Research
As a PhD candidate at the University of Bergen, I work directly under Professor Stephanie Le Hellard in the "Epigenetics and Multiomics" group. In my PhD project, I also work closely with the Polimanti Lab, led by Assoc. Professor Renato Polimanti, Yale University, USA.
My main interest is understanding complex disorders better, especially mental disorders, and the link between the human genome and phenome. To understand the relation, I study large datasets available through Biobanks, including different genetic ancestries using "-omics" methods like phenomics, genomics, proteomics, metabolomics and epigenomics.
As an MD, I have an overall reaching aim of these studies to lead us closer to precision medicine, both in diagnostics and treatment.
Publications
Academic article
- Koller, Dora; Friligkou, Eleni; Stiltner, Brendan et al. (2024). Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders. (external link)
- Koller, Dora; Mitjans, Marina; Kouakou, Manuela et al. (2024). Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders. (external link)
- Løkhammer, Solveig Brunstad; Koller, Dora; Wendt, Frank R. et al. (2024). Distinguishing vulnerability and resilience to posttraumatic stress disorder evaluating traumatic experiences, genetic risk and electronic health records. (external link)
- Friligkou, Eleni; Løkhammer, Solveig Brunstad; Cabrera-Mendoza, Brenda et al. (2024). Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study. (external link)
- Løkhammer, Solveig; Stavrum, Anne-Kristin Støbakk; Polushina, Tatiana et al. (2022). An epigenetic association analysis of childhood trauma in psychosis reveals possible overlap with methylation changes associated with PTSD. (external link)
See a complete overview of publications in Cristin.
Løkhammer, Solveig; Polushina, Tatiana; Stavrum, Anne-Kristin; Aas, Monica; Ottesen, Akiah; Andreassen, Ole A.; Melle, Ingrid; Le Hellard, Stephanie (2021). “An epigenetic association analysis of childhood trauma in psychosis reveals possible overlap with methylation changes associated with PTSD”, Transl Psychiatry 12, 177 (2022). https://doi.org/10.1038/s41398-022-01936-8
Unnarsdóttir, Anna Bára; Lovik, Anikó; Fawns-Ritchie, Chloe; Ask, Helga; Kõiv, Kadri; Hagen, Kristen; Didriksen, Maria; [and 42 others, including Løkhammer, Solveig]. (2021). ”Cohort profile: COVIDMENT: Covid-19 cohorts on mental health across six nations”, International Journal of Epidemiology, Volume 51, Issue 3, June 2022, Pages e108–e122, https://doi.org/10.1093/ije/dyab234
Projects
PhD degree project: "Molecular signatures in mental disorders: investigating risk and protection factors at the genetic, epigenetic and metabolomic levels"