• Pankreatitt (betennelse i bukspyttkjertelen)
• Pancreas-cancer (kreft i bukspyttkjertelen)
• MODY-diabetes (arvelig diabetes)

Tilknyttet følgende forskningsgrupper:

https://www.uib.no/diabetes

https://pancreas.w.uib.no

Vitenskapelig artikkel

• Brekke, Ranveig Seim; Svanbring, Anny Gravdal; Jellas, Khadija el et al. (2024). Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas. (ekstern lenke)
• Jellas, Khadija el; Dušátková, Petra; Haldorsen, Ingfrid S. et al. (2022). Two New Mutations in the CEL Gene Causing Diabetes and Hereditary Pancreatitis: How to Correctly Identify MODY8 Cases. (ekstern lenke)
• Fjeld, Karianne; Svanbring, Anny Gravdal; Brekke, Ranveig Seim et al. (2022). The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice. (ekstern lenke)
• Tjora, Erling; Gravdal, Anny; Engjom, Trond et al. (2021). Protein misfolding in combination with other risk factors in CEL-HYB1-mediated chronic pancreatitis. (ekstern lenke)
• Svanbring, Anny Gravdal; Xiao, Xunjun; Cnop, Miriam et al. (2021). The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity. (ekstern lenke)
• Velasco Pinto, Kelly; St-Louis, Johanna Lüdeke; Hovland, Henrikke Nilsen et al. (2020). Functional evaluation of 16 SCHAD missense variants: Only amino acid substitutions causing congenital hyperinsulinism of infancy lead to loss-of-function phenotypes in vitro. (ekstern lenke)
• Valvatne, Monica Dalva; Lavik, Ida Marie Kjærefjord; el Jellas, Khadija et al. (2020). Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells . (ekstern lenke)
• Fjeld, Karianne; Masson, Emmanuelle; Lin, Jin-Huan et al. (2020). Characterization of CEL-DUP2: Complete duplication of the carboxyl ester lipase gene is unlikely to influence risk of chronic pancreatitis. (ekstern lenke)
• Cassidy, Brett M.; Zino, Sammy; Fjeld, Karianne et al. (2020). Single nucleotide polymorphisms in CEL-HYB1 increase risk for chronic pancreatitis through proteotoxic misfolding. (ekstern lenke)
• Oracz, Grzegorz; Kujko, Aleksandra Anna; Fjeld, Karianne et al. (2019). The hybrid allele 1 of carboxyl-ester lipase (CEL-HYB1) in Polish pediatric patients with chronic pancreatitis. (ekstern lenke)
• el Jellas, Khadija; Johansson, Bente Berg; Fjeld, Karianne et al. (2018). The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 O-glycans that can be modified by ABO blood group determinants. (ekstern lenke)
• Dalva, Monica; el Jellas, Khadija; Steine, Solrun et al. (2017). Copy number variants and VNTR length polymorphisms of the carboxyl-ester lipase (CEL) gene as risk factors in pancreatic cancer. (ekstern lenke)
• Johansson, Bente Berg; Fjeld, Karianne; Solheim, Marie Holm et al. (2017). Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation. (ekstern lenke)
• Fjeld, Karianne; Beer, Sebastian; Johnstone, Marianne et al. (2016). Length of variable numbers of tandem repeats in the carboxyl ester lipase (CEL) gene may confer susceptibility to alcoholic liver cirrhosis but not alcoholic chronic pancreatitis. (ekstern lenke)
• Kolar, Matthew J.; Kamat, Siddhesh S.; Parsons, William H. et al. (2016). Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. (ekstern lenke)
• Fjeld, Karianne; Weiss, Frank Ulrich; Lasher, Denise et al. (2015). A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis. (ekstern lenke)
• Irgens, Henrik Underthun; Fjeld, Karianne; Johansson, Bente Berg et al. (2015). Glycogenin-2 is dispensable for liver glycogen synthesis and glucagon-stimulated glucose release. (ekstern lenke)
• Torsvik, Janniche; Johansson, Bente Berg; Dalva, Monica et al. (2014). Endocytosis of secreted carboxyl ester lipase in a syndrome of diabetes and pancreatic exocrine dysfunction. (ekstern lenke)
• Ragvin, Anja; Fjeld, Karianne; Weiss, F. Ulrich et al. (2013). The number of tandem repeats in the carboxyl-ester lipase (CEL) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis. (ekstern lenke)
• Johansson, Bente Berg; Torsvik, Janniche; Bjørkhaug, Lise et al. (2011). Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE. (ekstern lenke)
• Nie, Xuguang; Luukko, Keijo; Fjeld, Karianne et al. (2005). Developmental expression of Dkk1-3 and Mmp9 and apoptosis in cranial base of mice. (ekstern lenke)
• Kettunen, Paivi; Løes, Sigbjørn Suk; Furmanek, Tomasz Michal et al. (2005). Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfβ1 regulate semaphorin 3a expression in the dental mesenchyme. (ekstern lenke)
• Fjeld, Karianne; Kettunen, Paivi; Furmanek, Tomasz Michal et al. (2005). Dynamic expression of Wnt signaling-related Dickkopf1,-2, and-3 mRNAs in the developing mouse tooth. (ekstern lenke)
• Kvinnsland, Inger Hals; Luukko, Keijo Aukusti; Fristad, Inge et al. (2004). Glial cell line-derived neurotrophic factor (GDNF) from adult rat tooth serves a distinct population of large-sized trigeminal neurons. (ekstern lenke)
• Luukko, Keijo; Løes, Sigbjørn Suk; Furmanek, Tomasz et al. (2003). Identification of a novel putative signaling center, the tertiary enamel knot in the postnatal mouse molar tooth. (ekstern lenke)
• Luukko, Keijo Aukusti; Loes, Sigbjorn; Furmanek, Tomasz et al. (2003). Identification of a novel putative signaling center, the tertiary enamel knot in the postnatal mouse molar tooth. (ekstern lenke)
• Fristad, Inge; Vandevska-Radunovic, Vaska; Fjeld, Karianne et al. (2003). NK1-, NK2-, NK3-, and CGRP1-receptors identified in rat oral soft tissues, bone- and hard tissue cells. (ekstern lenke)

Vitenskapelig oversiktsartikkel/review

• Johansson, Bente Berg; Fjeld, Karianne; el Jellas, Khadija et al. (2018). The role of the carboxyl ester lipase (CEL) gene in pancreatic disease. (ekstern lenke)

Leder

• Molven, Anders; Fjeld, Karianne; Lowe, Mark E. (2016). Lipase genetic variants in chronic pancreatitis: when the end is wrong, all's not well. (ekstern lenke)

Kronikk

• Fjeld, Karianne; Molven, Anders (2015). Du vet nesten ingenting om det, men dette er et av kroppens mest sentrale organer. (ekstern lenke)

Sammendrag/abstract

• Molven, Anders; Torsvik, Janniche; Johansson, Bente Berg et al. (2013). Cellular re-uptake of secreted carboxyl-ester lipase protein in CEL-MODY, a syndrome of diabetes and pancreatic exocrine dysfunction. (ekstern lenke)
• Fjeld, Karianne; Torsvik, Janniche; Johansson, Stefan et al. (2008). Structural changes in the repeated region of the carboxyl-ester lipase (CEL) gene and the development of diabetes. (ekstern lenke)

Doktorgradsavhandling

• Fjeld, Karianne; Kettunen, Paivi; Luukko, Keijo (2006). The Wnt pathway. Studies on Wnt signaling and regulation in the developing tooth. (ekstern lenke)

Intervju

• Kettunen, Paivi; Luukko, Keijo Aukusti; Fjeld, Karianne et al. (2004). Dyrking av det Perfekte Smil. (ekstern lenke)

Vitenskapelig foredrag

• Fjeld, Karianne; Luukko, Keijo Aukusti; Kettunen, Paivi Johanna et al. (2003). Functions of SLIT1 in tooth morphogenesis. (ekstern lenke)
• Fjeld, Karianne; Kettunen, Paivi Johanna; Luukko, Keijo Aukusti et al. (2003). Wnt signaling in tooth morphogenesis. (ekstern lenke)

Hovedfagsoppgave

• Fjeld, Karianne (2000). The effect of beta1-integins on the phenotype of human gliomas. (ekstern lenke)
• Fjeld, Karianne (2000). The effect of Beta1-integrins on the invasive phenotype of human gliomas. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin