Harald Gotten Wiker
Stilling
Professor, Knyttet til enhet for læring ved det medisinske fakultet Leder av programutvalget for medisin
Tilhørighet
Forskergrupper
Forskning
Clinical and experimental microbiology and immunology with an emphasis on characterization of bacteria using proteomic methods and the human microbiome using high throughput DNA sequencing
ORCID https://orcid.org/0000-0001-9452-243X
LOOP https://loop.frontiersin.org/people/2110415/overview
Publikasjoner
2022
- Martinsen, Einar Marius Hjellestad; Eagan, Tomas Mikal Lind; Wiker, Harald Gotten et al. (2022). A longitudinal study of the pulmonary mycobiome in subjects with and without chronic obstructive pulmonary disease. (ekstern lenke)
- Rosvold, Elin Olaug; Dahl, Christen Peder; Simpson, Melanie Rae et al. (2022). Fastlegevikar uten LIS1 er feil bruk av nye leger. (ekstern lenke)
- Lie, Anne Helene Kveim; Eriksen, Sara Soraya Aemsangthum; Sharma, Ritika et al. (2022). Klima og bærekraft i helseutdanningene. (ekstern lenke)
- Skutlaberg, Dag Harald; Wiker, Harald Gotten; Mylvaganam, Haima et al. (2022). Consistent biofilm formation by streptococcus pyogenes emm 1 isolated from patients With necrotizing soft tissue infections. (ekstern lenke)
2021
- Hoel, Ida Marie; Ali, Iman A Mohammed; Ishtiaq, Sheeba et al. (2021). Immunochemistry-based diagnosis of extrapulmonary tuberculosis: A strategy for large-scale production of mpt64-antibodies for use in the mpt64 antigen detection test. (ekstern lenke)
- Drengenes, Christine; Eagan, Tomas Mikal; Haaland, Ingvild et al. (2021). Exploring protocol bias in airway microbiome studies: one versus two PCR steps and 16S rRNA gene region V3 V4 versus V4. (ekstern lenke)
- Mohammed, Marwan; Pettersen, Veronika K.; Nerland, Audun Helge et al. (2021). Label-free quantitative proteomic analysis of the oral bacteria Fusobacterium nucleatum and Porphyromonas gingivalis to identify protein features relevant in biofilm formation. (ekstern lenke)
- Kveim Lie, Anne Helene; Frost Andersen, Lene; Sharma, Ritika et al. (2021). Rapport: Arbeidsgruppe for klima og bærekraft i helseutdanningene.. (ekstern lenke)
- Nielsen, Rune; Xue, Yaxin; Jonassen, Inge et al. (2021). Repeated bronchoscopy in health and obstructive lung disease: is the airway microbiome stable?. (ekstern lenke)
2020
- Leiten, Elise Orvedal; Nielsen, Rune; Wiker, Harald Gotten et al. (2020). The airway microbiota and exacerbations of COPD. (ekstern lenke)
- Jouleh, Bahareh; Haaland, Ingvild; Khorsand, Fahimeh et al. (2020). Levels of proteinase 3 and neutrophil elastase in plasma, BAL and biopsies in COPD. (ekstern lenke)
- Riaz, Syeda Mariam; Bjune, Gunnar Aksel; Wiker, Harald G et al. (2020). Mycobacterial antigens accumulation in foamy macrophages in murine pulmonary tuberculosis lesions: Association with necrosis and making of cavities. (ekstern lenke)
- Pettersen, Veronika Kucharova; Steinsland, Hans; Wiker, Harald G (2020). Distinct Metabolic Features of Pathogenic Escherichia coli and Shigella spp. Determined by Label‐Free Quantitative Proteomics. (ekstern lenke)
- Hoel, Ida Marie; Sviland, Lisbeth; Syre, Heidi et al. (2020). Diagnosis of extrapulmonary tuberculosis using the MPT64 antigen detection test in a high-income low tuberculosis prevalence setting. (ekstern lenke)
2019
- Machado, Karla C.T.; Fortuin, Suereta; Tomazella, Gisele Guicardi et al. (2019). On the impact of the pangenome and annotation discrepancies while building protein sequence databases for bacteria proteogenomics. (ekstern lenke)
- Nielsen, Rune; Xue, Yaxin; Jonassen, Inge et al. (2019). Repeated bronchoscopy examination of the airway microbiome. (ekstern lenke)
- Tangedal, Solveig; Nielsen, Rune; Aanerud, Marianne et al. (2019). Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients. (ekstern lenke)
- Drengenes, Christine; Wiker, Harald G; Kalananthan, Tharmini et al. (2019). Laboratory contamination in airway microbiome studies. (ekstern lenke)
2018
- Pettersen, Veronika Kucharova; Steinsland, Hans; Wiker, Harald G (2018). Comparative proteomics of enterotoxigenic escherichia coli reveals differences in surface protein production and similarities in metabolism. (ekstern lenke)
- Riaz, Syeda Mariam; Sviland, Lisbeth; Wiker, Harald G et al. (2018). Mycobacterial antigen accumulation in foamy macrophages in pulmonary tuberculosis lesions is associated with tissue destruction and disease severity. (ekstern lenke)
2017
- Hoel, Ida Marie; Sviland, Lisbeth; Wiker, Harald G et al. (2017). Implementation of a new immunohistochemistry-based test for diagnosing extrapulmonary tuberculosis by detection of mycobacterial antigen MPT64. (ekstern lenke)
- Kittang, Bård Reiakvam; Pettersen, Veronika Kucharova; Oppegaard, Oddvar et al. (2017). Zoonotic necrotizing myositis caused by Streptococcus equi subsp. zooepidemicus in a farmer. (ekstern lenke)
- Tangedal, Solveig; Aanerud, Marianne; Grønseth, Rune et al. (2017). Comparing microbiota profiles in induced and spontaneous sputum samples in COPD patients. (ekstern lenke)
- Mohammed, Marwan; Pettersen, Veronika Kucharova; Nerland, Audun Helge et al. (2017). Quantitative proteomic analysis of extracellular matrix extracted from mono- and dual-species biofilms of Fusobacterium nucleatum and Porphyromonas gingivalis. (ekstern lenke)
- Purohit, Manju; Sviland, Lisbeth; Wiker, Harald G et al. (2017). Rapid and specific diagnosis of extrapulmonary tuberculosis by immunostaining of tissues and aspirates with anti-MPT64. (ekstern lenke)
- Grønseth, Rune; Drengenes, Christine; Wiker, Harald G et al. (2017). Protected sampling is preferable in bronchoscopic studies of the airway microbiome. (ekstern lenke)
2015
- Mustafa, Tehmina; Brokstad, Karl Albert; Mfinanga, Sayoki Godfrey M. et al. (2015). Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients. (ekstern lenke)
- Pettersen, Veronika Kucharova; Steinsland, Hans; Wiker, Harald G (2015). Improving genome annotation of enterotoxigenic Escherichia coli TW10598 by a label-free quantitative MS/MS approach. (ekstern lenke)
- Fortuin, Suereta; Tomazella, Gisele Guicardi; Nagaraj, Nagarjuna et al. (2015). Phosphoproteomics analysis of a clinical Mycobacterium tuberculosis Beijing isolate: Expanding the mycobacterial phosphoproteome catalog. (ekstern lenke)
2014
- Mustafa, Tehmina; Wiker, Harald G; Harboe, Morten et al. (2014). Mycobacterial antigens disappear from host tissue during latent Mycobacterium tuberculosis infection. (ekstern lenke)
- Mustafa, Tehmina; Leversen, Nils Anders; Sviland, Lisbet et al. (2014). Differential in vivo expression of mycobacterial antigens in Mycobacterium tuberculosis infected lungs and lymph node tissues. (ekstern lenke)
- Kucharova, Veronika; Wiker, Harald G (2014). Proteogenomics in microbiology: Taking the right turn at the junction of genomics and proteomics. (ekstern lenke)
- Sivakumaran, Dhanasekaran; Jenum, Synne; Stavrum, Ruth et al. (2014). Effect of non-tuberculous mycobacteria on host biomarkers potentially relevant for tuberculosis management. (ekstern lenke)
- Grønseth, Rune; Haaland, Ingvild; Wiker, Harald G et al. (2014). The Bergen COPD microbiome study (MicroCOPD): rationale, design, and initial experiences. (ekstern lenke)
2012
- Leversen, Nils Anders; Wiker, Harald G (2012). Improved signal peptide predictions in mycobacteria?. (ekstern lenke)
- Leversen, Nils Anders; Sviland, Lisbeth; Wiker, Harald G et al. (2012). Long-term persistence of BCG Pasteur in lungs of C57BL/6 mice following intranasal infection. (ekstern lenke)
- Kommedal, Øyvind; Simmon, Keith; Karaca, Dilek et al. (2012). Dual-priming oligonucleotides for broad-range amplification of the bacterial 16S rRNA gene directly from human clinical specimens. (ekstern lenke)
- Tomazella, Gisele Guiqardi; Risberg, Kine; Mylvaganam, Haima et al. (2012). Proteomic analysis of a multi-resistant clinical Escherichia coli isolate of unknown genomic background. (ekstern lenke)
- Lindemann, Paul Christoffer; Risberg, Kine; Wiker, Harald G et al. (2012). Aminoglycoside resistance in clinical Escherichia coli and Klebsiella pneumoniae isolates from Western Norway. (ekstern lenke)
- Purohit, Manju; Mustafa, Tehmina; Wiker, Harald G et al. (2012). Rapid diagnosis of tuberculosis in aspirate, effusions, and cerebrospinal fluid by immunocytochemical detection of Mycobacterium tuberculosis complex specific antigen MPT64. (ekstern lenke)
2011
- Målen, Hiwa; De Souza, Gustavo Antonio; Pathak, Sharad et al. (2011). Comparison of membrane proteins of Mycobacterium tuberculosis H37Rv and H37Ra strains. (ekstern lenke)
- Wiker, Harald G; Tomazella, Gisele Guiqardi; De Souza, Gustavo Antonio (2011). A quantitative view on Mycobacterium leprae antigens by proteomics. (ekstern lenke)
- Fossum, Even; Leversen, Nils Anders; Wiker, Harald G et al. (2011). Targeted Vaccibodies against Mycobacterium tuberculosis. (ekstern lenke)
- De Souza, Gustavo Antonio; Wiker, Harald G (2011). A proteomic view of mycobacteria. (ekstern lenke)
- De Souza, Gustavo Antonio; Leversen, Nils Anders; Målen, Hiwa et al. (2011). Bacterial proteins with cleaved or uncleaved signal peptides of the general secretory pathway. (ekstern lenke)
- Kommedal, Øyvind; Lekang, Katrine; Langeland, Nina et al. (2011). Characterization of polybacterial clinical samples using a set of group-specific broad-range primers targeting the 16S rRNA gene followed by DNA sequencing and RipSeq analysis. (ekstern lenke)
- De Souza, Gustavo; Arntzen, Magnus Øverlie; Fortuin, Suereta et al. (2011). Proteogenomic analysis of polymorphisms and gene annotation divergences in prokaryotes using a clustered mass spectrometry-friendly database. (ekstern lenke)
2010
- De Souza, Gustavo; Wiker, Harald G (2010). Proteomic Approaches to Study Immunity in Infection. (ekstern lenke)
- Leversen, Nils Anders; Mustafa, Tehmina; Wiker, Harald G (2010). Comparison of Immune Response in Mice Infected with M-Bovis BCG Russia and M-Bovis BCG Pasteur. (ekstern lenke)
- Wiker, Harald G; Mustafa, Tehmina; Bjune, Gunnar et al. (2010). Evidence for waning of latency in a cohort study of tuberculosis. (ekstern lenke)
- De Souza, Gustavo; Fortuin, Suereta; Aguilar, Diana et al. (2010). Using a Label-free Proteomics Method to Identify Differentially Abundant Proteins in Closely Related Hypo- and Hypervirulent Clinical Mycobacterium tuberculosis Beijing Isolates. (ekstern lenke)
- Målen, Hiwa; Pathak, Sharad; Søfteland, Tina et al. (2010). Definition of novel cell envelope associated proteins in Triton X-114 extracts of Mycobacterium tuberculosis H37Rv. (ekstern lenke)
- De Souza, Gustavo; Arntzen, Magnus Øverlie; Wiker, Harald G (2010). MSMSpdbb: providing protein databases of closely related organisms to improve proteomic characterization of prokaryotic microbes. (ekstern lenke)
- Tomazella, Gisele Guiqardi; daSilva, Idalete; Thomé, Carolina H. et al. (2010). Analysis of detergent-insoluble and whole cell lysate fractions of resting neutrophils using high-resolution mass spectrometry. (ekstern lenke)
- Beyene, Demissew Balcha; Franken, Kees Lumc; Yamuah, Lawrence et al. (2010). Serodiagnosis of tuberculous lymnphadenitis using a combination of antigens. (ekstern lenke)
2009
- De Souza, Gustavo; Wiker, Harald G (2009). The impact of proteomic advances on bacterial gene annotation. (ekstern lenke)
- Wiker, Harald G (2009). MPB70 and MPB83 - Major Antigens of Mycobacterium bovis. (ekstern lenke)
- Beyene, Demissew Balcha; Bergval, Indra; Hailu, Elena et al. (2009). Identification and genotyping of the etiological agent of tuberculous lymphadenitis in Ethiopia. (ekstern lenke)
- Pathak, Sharad; De Souza, Gustavo; Salte, Tore et al. (2009). HIV Induces both a Down-Regulation of IRAK-4 that Impairs TLR Signalling and an Up-regulation of the Antibiotic Peptide Dermcidin in Monocytic Cells. (ekstern lenke)
- Olsen, Ingrid; Wiker, Harald G (2009). Diffusion blotting for rapid production of multiple identical imprints from sodium dodecyl sulfate polyacrylamide gel electrophoresis on a solid support. (ekstern lenke)
- Leversen, Nils Anders; De Souza, Gustavo; Målen, Hiwa et al. (2009). Evaluation of signal peptide prediction algorithms for identification of mycobacterial signal peptides using sequence data from proteomic methods. (ekstern lenke)
- de Souza, GA; De Souza, Gustavo; Softeland, T et al. (2009). Validating divergent ORF annotation of the Mycobacterium leprae genome through a full translation dataset and peptide identification by tandem mass spectrometry. (ekstern lenke)
- Kommedal, Øyvind; Kvello, Kristine Ringheim; Skjåstad, Rune et al. (2009). Direct 16S rDNA sequencing from clinical specimens with special focus on poly-bacterial samples and interpretation of mixed DNA chromatograms. (ekstern lenke)
- Tomazella, Gisele G; da Silva, Idalete; Laure, Helen J et al. (2009). Proteomic analysis of total cellular proteins of human neutrophils. (ekstern lenke)
- Ellertsen, Linda Kathrine; Storla, Dag G; Diep, Lien M et al. (2009). Allergic sensitisation in tuberculosis patients at the time of diagnosis and following chemotherapy. (ekstern lenke)
- Mustafa, Tehmina; Wiker, Harald G; Sviland, Lisbet (2009). Differential expression of mycobacterial antigen MPT64, apoptosis and inflammatory markers in multinucleated giant cells and epithelioid cells in granulomas caused by Mycobacterium tuberculosis. (ekstern lenke)
- Leversen, Nils Anders; De Souza, Gustavo; Målen, Hiwa et al. (2009). Evaluation of signal peptide prediction algorithms for identification of mycobacterial signal peptides using sequence data from proteomic methods. (ekstern lenke)
- De Souza, Gustavo; Fortuin, Suereta; McEvoy, Christopher R et al. (2009). A label-free method identified differentially abundant proteins in related M.tuberculosis Beijing strains. (ekstern lenke)
- Totland, Karin; Wiker, Harald G (2009). Kongelig tuberkulose-innblikk. (ekstern lenke)
- Wiker, Harald G (2009). Fra krysset immunelektroforese til tandem massespektrometri. (ekstern lenke)
- Wiker, Harald G (2009). Virulensfaktorer og immunitet ved mykobakterieinfeksjoner. (ekstern lenke)
- Wiker, Harald G (2009). Searching for new vaccine candidates - Proteomics against tuberculosis. (ekstern lenke)
- Wiker, Harald G; Kommedal, Øyvind; Kvello, Kristine Ringheim (2009). Identifisering av inntil tre ulike bakteriar direkte frå prøvematerialet ved hjelp av direkte 16S rDNA sekvensering. (ekstern lenke)
2008
- Målen, Hiwa; Berven, Frode; Søfteland, Tina et al. (2008). Membrane- and membrane associated proteins in Triton X-114 extracts of Mycobacterium bovis BCG identified using a combination of gel-based and gel-free fractionation strategies. (ekstern lenke)
- Målen, Hiwa; Søfteland, Tina; Wiker, Harald G (2008). Antigen analysis of Mycobacterium tuberculosis H37Rv culture filtrate proteins. (ekstern lenke)
- Mustafa, Tehmina; Wiker, Harald G; Mørkve, Odd et al. (2008). Differential expression of mycobacterial antigen MPT64, apoptosis and inflammatory markers in multinucleated giant cells and epithelioid cells in granulomas caused by Mycobacterium tuberculosis. (ekstern lenke)
- Beyene, Demissew Balcha; Ashenafi, Senait; Yamuah, Lawrence et al. (2008). Diagnosis of tuberculous lymphadenitis in Ethiopia: correlation with culture, histology and HIV status. (ekstern lenke)
- Baba, Kamaldeen; Dyrhol-Riise, Anne Ma ; Sviland, Lisbet et al. (2008). Rapid and Specific Diagnosis of Tuberculous Pleuritis With Immunohistochemistry by Detecting Mycobacterium tuberculosis Complex Specific Antigen MPT64 in Patients From a HIV Endemic Area. (ekstern lenke)
- De Souza, Gustavo Antonio; Målen, Hiwa; Søfteland, Tina et al. (2008). High accuracy mass spectrometry analysis as a tool to verify and improve gene annotation using Mycobacterium tuberculosis as an example. (ekstern lenke)
- Leversen, Nils Anders; De Souza, Gustavo Antonio; Målen, Hiwa et al. (2008). Evaluation of signal peptide prediction algoritms using sequence data from proteomic methods. (ekstern lenke)
- Pathak, Sharad; Leversen, Nils Anders; Wiker, Harald G et al. (2008). Rapid and reliable quantification of mycobacteria inside macrophages in vitro and mice using real-time quantitative PCR. (ekstern lenke)
- De Souza, Gustavo; Søfteland, Tina; Wiker, Harald G (2008). Proteomic analysis of Mycobacterium leprae. (ekstern lenke)
- Målen, Hiwa; Søfteland, Tina; Wiker, Harald G (2008). Antigen analysis of Mycobacterium tuberculosis H37Rv culture filtrate proteins. (ekstern lenke)
- De Souza, Gustavo; Målen, Hiwa; Søfteland, Tina et al. (2008). Validating divergent ORF annotation in M. tuberculosis datasets using a LTQ-Orbitrap. (ekstern lenke)
- Målen, Hiwa; Søfteland, Tina; Wiker, Harald G (2008). Antigen analysis of Mycobacterium tuberculosis H37Rv culture filtrate. (ekstern lenke)
- Målen, Hiwa; Berven, Frode; Søfteland, Tina et al. (2008). Membrane- and membrane-associated proteins in Triton X-114 extracts of Mycobacterium bovis BCG identified using a combination of gel-based and gel-free fractionation strategies. (ekstern lenke)
- Leversen, Nils Anders; De Souza, Gustavo; Målen, Hiwa et al. (2008). Evaluation of signal peptide prediction algorithms using sequence data from proteomic methods. (ekstern lenke)
- De Souza, Gustavo Antonio; Søfteland, Tina; Wiker, Harald G (2008). Proteomic analysis of Mycobacterium leprae. (ekstern lenke)
- Pathak, Sharad; Leversen, Nils Anders; Wiker, Harald G et al. (2008). Rapid and reliable quantification of Mycobacteria inside macrophages in vitro and mice mice using real-taime quantitative PCR. (ekstern lenke)
- Wiker, Harald G; Mustafa, Tehmina; Bjune, Gunnar et al. (2008). Estimating the half-life of latent Mycobacterium tuberculosis infection based on the decline of tuberculosis in Norway. (ekstern lenke)
- Målen, Hiwa; Søfteland, Tina; Wiker, Harald G (2008). Antigen analysis of Mycobacterium tuberculosis H37Rv culture filtrate. (ekstern lenke)
- De Souza, Gustavo; Målen, Hiwa; Søfteland, Tina et al. (2008). Validating divergent ORF annotation in M. tuberculosis datasets using LTQ-Orbitrap. (ekstern lenke)
- Målen, Hiwa; Berven, Frode; Søfteland, Tina et al. (2008). Membrane- and membrane-associated proteins in Triton X-114 extracts of Mycobacterium bovis BCG identified using a combination of gel-based and gel-free fractionation strategies. (ekstern lenke)
- De Souza, Gustavo Antonio; Målen, Hiwa; Søfteland, Tina et al. (2008). Validating divergent ORF annotation in M. tuberculosis datasets using a LTQ-Orbitrap. (ekstern lenke)
- Wiker, Harald G (2008). TB antigen identification. (ekstern lenke)
- Wiker, Harald G (2008). En vaksine mot nye epidemier. (ekstern lenke)
- Wiker, Harald G (2008). Historieløst om kost og leddgikt. (ekstern lenke)
- Wiker, Harald G (2008). Den norske vaksinen - venn eller fiende?. (ekstern lenke)
- Wiker, Harald G; Skutlaberg, Dag Harald; Bruarøy, Linda Selstad (2008). Etiologi og resistensmønster ved urinveisinfeksjoner. (ekstern lenke)
- Wiker, Harald G; Namork, Ellen; Løvik, Martinus et al. (2008). Matallergi - Hvor alvorlig er det? og hva er det man ikke tåler?. (ekstern lenke)
2007
- Sviland, Lisbet; Mustafa, Tehmina; Purohit, Manju et al. (2007). Immunohistochemistry for the detection of Mycobacterium tuberculosis complex specific antigen (MPT64) improves the diagnosis of extrapulmonary tuberculosis caused by pathogenic mycobacteria. (ekstern lenke)
- Abebe, F; Holm-Hansen, Carol; Wiker, HG et al. (2007). Progress in serodiagnosis of Mycobacterium tuberculosis infection. (ekstern lenke)
- Rydjord, Britt; Namork, Ellen; Nygaard, Unni Cecilie et al. (2007). Quantification and characterisation of IgG binding to mould spores by flow cytometry and scanning electron microscopy. (ekstern lenke)
- Mustafa, Tehmina; Wiker, Harald G; Mørkve, Odd et al. (2007). Reduced apoptosis and increased inflammatory cytokines in granulomas caused by tuberculous compared to non-tuberculous mycobacteria: role of MPT64 antigen in apoptosis and immune response. (ekstern lenke)
- Purohit, Manju Raj; Mustafa, Tehmina; Wiker, Harald G et al. (2007). Immunohistochemical diagnosis of abdominal and lymph node tuberculosis by detecting Mycobacterium tuberculosis complex specific antigen MPT64. (ekstern lenke)
- Målen, Hiwa; Berven, Frode; Fladmark, Kari Espolin et al. (2007). Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv. (ekstern lenke)
- Rydjord, Britt; Eduard, W.; Stensby, Berit Arvesen et al. (2007). Antibody response to long-term and high-dose mould-exposed sawmill workers. (ekstern lenke)
- Målen, Hiwa; Berven, Frode; Fladmark, Kari et al. (2007). The secreted subproteome and determination of cleavage sites for Signal peptidase I. (ekstern lenke)
- Purohit, Manju; Mustafa, Tehmina; Wiker, Harald G et al. (2007). Detection of mycobacterium tuberculosis specific antigens by immunohistochemical technique: application for improved diagnosis of abdominal tuberculosis. (ekstern lenke)
- Mustafa, Tehmina; Wiker, Harald G; Mørkve, Odd et al. (2007). Correlation of Mycobacterium tuberculosis antigen MPT64 expression and apoptosis in human tuberculosis lesions. (ekstern lenke)
- Wiker, Harald G (2007). Hvor lenge varer tuberkuløs latens?. (ekstern lenke)
- Wiker, Harald G (2007). Innate and specific immune responses to Mycobacterium turberculosis. (ekstern lenke)
- Wiker, Harald G; Westbrook, Jules (2007). Analysis of exported proteins from Mycobacterium tuberculosis H37Rv. (ekstern lenke)
- Wiker, Harald G; Fugelsnes, Elin (2007). Vaksiner - Dårligere tuberkulose-vaksine. (ekstern lenke)
- Wiker, Harald G; Storvik, Anne Grete (2007). Nyttig Vaksine. (ekstern lenke)
2006
- Wiker, Harald G; Mustafa, Tehmina; Målen, Hiwa et al. (2006). Vaccine approaches to prevent tuberculosis. (ekstern lenke)
- Wiker, Harald G; Bjune, Gunnar Aksel (2006). Vaksiner mot tuberkulose. (ekstern lenke)
- Wiker, Harald G (2006). Mykobakterieinfeksjoner. (ekstern lenke)
- Hetland, G.; Rydjord, Britt; Svenningsen, V. et al. (2006). Immunoglobulin G antibodies against environmental moulds in a Norwegian healthy population shows a bimodal distribution for Aspergillus versicolor. (ekstern lenke)
- Mustafa, Tehmina; Wiker, Harald G; Mfinanga, Sayoki Godfrey M. et al. (2006). Immunohistochemistry using a Mycobacterium tuberculosis complex specific antibody for improved diagnosis of tuberculous lymphadenitis. (ekstern lenke)
- Al-Attiyah, Raja; Madi, Nada M; El-shamy, Abdul Salaam M et al. (2006). Cytokine profiles in tuberculosis patients and healthy subjects in response to complex and single antigens of Mycobacterium tuberculosis. (ekstern lenke)
- Shrivastava, Rashmi; Das, Dibya Ranjan; Wiker, Harald G et al. (2006). Functional insights from the molecular modelling of a novel two-component system. (ekstern lenke)
- Wiker, Harald G.; Bjune, Gunnar Aksel (2006). Vaksiner mot tuberkulose. (ekstern lenke)
- Wiker, Harald G (2006). Kommentarer til MRSA retningslinjene basert på erfaringer fra epidemien i Hordaland. (ekstern lenke)
- Wiker, Harald G (2006). MRSA - status og framtid. (ekstern lenke)
- Wiker, Harald G; Målen, Hiwa; Berven, Frode et al. (2006). Late breaker: Revealing the secreted proteome of Mycobacterium tuberculosis H37Rv. (ekstern lenke)
- Wiker, Harald G (2006). Revealing the secreted proteome of Mycobacterium tuberculosis H37Rv. (ekstern lenke)
- Wiker, Harald G (2006). Identification of secreted proteins of M. tuberculosis as a basis for vaccine development. (ekstern lenke)
- Wiker, Harald G (2006). Vaccine research in Norway: Status and future prospects. (ekstern lenke)
- Wiker, Harald G (2006). Secreted antigens of Mycobacterium tuberculosis H37Rv for novel vaccine design. (ekstern lenke)
- Wiker, Harald G (2006). Secreted antigens of Mycobacterium tuberculosis H37Rv for novel vaccine design. (ekstern lenke)
- Wiker, Harald G; Hafstad, Anne (2006). Aldri har flere blitt smittet. (ekstern lenke)
- Wiker, Harald G (2006). Ny vaksine mot tuberkulose i Bergen. (ekstern lenke)
- Berven, Frode; Målen, Hiwa; Fladmark, Kari Espolin et al. (2006). Comparing the protein identifications obtained using two-dimensional gel electrophoresis or liquid chromatography mass spectrometry on the secreted proteome of Mycobacterium tuberculosis. (ekstern lenke)
- Wiker, Harald G; Mustafa, Tehmina; Mustafa, Tehmina et al. (2006). Vaccine approaches to prevent tuberculosis.. (ekstern lenke)
2005
- Ellertsen, Linda Katrine; Wiker, Harald G; Egeberg, NT et al. (2005). Allergic sensitization in tuberculosis and leprosy patients. (ekstern lenke)
- Madhurantakam, Chaithanya; Rajakumara, Eerappa; Mazumdar, Pooja Anjali et al. (2005). Crystal Structure of Low Molecular Weight Protein Tyrosine Phosphatase (MPtpA) from Mycobacterium tuberculosis at 1.9 Å resolution. (ekstern lenke)
- Charlet, Danielle; Mostowy, Serge; Alexander, David et al. (2005). Reduced expression of antigenic proteins MPB70 and MPB83 in Mycobacterium bovis BCG strains due to a start codon mutation in sigK. (ekstern lenke)
- Rydjord, Britt; Hetland, Geir; Wiker, Harald G (2005). Immunoglobulin G antibodies against environmental moulds in a Norwegian healthy population shows a bimodal distribution for Aspergillus versicolor. (ekstern lenke)
- Mitra, Devrani; Saha, Baisakhee; Das, Debabrata et al. (2005). Correlating sequential homology of Mce1A, Mce2A, Mce3A and Mce4A with their possible functions in mammalian cell entry of Mycobacterium tuberculosis by homology modeling. (ekstern lenke)
- Målen, Hiwa; Wiker, Harald G (2005). Identification of N-terminal peptides by MALDI-TOF of processed proteins secreted through the general secretory pathway. (ekstern lenke)
- Kindingstad, Louise; Fylkesnes, Svein Ivar; Harthug, Stig et al. (2005). Epidemiological analysis of MRSA in two counties in Western Norway. (ekstern lenke)
- Wiker, Harald G (2005). Molekylær epidemiologi av MRSA utenfor sykehus. (ekstern lenke)
- Wiker, Harald G (2005). Plenary lecture: The secreted proteomes of Mycobacterium tuberculosis and Mycobacterium leprae. (ekstern lenke)
- Wiker, Harald G (2005). Får vi snart en ny og bedre vaksine mot tuberkulose?. (ekstern lenke)
- Wiker, Harald G (2005). Regulation of expression of MPB70 and MPB83 in Mycobacterium bovis BCG substrains. (ekstern lenke)
- Wiker, Harald G; Gripsrud, Silje (2005). Klistreprotein skaper vaksinekomplikasjoner. (ekstern lenke)
- Charlet, D; Mostowy, S; Alexander, D et al. (2005). Expression of Mycobacterium bovis antigenic proteins MPB70 and MPB83 is controlled by the alternate sigma factor sigK. (ekstern lenke)
- Målen, Hiwa; Wiker, Harald G (2005). Identification of N-terminal peptides by MALDI-TOF of processed proteins secreted through the general secretory pathway. (ekstern lenke)
- Wiker, Harald G (2005). Predicting proteins exported through the general secretory pathway in Mycobacterium tuberculosis H37Rv. (ekstern lenke)
- Wiker, Harald G (2005). Predicting proteins exported through the general secretory pathway in Mycobacterium tuberculosis H37Rv. (ekstern lenke)
- Rydjord, B; Wiker, Harald G; Hetland, G (2005). Assay for quantifying mould-specific IgG antibodies in serum by flow cytometry using intact mould spores. (ekstern lenke)
- Charlet, D; Mostowy, S; Alexander, D et al. (2005). Expression of Mycobacterium bovis antigenic proteins MPB70 and MPB83 is controlled by the alternate sigma factor sigK. (ekstern lenke)
- Kindingstad, L; Fylkesnes, Svein Ivar; Harthug, Stig et al. (2005). Epidemiological analysis of MRSA in two counties in western Norway. (ekstern lenke)
- Mitra, D; Saha, B; Das, D et al. (2005). Correlating sequential homology of Mce1A, Mce2A, Mce3A and Mce4A with their possible functions in mammalian cell entry of Mycobacterium tuberculosis by homology modeling. (ekstern lenke)
2004
- Faeste, CK; Løvik, M; Wiker, Harald G et al. (2004). A Case of Peanut Cross-Allergy to Lupine Flour in a Hot Dog Bread. (ekstern lenke)
- Harboe, M; Das, AK; Mitra, D et al. (2004). Immunodominant B-cell epitope in the Mce1A mammalian cell entry protein of Mycobacterium tuberculosis cross-reacting with glutathione S-transferase. (ekstern lenke)
- Wiker, Harald G (2004). Unmatched sequences in public databases - Exemplified by tuberculin-active protein. (ekstern lenke)
- Instanes, C; Ormstad, Heidi; Rydjord, Britt et al. (2004). Mould extracts increase the allergic response to ovalbumin in mice. (ekstern lenke)
2003
- Tollefsen, Stig; Pollock, J.M.; Lea, Tor Erling et al. (2003). T- and B-cell epitopes in the secreted Mycobacterium bovis antigen MPB70 in mice. (ekstern lenke)
- Das, A. K.; Mitra, D.*; Harboe, Morten et al. (2003). Predicted molecular structure of the mammalian cell entry protein Mce1A of Mycobacterium tuberculosis. (ekstern lenke)
2002
- Harboe, Morten; Christensen, A.; Ahmed, S. et al. (2002). Cross-reaction between mammalian cell entry (Mce) proteins of Mycobacterium tuberculosis. (ekstern lenke)
- Harboe, Morten; Whelan, A.O.; Ulvund, Gunni et al. (2002). Generation of antibodies to the signal peptide of the MPT83 lipoprotein of Mycobacterium tuberculosis. (ekstern lenke)
- Tollefsen, Stig; Tjelle, Torunn Elisabet; Schneider, J. et al. (2002). Improved cellular and humoral immune responses against Mycobacterium tuberculosis antigens after intramuscular DNA immunisation combined with muscle electroporation. (ekstern lenke)
2001
- Johnson, S.; Brusasca, P.; Lyashcencko, K. et al. (2001). Characterization of the secreted MPT53 antigen of Mycobacterium tuberculosis. (ekstern lenke)
- Lyashcencko, K.; Wiker, Harald G.; Harboe, Morten et al. (2001). Novel monoclonal antibodies against major antigens of Mycobacterium bovis. (ekstern lenke)
- Olsen, Ingrid; Wiker, Harald G; Johnson, E et al. (2001). Elevated antibody responses in patients with Crohn’s disease against a 14-kDa secreted protein purified from Mycobacterium avium subsp. paratuberculosis. (ekstern lenke)
- Olsen, Ingar; Wiker, Harald G.; Johnson, Egil et al. (2001). Elevated antibody responses in patients with Crohn's disease against a 14 kDa secreted protein purified from Mycobacterium avium subspecies paratuberculosis. (ekstern lenke)
2000
- Olsen, Ingrid; Holstad, Gudmund; Wiker, Harald G et al. (2000). Alkyl hydroperoxide reductases C and D are major antigens constitutively expressed by Mycobacterium avium subsp. paratuberculosi. (ekstern lenke)
- Olsen, Ingrid; Reitan, Liv Jorun; Wiker, Harald G (2000). Distinct differences in repertoires of low-molecular-mass secreted antigens of Mycobacterium avium complex and Mycobacterium tuberculosis. (ekstern lenke)
1999
- Wiker, Harald G.; Spierings, E.; Kolkman, M.A.B. et al. (1999). The mammalian cell entry operon 1 (mce1) of Mycobacterium leprae and Mycobacterium tuberculosis. (ekstern lenke)
- Harboe, Morten; Wiker, Harald G. (1999). Searching for secreted proteins of Mycobacterium leprae. (ekstern lenke)
- Ahmed, S.; Akbar, P.K.; Wiker, Harald G. et al. (1999). Cloning, expression and immunological reactivity of two mammalian cell entry proteins encoded by the mce1 operon pf Mycobacterium tuberculosis. (ekstern lenke)
- Harboe, Morten; Christensen, A.; Haile, Y. et al. (1999). Demonstration of expression of six proteins of the mammalian cell entry (mce1) operon of Mycobacterium tuberculosis by anti-peptide antibodies, enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction. (ekstern lenke)
- Wiker, Harald G.; Michell, S.Ll; Hewinson, R.G. et al. (1999). Cloning, expression and significance of MPT53 for identification of secreted proteins of Mycobacterium tuberculosis. (ekstern lenke)
1998
- Harboe, Morten; Wiker, Harald G.; Ulvund, Gunni et al. (1998). MPB70 and MPB83 as indicators of protein localization in mycobacterial cells. (ekstern lenke)
- Harboe, Morten; Wiker, Harald G. (1998). Secreted proteins of Mycobacterium leprae. (ekstern lenke)
- Olsen, Ingrid; Wiker, Harald G. (1998). Diffusion blotting for rapid production of multiple identical imprints from SDS-PAGE on a solid support. (ekstern lenke)
- Wiker, Harald G.; Lyashcencko, K.; Aksoy, A.M. et al. (1998). Immunochemical characterization of the MPB70/80 and MPB83 proteins of Mycobacterium bovis. (ekstern lenke)
- Harboe, Morten; Malin, A.S.; Dockrell, H.S. et al. (1998). B-cell epitopes and quantification of the ESAT-6 protein of Mycobacterium tuberculosis. (ekstern lenke)
- Hetland, Geir; Wiker, Harald G.; Høgåsen, Kolbjørn et al. (1998). Involvement of antilipoarabinomannan antibodies in classical complement activation in tuberculosis. (ekstern lenke)
- Mustafa, AS; Amoudy, H.A.; Wiker, Harald G. et al. (1998). Comparison of antigen-specific T-cell responses of tuberculosis patients using complex or single antigens of Mycobacterium tuberculosis. (ekstern lenke)
- Hetland, Geir; Løvik, M.; Wiker, Harald G. (1998). Protective effect of beta-glucan against Mycobacterium bovis BCG infection in Balb/c mice. (ekstern lenke)
1997
- Manca, C.; Lyashcencko, K.; Wiker, Harald G. et al. (1997). Gene cloning, expression and sequence determination of MPT63, a novel secreted antigen from Mycobacterium tuberculosis. (ekstern lenke)
- Harboe, Morten; Wiker, Harald G. (1997). Different localization of the homologous MPB70 and MPB83 proteins of Mycobacterium bovis. (ekstern lenke)
- Manca, C.; Lyashcencko, K.; Wiker, Harald G. et al. (1997). Molecular cloning, purification, and serological characterization of MPT63, a novel antigen secreted by Mycobacterium tuberculosis. (ekstern lenke)
- Oftung, Fredrik; Wiker, Harald G.; Deggerdal, Arne et al. (1997). A novel mycobacterial antigen relevant to cellular immunity belongs to a family of secreted lipoproteins. (ekstern lenke)
1996
- Harboe, Morten; Oettinger, T; Wiker, Harald G. et al. (1996). Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. (ekstern lenke)
- Wiker, Harald G.; Nagai, S; Hewinson, R.G. et al. (1996). Heterogenous expression of the related MPB70 and MPB83 proteins distinguish various substrains of Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv. (ekstern lenke)
Kompetanse
MD, PhD, Medical speciality in Immunology