal transplant recipients with and without squamous cell carcinomas. (external link)
• Haldorsen, Karstein; Appel, Silke; Le Hellard, Stephanie et al. (2013). No association of primary Sjögren's syndrome with Fcγ receptor gene variants. (external link)
• Volchenkov, Roman; Karlsen, Marie; Jonsson, Roland et al. (2013). Type 1 regulatory T cells and regulatory B cells induced by tolerogenic dendritic cells. (external link)
• Landsverk, Ole J. B.; Ottesen, Anett Hellebø; Berg-Larsen, Axel et al. (2012). Differential regulation of MHC II and invariant chain expression during maturation of monocyte-derived dendritic cells. (external link)
• Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland et al. (2012). The bacterial preparation OK432 induces IL-12p70 secretion in human dendritic cells in a TLR3 dependent manner. (external link)
• Sprater, Florian; Hovden, Arnt-Ove; Appel, Silke (2012). Expression of ESE-3 isoforms in immunogenic and tolerogenic human monocyte-derived dendritic cells. (external link)
• Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland et al. (2011). Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses. (external link)
• Lied, Gülen Arsland; Vogelsang, Petra; Berstad, Arnold et al. (2011). Dendritic cell populations in patients with self-reported food hypersensitivity. (external link)
• Karlsen, Marie; Hovden, Arnt-Ove; Vogelsang, Petra et al. (2011). Bromelain Treatment Leads to Maturation of Monocyte-derived Dendritic Cells but Cannot Replace PGE(2) in a Cocktail of IL-1 beta, IL-6, TNF-alpha and PGE(2). (external link)
• Appel, Silke; Le Hellard, Stephanie; Bruland, Ove et al. (2011). Potential association of muscarinic receptor 3 gene variants with primary Sjögren's syndrome. (external link)
• Nordmark, Gunnel; Kristjansdottir, Gudlaug; Theander, Elke et al. (2011). Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome. (external link)
• Vogelsang, Petra; Brun, Johan G; Øijordsbakken, Gunnvor et al. (2010). Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjögren's syndrome. (external link)
• Vogelsang, Petra; Hovden, Arnt-Ove; Jonsson, Roland et al. (2009). Levels of dendritic cell populations and regulatory T cells vary significantly between two commonly used mouse strains. (external link)
• Delaleu, Nicolas; Jonsson, Malin V; Appel, Silke et al. (2008). New Concepts in the Pathogenesis of Sjogren's Syndrome. (external link)
• Appel, Silke; Brossart, P. (2007). Development of novel compounds to treat autoimmune and inflammatory diseases and graft versus host reactions. (external link)
• Appel, Silke; Bringmann, Anita; Grünebach, Frank et al. (2006). Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs. (external link)

Academic lecture

• Osmani, Dorentina; Hans, Manpret Kour; Jakobsen, Kjerstin et al. (2023). Planter vs. dødelig virus. (external link)

Interview

• Riise, Ivar Lid; Kleiveland, Mathias; Andersen, Heidi Lie et al. (2023). Dreper kreftceller med hageplanter. (external link)

Academic literature review

• Ten Bergen, Lisa Lynn; Petrovic, Aleksandra; Aarebrot, Anders K. et al. (2020). Current knowledge on autoantigens and autoantibodies in psoriasis. (external link)
• Ten Bergen, Lisa Lynn; Petrovic, Aleksandra; Aarebrot, Anders K. et al. (2020). The TNF/IL-23/IL-17 axis-Head-to-head trials comparing different biologics in psoriasis treatment. (external link)
• Yi, Dag Heiro; Appel, Silke (2013). Current status and future perspectives of dendritic cell-based cancer immunotherapy. (external link)
• Volchenkov, Roman; Sprater, Florian; Vogelsang, Petra et al. (2012). The 2011 Nobel Prize in physiology or medicine. (external link)
• Jonsson, Roland; Vogelsang, Petra; Volchenkov, Roman et al. (2011). The complexity of Sjögren's syndrome: Novel aspects on pathogenesis. (external link)
• Vogelsang, Petra; Jonsson, Malin V; Dalvin, Sussie Trine et al. (2006). Role of dendritic cells in Sjögren´s syndrome. (external link)

Doctoral dissertation

• Solberg, Silje Michelsen; Appel, Silke; Bryceson, Yenan et al. (2019). Systemic inflammation in psoriasis: Circulating immune cells and cytokines. (external link)
• Davies, Richard Allan; Appel, Silke; Vogelsang, Petra et al. (2017). Flow cytometry based analyses as a tool in biomarker discovery for patient stratification in primary Sjögren’s syndrome. (external link)
• Karlsen, Marie; Appel, Silke; Hansen, Torbjørn (2015). Toll-like receptors in primary Sjögren’s syndrome. Special emphasis on B cells. (external link)
• Haldorsen, Karstein; Bolstad, Anne Isine; Brun, Johan G et al. (2011). Epidemiological, clinical, and immunogenetic aspects of primary Sjögren's syndrome. (external link)

Reader opinion piece

• Haldorsen, Karstein; Bruland, Ove; Appel, Silke et al. (2013). Reply to 'Comment on No association of primary Sjogren's syndrome with Fc gamma receptor gene variants'. (external link)
• Sandvik, Lene Frøyen; Vogelsang, Petra; Leivestad, Torbjørn et al. (2012). Quantification of Plasmacytoid Dendritic Cells and Type 1 Myeloid Dendritic Cells in Peripheral Blood of Renal Transplant Recipients With and Without Squamous Cell Carcinoma. (external link)
• Volchenkov, Roman; Jonsson, Roland; Appel, Silke (2012). Anti-Ro and anti-La autoantibody profiling in Norwegian patients with primary Sjogren's syndrome using luciferase immunoprecipitation systems (LIPS). (external link)
• Hovden, Arnt-Ove; Appel, Silke (2010). The First Dendritic Cell-Based Therapeutic Cancer Vaccine is Approved by the FDA. (external link)

Abstract

• Volchenkov, Roman; Karlsen, Marie; Jonsson, Roland et al. (2013). Type 1 Regulatory T cells and Regulatory B Cells Induced by Dexamethasone and 1,25-Dihydroxyvitamin D3 Treated Monocyte-Derived Dendritic Cells. (external link)
• Volchenkov, Roman; Karlsen, Marie; Jonsson, Roland et al. (2012). Comparison of different protocols for the generation of monocytes-derived tolerogenic dendritic cells for immunotherapy. (external link)
• Karlsen, Marie; Hansen, Torbjørn; Jonsson, Roland et al. (2012). Expression of Toll-like receptors 7 and 9 in B cell populations of patients with Sjogren's syndrome. (external link)
• Haldorsen, Karstein; Appel, Silke; Le Hellard, Stephanie et al. (2012). No association of primary Sjögren's Syndrome with Fc gamma? Receptor gene variants. (external link)
• Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland et al. (2011). Maturation of Dendritic Cells with the Bacterial Compound OK432 Induces High Secretion of IL-12p70 in a TLR3 Dependent Manner. (external link)
• Sandvik, Lene Frøyen; Leivestad, Torbjørn; Sandnes, Dagny Ann et al. (2011). Can Levels of Blood Plasmacytoid Dendritic Cells be used as a Prognostic Factor for Development of Squamous Cell Carcinomas in Organ Transplant Recipients?. (external link)
• Volchenkov, Roman; Hovden, Arnt-Ove; Karlsen, Marie et al. (2011). Generation of Tolerogenic Monocyte-Derived Dendritic Cells. (external link)
• Sprater, Florian; Hovden, Arnt-Ove; Niere, Marc et al. (2011). The Epithelial Specific Transcription Factor ESE-3 is Expressed in Immature Dendritic Cells and Occurs Primarily as the ESE-3b Isoform. (external link)
• Hovden, Arnt-Ove; Karlsen, Marie; Sandnes, Dagny Ann et al. (2010). Maturation of Monocyte Derived Dendritic Cells With OK432 Leads to Altered Expression of Surface Markers. (external link)
• Appel, Silke; Vogelsang, Petra; Brun, Johan G et al. (2010). Patients with Primary Sjogren's Syndrome have Significantly Reduced Amounts of Plasmacytoid and Type 2 Myeloid Dendritic Cells in Peripheral Blood. (external link)
• Nordmark, Gunnel; Kristjansdotti, Gudlaug; Theander, Elke et al. (2010). Gene Variants in Fam167A-Blk and Tnfsf4 are associated with Primary Sjogren's Syndrome. (external link)
• Haldorsen, Karstein; Appel, Silke; Bruland, Ove et al. (2010). Fc gamma receptor IIA, IIIA and IIIB single nucleotide polymorphisms and Fc gamma receptor IIIB copy number variation: No association with primary Sjögren's syndrome. (external link)
• Karlsen, Marie; Hovden, Arnt-Ove; Vogelsang, Petra et al. (2010). Bromelain Treatment Leads to Maturation of Monocyte Derived Dendritic Cells. (external link)
• Lied, Gülen Arsland; Vogelsang, Petra; Berstad, Arnold et al. (2010). Dendritic cell populations in patients with self-reported food hypersensitivity. (external link)
• Vogelsang, Petra; Deswaerte, Virginie; Jonsson, Malin V et al. (2008). Age-related distribution of cDC and pDC in salivary glands of NOD mice. (external link)
• Hovden, Arnt-Ove; Sandnes, Dagny Ann; Jonsson, Roland et al. (2008). Maturation of monocyte derived dendritic cells with OK432 leads to altered expression of surface markers. (external link)
• Bringmann, Anita; Hilgendorf, Ingo; Appel, Silke et al. (2008). Characterization of Gene p306 Expressed in Monocyte Derived Dendritic Cells. (external link)

See a complete overview of publications in Cristin.