Deciphering the role of exosomes in brain tumor microenvironment. Isolating and characterising exosomes from different grades of glioblastoma multiforme. 

Academic literature review

• Lunavat, Taral ; Nieland, Lisa; Vrijmoet, Anne B. et al. (2023). Roles of extracellular vesicles in glioblastoma: foes, friends and informers. (external link)

Academic article

• Watson, Dionysios C.; Bayik, Defne; Storevik, Simon Humberto et al. (2023). GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity. (external link)
• Rigg, Emma Kayleigh; Wang, Jiwei; Xue, Zhiwei et al. (2023). Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes. (external link)
• Lunavat, Taral Rameshchand (2016). RNAi delivery by exosome-mimetic nanovesicles–Implications for targeting c-Myc in cancer. (external link)
• Lunavat, Taral Rameshchand; Lötvall, Jan (2015). Small RNA deep sequencing discriminates subsets of extracellular vesicles released by melanoma cells – Evidence of unique microRNA cargos. (external link)

Editorial

• Repiska, Gabriela; Crescitelli, Rossella; Lunavat, Taral Rameshchand et al. (2023). Editorial: The role of extracellular vesicles in diseases: Shedding light on their role in cell-to-cell communication. (external link)

See a complete overview of publications in Cristin.

1) Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. Théry C, Witwer KW, Aikawa E,..., Lunavat TR, et. al., J Extracell Vesicles. 2018 Nov 23;7(1):1535750. doi: 10.1080/20013078.2018.1535750. eCollection 2018 PMID: 30637094 

2) Pediatric brain tumor cells release exosomes with a miRNA repertoire that differs from exosomes secreted by normal cells. Tűzesi Á, Kling T, Wenger A, Lunavat TR, Jang SC, Rydenhag B, Lötvall J, Pollard SM, Danielsson A, Carén H. Oncotarget. 2017 Oct 6;8(52):90164-90175. doi: 10.18632/oncotarget.21621. eCollection 2017 Oct 27. PMID: 29163818

3) A novel community driven software for functional enrichment analysis of extracellular vesicles data. Pathan M, Keerthikumar S, Chisanga D, Alessandro R, Ang CS, Askenase P, Batagov AO, Benito-Martin A, Camussi G, Clayton A, Collino F, Di Vizio D, Falcon-Perez JM, Fonseca P, Fonseka P, Fontana S, Gho YS, Hendrix A, Hoen EN, Iraci N, Kastaniegaard K, Kislinger T, Kowal J, Kurochkin IV, Leonardi T, Liang Y, Llorente A, Lunavat TR, et. al., J Extracell Vesicles. 2017 May 26;6(1):1321455. doi: 10.1080/20013078.2017.1321455. eCollection 2017. PMID: 28717418

4) BRAF^V600 inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells. Lunavat TR, Cheng L, Einarsdottir BO, et. al., Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5930-E5939. doi: 10.1073/pnas.1705206114. Epub 2017 Jul 6. PMID: 28684402

5) Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper. Mateescu B, Kowal EJ, van Balkom BW, Bartel S, Bhattacharyya SN, Buzás EI, Buck AH, de Candia P, Chow FW, Das S, Driedonks TA, Fernández-Messina L, Haderk F, Hill AF, Jones JC, Van Keuren-Jensen KR, Lai CP, Lässer C, Liegro ID, Lunavat TR, et. al., J Extracell Vesicles. 2017 Mar 7;6(1):1286095. doi: 10.1080/20013078.2017.1286095. eCollection 2017. PMID: 28326170.

6) Distinct prostate cancer-related mRNA cargo in extracellular vesicle subsets from prostate cell lines. Lázaro-Ibáñez E, Lunavat TR, Jang SC, et.al., BMC Cancer. 2017 Feb 1;17(1):92. doi: 10.1186/s12885-017-3087-x. PMID: 28143451.

7) RNAi delivery by exosome-mimetic nanovesicles - Implications for targeting c-Myc in cancer. Lunavat TR, Jang SC, Nilsson L et. al., Biomaterials. 2016 Sep;102:231-8. doi: 10.1016/j.biomaterials.2016.06.024. Epub 2016 Jun 15. PMID: 27344366

8) Small RNA deep sequencing discriminates subsets of extracellular vesicles released by melanoma cells--Evidence of unique microRNA cargos. Lunavat TR, Cheng L, Kim DK et. al., RNA Biol. 2015;12(8):810-23. doi: 10.1080/15476286.2015.1056975. PMID: 26176991

9) A Systematic Approach to Defining the microRNA Landscape in Metastasis. Mudduluru G, Abba M, Batliner J, Patil N, Scharp M, Lunavat TR, et. al., Cancer Res. 2015 Aug 1;75(15):3010-9. doi: 10.1158/0008-5472.CAN-15-0997. Epub 2015 Jun 11. PMID: 26069251

10) Mast cell exosomes promote lung adenocarcinoma cell proliferation - role of KIT-stem cell factor signaling. Xiao H, Lässer C, Shelke GV, Wang J, Rådinger M, Lunavat TR, et. al., Cell Commun Signal. 2014 Oct 14;12:64. doi: 10.1186/s12964-014-0064-8. PMID: 25311367