Medisinsk spesialist og konsulent

Prof Francisco Gómez Real, MD PhD, deler sin tid mellom vitenskapelig og klinisk arbeid. Han er professor ved Institutt for Klinisk medisin (K2), Det Medisinske Fakultet (MOF) ved Universitetet i Bergen, Norge. Han er spesialist i gynekologi og fødselshjelp, jobber som konsulent ved Kvinneklinikken, Haukeland Universitetssykehus, og er ansvarlig for oppfølgingen av gravide kvinner med fedme. Han har erfaring fra allmennmedisin og lungemedisin.

Forskning

Real er banebryter og internasjonal ekspert innen forskning om kjønnshormoner, reproduktive- og metabolske faktorer, og tidlige livsfaktorer for lungehelse. Han er banebrytende for dette feltet gjennom sin egen doktorgrad, postdoktorarbeid, doktorgradsstudenter og postdoktor. Han er ansvarlig for kvinnehelse studier i kohortene Respiratory Health in Northern Europe (RHINE) og Respiratory Health in Northern Europe, Spain and Australia (RHINESSA), og medansvarlig for kvinnehelse studier i Europaen Community Respiratory Health Survey (ECRHS).

Han leder Forskningsenhet for helseundersøkelser (FHU), en kjernefasilitet ved Universitetet i Bergen som gjennomfører kliniske forskningsprosjekter som ikke krever sykehusinfrastruktur. FHU er et samarbeid mellom Det Medisinske Fakultet og Haukeland universitetssykehus (HUS), administrativt underlagt Institutt for klinisk medisin, og finansiert av Trond Mohn Foundation/Trond Mohn Stiftelse (TMS).

Omfattende dekning av forskningsaktiviteter gjennom nasjonale og internasjonale medier (inkl. Reuters) - aviser (inkl. New York Times, Washington Post, Der Standard, El Pais, Aftenposten), magasiner (inkl. Dagens Medisin, Allergi i Praksis, Tidskriftet for den Norske Legeforeningen), kvinneblader (inkl. Women's Weekly magazine, SELF magazine), radio (inkl. BBC-nyheter, ABC-nyheter, norske radiostasjoner) og elektroniske medier (inkl. Times News, Medical News Today, American Academy of Allergy Asthma & Immunology, RT online, Web MD, Women's Day, På Høyden).

Han har mottatt Best Paper Awards, Norsk forning for lungemedisin, 2007 som første forfatter, og 2011, 2016 og 2017 som siste forfatter.

Han foreleser for 5. års medisinstudenter i gynekologi og fødselslære, i det engelske semsesteret, ved Universitetet i Bergen.

Han var ansvarlig for å organisere og starte klinisk praksis for 5. års medisinstudenter i det engelse semestert for gynekologi og fødselslære, Universitetet i Bergen.

Vitenskapelig artikkel

• Gyawali, Sanjay; Svanes, Cecilie; Viken, Anders Flataker et al. (2025). Asthma and Asthma Symptoms Associated with Endometriosis and Dysmenorrhea in a Nordic-Baltic Population. (ekstern lenke)
• Van Der Plaat, Diana A.; Lenoir, Alexandra; Dharmage, Shyamali et al. (2024). Effects of testosterone and sex hormone binding globulinon lung function in males and females: A multivariable Mendelian Randomisation study. (ekstern lenke)
• Sinsamala, Robin Mzati; Johannessen, Ane; Bertelsen, Randi Jacobsen et al. (2024). Pregnancy outcomes as related to in utero exposure to air pollution and greenness: The Life-GAP Project. (ekstern lenke)
• Viken, Anders Flataker; Siiak, Silver Peeter; Schlünssen, Vivi et al. (2024). Muscle Strength and Male Sexual Function. (ekstern lenke)
• Nilsen, Roy Miodini; Strandberg, Ragnhild Bjarkøy; Yaya, Yaliso et al. (2024). Pre-pregnancy obesity among immigrant and non-immigrant women in Norway: Prevalence, trends, and subgroup variations. (ekstern lenke)
• Emilsson, Össur Ingi; Johansson, Henrik; Johannessen, Ane et al. (2024). Heritability of cough across two generations: the RHINESSA study. (ekstern lenke)
• Kirkeleit, Jorunn; Riise, Trond; Wielscher, Mathias et al. (2023). Early life exposures contributing to accelerated lung function decline in adulthood – a follow-up study of 11,000 adults from the general population. (ekstern lenke)
• Abouelhana, Hesham Amin Mohamed; Šantl-Temkiv, Tina; Cramer, Christine et al. (2023). Indoor Airborne Microbiome and Endotoxin: Meteorological Events and Occupant Characteristics Are Important Determinants. (ekstern lenke)
• Shigdel, Rajesh; Johannessen, Ane; Lin, Huang et al. (2023). Oral bacterial composition associated with lung function and lung inflammation in a community-based Norwegian population. (ekstern lenke)
• Khomich, Maryia; Lin, Huang; Malinovschi, Andrei et al. (2023). Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort. (ekstern lenke)
• Kisiel, Marta A.; Arnfelt, Oscar; Lindberg, Eva et al. (2023). Association between abdominal and general obesity and respiratory symptoms, asthma and COPD. Results from the RHINE study. (ekstern lenke)
• Kitaba, Negusse Tadesse; Knudsen, Gerd Toril Mørkve; Johannessen, Ane et al. (2023). Fathers’ preconception smoking and offspring DNA methylation. (ekstern lenke)
• Vindenes, Hilde Kristin; Lin, Huang; Shigdel, Rajesh et al. (2022). Exposure to Antibacterial Chemicals Is Associated With Altered Composition of Oral Microbiome. (ekstern lenke)
• Lønnebotn, Marianne; Calciano, Lucia; Johannessen, Ane et al. (2022). Parental Prepuberty Overweight and Offspring Lung Function. (ekstern lenke)
• Bertelsen, Randi Jacobsen; Perez Barrionuevo, Antonio Manuel; Shigdel, Rajesh et al. (2022). Association of oral bacteria with oral hygiene habits and self-reported gingival bleeding. (ekstern lenke)
• Svanes, Cecilie; Johannessen, Ane; Bertelsen, Randi Jacobsen et al. (2022). Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort. (ekstern lenke)
• Vogt, Elinor Margrethe Chelsom; Real, Francisco Gomez; Husebye, Eystein Sverre et al. (2022). Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts. (ekstern lenke)
• Moitra, Subhabrata; Carsin, Anne-Elie; Abramson, Michael J et al. (2022). Long-term effect of asthma on the development of obesity among adults: an international cohort study, ECRHS. (ekstern lenke)
• Sigurðardóttir, Erla S.; Gislason, Thorarinn; Benediktsdottir, Bryndis et al. (2022). Female sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort. (ekstern lenke)
• Triebner, Kai Philipp; Markevych, Iana; Bertelsen, Randi Jacobsen et al. (2022). Lifelong exposure to residential greenspace and the premenstrual syndrome: A population-based study of Northern European women. (ekstern lenke)
• Grindheim, Sindre; Ebbing, Cathrine; Karlsen, Henriette Odland et al. (2022). Metformin exposure, maternal PCOS status and fetal venous liver circulation: A randomized, placebo-controlled study. (ekstern lenke)
• Wåtevik, Marie ; Frisk, Bente; Real, Francisco Gomez et al. (2021). CT-defined emphysema in COPD patients and risk for change in desaturation status in 6-min walk test. (ekstern lenke)
• Ekström, Magnus; Johannessen, Ane; Abramson, Michael J. et al. (2021). Breathlessness across generations: Results from the RHINESSA generation study. (ekstern lenke)
• Krantz, Christina; Accordini, Simone; Alving, Kjell et al. (2021). Cross-sectional study on exhaled nitric oxide in relation to upper airway inflammatory disorders with regard to asthma and perennial sensitization. (ekstern lenke)
• Tjalvin, Gro; Svanes, Øistein; Igland, Jannicke et al. (2021). Maternal preconception occupational exposure to cleaning products and disinfectants and offspring asthma. (ekstern lenke)
• Accordini, Simone; Calciano, Lucia; Johannessen, Ane et al. (2021). Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach. (ekstern lenke)
• Triebner, Kai Philipp; Bui, Dinh S.; Walters, E. Haydn et al. (2021). Childhood lung function as a determinant of menopause-dependent lung function decline. (ekstern lenke)
• Nerpin, Elisabet; Ferreira, Diogenes Seraphim; Weyler, Joost et al. (2021). Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status. (ekstern lenke)
• Vindenes, Hilde Kristin; Svanes, Cecilie; Lygre, Stein Håkon Låstad et al. (2021). Exposure to environmental phenols and parabens, and relation to body mass index, eczema and respiratory outcomes in the Norwegian RHINESSA study. (ekstern lenke)
• Triebner, Kai; Bifulco, Ersilia; Barrera-Gómez, Jose et al. (2021). Ultraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS). (ekstern lenke)
• Lenoir, Alexandra; Fuertes, Elaine; Gomez Real, Francisco et al. (2020). Lung function changes over 8 years and testosterone markers in both sexes: Uk biobank. (ekstern lenke)
• Rezwan, Faizal I; Imboden, Medea; Amaral, André F.S. et al. (2020). Association of adult lung function with accelerated biological aging. (ekstern lenke)
• Lindberg, Eva; Janson, Christer; Johannessen, Ane et al. (2020). Sleep time and sleep-related symptoms across two generations – results of the community-based RHINE and RHINESSA studies. (ekstern lenke)
• Wåtevik, Marie Johanne; Frisk, Bente; Gomez Real, Francisco et al. (2020). One Year Change in 6-Minute Walk Test Outcomes is Associated with COPD Prognosis. (ekstern lenke)
• Knudsen, Gerd Toril Mørkve; Dharmage, Shyamali C.; Janson, Christer et al. (2020). Parents’ smoking onset before conception as related to body mass index and fat mass in adult offspring: Findings from the RHINESSA generation study. (ekstern lenke)
• Triebner, Kai; Johannessen, Ane; Svanes, Cecilie et al. (2020). Describing the status of reproductive ageing simply and precisely: A reproductive ageing score based on three questions and validated with hormone levels. (ekstern lenke)
• Campbell, Brittany; Bui, Dinh S.; Simpson, Julie A. et al. (2020). Early Age at Natural Menopause Is Related to Lower Post-Bronchodilator Lung Function. A Longitudinal Population-based Study. (ekstern lenke)
• Carsin, Anne-Elie; Keidel, Dirk; Fuertes, Elaine et al. (2020). Regular Physical Activity Levels and Incidence of Restrictive Spirometry Pattern: A Longitudinal Analysis of 2 Population-Based Cohorts. (ekstern lenke)
• Triebner, Kai; Accordini, Simone; Calciano, Lucia et al. (2019). Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS). (ekstern lenke)
• Carsin, Anne-Elie; Fuertes, Elaine; Schaffner, Emmanuel et al. (2019). Restrictive spirometry pattern is associated with low physical activity levels. A population based international study. (ekstern lenke)
• van der Plaat, Diana A.; Pereira, Miguel; Pesce, Giancarlo et al. (2019). Age at menopause and lung function: a Mendelian randomisation study. (ekstern lenke)
• Knudsen, Gerd Toril Mørkve; Rezwan, FI; Johannessen, Ane et al. (2019). Epigenome-wide association of father's smoking with offspring DNA methylation: A hypothesis-generating study. (ekstern lenke)
• Løvvik, Tone Shetelig; Carlsen, Sven Magnus; Salvesen, Øyvind et al. (2019). Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial. (ekstern lenke)
• Campbell, Brittany; Simpson, Julie A.; Bui, Dinh S. et al. (2019). Early menarche is associated with lower adult lung function: A longitudinal cohort study from the first to sixth decade of life. (ekstern lenke)
• Triebner, Kai; Markevych, Iana; Hustad, Simon Steinar et al. (2019). Residential surrounding greenspace and age at menopause: A 20-year European study (ECRHS). (ekstern lenke)
• Emilsson, Össur Ingi; Hägg, Shadi Amid; Lindberg, Eva et al. (2019). Snoring and nocturnal reflux: Association with lung function decline and respiratory symptoms. (ekstern lenke)
• van der Plaat, Diana; Minelli, Cosetta; Jarvis, Deborah et al. (2019). Polycystic ovary syndrome and lung function: a Mendelian randomization study. (ekstern lenke)
• Johannessen, Ane; Lønnebotn, Marianne; Calciano, Lucia et al. (2019). Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?. (ekstern lenke)
• Kuiper, Ingrid Nordeide; Svanes, Cecilie; Benediktsdóttir, Bryndís et al. (2018). Agreement in reporting of asthma by parents or offspring - the RHINESSA generation study. (ekstern lenke)
• Perez Barrionuevo, Antonio Manuel; Gomez Real, Francisco; Igland, Jannicke et al. (2018). Periodontal Health status and lung function in two Norwegian cohorts. (ekstern lenke)
• Accordini, Simone; Calciano, Lucia; Johannessen, Ane et al. (2018). A three-generation study on the association of tobacco smoking with asthma. (ekstern lenke)
• Jögi, Nils Oskar; Svanes, Cecilie; Siiak, Silver Peeter et al. (2018). Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway. (ekstern lenke)
• Lønnebotn, Marianne; Natvig, Gerd Karin; Benediktsdóttir, Bryndís et al. (2018). Polycystic ovary syndrome, body mass index and hypertensive disorders in pregnancy. (ekstern lenke)
• Lønnebotn, Marianne; Svanes, Cecilie; Igland, Jannicke et al. (2018). Body silhouettes as a tool to reflect obesity in the past. (ekstern lenke)
• Fuertes, Elaine; Carsin, Anne Elie; Antó, Jósep Maria et al. (2018). Leisure-time vigorous physical activity is associated with better lung function: The prospective ECRHS study. (ekstern lenke)
• Erbas, Bircan; Knudsen, Gerd Toril Mørkve; Janson, Christer et al. (2018). Critical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokers. (ekstern lenke)
• Björnsdóttir, Erla; Janson, Christer; Lindberg, Eva et al. (2017). Respiratory symptoms are more common among short sleepers independent of obesity. (ekstern lenke)
• Gill, Dipender; Sheehan, Nuala A.; Wielscher, Matthias et al. (2017). Age at menarche and lung function: a Mendelian randomization study. (ekstern lenke)
• Hansen, Sofie; Probst-Hensch, Nicole; Bettschart, Robert et al. (2017). Early menarche and new onset of asthma: Results from the SAPALDIA cohort study. (ekstern lenke)
• Htet, Thaw D.; Teede, Helena J.; De Courten, Barbora et al. (2017). Asthma in reproductive-aged women with polycystic ovary syndrome and association with obesity. (ekstern lenke)
• Lindberg, Eva; Benediktsdóttir, Bryndís; Franklin, Karl A. et al. (2017). Women with symptoms of sleep-disordered breathing are less likely to be diagnosed and treated for sleep apnea than men. (ekstern lenke)
• Triebner, Kai; Matulonga, Bobette; Johannessen, Ane et al. (2017). Menopause is associated with accelerated lung function decline.. (ekstern lenke)
• Russell, Melissa A.; Janson, Christer; Gomez Real, Francisco et al. (2017). Physical activity and asthma: A longitudinal and multi-country study. (ekstern lenke)
• Campbell, Brittany; Rahérison, Chantal; Lodge, Caroline Jane et al. (2017). The effects of growing up on a farm on adult lung function and allergic phenotypes: An international population-based study. (ekstern lenke)
• Lowe, Adrian J.; Lodge, Caroline J.; Allen, Katrina J. et al. (2017). Cohort Profile: Melbourne Atopy Cohort study (MACS). (ekstern lenke)
• Skulstad, Svein Magne; Igland, Jannicke; Johannessen, Ane et al. (2017). Validation of maternal reported pregnancy and birth characteristics against the Medical Birth Registry of Norway. (ekstern lenke)
• Amaral, André F.S.; Strachan, David P.; Gomez Real, Francisco et al. (2016). Lower lung function associates with cessation of menstruation: UK Biobank data. (ekstern lenke)
• Gíslason, Þórarinn; Bertelsen, Randi Jacobsen; Gomez Real, Francisco et al. (2016). Self-reported exposure to traffic pollution in relation to daytime sleepiness and habitual snoring: a questionnaire study in seven North-European cities. (ekstern lenke)
• Dratva, Julia; Bertelsen, Randi Jacobsen; Janson, Christer et al. (2016). Validation of self-reported figural drawing scales against anthropometric measurements in adults. (ekstern lenke)
• Gomez Real, Francisco; Barrionuevo, Laura Perez; Franklin, K. et al. (2016). The Association of gum bleeding With respiratory Health in a population based study from Northern Europe. (ekstern lenke)
• Triebner, Kai; Johannessen, Ane; Puggini, Luca et al. (2016). Menopause as a predictor of new-onset asthma: A longitudinal Northern European population study. (ekstern lenke)
• Svanes, Cecilie; Koplin, Jennifer; Skulstad, Svein Magne et al. (2016). Father’s environment before conception and asthma risk in his children: a multi-generation analysis of the Respiratory Health In Northern Europe study. (ekstern lenke)
• Wåtevik, Marie Johanne; Johannessen, Ane; Gomez Real, Francisco et al. (2016). Oxygen desaturation in 6-min walk test is a risk factor for adverse outcomes in COPD patients.. (ekstern lenke)
• Dratva, Julia; Zemp, Elisabeth; Dharmage, Shyamali C. et al. (2016). Early life origins of lung ageing: Early life exposures and lung function decline in adulthood in two European cohorts aged 28-73 years. (ekstern lenke)
• Matheson, Melanie C.; Burgess, John A.; Lau, Melisa Y.Z. et al. (2015). Hormonal contraception increases risk of asthma among obese but decreases it among nonobese subjects: A prospective, population-based cohort study. (ekstern lenke)
• Svanes, Øistein; Skorge, Trude Duelien; Johannessen, Ane et al. (2015). Respiratory health in cleaners in Northern Europe: Is susceptibility established in early life?. (ekstern lenke)
• Johannessen, Ane; Verlato, Guiseppe; Benediktsdottir, Bryndis et al. (2014). Longterm follow-up in European respiratory health studies - patterns and implications. (ekstern lenke)
• Leynaert, Bénédicte; Sunyer, Jordi; Garcia-Esteban, Raquel et al. (2012). Gender differences in prevalence, diagnosis and incidence of allergic and non-allergic asthma: a population-based cohort. (ekstern lenke)

Sammendrag/abstract

• Gyawali, Sanjay; Lønnebotn, Marianne; Johannessen, Ane et al. (2023). Asthma and asthma-like symptoms as associated with endometriosis and menstrual pain. (ekstern lenke)

Doktorgradsavhandling

• Lønnebotn, Marianne; Real, Francisco Gomez (2022). Parental body size and offspring lung health: preparing for parenthood already in childhood?. (ekstern lenke)
• Triebner, Kai; Gomez Real, Francisco (2017). Respiratory health in aging women. The influence of menopause on asthma incidence and lung function decline. (ekstern lenke)

Vitenskapelig oversiktsartikkel/review

• Svanes, Cecilie; Bertelsen, Randi Jacobsen; Accordini, Simone et al. (2021). Exposures during the prepuberty period and future offspring's health: evidence from human cohort studies. (ekstern lenke)
• López Cervantes, Juan Pablo; Lønnebotn, Marianne; Jögi, Nils Oskar et al. (2021). The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?. (ekstern lenke)
• Gomez Real, Francisco; Burgess, John A.; Villani, Simona et al. (2018). Maternal age at delivery, lung function and asthma in offspring: A population-based survey. (ekstern lenke)
• Lønnebotn, Marianne; El-Merhie, Natalia; Holloway, John W et al. (2018). Environmental Impact on Health across Generations: Policy Meets Biology. A Review of Animal and Human Models.. (ekstern lenke)
• Sánchez-Ramos, José L.; Pereira-Vega, Antonio R.; Alvarado-Gómez, Francisco et al. (2017). Risk factors for premenstrual asthma: a systematic review and meta-analysis. (ekstern lenke)

Brev til redaktøren

• van der Plaat, Diana A.; Minelli, Cosetta; Jarvis, Deborah L. et al. (2020). Polycystic ovary syndrome and lung function: a Mendelian randomization study. (ekstern lenke)

Poster

• Lønnebotn, Marianne; Nilsen, Roy Miodini; Dharmage, Shyamali et al. (2018). Associations of fathers and their offsprings weight gain With non-allergic asthma. (ekstern lenke)

Vitenskapelig foredrag

• Waatevik, Marie; Eagan, Tomas Mikal; Hardie, Jon Andrew et al. (2017). Repeated desaturation in 6 minute walk test increases risk for mortality in COPD patients. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

Han har bygget en utmerket karriere innen reproduksjon og lungehelse hos kvinner, og over generasjoner. Han har 89 fagfellevurderte publikasjoner, inkludert 54 de siste 5 årene. Hans vitenskapelige produksjon er stigende, med 20 publikasjoner det siste to årene, 31 publikasjoner i topprangerte tidsskrifter (IF 8 eller høyere), og han er første/andre/ seniorforfatter på 26. Han er en erfaren veileder for forskere. Han har bidratt til 3 bokkapitler. Han er en erfaren forskningsveileder.

Prosjektleder og samarbeidspartner

Han samarbeider i sin forskning med Respiratory Health in Northern Europe (RHINE), European Community Respiratory Health Survey (ECRHS), Tasmanian Health Survey (TAHS), den sveitsiske kohortstudien om luftforurensning og lungesykdommer hos voksne (SAPALDIA), UK BioBank, PregMet-studien, og den transgenerasjonelle Respiratory Health in Northern Europe, Spain and Australia (RHINESSA). Han var PI i den banebrytende studien om Overgangsalder og respiratorisk helse, som Norges forskningsråd (NFR) finansierte, hvor ECRHS, RHINE og TAHS samarbeidet. Han tilbrakte seks måneder som postdoktor ved prof Shyamali Dharmage´s Allergy and Lung Health Unit, University of Melbourne. Han leder Reproductive Respiratory Health arbeidsgruppen for RHINE og RHINESSA studier, er med-leder i ECRHS Gender Working Group med AI Leynaert, og PI for ECRHS i Bergen.

Hans styrker som forsker er original- og innovativ tenkning, god nettverksbyggingskapasitet og erfaring med forskningsadministrasjon. Dette vises i artikler som har bidratt til ny tenkning i feltet.

Hans doktorgradsstudent og postdoktorforsker, Kai Triebner, har publiserte artikler som har vist at overgangsalderen er relatert til nyoppstått astma og akselerert lungefunksjonsfall (publisert i ledende luftveis- og allergitidsskrifter).

 

2018-2023        Partner, “Preconception exposures and related epigenetic mechanisms in Asthma and allergies”. TOPFORSK Norwegian Research Council (NRC) grant, 25,000,000 NOK

2018-2021        Veileder, «Life course with good Health» program, West Health Council (Helse Vest) grant, PhD research fellowship, PhD candidate Marianne Lønnebotn

2017-2021        Leder, Forskningsenhet for helseundersøkelser, Trond Mohn stiftelse (TMS) stipend 11,000,000 NOK

2017-2020        Veileder, “Post-menopausal deterioration of respiratory health:  Lifestyle strategies to preserve healthy lungs in aging women”, Universitet i Bergen stipend , postdoctoral research fellowship, PhD Kai Triebner