Research
Our laboratory uses state-of-art methods to investigate cell metabolism and mitochondrial biology, and the interactions with cell signaling. Through collaborations with our scientific and clinical partners, the overall aim is to contribute with knowledge and treatments for diseases involving metabolism dysfunctions.
Cell metabolism
Cell metabolism is influenced by many factors in the microenvironment, including nutrients, signaling molecules and oxygen supply. Metabolic adaptation occurs via cellular processes such as signal transduction, gene transcription and enzymatic regulation, and involves tuning of mitochondrial functions. The mitochondrial organelle serves as a major energy producer (ATP), and consititutes a hub for multiple pathways that sense and coordinate cellular responses to maintain homeostasis. Our hypothesis is that changes in cell physiology may be controlled by specific metabolic pathways, and consequently, that pathological shifts may be prevented or modulated by metabolic interventions. Currently, we are investigating these aspects in relation to cancer cell plasticity and therapy resistance; and in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) where we recently found indications of a specific metabolic obstruction that may explain several symptoms of this debilitating disease.
Main projects:
- Mitochondria, metabolic flexibility and stress responses in mammalian cells.
- Metabolic inflexibility as a possible weakness in cancer cells.
- Metabolism and cellular energetics in ME/CFS.
Funding:
The Norwegian Research Council (external link)
The Kavli Trust (external link)