My main research interests are in the field of tumour biology, particularly of head and neck carcinogenesis, focusing on the role of normal neighbouring cells (fibroblasts) on the invasive and self renewal properties of cancer cells. I am however, fascinated by the cell-to-cell interactions, such that I am currently involved in research projects looking at cell-to-cell interactions in normal human oral tissues as well, and between human cells and periodontal bacterial cells.

Oral pathology and tumour biology

Vitenskapelig artikkel

• Tornaas, Stian; Kleftogiannis, Dimitrios; Fromreide, Siren et al. (2024). Development of a high dimensional imaging mass cytometry panel to investigate spatial organization of tissue microenvironment in formalin-fixed archival clinical tissues. (ekstern lenke)
• Nordanger, Ida Marie; Beisland, Christian; Thorkelsen, Tor Kristian et al. (2024). The Prognostic Value of Human Papillomavirus Status in Penile Cancer: Outcomes From a Norwegian Cohort Study. (ekstern lenke)
• Das, Ridhima; Harper, Lisa; Kitajima, Kayoko et al. (2023). Embryonic Stem Cells Can Generate Oral Epithelia under Matrix Instruction. (ekstern lenke)
• Dongre, Harsh Nitin; Elnour, Rammah; Tornaas, Stian et al. (2023). TP53 mutation and human papilloma virus status as independent prognostic factors in a Norwegian cohort of vulva squamous cell carcinoma. (ekstern lenke)
• Moe, Svein Erik Emblem; Erland, Fredrik Atteraas; Fromreide, Siren et al. (2023). The TP53 Codon 72 Arginine Polymorphism Is Found with Increased TP53 Somatic Mutations in HPV(−) and in an Increased Percentage among HPV(+) Norwegian HNSCC Patients. (ekstern lenke)
• Ali, Hassan Abdel-Raouf Abdel-Wahab; Suliman, Salwa; Osman, Tarig Al-Hadi et al. (2023). Xeno-free generation of human induced pluripotent stem cells from donor-matched fibroblasts isolated from dermal and oral tissues. (ekstern lenke)
• Kråkenes, Torbjørn; Wergeland, Stig; Al-Sharabi, Niyaz Abdulbaqi Abdulmajid et al. (2023). The neuroprotective potential of mesenchymal stem cells from bone marrow and human exfoliated deciduous teeth in a murine model of demyelination. (ekstern lenke)
• Moen, Christian Arvei; Falkenthal, Thea Eline Hetland; Torkelsen, Tor Kristian et al. (2023). Penile Cancers Attributed to Human Papillomavirus Are Associated with Improved Survival for Node-positive Patients. Findings from a Norwegian Cohort Study Spanning 50 Years. (ekstern lenke)
• Rajthala, Saroj; Parajuli, Himalaya; Dongre, Harsh Nitin et al. (2022). MicroRNA-138 abates fibroblast motility with effect on invasion of adjacent cancer cells. (ekstern lenke)
• Das, Ridhima; Virlan, Maria Justina Roxana; Xenaki, Victoria et al. (2022). Granulocyte macrophage-colony stimulating factor and keratinocyte growth factor control of early stages of differentiation of oral epithelium. (ekstern lenke)
• Tornaas, Stian; Kleftogiannis, Dimitrios; Fromreide, Siren et al. (2022). Development of an antibody panel for imaging mass cytometry to investigate cancer-associated fibroblast heterogeneity and spatial distribution in archival tissues. (ekstern lenke)
• Sapkota, Dipak; Vallenari, Evan Michael; Tamatam, Dhanalakshmi et al. (2022). Investigation of Cross-Reactivity of Anti-Ephrin-B2 Antibody to Other Ephrin-B Members in an Immunohistochemical Study in a Cohort of Oral Squamous Cell Carcinoma . (ekstern lenke)
• Mohamed, Nuha Mohamed Gaafar; Osman, Tarig Al-Hadi; Elsheikh, Mariam et al. (2022). Epithelial PD-L1 expression at tumor front predicts overall survival in a cohort of oral squamous cell carcinomas from Sudan. (ekstern lenke)
• Mohamed, Nazar; van de Goor, Rens; El-Sheikh, Mariam et al. (2021). Feasibility of a portable electronic nose for detection of oral squamous cell carcinoma in sudan. (ekstern lenke)
• Mohamed, Nazar; Litlekalsøy, Jorunn; Ahmed, Israa Abdul Rhman et al. (2021). Analysis of salivary mycobiome in a cohort of oral squamous cell carcinoma patients from Sudan identifies higher salivary carriage of malassezia as an independent and favorable predictor of overall survival. (ekstern lenke)
• Rajthala, Saroj; Min, Anjie; Parajuli, Himalaya et al. (2021). Profiling and functional analysis of microrna deregulation in cancer-associated fibroblasts in oral squamous cell carcinoma depicts an anti-invasive role of microrna-204 via regulation of their motility. (ekstern lenke)
• Xenaki, Victoria; Cuida Marthinussen, Ileana Mihaela; Costea, Daniela Elena et al. (2021). Predicting intention of Norwegian dental health-care workers to use nanomaterials: An application of the augmented theory of planned behavior. (ekstern lenke)
• Rajthala, Saroj; Dongre, Harsh; Parajuli, Himalaya et al. (2021). Combined in situ hybridization and immunohistochemistry on archival tissues reveals stromal microRNA-204 as prognostic biomarker for oral squamous cell carcinoma. (ekstern lenke)
• Pandey, Sushma; Søland, Tine Merete; Bjerkli, Inger-Heidi et al. (2021). Combined loss of expression of involucrin and cytokeratin 13 is associated with poor prognosis in squamous cell carcinoma of mobile tongue. (ekstern lenke)
• Golburean, Olga; Hagen, Maria Helene; Uncuta, Diana et al. (2021). Knowledge, opinions, and practices related to oral cancer prevention and oral mucosal examination among dentists in Moldova, Belarus and Armenia: a multi-country cross-sectional study. (ekstern lenke)
• Mohamed, Nuha Mohamed Gaafar; Osman, Tarig Al-Hadi; Ahmed, Israa A.H. et al. (2021). Characterization of immune cell infiltrate in tumor stroma and epithelial compartments in oral squamous cell carcinomas of Sudanese patients. (ekstern lenke)
• Shanbhag, Siddharth; Kampleitner, Carina; Mohamed-Ahmed, Samih Salah Eldin Mahgoub et al. (2021). Ectopic Bone Tissue Engineering in Mice Using Human Gingiva or Bone Marrow-Derived Stromal/Progenitor Cells in Scaffold-Hydrogel Constructs. (ekstern lenke)
• Ando, Toshinori; Arang, Nadia; Wang, Zhiyong et al. (2021). EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1. (ekstern lenke)
• Dongre, Harsh N.; Haave, Hilde; Fromreide, Siren et al. (2021). Targeted Next-Generation Sequencing of Cancer-Related Genes in a Norwegian Patient Cohort With Head and Neck Squamous Cell Carcinoma Reveals Novel Actionable Mutations and Correlations With Pathological Parameters. (ekstern lenke)
• Steigen, Sonja Eriksson; Søland, Tine Merete; Nginamau, Elisabeth Sivy et al. (2020). Grading of oral squamous cell carcinomas – Intra and interrater agreeability: Simpler is better?. (ekstern lenke)
• Dongre, Harsh; Rana, Neha; Fromreide, Siren et al. (2020). Establishment of a novel cancer cell line derived from vulvar carcinoma associated with lichen sclerosus exhibiting a fibroblast-dependent tumorigenic potential. (ekstern lenke)
• Pandey, Sushma; Osman, Tarig Al-Hadi; Sharma, Sunita et al. (2020). Loss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma. (ekstern lenke)
• Haugse, Ragnhild; Langer, Anika; Murvold, Elisa Thodesen et al. (2020). Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells. (ekstern lenke)
• Gajurel, Rashmi; Gautam, Dej Kumar; Pun, Chin Bahadur et al. (2020). Trends and clinicopathological characteristics of oral squamous cell carcinomas reported at a tertiary cancer hospital in Nepal during 1999 to 2009. (ekstern lenke)
• Bjerkli, Inger-Heidi; Hadler-Olsen, Elin Synnøve; Nginamau, Elisabeth Sivy et al. (2020). A combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue cancer. (ekstern lenke)
• Pandey, Sushma; Follin-Arbelet, Benoit; Bahadur Pun, Chin et al. (2020). Helicobacter pylori was not detected in oral squamous cell carcinomas from cohorts of Norwegian and Nepalese patients. (ekstern lenke)
• Mazagão Guerreiro, Eduarda; Øvstebø, Reidun; Thiede, Bernd et al. (2020). Cancer cell line-specific protein profiles in extracellular vesicles identified by proteomics. (ekstern lenke)
• Bjerkli, Inger-Heidi; Laurvik, Helene; Nginamau, Elisabeth Sivy et al. (2020). Tumor budding score predicts lymph node status in oral tongue squamous cell carcinoma and should be included in the pathology report. (ekstern lenke)
• Suliman, Salwa; Ali, Hassan Mohamed Abdel-Raouf; Karlsen, Tommy Aleksander et al. (2019). Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells. (ekstern lenke)
• Xenaki, Victoria; Cuida Marthinussen, Ileana Mihaela; Costea, Daniela Elena et al. (2019). Knowledge about nanotechnology and intention to use nanomaterials: a comparative study among dental students in Norway and Romania. (ekstern lenke)
• Xenaki, Victoria; Costea, Daniela Elena; Cuida Marthinussen, Ileana Mihaela et al. (2019). Use of nanomaterials in dentistry: covariates of risk and benefit perceptions among dentists and hygienists in Norway. (ekstern lenke)
• Zeltz, Cedric; Alam, Jahedul; Liu, Hengshuo et al. (2019). α11β1 integrin is induced in a subset of cancer- associated fibroblasts in desmoplastic tumor stroma and mediates in vitro cell migration. (ekstern lenke)
• Zhuoyuan, Zhang; Gao, Zhenjie; Rajthala, Saroj et al. (2019). Metabolic reprogramming of normal oral fibroblasts correlated with increased glycolytic metabolism of oral squamous cell carcinoma and precedes their activation into carcinoma associated fibroblasts. (ekstern lenke)
• Zhang, Zhuoyuan; Liang, Xiao; Fan, Yaping et al. (2019). Fibroblasts rescue oral squamous cancer cell from metformin-induced apoptosis via alleviating metabolic disbalance and inhibiting AMPK pathway. (ekstern lenke)
• Kvalheim, Siri Flagestad; Xenaki, Victoria; Kvalheim, Arild et al. (2018). Effect of glycerol on reconstructed human oral mucosa. (ekstern lenke)
• Dmello, Crismita; Sawant, Sharada; Chaudhari, Pratik Rajeev et al. (2018). Aberrant expression of vimentin predisposes oral premalignant lesion derived cells towards transformation. (ekstern lenke)
• Guerreiro, Eduarda; Vestad, Beate; Steffensen, Lilly Alice et al. (2018). Efficient extracellular vesicle isolation by combining cell media modifications, ultrafiltration, and size-exclusion chromatography. (ekstern lenke)
• Bruserud, Øyvind; Costea, Daniela Elena; Laakso, Saila et al. (2018). Oral tongue malignancies in Autoimmune polyendocrine syndrome type 1. (ekstern lenke)
• Kitajima, Kayoko; Das, Ridhima; Liang, Xiao et al. (2018). Isolation and characterization of cells derived from human epithelial rests of Malassez. (ekstern lenke)
• Virlan, Maria Justina; Calenic, Bogdan; Cimpan, Mihaela Roxana et al. (2017). CHITOSAN MODIFIED POLY(LACTIC-CO-GLYCOLIC) ACID NANOPARTICLES INTERACTION WITH NORMAL, PRECANCEROUS KERATINOCYTES AND DENTAL PULP CELLS. (ekstern lenke)
• Konstantinova, Victoria; Ibrahim, Mohamed; Lie, Stein Atle et al. (2017). Nano-TiO2 penetration of oral mucosa: in vitro analysis using 3D organotypic human buccal mucosa models. (ekstern lenke)
• Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve; Costea, Daniela Elena et al. (2017). Cleavage of the urokinase receptor (uPAR) on oral cancer cells: Regulation by transforming growth factor - beta1 (TGF-beta1) and potential effects on migration and invasion. (ekstern lenke)
• Parajuli, Himalaya; Teh, Muy-Teck; Abrahamsen, Siren et al. (2016). Integrin α11 is overexpressed by tumour stroma of head and neck squamous cell carcinoma and correlates positively with alpha smooth muscle actin expression. (ekstern lenke)
• Biddle, Adrian; Gammon, Luke; Liang, Xiao et al. (2016). Phenotypic plasticity determines cancer stem cell therapeutic resistance in oral squamous cell carcinoma. (ekstern lenke)
• Sawant, Sharada; Dongre, Harsh; Singh, Archana Kumari et al. (2016). Establishment of 3D co-culture models from different stages of human tongue tumorigenesis: Utility in understanding neoplastic progression. (ekstern lenke)
• Konstantinova, Victoria; Ibrahim, Mohammad Madani; Lie, Stein Atle et al. (2016). Nano-TiO2 penetration of oral mucosa: in vitro analysis using 3D organotypic human buccal mucosa models. (ekstern lenke)
• Suliman, Salwa; Mustafa, Kamal Babikeir Eln; Krueger, Anke et al. (2016). Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes. (ekstern lenke)
• Suliman, Salwa; Sun, Yang; Pedersen, Torbjørn Østvik et al. (2016). In vivo host response and degradation of copolymer scaffolds functionalized with nanodiamonds and bone morphogenetic protein 2. (ekstern lenke)
• Suliman, Salwa; Parajuli, Himalaya; Sun, Yang et al. (2016). Establishment of a bioluminescence model for microenvironmentally induced oral carcinogenesis with implications for screening bioengineered scaffolds. (ekstern lenke)
• Dmello, Crismita; Sawant, Sharada; Alam, Hunain et al. (2016). Vimentin-mediated regulation of cell motility through modulation of beta4 integrin protein levels in oral tumor derived cells. (ekstern lenke)
• Sapkota, Dipak; Bruland, Ove; Parajuli, Himalaya et al. (2015). S100A16 promotes differentiation and contributes to a less aggressive tumor phenotype in oral squamous cell carcinoma. (ekstern lenke)
• Osman, Tarig Al-Hadi; Parajuli, Himalaya; Sapkota, Dipak et al. (2015). The low-affinity nerve growth factor receptor p75NTR identifies a transient stem cell-like state in oral squamous cell carcinoma cells. (ekstern lenke)
• Liang, Xiao; Osman, Tarig Al-Hadi; Sapkota, Dipak et al. (2014). Rapid adherence to collagen IV enriches for tumour initiating cells in oral cancer.. (ekstern lenke)
• Yang, Ning; Yan, Tao; Zhu, Huaiyang et al. (2014). A co-culture model with brain tumor-specific bioluminescence demonstrates astrocytes-induced drug resistance in glioblastoma.. (ekstern lenke)
• Liang, Xiao; Graham, Karen A.; Johannessen, Anne Christine et al. (2014). Human oral cancer cells with increasing tumorigenic abilities exhibit higher effective membrane capacitance. (ekstern lenke)
• Dabija-Wolter, Gabriela; Bakken, Vidar; Cimpan, Mihaela Roxana et al. (2013). In vitro reconstruction of human junctional and sulcular epithelium. (ekstern lenke)
• Costea, Daniela Elena; Hills, Allison; Osman, Amani Hamza Ali et al. (2013). Identification of two distinct carcinoma-associated fibroblast subtypes with differential tumor-promoting abilities in oral squamous cell carcinoma. (ekstern lenke)
• Hwang, Sungjae; Mahadevan, Swarna; Quadir, Fatima et al. (2013). Identification of FOXM1-induced epigenetic markers for head and neck squamous cell carcinomas. (ekstern lenke)
• Sapkota, Dipak; Costea, Daniela Elena; Ibrahim, Salah Osman et al. (2013). S100A14 interacts with S100A16 and regulates its expression in human cancer cells. (ekstern lenke)
• Kidwai, Fahad; Costea, Daniela Elena; Hutchison, Iain et al. (2013). The effects of CD44 down-regulation on stem cell properties of head and neck cancer cell lines. (ekstern lenke)
• Teh, Muy-Teck; Hutchison, Iain L.; Costea, Daniela Elena et al. (2013). Exploiting FOXM1-orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis. (ekstern lenke)
• Salo, Sirpa; Bitu, Carolina; Merkku, Kalle et al. (2013). Human bone marrow mesenchymal stem cells induce collagen production and tongue cancer invasion. (ekstern lenke)
• Osman, Tarig; Øijordsbakken, Gunnvor; Costea, Daniela Elena et al. (2013). Successful triple immuno enzymatic method employing primary antibodies from same species and same immunoglobulin subclass. (ekstern lenke)
• Sapkota, Dipak; Costea, Daniela Elena; Blø, Magnus et al. (2012). S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest. (ekstern lenke)
• Dabija-Wolter, Gabriela; Sapkota, Dipak; Cimpan, Mihaela Roxana et al. (2012). Limited in-depth invasion of Fusobacterium nucleatum into in vitro reconstructed human gingiva. (ekstern lenke)
• Litlekalsøy, Jorunn Inglaug; Høstmark, Jens; Costea, Daniela Elena et al. (2012). Time-dependent biological differences in molecular markers of high-grade urothelial cancer over 7 decades (ras proteins, pTEN, uPAR, PAI-1 and MMP-9). (ekstern lenke)
• Dayan, Daniel; Salo, Tuula; Salo, Simo et al. (2012). Molecular crosstalk between cancer cells and tumor microenvironment components suggests potential targets for new therapeutic approaches in mobile tongue cancer. (ekstern lenke)
• Sapkota, Dipak; Bruland, Ove; Costea, Daniela Elena et al. (2011). S100A14 regulates the invasive potential of oral squamous cell carcinoma derived cell-lines in vitro by modulating expression of matrix metalloproteinases, MMP1 and MMP9. (ekstern lenke)
• Berge, Gisle; Costea, Daniela Elena; Rasmussen, Marianne Berg et al. (2011). Coexpression and nuclear colocalization of metastasis-promoting protein S100A4 and p53 without mutual regulation in colorectal carcinoma. (ekstern lenke)
• Mulhall, Hayley J.; Labeed, Fatima H.; Kazmi, Batool et al. (2011). Cancer, pre-cancer and normal oral cells distinguished by dielectrophoresis. (ekstern lenke)
• Wiklund, Erik D; Gao, Shan; Hulf, Toby et al. (2011). MicroRNA Alterations and Associated Aberrant DNA Methylation Patterns across Multiple Sample Types in Oral Squamous Cell Carcinoma. (ekstern lenke)
• Biddle, Adrian; Liang, Xiao; Gammon, Luke et al. (2011). Cancer Stem Cells in Squamous Cell Carcinoma Switch between Two Distinct Phenotypes That Are Preferentially Migratory or Proliferative. (ekstern lenke)
• Gemenetzidis, Emilios; Costea, Daniela Elena; Parkinson, Eric K et al. (2010). Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1. (ekstern lenke)
• Harper, Lisa J.; Costea, Daniela Elena; Gammon, Luke et al. (2010). Normal and malignant epithelial cells with stem-like properties have an extended G2 cell cycle phase that is associated with apoptotic resistance. (ekstern lenke)
• Costea, Daniela Elena; Lukandu, Ochiba Mohammed; Bui, Linh Vu Duy et al. (2010). Adverse effects of Sudanese toombak vs. Swedish snuff on human oral cells. (ekstern lenke)
• Lukandu, Ochiba Mohammed; Neppelberg, Evelyn; Vintermyr, Olav Karsten et al. (2010). Khat alters the phenotype of in vitro-reconstructed human oral mucosa. (ekstern lenke)
• Costea, Daniela Elena; Lukandu, Ochiba Mohammed; Bui, Linh Vu Duy et al. (2009). Adverse effects of Sudanese toombak vs Swedish snuff on human oral cells. (ekstern lenke)
• Dabija-Wolter, Gabriela; Cimpan, Mihaela Roxana; Costea, Daniela Elena et al. (2009). Fusobacterium nucleatum Enters Normal Human Oral Fibroblasts In Vitro. (ekstern lenke)
• Lukandu, Ochiba Mohammed; Neppelberg, Evelyn; Vintermyr, Olav Karsten et al. (2009). Khat Alters the Phenotype of in vitro-reconstructed Human Oral Mucosa. (ekstern lenke)
• Kulasekara, Kulasekara M. Keerthi Kumara; Lukandu, Ochiba Mohammed; Neppelberg, Evelyn et al. (2009). Cancer progression is associated with increased expression of basement membrane proteins in three-dimensional in vitro models of human oral cancer. (ekstern lenke)
• Lukandu, Ochiba Mohammed; Bredholt, Therese; Neppelberg, Evelyn et al. (2009). Early loss of mitochondrial inner transmembrane potential in khat-induced cell death of primary normal human oral cells. (ekstern lenke)
• Gaballah, Kamis; Costea, Daniela Elena; Hills, Allison et al. (2008). Tissue engineering of oral dysplasia. (ekstern lenke)
• Lukandu, Ochiba Mohammed; Costea, Daniela Elena; Neppelberg, Evelyn et al. (2008). Khat (Catha edulis) induces reactive oxygen species and apoptosis in normal human oral keratinocytes and fibroblasts. (ekstern lenke)
• Lukandu, Ochiba Mohammed; Costea, Daniela Elena; Dimba, Elisabeth Anne Okumu et al. (2008). Khat induces G1-phase arrest and increased expression of stress-sensitive p53 and p16 proteins in normal human oral keratinocytes and fibroblasts. (ekstern lenke)
• Neppelberg, Evelyn; Costea, Daniela Elena; Vintermyr, Olav Karsten et al. (2007). Dual effects of sodium lauryl sulphate on human oral epithelial structure. (ekstern lenke)
• Costea, Daniela Elena; Kulasekara, Kulasekara M. Keerthi Kumara; Neppelberg, Evelyn et al. (2006). Species-specific fibroblasts required for triggering invasiveness of partially transformed oral keratinocytes. (ekstern lenke)
• Costea, Daniela-Elena; Dimba, Elisabeth Anne Okumu; Loro, Lado Lako et al. (2005). The phenotype of in vitro reconstituted normal human oral epithelium is essentially determined by culture medium. (ekstern lenke)
• Costea, Daniela-Elena; Johannessen, Anne Chr.; Vintermyr, Olav Karsten (2005). Fibroblast control on epithelial differentiation is gradually lost during <EM>in vitro</EM> tumor progression. (ekstern lenke)
• Dimba, E.A.; Gjertsen, Bjørn Tore; Bredholt, Therese et al. (2004). Khat (Catha edulis)-induced apoptosis is inhibited by antagonists of caspase-1 and -8 in human leukaemia cells. (ekstern lenke)
• Costea, Daniela-Elena; Loro, Lado Lako; Dimba, Elizabeth Anne et al. (2003). Crucial effects of fibroblasts and keratinocyte growth factor on morphogenesis of reconstructed human oral epithelium. (ekstern lenke)

Vitenskapelig oversiktsartikkel/review

• El Herch, Imane; Tornaas, Stian; Dongre, Harsh Nitin et al. (2024). Heterogeneity of cancer-associated fibroblasts and tumor-promoting roles in head and neck squamous cell carcinoma. (ekstern lenke)
• Vîrlan, Maria Justina Roxana; Costea, Daniela Elena; Păun, Diana Loreta et al. (2022). Degenerative bony changes in the temporal component of the temporomandibular joint – review of the literature. (ekstern lenke)
• Basnet, Suyog; Sharma, Sunita; Costea, Daniela Elena et al. (2019). Expression profile and functional role of S100A14 in human cancer. (ekstern lenke)
• Lupu, Mihai; Caruntu, Constantin; Ghita, Mihaela Adriana et al. (2016). Gene expression and proteome analysis as sources of biomarkers in basal cell carcinoma. (ekstern lenke)
• Min, Anjie; Zhu, Chao; Peng, Shuping et al. (2015). MicroRNAs as important players and biomarkers in oral carcinogenesis. (ekstern lenke)
• Osman, Tarig; Costea, Daniela Elena; Johannessen, Anne Chr. (2012). The use of salivary cytokines as a screening tool for oral squamous cell carcinoma: A review of the literature. (ekstern lenke)
• Costea, Daniela Elena; Gammon, Luke; Kitajima, Kayoko et al. (2008). Epithelial stem cells and malignancy. (ekstern lenke)
• Partridge, Max; Costea, Daniela Elena; Huang, Xiaohong (2007). The changing face of p53 in head and neck cancer. (ekstern lenke)
• Costea, Daniela Elena; Tsinkalovsky, Oleg; Vintermyr, Olav Karsten et al. (2006). Cancer Stem Cells – New and Potentially Important Targets for the Therapy of Oral Squamous Cell Carcinoma. (ekstern lenke)

Vitenskapelig foredrag

• Xenaki, Victoria; Xue, Ying; Lie, Stein Atle et al. (2023). Effect of titanium dioxide nanoparticles on oral cells and 3D oral mucosa models. (ekstern lenke)
• Gjerde, Christiane Helgestad; Langer, Anika; Ruiz de Garibay, Gorka et al. (2022). Establishment of ovarian cancer organoids on peritoneal dECM scaffolds. (ekstern lenke)
• Gjerde, Christiane Helgestad; Langer, Anika; Ruiz de Garibay, Gorka et al. (2022). Establishment of peritoneal dECM scaffolds for culture of ovarian cancer organoids. (ekstern lenke)
• Ibrahim, Mohamed; Konstantinova, Victoria; Lie, Stein Atle et al. (2016). Nano-TiO2 Penetrates Human Oral Mucosa. (ekstern lenke)
• Rolland Jacobsen, Martha; Sapkota, Dipak; Johannessen, Anne Christine et al. (2015). Oral premalignant lesions overexpress the collagen-elastin crosslinking enzyme LOXL4. (ekstern lenke)
• Suliman, Salwa; Costea, Daniela Elena; Mustafa, Kamal Babikeir Eln (2015). Development of a novel scaffold stimulating stem cells growth, differentiation and bone regeneration. (ekstern lenke)
• Rajthala, Saroj; Parajuli, Himalaya; Sapkota, Dipak et al. (2015). Expression of integrin α-11 by carcinoma associated fibroblasts modulates oral squa- mous cell carcinoma behaviour . (ekstern lenke)
• Costea, Daniela Elena (2015). Transforming growth factor beta 1 (TGFβ1) induces stem cell-like properties preferentially in cancer stem cell like–depleted cell subpopulations in human oral squamous cell carcinoma. (ekstern lenke)
• Costea, Daniela Elena; Hills, Allison; Osman, Amani Hamza Ali et al. (2015). Different subsets of carcinoma-associated fibroblasts promote oral carcinoma cell invasion by distinct mechanisms.. (ekstern lenke)
• Costea, Daniela Elena (2015). In vitro reconstruction of tumor microenvironment by use of organotypic 3D models . (ekstern lenke)
• Parajuli, Himalaya; Sapkota, Dipak; Suliman, Salwa et al. (2015). Expression of integrin α-11 by carcinoma associated fibroblasts modulates oral squamous cell carcinoma behaviour. (ekstern lenke)
• Osman, Amani Hamza Ali; Liang, Xiao; bilal, fazil et al. (2014). Carcinoma-associated fibroblasts promote a cancer stem cell-like phenotype. (ekstern lenke)
• Sapkota, Dipak; Costea, Daniela Elena; himalaya, parajuli et al. (2014). Role of S100A16 in Differentiation of Oral Squamous Cell Carcinoma. (ekstern lenke)
• Konstantinova, Victoria; Ibrahim, Mohamed; Birkeland, Eivind et al. (2014). Nanoparticle penetration in 3D oral mucosa models. (ekstern lenke)
• Costea, Daniela Elena (2013). Cancer associated fibroblasts increase stem cell -like properties of oral cancer cells. (ekstern lenke)
• Costea, Daniela Elena (2013). Cancer associated fibroblast stimulate self-renewal and invasion of oral cancer cells through TGFb secretion. (ekstern lenke)
• Costea, Daniela Elena (2008). Epithelial mesenchymal interactions in oral squamous cell carcinomas - in vitro studies on three. (ekstern lenke)
• Osman, Amani; Tsinkalovsky, Oleg; Costea, Daniela Elena et al. (2008). Phenotypic and functional differences between oral carcinoma-associated fibroblasts and normal oral. (ekstern lenke)
• Gemenetzidis, Emilios; Costea, Daniela Elena; Chaplin, T (2008). FOXM1 is Upregulated in Oral Cancer and Induces Genomic Instability. (ekstern lenke)
• Costea, Daniela Elena (2008). Interactions between stromal fibroblasts, normal oral keratinocytes and oral cancer-derived kerat. (ekstern lenke)
• Farøy, Anna; Osman, Amani; Johannessen, Anne Chr. et al. (2008). Migratory cancer stem cells exist in oral cancers. (ekstern lenke)
• Kidway, Fahad; Costea, Daniela Elena; Gammon, Luke et al. (2008). CD44 down-regulation reduces self-renewal of oral carcinoma stem cells. (ekstern lenke)
• Costea, Daniela Elena; Harper, Lisa; Gammon, Luke et al. (2008). Cell cycle particularities and selective resistance of cancer stem cells to drug induced apoptosi. (ekstern lenke)
• Costea, Daniela Elena; Neppelberg, Evelyn; Harper, Lisa et al. (2008). Stromal fibroblasts enhance clonogenic growth of transformed oral keratinocytes. (ekstern lenke)
• Nilsson, Helene; Costea, Daniela Elena; Gemenetzidis, Emilios et al. (2008). Oral squamous cell carcinoma cells inhibit the growth and induce apoptosis of normal oral keratin. (ekstern lenke)
• Dabija, Gabriela; Cimpan, Mihaela Roxana; Costea, Daniela Elena et al. (2008). Fusobacterium nucleatum Enters Oral Fibroblasts. (ekstern lenke)
• Mackenzie, IC; Costea, Daniela Elena; Harper, Lisa (2007). Tumour initiating cells spend an extended time in the g2 phase of the cell cycle. (ekstern lenke)
• Lukandu, Ochiba Mohammed; Costea, Daniela Elena; Dimba, Elisabeth Anne Okumu et al. (2007). Reactive Oxygen Species Mediate Khat Induced Cytotoxicity in Oral Cells. (ekstern lenke)
• Mackenzie, IC; Costea, Daniela Elena; Harper, Lisa (2007). The cd44+ fraction of carcinoma cells shows apoptotic resistance and spends an extended time in the g2 phase of the cell cycle. (ekstern lenke)
• Costea, Daniela Elena; Neppelberg, Evelyn; Harper, Lisa et al. (2007). Tumour fibroblasts enhance the self renewal properties of malignant epithelial cells. (ekstern lenke)
• Costea, Daniela Elena; Kulasekara, Keerthi; Neppelberg, Evelyn et al. (2006). Spontaneous sorting of fibroblasts and keratinocytes in organotypic oral mucosa. (ekstern lenke)
• Lukandu, Ochiba Mohammed; Costea, Daniela Elena; Bredholt, Therese et al. (2006). Characterisation of Khat Induced Cell Death in Oral Fibroblasts. (ekstern lenke)
• Nilsson, Helene; Costea, Daniela Elena; Otterlei, Maria Kristine et al. (2006). Normal Oral Keratinocytes and Fibroblasts Stimulate Clonal Expansion of Oral Squamous Cell Carcinoma – Derived Cells. (ekstern lenke)
• Kulasekara, Kulasekara M. Keerthi Kumara; Ochiba, Lukandu; Costea, Daniela-Elena et al. (2005). Stromal fibroblasts modulate tumuor invasion and expression of Basement membarne(BM) proteins in in vitro models of normal and neoplastic oral mucosa. (ekstern lenke)
• Dimba, Elisabeth Anne Okumu; Bredholt, Therese; Costea, Daniela-Elena et al. (2005). Mechanisms of apoptosis induction by khat alkaloids in leukaemia cells. (ekstern lenke)
• Kulasekara, Kulasekara M. Keerthi Kumara; Ochiba, Lukandu; Costea, Daniela-Elena et al. (2005). Stromal fibroblasts modulate tumuor invasion and expression of Basement membarne(BM) proteins in in vitro models of normal and neoplastic oral mucosa. (ekstern lenke)
• Costea, Daniela-Elena; Loro, Lado Lako; Kulasekara, Keerthi et al. (2004). Invasion of early neoplastic oral keratinocytes is triggered by species specific diffusible factors. (ekstern lenke)
• Costea, Daniela-Elena; Loro, Lado Lako; Kulasekara, Keerthi et al. (2004). Diffusible factors derived from species-specific oral fibroblasts trigger invasiveness of early neoplastic oral keratinocytes. (ekstern lenke)
• Costea, Daniela-Elena; Loro, Lado Lako; Vintermyr, Olav Karsten et al. (2004). Significance of epithelial-mesenchymal interactions for morphogenesis of in vitro reconstituted dysplastic human oral epithelium. (ekstern lenke)
• Costea, Daniela-Elena; Loro, Lado Lako; Kulasekara, Keerthi et al. (2004). Invasion of early neoplastic oral keratinocytes is triggered by species specific diffusible factors. (ekstern lenke)
• Costea, Daniela-Elena; Loro, Lado Lako; Kulasekara, Keerthi et al. (2004). Diffusible factors derived from species-specific oral fibroblasts trigger invasiveness of early neoplastic oral keratinocytes. (ekstern lenke)
• Costea, Daniela-Elena; Loro, Lado Lako; Vintermyr, Olav Karsten et al. (2004). Fibroblasts modulate the pattern of epithelial cell death in vitro reconstituted human oral mucosa through a mechanism independent of keratinocyte growth factor synthesis. (ekstern lenke)
• Costea, Daniela-Elena; Loro, Lado Lako; Vintermyr, Olav Karsten et al. (2004). Local invasiveness of oral epithelial dysplastic cells is triggered by human but not mouse fibroblasts: study on in vitro models of normal, dysplastic and neoplastic human oral mucosa. (ekstern lenke)
• Costea, Daniela-Elena; Loro, Lado Lako; Vintermyr, Olav Karsten et al. (2004). Significance of epithelial-mesenchymal interactions for morphogenesis of in vitro reconstituted dysplastic human oral epithelium. (ekstern lenke)
• Costea, Daniela-Elena; Loro, Lado Lako; Vintermyr, Olav Karsten et al. (2004). Local invasiveness of oral epithelial dysplastic cells is triggered by human but not mouse fibroblasts: study on in vitro models of normal, dysplastic and neoplastic human oral mucosa. (ekstern lenke)
• Costea, Daniela-Elena; Loro, Lado Lako; Vintermyr, Olav Karsten et al. (2004). Fibroblasts modulate the pattern of epithelial cell death in in vitro reconstituted human oral mucosa through a mechanism independent of keratinocyte growth factor synthesis. (ekstern lenke)
• Costea, Daniela-Elena; Dimba, Elizabeth Anne; Loro, Lado Lako et al. (2002). Serum free organotypic cultures of normal human oral mucosa. (ekstern lenke)
• Dimba, Elizabeth Anne; Costea, Daniela-Elena; Loro, Lado Lako et al. (2002). Cytotoxic effects of Catha edulis on leukemia cell lines and primary human oral cells. (ekstern lenke)
• Dimba, Elizabeth Anne; Costea, Daniela-Elena; Loro, Lado Lako et al. (2002). Cytotoxic effects of Catha edulis on human oral cells in vitro. (ekstern lenke)
• Costea, Daniela-Elena; Dimba, Elizabeth Anne; Loro, Lado Lako et al. (2002). Proliferation, differentiation and cell death in organotypic serum free cultures of normal human oral mucosa. (ekstern lenke)

Vitenskapelig Kapittel/Artikkel/Konferanseartikkel

• Dongre, Harsh Nitin; Costea, Daniela Elena (2022). Tumor-Fibroblast Interactions in Carcinomas. (ekstern lenke)
• Costea, Daniela-Elena; Dimba, Elizabeth Anne; Loro, Lado Lako et al. (2002). Proliferation and differentiation in organotypic serum free cultures of normal oral mucosa. (ekstern lenke)

Errata

• Shanbhag, Siddharth; Kampleitner, Carina; Mohamed-Ahmed, Samih Salah Eldin Mahgoub et al. (2022). Corrigendum: Ectopic Bone Tissue Engineering in Mice Using Human Gingiva or Bone Marrow-Derived Stromal/Progenitor Cells in Scaffold-Hydrogel Constructs (Front. Bioeng. Biotechnol., (2021), 9, (783468), 10.3389/fbioe.2021.783468). (ekstern lenke)

Poster

• Gjerde, Christiane Helgestad; Langer, Anika; Ruiz de Garibay, Gorka et al. (2022). Establishment of peritoneal dECM scaffolds for 3D culture of ovarian cancer organoids. (ekstern lenke)
• Xenaki, Victoria; Cuida Marthinussen, Ileana Mihaela; Costea, Daniela Elena et al. (2021). Factors Influencing the use of Nanomaterials in Dentistry. (ekstern lenke)
• Pandey, Sushma; Søland, Tine Merete; Bjerkli, Inger-Heidi et al. (2020). Low involucrin expression correlates to poor prognosis in oral squamous cell carcinoma of mobile tongue . (ekstern lenke)
• Xenaki, Victoria; Costea, Daniela Elena; Marthinussen, Mihaela Cuida et al. (2019). Dental Health Care Workers’ Intention to Use Nanomaterials. (ekstern lenke)
• Pandey Dhakal, Sushma; Osman, Tarig A.; Sharma, Sunita et al. (2019). Oral squamous cell carcinomas expressing higher levels of S100A14 correlate with prognosis. (ekstern lenke)
• Xenaki, Victoria; Cimpan, Mihaela Roxana; Marthinussen, Mihaela Cudia et al. (2018). Perception of risks and benefits related to nanomaterials. (ekstern lenke)
• Konstantinova, Victoria; Ibrahim, Mohamed; Lie, Stein Atle et al. (2016). Nano-TiO2 penetrates human oral mucosa. (ekstern lenke)
• Birkeland, Eivind; Konstantinova, Victoria; Ibrahim, Mohamed et al. (2014). Deeper penetration of TiO2 nanoparticles in neoplastic vs. Normal human oral mucosa models. (ekstern lenke)
• Konstantinova, Victoria; Ibrahim, Mohamed; Birkeland, Eivind et al. (2014). Comparison of uptake of TiO2 nanoparticles in normal and cancer human oral mucosa models. (ekstern lenke)
• Konstantinova, Victoria; Cimpan, Mihaela Roxana; Costea, Daniela Elena et al. (2014). Assessment of knowledge about nanotechnology in dentistry among dental students. (ekstern lenke)
• Konstantinova, Victoria; Ibrahim, Mohamed; Cuida Marthinussen, Ileana Mihaela et al. (2014). Uptake of TiO2 nanoparticles in a human oral mucosa model. (ekstern lenke)
• Suliman, Salwa Mustafa Nourelhuda; Parajuli, Himalaya; McCormack, Emmet et al. (2013). A novel model: Microenvironmentally-induced carcinogenesis for screening bone regeneration scaffolds. (ekstern lenke)
• Osman, Tarig; Johannessen, Anne Chr.; Costea, Daniela Elena (2012). Expression of cancer stem cell markers in oral squamous cell carcinoma. (ekstern lenke)
• Costea, Daniela Elena; Harper, Lisa; Kitajima, Kayoko et al. (2008). Generation of skin and oral mucosa from mouse embryonic stem cells under the influence of regional specific cells. (ekstern lenke)
• Gammon, Luke; Costea, Daniela Elena; Harper, Lisa et al. (2008). CD44+ carcinoma cells show apoptotic resistance and cell cycle differences. (ekstern lenke)
• Costea, Daniela Elena; Neppelberg, Evelyn; Harper, Lisa et al. (2008). Stromal fibroblasts enhance self renewal properties of transformed oral keratinocytes. (ekstern lenke)
• Kitajima, Kayoko; Harper, Lisa; Costea, Daniela Elena et al. (2008). The colony forming ability of HNSCC lines in-vitro. (ekstern lenke)
• Dabija, Gabriela; Cimpan, Mihaela Roxana; Bakken, Vidar et al. (2008). Fusobacterium nucleatum Enters the in Vitro Engineered Human Oral Mucosa. (ekstern lenke)
• Dabija, Gabriela; Neppelberg, Evelyn; Nielsen, Øyunn et al. (2008). In vitro reconstruction of human sulcular epithelium. (ekstern lenke)
• Dabija, Gabriela; Costea, Daniela Elena; Cimpan, Mihaela Roxana et al. (2007). Fusobacterium nucleatum Invades Primary Normal Human Gingival Fibroblasts. (ekstern lenke)
• Harper, Lisa; Costea, Daniela Elena; Mackenzie, IC (2007). Differential apoptotic cell responses within malignant cell lines. (ekstern lenke)
• Costea, Daniela Elena; Harper, Lisa; Mackenzie, IC (2007). Targeting cancer treatment at oral cancer stem cells. (ekstern lenke)
• Costea, Daniela Elena; Harper, Lisa; Mackenzie, IC (2007). 0ral malignancies show similar hierarchical stem cell patterns in vivo and in vitro. (ekstern lenke)
• Costea, Daniela Elena; Harper, Lisa; Mackenzie, IC (2007). Mechanisms of selective resistance of malignant stem cells to the induction of apoptotic cell death. (ekstern lenke)
• Harper, Lisa; Costea, Daniela Elena; Mackenzie, IC (2007). Targeting cancer treatment at breast cancer stem cells. (ekstern lenke)
• Costea, Daniela Elena; Harper, Lisa; Mackenzie, IC (2007). Similar hierarchical stem cell patterns in vivo and in vitro in oral malignancies. (ekstern lenke)
• Dabija, Gabriela; Costea, Daniela Elena; Cimpan, Mihaela Roxana et al. (2007). Fusobacterium nucleatum Invades Primary Normal Human Gingival Fibroblasts. (ekstern lenke)
• Nilsson, Helene; Otterlei, Maria Kristine; Costea, Daniela Elena et al. (2006). Normal Keratinocytes and Fibroblasts Control Oral Cancer Cell Expansion. (ekstern lenke)
• Kulasekara, Kulasekara M. Keerthi Kumara; Costea, Daniela-Elena; Øjordsbakken, Gunnvor et al. (2005). Basement membrane proteins during in vitro tumour progression. (ekstern lenke)
• Costea, Daniela-Elena; Øjordsbakken, Gunnvor; Kulasekara, Kulasekara M. Keerthi Kumara et al. (2005). Keratinocyte Sensitivity To Fibroblast-Derived Differentiation Signals Is Gradually Lost During In Vitro Tumour Progression. (ekstern lenke)
• Costea, Daniela-Elena; Loro, Lado Lako; Kulasekara, Kulasekara M. Keerthi Kumara et al. (2005). Species-Specific Fibroblasts Trigger Invasiveness of Early Neoplastic Oral Keratinocytes. (ekstern lenke)
• Costea, Daniela-Elena; Loro, Lado Lako; Kulasekara, Keerthi et al. (2004). Invasion of early neoplastic oral keratinocytes is triggered by species specific diffusable factors. (ekstern lenke)
• Costea, Daniela-Elena; Loro, Lado Lako; Kulasekara, Keerthi et al. (2004). Invasion of early neoplastic oral keratinocytes is triggered by species specific diffusable factors. (ekstern lenke)
• Costea, Daniela-Elena; Dimba, Elizabeth Anne; Loro, Lado Lako et al. (2002). Establishment of organotypic cultures of normal human oral mucosa. (ekstern lenke)
• Dimba, Elizabeth Anne; Costea, Daniela-Elena; Loro, Lado Lako et al. (2002). Cytotoxic effects of Catha edulis on human oral cells in vitro. (ekstern lenke)

Doktorgradsavhandling

• Costea, Daniela Elena; Mohamed, Nazar Gafar Abdulrahman (2020). Biomarker Identification in Oral Squamous Cell Carcinoma Study on Cohorts of Patients from Sudan. (ekstern lenke)
• Costea, Daniela Elena; Johannessen, Anne Christine; Suleiman, Ahmed et al. (2020). Biomarker identification in oral squamous cell carcinoma : study on cohorts of patients from Sudan. (ekstern lenke)
• Costea, Daniela Elena; Bjørge, Line; Johannessen, Anne Christine et al. (2020). Biomarkers and preclinical models for more precise diagnosis and personalized treatment of oral and vulva carcinomas - Study on human samples and experimental models. (ekstern lenke)
• Ahmed, Israa Abdul Rhman; Costea, Daniela Elena (2018). Identification of prognostic biomarkers for oral squamous cell carcinoma. Study on human samples and experimental models. (ekstern lenke)
• Parajuli, Himalaya; Costea, Daniela Elena (2016). Role of integrin α11 in oral carcinogenesis. In vitro and in vivo studies. (ekstern lenke)
• Suliman, Salwa; Mustafa, Kamal Babikeir Eln; Costea, Daniela Elena et al. (2015). Bioactive copolymer scaffolds for bone tissue engineering. Efficacy and host response.. (ekstern lenke)
• Litlekalsøy, Jorunn; Lærum, Ole Didrik; Bakke, August et al. (2015). Time relations of biological markers in urothelial carcinomas. (ekstern lenke)
• Dabija-Wolter, Gabriela; Bakken, Vidar; Costea, Daniela Elena et al. (2012). Interactions between Fusobacterium nucleatum and Primary Oral cells, In Vitro Studies in Monolayer and Organotypic Culture Models. (ekstern lenke)
• Gammon, Luke Antony; Johannessen, Anne Chr.; Costea, Daniela Elena et al. (2012). Cancer stem cells in oral squamous cell carcinomas - identification and characterization. (ekstern lenke)
• Lukandu, Ochiba Mohammed; Johannessen, Aina Elisabeth; Vintermyr, Olav Karsten et al. (2009). Toxicity of khat on normal human oral cells. In vitro studies using primary human oral keratinocytes and fibroblasts in monolayer and organotyic cultures. (ekstern lenke)
• Costea, Daniela-Elena; Johannessen, Anne Chr.; Vintermyr, Olav Karsten (2005). Epithelial-Mesenchymal Interactions in Normal and Neoplastic Human Oral Mucosa - A Study on in Vitro Organotypic Models. (ekstern lenke)

Populærvitenskapelig foredrag

• Pandey, Sushma; Follin-Arbelet, Benoit; Pun, Chin Babadur et al. (2019). Helicobacter pylori is not present in oral squamous cell carcinomas from cohorts of Norwegian and Nepalese patients . (ekstern lenke)
• Costea, Daniela Elena (2013). Possibilitites to study at University of Bergen through Quota Programme. (ekstern lenke)
• Costea, Daniela Elena (2013). Possibilitites to study at University of Bergen through Quota Programme. (ekstern lenke)
• Costea, Daniela Elena (2013). Possibilitites to study at University of Bergen through Quota Programme. (ekstern lenke)
• Costea, Daniela Elena (2013). Possibilitites to study at University of Bergen through Quota Programme. (ekstern lenke)
• Costea, Daniela Elena (2013). Possibilitites to study at University of Bergen through Quota Programme. (ekstern lenke)
• Costea, Daniela-Elena (2005). Kunstige slimhinners uante muligheter. (ekstern lenke)
• Costea, Daniela-Elena; Vintermyr, Olav Karsten; Johannessen, Anne Chr. (2004). Artificial human oral mucosa - new tools in dental research. (ekstern lenke)

Mastergradsoppgave

• Birkeland, Eivind; Cimpan, Mihaela Roxana; Costea, Daniela Elena (2016). Penetration of negatively and positively charged SiO2 nanoparticles into normal, dysplastic, and cancer human oral mucosa. (ekstern lenke)
• Konstantinova, Victoria; Cuida Marthinussen, Ileana Mihaela; Cimpan, Mihaela Roxana et al. (2015). Nanotechnology in dentistry. Assessment of current knowledge of dental students on the use of nanomaterials in dentistry and investigation of nanoparticle internalization in a human oral mucosa model. (ekstern lenke)
• Kvåle, Joakim; Cimpan, Mihaela Roxana; Costea, Daniela Elena (2015). FREMSKRITT INNENFOR NANOTEKNOLOGI VED DIAGNOSTIKK OG BEHANDLING AV KREFT. (ekstern lenke)

Faglig foredrag

• Costea, Daniela Elena (2016). The role of fibroblasts on tumor progression. (ekstern lenke)
• Costea, Daniela Elena (2015). Identification of Phenotypically Distinct Cancer Stem Cell Subpopulations in Oral Squamous Cell Carcinoma. (ekstern lenke)
• Costea, Daniela Elena (2013). The role of tumor microenvironment on oral cancer invasion. (ekstern lenke)
• Costea, Daniela Elena (2013). Carcinoma-associated fibroblasts promote a cancer stem cell-like phenotype through TGFβ1 secretion. (ekstern lenke)
• Costea, Daniela Elena (2013). The role of tumor microenvironment on oral cancer invasion. (ekstern lenke)
• Costea, Daniela Elena (2013). The role of tumor microenvironment on oral cancer invasion. (ekstern lenke)
• Costea, Daniela Elena (2013). The role of tumor microenvironment on oral cancer invasion. (ekstern lenke)

Intervju

• Costea, Daniela Elena; Timus, Cristina (2014). Daniela Costea, cercetătoarea care aparţine Europei, marţi la “Lumea şi noi”. (ekstern lenke)

Sammendrag/abstract

• Liang, Xiao; Labeed, FH; Abdallat, R et al. (2010). Rapid adherence to collagen IV enriches for tumour initiating cells. (ekstern lenke)
• Osman, Amani Hamza Ali; Costea, Daniela Elena; Tsinkalovsky, Oleg et al. (2009). Phenotypic and functional differences between oral carcinoma-associated fibroblasts and normal oral fibroblasts. (ekstern lenke)
• Berge, Gisle; Costea, Daniela Elena; Berg, Marianne et al. (2009). Coexpression and nuclear colocalization of metastasis-promoting protein S100A4 and p53 without mutual regulation in colorectal carcinoma. (ekstern lenke)
• Costea, Daniela Elena; Osman, Amani Hamza Ali; Ipatova, A et al. (2009). Enhanced self-renewal properties of transformed oral epithelial cells after interactions with stromal fibroblasts. (ekstern lenke)
• Costea, Daniela Elena; Harper, Lisa; Kitajima, Koichi et al. (2008). Generation of skin and oral mucosa from mouse embryonic stem cells under the influence of regional specific components. (ekstern lenke)
• Lukandu, Ochiba Mohammed; Dimba, Elisabeth Anne Okumu; Vintermyr, Olav et al. (2007). Khat inhibits proliferation of normal oral keratinocytes in monolayers and organotypic cultures. (ekstern lenke)
• Nilsson, Helene; Costea, Daniela Elena; Otterlei, Maria Kristine et al. (2007). Oral squamous cell carcinoma cells inhibit the growth of normal oral keratinocytes: a putative mechanism for intraepithelial tumour expansion. (ekstern lenke)
• Partridge, Max; Costea, Daniela Elena; Gaballah, Kamis et al. (2007). Recapitulating the features of mild, moderate and severe dysplasia using keratinocytes derived from clinical lesions and artificial connective tissue supports. (ekstern lenke)
• Costea, Daniela Elena; Kulasekara, KK; Neppelberg, Evelyn et al. (2006). Differentiation of oral epithelium is regulated by GM-CSF and KGF at early but not terminal stages. (ekstern lenke)
• Lukandu, MO; Costea, Daniela Elena; Bredholt, Therese et al. (2006). Effects of khat (Catha edulis) on normal human oral cells. (ekstern lenke)
• Johannessen, Anne Chr.; Costea, Daniela Elena; Øijordsbakken, Gunnvor et al. (2005). Keratinocyte sensitivity to fibroblast-derived differentiation signals is gradually lost during in vitro tumour progression. (ekstern lenke)
• Kulasekara, Kulasekara M. Keerthi Kumara; Costea, Daniela Elena; Øijordsbakken, Gunnvor et al. (2005). Basement membrane proteins in step-wise in vitro culture models of oral cancer progression. (ekstern lenke)
• Bredholt, Therese; Dimba, Elisabeth Anne Okumu; Johannessen, Anne Chr. et al. (2005). The role of Bcl-2 in apoptosis induced by khat (Catha edulis) in acute myeloid leukemia cell lines. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

Dr.Odont Thesis:

“Epithelial-Mesenchymal Interactions in Normal and Neoplastic Human Oral Mucosa - Studies on in Vitro Organotypic Models” ISBN 82-8006-022-70, UoB, Norway, 2005

Publications in peer reviewed international journals:

1. Costea DE, Loro LL, Dimba EA, Vintermyr OK, Johannessen AC (2003): Crucial effects of fibroblasts and keratinocyte growth factor on morphogenesis of reconstituted human oral epithelium. J Invest Dermatol. 121(6):1479-86.

2. Dimba EA, Gjertsen BT, Bredholt T, Fossan KO, Costea DE, Francis GW, Johannessen AC,Vintermyr OK (2004): Khat (Catha edulis)-induced apoptosis is inhibited by antagonists of
caspase-1 and -8 in human leukaemia cells. Br J Cancer. 91(9):1726-34.

3. Costea DE, Dimba AO, Loro LL, Vintermyr OK, Johannessen AC (2005): The phenotype of in vitro reconstituted normal human oral epithelium is essentially determined by culture medium. J
Oral Pathol Med. 34(4):247-52.

4. Costea DE, Johannessen AC, Vintermyr OK (2005): Fibroblast control on epithelial differentiation is gradually lost during in vitro tumor progression. Differentiation. 73(4):134-41.

5. Costea DE, Kulasekara K, Neppelberg E, Johannessen AC, Vintermyr OK (2006): Species-specific fibroblasts required for triggering invasiveness of partially transformed oral keratinocytes. Am J Pathol. 168(6):1889-97.

6. Costea DE, Tsinkalovsky O, Vintermyr OK, Johannessen AC, Mackenzie IC (2006): Cancer stem cells - new and potentially important targets for the therapy of oral squamous cell carcinoma. Oral Dis. 12(5):443-54. Review.

7. Neppelberg E, Costea DE, Vintermyr OK, Johannessen AC (2007): Dual effects of sodium lauryl sulphate on human oral epithelial structure. Exp Dermatol. 16(7):574-9.

8. Partridge M, Costea DE, Huang X (2007): The changing face of p53 in head and neck cancer. Int J Oral Maxillofac Surg. 36(12):1123-38. Review.

9. Costea DE (2007): Meeting students’ and supervisors’ expectations - findings from a pilot study done at Centre for International Health, University of Bergen; Bergen Open Research Archive (BORA).

10. Lukandu OM, Costea DE, Dimba EA, Neppelberg E, Bredholt T, Gjertsen BT, Vintermyr OK, Johannessen AC (2008): Khat induces G1-phase arrest and increased expression of stress-sensitive
p53 and p16 proteins in normal human oral keratinocytes and fibroblasts. Eur J Oral Sci. 116(1):23-30.

11. Lukandu OM, Costea DE, Neppelberg E, Johannessen AC, Vintermyr OK (2008): Khat (Catha edulis) induces reactive oxygen species and apoptosis in normal human oral keratinocytes and
fibroblasts. Toxicol Sci. 103(2):311-24.

12. Costea DE, Gammon L, Kitajima K, Harper L and Mackenzie IC (2008): Epithelial stem cells and malignancy. J Anat. 213(1):45-51.Review.

13. Gaballah K, Costea DE, Hills A, Gollin SM, Harrison P, Partridge M (2008): Tissue engineering of oral dysplasia, J Pathol, 215(3):280-9.

14. Dabija-Wolter G, Cimpan MR, Costea DE, Johannessen AC, Sornes S, Neppelberg E, Al-Haroni M, Skaug N, Bakken V (2009): Fusobacterium nucleatum enters normal human oral fibroblasts in vitro, J Periodontol., 80(7):1174-83.

15. Lukandu OM, Bredholdt T, Neppelberg E, Gjertsen BT, Johannessen AC , Vintermyr OK , Costea DE (2009):Early Loss of Mitochondrial Membrane Potential in Khat-Induced Cell Death of
Primary Normal Human Oral Cells, Toxicology, 263(2-3):108-16.

16. Kulasekara KK, Lukandu OM, Neppelberg E, Vintermyr OK , Johannessen AC, Costea DE (2009) Increased basement membrane protein expression during cancer progression and under stromal
influence in experimental three-dimensional models of human oral mucosa, Arch Oral Biol. e-pub ahead of print.

17. Lukandu OM, Neppelberg E, Vintermyr OK , Johannessen AC , Costea DE (2009): Khat alters the phenotype of in vitro reconstructed human oral mucosa, accepted to J Dent Res.

18. Costea DE, Lukandu OM, Bui L, Ibrahim MJ, Lygre R, Neppelberg E, Ibrahim SO, Vintermyr OK, Johannessen AC (2009): Adverse effects of Sudanese Toombak versus Swedish snuff on primary human oral cells, accepted to J Oral Pathol Med.

Main research project  

·      The role of normal neighbouring cells on invasive and self renewal properties of oral cancer cells

 

Collaborative research projects - directly related to the main project

·      Characterization of normal, dysplastic and tumour associated fibroblasts and their interactions with early transformed keratinocytes (with prof. M Partridge, Oncology, King’s College, UK, and prof. T Salo and postdoc P Nyberg, University of Oulu, Finland)

·      Sensitivity of oral and breast cancer stem cells to apoptotic cell death induced by therapeutic agents (with prof. IC Mackenzie, Stem Cell Initiative, QMUL,UK, and assoc.prof. K Kitajima, Niigata Dental School, Japan)

·      Identification and isolation of cancer stem cells in oral and colon cancers (collaboration with assoc. prof. F Labeed, University of Surrey, UK, postdoc O Tsinkalovsky and prof. OD Lærum , The Gade Institute,  assoc. prof. PØ Enger, Institute of Biomedicine, University of Bergen, Norway)

 

Collaborative research projects – affiliated to the main project

·      Interactions between oral cells and periodontal pathogens (collaboration with prof. V Bakken at Department of Microbiology, University of Bergen, Norway)

·      Cytotoxic effects of Catha Edulis on oral cells (collaboration with prof. BT Gjertsen, Department of Internal Medicine, University of Bergen, Norway)