Brystkreft; Molekylære endringer i ulike subgrupper (postdoc-prosjekt)

Genekspresjonsanalyser

Erfaring fra forskning på genekspresjonsforandringer ved endometriecancer (PhD)

PÅGÅENDE UNDERVISNING (2015):

Kordinator for PhD-kurset "CCBIO Junior Symposium" (CCBIO-901).

Timeundervisning ved PhD-kursene "Methods i Cancer Biomarker Research" (CCBIO-905) og "Biomarkers and Tumor Biology in Clinical Practice" (CCBIO-904).

Undervisning i patologi (obduksjon/makro) for medisinerstudenter.

TIDLIGERE UNDERVISNING:

Timeundervisning for medisinerstudenter i Gynekolog og obstetrikk.

Timeundervisning for masterstudenter i ernæringsfysiologi.

Vitenskapelig artikkel

• Svanøe, Amalie Abrahamsen; Humlevik, Rasmus O. C.; Knutsvik, Gøril et al. (2024). Age-related phenotypes in breast cancer: A population-based study. (ekstern lenke)
• Furriol Palmer, Jessica; Wik, Elisabeth; Aziz, Sura Mohammed et al. (2024). VEGFA gene variants are associated with breast cancer progression. (ekstern lenke)
• Ingebriktsen, Lise Martine; Svanøe, Amalie Abrahamsen; Sæle, Anna Kristine Myrmel et al. (2024). Age-Related Clusters and Favorable Immune Phenotypes in Breast Cancer of the Young Patients. (ekstern lenke)
• Lokøy, Ingvild Kathrin; Bakken, Inga Sofie; Wik, Elisabeth et al. (2024). Brystkreft hos menn – histopatologi og biomarkører. (ekstern lenke)
• Milosevic, Vladan; Edelmann, Reidunn Jetne; Winge, Ingeborg et al. (2023). Vessel size as a marker of survival in estrogen receptor positive breast cancer. (ekstern lenke)
• Chen, Ying; Klingen, Tor Audun; Aas, Hans et al. (2023). CD47 and CD68 expression in breast cancer is associated with tumor-infiltrating lymphocytes, blood vessel invasion, detection mode, and prognosis. (ekstern lenke)
• Kjølle, Silje; Finne, Kenneth; Birkeland, Even et al. (2023). Hypoxia induced responses are reflected in the stromal proteome of breast cancer. (ekstern lenke)
• Ingebriktsen, Lise Martine; Finne, Kenneth; Akslen, Lars Andreas et al. (2022). A novel age-related gene expression signature associates with proliferation and disease progression in breast cancer. (ekstern lenke)
• Wik, Elisabeth; Aziz, Sura Mohammed; Vethe, Heidrun et al. (2022). Neurogenesis and angiogenesis are associated features of aggressive breast cancer . (ekstern lenke)
• Chen, Ying; Klingen, Tor Audun; Aas, Hans et al. (2021). Tumor-associated lymphocytes and macrophages are related to stromal elastosis and vascular invasion in breast cancer. (ekstern lenke)
• Krüger, Kristi; Silwal-Pandit, Laxmi; Wik, Elisabeth et al. (2021). Baseline microvessel density predicts response to neoadjuvant bevacizumab treatment of locally advanced breast cancer. (ekstern lenke)
• Klingen, Tor Audun; Chen, Ying; Aas, Hans et al. (2021). Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer. (ekstern lenke)
• Klæstad, Elise; Opdahl, Signe; Engstrøm, Monica J et al. (2020). MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes. (ekstern lenke)
• Askeland, Cecilie; Wik, Elisabeth; Finne, Kenneth et al. (2020). Stathmin expression associates with vascular and immune responses in aggressive breast cancer subgroups. (ekstern lenke)
• Holst, Frederik; Werner, Henrica Maria Johanna; Mjøs, Siv et al. (2019). PIK3CA amplification associates with aggressive phenotype but not markers of AKT-mTOR signaling in endometrial carcinoma. (ekstern lenke)
• Smeland, Hilde Ytre-Hauge; Askeland, Cecilie; Wik, Elisabeth et al. (2019). Integrin α11β1 is expressed in breast cancer stroma and associates with aggressive tumor phenotypes.. (ekstern lenke)
• Hanevik, Kurt; Wik, Elisabeth; Langeland, Nina et al. (2018). Transient elevation of anti-transglutaminase and anti-endomysium antibodies in Giardia infection. (ekstern lenke)
• Kusonmano, Kanthida; Halle, Mari Kyllesø; Wik, Elisabeth et al. (2018). Identification of highly connected and differentially expressed gene subnetworks in metastasizing endometrial cancer. (ekstern lenke)
• Dimitrakopoulou, Konstantina; Wik, Elisabeth; Akslen, Lars A. et al. (2018). Deblender: A semi-/unsupervised multi-operational computational method for complete deconvolution of expression data from heterogeneous samples. (ekstern lenke)
• Aziz, Sura Mohammed; Wik, Elisabeth; Knutsvik, Gøril et al. (2017). Extra-nodal extension is a significant prognostic factor in lymph node positive breast cancer. (ekstern lenke)
• Klingen, Tor Audun; Chen, Ying; Aas, Hans et al. (2017). Tumor-associated macrophages are strongly related to vascular invasion, non-luminal subtypes, and interval breast cancer. (ekstern lenke)
• Landskron, Johannes; Kraggerud, Sigrid M.; Wik, Elisabeth et al. (2017). C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease. (ekstern lenke)
• Krüger, Kristi; Wik, Elisabeth; Knutsvik, Gøril et al. (2017). Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer. (ekstern lenke)
• Klingen, Tor Audun; Chen, Ying; Stefansson, Ingunn et al. (2016). Tumour cell invasion into blood vessels is significantly related to breast cancer subtypes and decreased survival. (ekstern lenke)
• Aziz, Sura Mohammed; Wik, Elisabeth; Knutsvik, Gøril et al. (2016). Evaluation of Tumor Cell Proliferation by Ki-67 Expression and Mitotic Count in Lymph Node Metastases from Breast Cancer. (ekstern lenke)
• Mauland, Karen Klepsland; Wik, Elisabeth; Høivik, Erling Andre et al. (2016). Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival. (ekstern lenke)
• Berg, Anna; Høivik, Erling Andre; Mjøs, Siv et al. (2015). Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients. (ekstern lenke)
• Stefansson, Ingunn; Ræder, Maria B; Wik, Elisabeth et al. (2015). Increased angiogenesis is associated with a 32-gene expression signature and 6p21 amplification in aggressive endometrial cancer. (ekstern lenke)
• Teschendorff, Andrew E.; Lee, Shih-Han; Jones, Allison et al. (2015). HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer. (ekstern lenke)
• Bredholt, Geir; Mannelqvist, Monica; Stefansson, Ingunn et al. (2015). Tumor necrosis is an important hallmark of aggressive endometrial cancer and associates with hypoxia, angiogenesis and inflammation responses. (ekstern lenke)
• Bartlett, Thomas E.; Jones, Alison; Goode, Ellen L. et al. (2015). Intra-gene DNA methylation variability is a clinically independent prognostic marker in women's cancers. (ekstern lenke)
• Earp, Magdalene A; Kelemen, Linda E.; Magliocco, Anthony M. et al. (2014). Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA. (ekstern lenke)
• Ojesina, Akinyemi; Lichtenstein, Lee; Freeman, Samuel S. et al. (2014). Landscape of genomic alterations in cervical carcinomas. (ekstern lenke)
• Werner, Henrica Maria Johanna; Trovik, Jone; Halle, Mari Kyllesø et al. (2014). Stathmin Protein Level, a Potential Peredictive Marker for Taxane Treatment Response in Endometrial Cancer. (ekstern lenke)
• Charbonneau, Bridget; Block, MS; Bamlet, WR et al. (2014). Risk of ovarian cancer and the NF-kB pathway: Genetic association with IL1A and TNFSF10. (ekstern lenke)
• Høivik, Erling Andre; Kusonmano, Kanthida; Halle, Mari Kyllesø et al. (2014). Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene. (ekstern lenke)
• Wik, Elisabeth; Trovik, Jone; Kusonmano, Kanthida et al. (2014). Endometrial Carcinoma Recurrence Score (ECARS) validates to identify aggressive disease and associates with markers of epithelial-mesenchymal transition and PI3K alterations. (ekstern lenke)
• Alonso-Alconada, Lorena; Muinelo-Romay, Laura; Madissoo, Kadri et al. (2014). Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer. (ekstern lenke)
• Mannelqvist, Monica; Wik, Elisabeth; Stefansson, Ingunn et al. (2014). An 18-Gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer. (ekstern lenke)
• Chen, Ying; Klingen, Tor Audun; Wik, Elisabeth et al. (2014). Breast cancer stromal elastosis is associated with mammography screening detection, low Ki67 expression and favourable prognosis in a population-based study. (ekstern lenke)
• Doufekas, Konstantinos; Hadwin, Richard B.M.; Kandimalla, Raju et al. (2013). GALR1 methylation in vaginal swabs is highly accurate in identifying women with endometrial cancer. (ekstern lenke)
• Trovik, Jone; Wik, Elisabeth; Werner, Henrica Maria Johanna et al. (2013). Hormone receptor loss in endometrial carcinoma curettage predicts lymph node metastasis and poor outcome in prospective multicentre trial. (ekstern lenke)
• Jones, Allison; Teschendorff, Andrew E.; Li, Quanxi et al. (2013). Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development. (ekstern lenke)
• Wik, Elisabeth; Ræder, Maria B; Krakstad, Camilla et al. (2013). Lack of estrogen receptor-alpha is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma. (ekstern lenke)
• Werner, Henrica Maria Johanna; Berg, Anna; Wik, Elisabeth et al. (2013). ARID1A loss is prevalent in endometrial hyperplasia with atypia and low-grade endometrioid carcinomas. (ekstern lenke)
• Shen, Hui; Fridley, BL; Song, HL et al. (2013). Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. (ekstern lenke)
• Wik, Elisabeth; Birkeland, Even; Trovik, Jone et al. (2013). High phospho-stathmin(Serine38) expression identifies aggressive endometrial cancer and suggests an association with PI3K inhibition. (ekstern lenke)
• Bojesen, Stig E.; Pooley, Karen A; Johnatty, Sharon E et al. (2013). Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. (ekstern lenke)
• Permuth-Wey, Jennifer; Lawrenson, K; Shen, HC et al. (2013). Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. (ekstern lenke)
• Pharoah, Paul D.P.; Halle, Mari Kyllesø; Krakstad, Camilla et al. (2013). GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (ekstern lenke)
• Ræder, Maria B; Birkeland, Even; Trovik, Jone et al. (2013). Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers. (ekstern lenke)
• Krakstad, Camilla; Trovik, Jone; Wik, Elisabeth et al. (2012). Loss of GPER identifies new targets for therapy among a subgroup of ER alpha-positive endometrial cancer patients with poor outcome. (ekstern lenke)
• Trovik, Jone; Mauland, Karen Klepsland; Werner, Henrica Maria Johanna et al. (2012). Improved survival related to changes in endometrial cancer treatment, a 30-year population based perspective. (ekstern lenke)
• Birkeland, Even; Wik, Elisabeth; Mjøs, Siv et al. (2012). KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer. (ekstern lenke)
• Krakstad, Camilla; Birkeland, Even; Seidel, Danila et al. (2012). High-throughput mutation profiling of primary and metastatic endometrial cancers identifies KRAS, FGFR2 and PIK3CA to be frequently mutated. (ekstern lenke)
• Mannelqvist, Monica; Stefansson, Ingunn Marie; Wik, Elisabeth et al. (2012). Lipocalin 2 expression is associated with aggressive features of endometrial cancer. (ekstern lenke)
• Mauland, Karen Klepsland; Trovik, Jone; Wik, Elisabeth et al. (2011). High BMI is significantly associated with positive progesterone receptor status and clinico-pathological markers for non-aggressive disease in endometrial cancer. (ekstern lenke)
• Vandenput, Ingrid; Trovik, Jone; Leunen, Karin et al. (2011). Evolution in endometrial cancer evidence from an immunohistochemical study. (ekstern lenke)
• Trovik, Jone; Wik, Elisabeth; Stefansson, Ingunn Marie et al. (2011). Stathmin Overexpression Identifies High-Risk Patients and Lymph Node Metastasis in Endometrial Cancer. (ekstern lenke)
• Staff, Anne Cathrine; Trovik, Jone; Eriksson, Ane Gerda Zahl et al. (2011). Elevated plasma growth differentiation factor-15 correlates with lymph node metastases and poor survival in endometrial cancer. (ekstern lenke)
• Salvesen, Helga Birgitte; Carter, Scott L.; Mannelqvist, Monica et al. (2009). Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation. (ekstern lenke)
• Albrektsen, Grethe; Heuch, Ivar; Wik, Elisabeth et al. (2009). Prognostic Impact of Parity in 493 Uterine Sarcoma Patients. (ekstern lenke)
• Bhriain, Hannah Ni; Trovik, Jone; Wik, Elisabeth et al. (2009). Plasma calprotectin concentrations in women with endometrial carcinoma. (ekstern lenke)
• Wik, Elisabeth; Trovik, Jone; Iversen, Ole-Erik et al. (2009). Deoxyribonucleic acid ploidy in endometrial carcinoma: a reproducible and valid prognostic marker in a routine diagnostic setting. (ekstern lenke)
• Albrektsen, Grethe; Heuch, Ivar; Wik, Elisabeth et al. (2009). Parity and time interval since childbirth influence survival in endometrial cancer patients. (ekstern lenke)

Vitenskapelig Kapittel/Artikkel/Konferanseartikkel

• Blanchard, Anne; Wik, Elisabeth; Akslen, Lars Andreas (2022). HER2 Revisited: Reflections on the Future of Cancer Biomarker Research. (ekstern lenke)
• Wik, Elisabeth; Akslen, Lars A. (2017). Gene expression signatures of the tumor microenvironment: relation to tumor progress in breast cancer. (ekstern lenke)

Faglig kapittel

• Wik, Elisabeth; Ingebriktsen, Lise Martine; Akslen, Lars Andreas (2022). Gene Expression Signatures of the Tumor Micoenvironment: Relation to Tumor Phenotypes and Progress in Breast Cancer . (ekstern lenke)

Intervju

• Wik, Elisabeth; Steigen, Sonja Eriksson (2017). Med forskning som ståsted i patologien. (ekstern lenke)

Vitenskapelig antologi/Konferanseserie

• Bremer, Anne; Strand, Roger; Cairns, John Alexander et al. (2017). Cancer Biomarkers: Ethics, Economics and Society. (ekstern lenke)

Vitenskapelig oversiktsartikkel/review

• Mauland, Karen Klepsland; Wik, Elisabeth; Salvesen, Helga (2014). Clinical value of DNA content assessment in endometrial cancer. (ekstern lenke)

Doktorgradsavhandling

• Wik, Elisabeth (2013). Endometrial carcinoma: a step closer to individualized therapy? Exploring transcriptional alterations in relation to prognostic biomarkers. (ekstern lenke)

Leserinnlegg

• Halle, Mari Kyllesø; Werner, Henrica Maria Johanna; Krakstad, Camilla et al. (2012). Stratification based on high tumour cell content in fresh frozen tissue promotes selection of aggressive endometrial carcinomas. (ekstern lenke)
• Trovik, Jone; Wik, Elisabeth; Stefansson, Ingunn Marie et al. (2010). Stathmin is superior to AKT and phospho-AKT staining for the detection of phosphoinositide 3-kinase activation and aggressive endometrial cancer. (ekstern lenke)

Poster

• Kusonmano, Kanthida; Wik, Elisabeth; Salvesen, Helga Birgitte et al. (2012). Identification of metastasis subnetworks in endometrial cancer. (ekstern lenke)
• Kusonmano, Kanthida; Wik, Elisabeth; Salvesen, Helga Birgitte et al. (2012). An ensemble-based feature selection algorithm for identifying candidate metastasis marker genes in endometrial cancer. (ekstern lenke)
• Trovik, Jone; Wik, Elisabeth; Stefansson, Ingunn Marie et al. (2009). Stathmin is superior to AKT and Phospho-AKT staining to detect PI3Kinase activation and aggressive endometrial cancer. (ekstern lenke)

Sammendrag/abstract

• Wik, Elisabeth; Rader, Maria; Krakstad, Camilla et al. (2012). Estrogen receptor a loss in endometrial carcinoma is associated with epithelial-to-mesenchymal transition and a potential for PI3Kinase inhibition. (ekstern lenke)
• Wik, Elisabeth; Rader, Maria; Krakstad, Camilla et al. (2012). Estrogen receptor a loss in endometrial carcinoma is associated with epithelial-to-mesenchymal transition and a potential for PI3Kinase inhibition. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

Endometrial Carcinoma Recurrence Score (ECARS) validates to identify aggressive disease and associates with markers of epithelial-mesenchymal transition and PI3K alterations.
Wik E, Trovik J, Kusonmano K, Birkeland E, Raeder MB, Pashtan I, Hoivik EA, Krakstad C, Werner HM, Holst F, Mjøs S, Halle MK, Mannelqvist M, Mauland KK, Oyan AM, Stefansson IM, Petersen K, Simon R, Cherniack AD, Meyerson M, Kalland KH, Akslen LA, Salvesen HB.
Gynecol Oncol. 2014 Sep;134(3):599-606. PMID: 24995579

High phospho-Stathmin(Serine38) expression identifies aggressive endometrial cancer and suggests an association with PI3K inhibition.
Wik E, Birkeland E, Trovik J, Werner HM, Hoivik EA, Mjos S, Krakstad C, Kusonmano K, Mauland K, Stefansson IM, Holst F, Petersen K, Oyan AM, Simon R, Kalland KH, Ricketts W, Akslen LA, Salvesen HB.
Clin Cancer Res. 2013 May 1;19(9):2331-41. PMID: 23538402

Lack of estrogen receptor-α is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma.
Wik E, Ræder MB, Krakstad C, Trovik J, Birkeland E, Hoivik EA, Mjos S, Werner HM, Mannelqvist M, Stefansson IM, Oyan AM, Kalland KH, Akslen LA, Salvesen HB.
Clin Cancer Res. 2013 Mar 1;19(5):1094-105. PMID: 23319822

An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer.
Mannelqvist M, Wik E, Stefansson IM, Akslen LA.
PLoS One. 2014 Jun 6;9(6):e98787.
PMID: 24905342

Increased angiogenesis is associated with a 32-gene expression signature and 6p21 amplification in aggressive endometrial cancer.
Stefansson IM, Raeder M, Wik E, Mannelqvist M, Kusonmano K, Knutsvik G, Haldorsen I, Trovik J, Øyan AM, Kalland KH, Staff AC, Salvesen HB, Akslen LA.
Oncotarget. 2015 Mar 10. PMID: 25860936

Breast cancer stromal elastosis is associated with mammography screening detection, low Ki67 expression and favourable prognosis in a population-based study.
Chen Y, Klingen TA, Wik E, Aas H, Vigeland E, Liestøl K, Garred Ø, Mæhlen J, Akslen LA, Lømo J. Diagn Pathol. 2014 Dec 19;9(1):230. PMID: 25522915

 

For other publications, see: http://www.ncbi.nlm.nih.gov/pubmed/?term=wik+e

 

 

 

 

Postdoc prosjekt:

Biomarkers and gene expression profiles for disease progression across different molecular subtypes of breast cancer