Jeg er professor ved Institutt for biomedisin ved Universitetet i Bergen, og en av flere gruppeleder i Metabolisme og kreft-gruppen. Forskningen i vår gruppe har som mål å forstå molekylære interaksjoner på atomnivå og de nyanserte sammenhengene mellom struktur, dynamikk og funksjon av biomolekyler. Vi utvikler og anvender beregningsmetoder for å simulere molekylære bevegelser, som supplerer eksperimentelle observasjoner.

Gjennom samarbeid med grupper som utvikler Amber-programvaren for molekylære simuleringer, har vi utviklet Amber-kraftfeltet for å simulere molekylære interaksjoner i lipidkomplekser. Med Amber programvaren er vi nå i stand til å simulere komplekse molekylære systemer av hvilken som helst sammensetning. Vi anvender disse metodene for å forstå funksjonen til store molekylære systemer basert på intermolekylære krefter og iboende dynamikk.

Vår kraftfeltutvikling er også relevant for metoder for virtuell screening, der vi ønsker å finne små molekyler med potensiale til å utvikles til et medikament. Den virtuelle screeningen integreres med eksperimentell screening av små forbindelser utført av andre grupper ved Institutt for Biomedisin.

Jeg er medgründer og aksjonær i selskapet Pluvia Pharma AS, et oppstarts-biotec firma i Bergen som har som mål å utvikle molekyler med potensiale for å korrigere medfødte arvelige sykdommer som skyldes misfolding av proteiner.

Jeg er semesterstyreleder og har ansvar for innholdet i andre semester på medisinstudiet i Bergen og er medlem av Programutvalget i Medisin ved UiB. Jeg underviser i basalfagene for farmasi, tannlege og medisin og har i tillegg undervisning om strukturbiologi på master- og phd-emner ved instituttet. Jeg tilbyr masteroppgaver for studenter i farmasi, nanovitenskap, biomedisin og medisinsk teknologi i tillegg til prosjekter for forskerlinjen på medisin. Gjennom FEBS (Federation of European Biochemical Societies) er jeg involvert i utvikling av biokjemi-undervisning og deltar i FEBS-fora som Norges ambassadør for biokjemi-undervisning.

Når jeg ikke underviser i biokjemi, har jeg en lidenskap for ski og skikjøring. Som medlem av utdanningskomiteen i Den Norske Skiskole bidrar jeg med opplæring og internasjonal ISIA sertifisering av skilærere i Norge.

Poster

• Støve, Svein Isungset; Skjevik, Åge Aleksander; Teigen, Knut et al. (2022). High-throughput screening for VMAT2 activity modulators. (ekstern lenke)
• Skjevik, Åge Aleksander; Støve, Svein Isungset; Teigen, Knut et al. (2020). Identification of VMAT2 inhibitory compounds. (ekstern lenke)
• Støve, Svein Isungset; Skjevik, Åge Aleksander; Teigen, Knut et al. (2020). Searching for new inhibitors of vesicular monoamine transporter 2 by differential scanning fluorimetry. (ekstern lenke)
• Olsson, Elaine; Martinez, Aurora; Teigen, Knut et al. (2010). Dioxygen Binding and Formation of the Hydroxylating FeIV=O Intermediate in Aromatic Amino Acid Hydroxylases. (ekstern lenke)
• Skjevik, Åge Aleksander; Lygre, Henning; Teigen, Knut (2010). Can intramolecular hydrogen bonding in articaine be related to superior bone tissue penetration? A molecular dynamics study. (ekstern lenke)
• Skjevik, Åge Aleksander; Lygre, Henning; Teigen, Knut (2009). Molecular dynamics simulation: Interaction between the local anaesthetic articaine and membrane models. (ekstern lenke)
• Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut et al. (2009). Catalytic cycle of phenylalanine hydroxylase. (ekstern lenke)
• Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut et al. (2009). Catalytic cycle of phenylalanine hydroxylase. (ekstern lenke)
• Pedersen, Ida Benedikte; Skjevik, Åge Aleksander; Lygre, Henning et al. (2008). Drug-membrane interactions. An explanation for the anti-inflammatory effect of local anesthetics?. (ekstern lenke)
• Skjevik, Åge Aleksander; Pedersen, Ida Benedikte; Lygre, Henning et al. (2008). Interactions between the local anesthetic articaine and membranes: A theoretical and experiemntal study. (ekstern lenke)
• Skjevik, Åge Aleksander; Lygre, Henning; Teigen, Knut (2008). Interaction of a local anaesthetic with lipid membranes studied by computer modelling. (ekstern lenke)

Vitenskapelig artikkel

• Støve, Svein Isungset; Skjevik, Åge Aleksander; Teigen, Knut et al. (2022). Inhibition of VMAT2 by β2-adrenergic agonists, antagonists, and the atypical antipsychotic ziprasidone. (ekstern lenke)
• Bueno-Carrasco, María Teresa; Cuellar, Jorge; Flydal, Marte Innselset et al. (2022). Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. (ekstern lenke)
• Zhang, Aidan; Teigen, Knut; Kouznetsova, Valentina L. et al. (2022). Modeling of mutant superoxide dismutase 1 octamers with cross-linked disulfide bonds. (ekstern lenke)
• Betari, Nibal; Teigen, Knut; Sahlholm, Kristoffer et al. (2021). Synthetic corticosteroids as tryptophan hydroxylase stabilizers. (ekstern lenke)
• Dobrovolska, Olena; Strømland, Øyvind; Handegård, Ørjan Sele et al. (2021). Investigating the Disordered and Membrane-Active Peptide A-Cage-C Using Conformational Ensembles. (ekstern lenke)
• Pedersen, Line; Panahandeh, Pouda; Siraji, Muntequa Ishtiaq et al. (2020). Golgi-Localized PAQR4 Mediates Antiapoptotic Ceramidase Activity in Breast Cancer. (ekstern lenke)
• Flydal, Marte Innselset; Kråkenes, Trond-André; Tai, Mary Dayne Sia et al. (2020). Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase. (ekstern lenke)
• Betari, Nibal; Sahlholm, Kristoffer; Morató, Xavier et al. (2020). Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole—In Vitro and In Vivo Investigations. (ekstern lenke)
• Dobrovolska, Olena; Brilkov, Maxim; Madeleine, Noëlly et al. (2020). The Arabidopsis (ASHH2) CW domain binds monomethylated K4 of the histone H3 tail through conformational selection. (ekstern lenke)
• Betari, Nibal; Sahlholm, Kristoffer; Ishizuka, Yuta et al. (2020). Discovery and biological characterization of a novel scaffold for potent inhibitors of peripheral serotonin synthesis. (ekstern lenke)
• Humisto, Anu; Jokela, Jouni; Teigen, Knut et al. (2019). Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes. (ekstern lenke)
• Holtan, Josephine Prener; Teigen, Knut; Aukrust, Ingvild et al. (2019). Dominant ARL3-related retinitis pigmentosa. (ekstern lenke)
• Kouznetsova, Valentina L.; Hu, Hannah; Teigen, Knut et al. (2017). Cripto stabilizes GRP78 on the cell membrane. (ekstern lenke)
• Leandro, João; Stokka, Anne Jorunn; Teigen, Knut et al. (2017). Substituting Tyr138 in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation. (ekstern lenke)
• Skjevik, Åge Aleksander; Madej, Benjamin D.; Dickson, Callum J. et al. (2016). Simulation of lipid bilayer self-assembly using all-atom lipid force fields. (ekstern lenke)
• Skjevik, Åge Aleksander; Madej, Benjamin D.; Dickson, Callum J. et al. (2015). All-atom lipid bilayer self-assembly with the AMBER and CHARMM lipid force fields. (ekstern lenke)
• Hole, Magnus; Underhaug, Jarl; Diez, Hector et al. (2015). Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms. (ekstern lenke)
• Winge, Ingeborg; Teigen, Knut; Fossbakk, Agnete et al. (2015). Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression. (ekstern lenke)
• Herfindal, Lars; Krakstad, Camilla; Myhren, Lene Elisabeth et al. (2014). Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3. (ekstern lenke)
• Skjevik, Åge Aleksander; Mileni, Mauro; Baumann, Anne et al. (2014). The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes. (ekstern lenke)
• Dickson, Callum J.; Madej, Benjamin D.; Skjevik, Åge Aleksander et al. (2014). Lipid14: The amber lipid force field. (ekstern lenke)
• Lindstad, Rune I.; Teigen, Knut; Skjeldal, Lars (2013). Inhibition of sorbitol dehydrogenase by nucleosides and nucleotides. (ekstern lenke)
• Martin, Ianire; Underhaug, Jarl; Celaya, Garbiñe et al. (2013). Screening and evaluation of small organic molecules as ClpB inhibitors and potential antimicrobials. (ekstern lenke)
• Myhren, Lene Elisabeth; Nygaard, Gyrid; Gausdal, Gro et al. (2013). Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. (ekstern lenke)
• Skjevik, Åge Aleksander; Madej, Benjamin D.; Walker, Ross C. et al. (2012). LIPID11: A modular framework for lipid simulations using amber. (ekstern lenke)
• Skjevik, Åge Aleksander; Haug, Bengt Erik; Lygre, Henning et al. (2011). Intramolecular hydrogen bonding in articaine can be related to superior bone tissue penetration: A molecular dynamics study. (ekstern lenke)
• Molnes, Janne; Teigen, Knut; Aukrust, Ingvild et al. (2011). Binding of ATP at the active site of human pancreatic glucokinase - nucleotide-induced conformational changes with possible implications for its kinetic cooperativity. (ekstern lenke)
• Skjærven, Lars; Grant, Barry; Muga, Arturo et al. (2011). Conformational sampling and nucleotide-dependent transitions of the GroEL subunit probed by unbiased molecular dynamics simulations. (ekstern lenke)
• Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut et al. (2011). Formation of the Iron-Oxo Hydroxylating Species in the Catalytic Cycle of Aromatic Amino Acid Hydroxylases. (ekstern lenke)
• Dao, Khanh Kim; Pey, Angel L.; Gjerde, Anja Underhaug et al. (2011). The regulatory subunit of PKA-I remains partially structured and undergoes beta-aggregation upon thermal denaturation. (ekstern lenke)
• Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut et al. (2011). Substrate Hydroxylation by the Oxido-Iron Intermediate in Aromatic Amino Acid Hydroxylases: A DFT Mechanistic Study. (ekstern lenke)
• Flydal, Marte Innselset; Mohn, Tonje Cecilie; Pey, Rodroguez Angel Luis et al. (2010). Superstoichiometric binding of L-Phe to phenylalanine hydroxylase from Caenorhabditis elegans: evolutionary implications. (ekstern lenke)
• Siltberg-Liberles, Jessica; Flydal, Marte Innselset; Teigen, Knut et al. (2009). Evolution of regulation, structure and function in phenylalanine hydroxylase. (ekstern lenke)
• Skjevik, Åge Aleksander; Teigen, Knut; Martinez, Aurora (2009). Overview of computational methods employed in early-stage drug discovery. (ekstern lenke)
• Hodneland, Erlend; Teigen, Knut (2007). A simple method to calculate the accessible volume of protein-bound ligands: Application for ligand selectivity. (ekstern lenke)
• Pey, Angel; Martinez, Aurora; Charubala, Ramamurthy et al. (2006). Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo. (ekstern lenke)
• Dao, Khanh Kim; Teigen, Knut; Kopperud, Reidun Kristin et al. (2006). Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition. (ekstern lenke)
• Teigen, Knut; Jensen, Vidar Remi; Martinez, Aurora (2005). The reaction mechanism of phenylalanine hydroxylase. A question of coordination. (ekstern lenke)
• Pey, Angel; Thorolfsson, Matthias; Teigen, Knut et al. (2004). Thermodynamic characterization of the binding of tetrahydropterins to phenylalanine hydroxylase . (ekstern lenke)
• Teigen, Knut; Dao, Khanh Kim; Mckinney, Jeffrey Alan et al. (2004). Tetrahydrobiopterin binding to aromatic amino acid hydroxylases. Ligand recognition and specificity. (ekstern lenke)
• Miranda, Frederico F.; Thorolfsson, Matthias; Teigen, Knut et al. (2004). Structural and stability effects of phosphorylation � Localized structural changes in phenylalanine hydroxylase. (ekstern lenke)
• Teigen, Knut; Frøystein, Nils Åge; Martinez, Aurora (1999). The structural Basis of the Recognition of Phenylalanine and Pterine Cofactors by Phenylalanine Hydroxylase. Implications for the Catalytic Mechanism. (ekstern lenke)
• Teigen, Knut; Frøystein, Nils Åge; Martinez, Aurora (1999). The structural basis of the recognition of phenylalanine and pterin cofactors by phenylalanine hydroxylase. Implications for the catalytic mechanism. (ekstern lenke)

Vitenskapelig oversiktsartikkel/review

• Hole, Magnus; Jorge Finnigan, Ana; Underhaug, Jarl et al. (2016). Pharmacological chaperones that protect Tetrahydrobiopterin dependent aromatic amino acid hydroxylases through different mechanisms. (ekstern lenke)
• Olsson, Elaine; Teigen, Knut; Martinez, Aurora et al. (2010). The aromatic amino acid hydroxylase mechanism: A perspective from computational chemistry. (ekstern lenke)
• Martinez, Aurora; Calvo, Ana C; Teigen, Knut et al. (2009). Rescuing proteins of low kinetic stability by chaperones and natural ligands; phenylketonuria, a case study. (ekstern lenke)
• Teigen, Knut; Mckinney, Jeffrey Alan; Haavik, Jan et al. (2007). Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. (ekstern lenke)

Errata

• Hole, Magnus; Underhaug, Jarl; Diez, Hector et al. (2016). Erratum: Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms (Biochimica et Biophysica Acta - Proteins and Proteomics (2015) 1854:9 (1078-1089) DOI: 10.1016/j.bbapap.2015.04.030). (ekstern lenke)

Mastergradsoppgave

• Hjelmdal, Ellen Hovind; Teigen, Knut; Martinez, Aurora (2016). Characterization of prevalent phenylketonuria mutations Effect of potential pharmacological chaperones . (ekstern lenke)
• Skogheim, Elise; Teigen, Knut; Kleppe, Rune (2015). Identification of small molecular modulators of 14-3-3 functions. A virtual screening approach with experimental validation. (ekstern lenke)
• Akerholdt, Monica Hallem; Teigen, Knut; Kleppe, Rune (2015). Discovery of small-molecular disruptors of protein-protein inteactions A virtual screening approach applied to 14-3-3¿ and tyrosine hydroxylase. (ekstern lenke)
• Harris, Gerd Marie Eskerud; Teigen, Knut; Martinez, Aurora (2014). Identification of pharmacological chaperones for Phenylalanine Hydroxylase A virtual screening approach to discover novel drug candidates for treatment of phenylketonuria. (ekstern lenke)
• Berg, Rikke Landsvik; Teigen, Knut; Haavik, Jan (2014). IDENTIFICATION OF INHIBITORS OF TRYPTOPHAN HYDROXYLASE 1. (ekstern lenke)
• Hole, Magnus; Teigen, Knut; Martinez, Aurora (2012). SEARCH AND ANALYSIS OF COMPOUNDS THAT STABILIZE TYROSINE HYDROXYLASE - IDENTIFICATION OF PHARMACOLOGICAL CHAPERONES. (ekstern lenke)
• Bezem, Maria Teresa; Martinez, Aurora; Teigen, Knut (2012). Stabilisation of Tyrosine Hydroxylase in Nanoparticles for Enzyme Replacement Therapy. (ekstern lenke)
• Aardal, Marit Elisabet; Teigen, Knut; Meier, Sonnich et al. (2011). Interactions between polychlorinated biphenyls (PCBs) and a phospholipid bilayer: A molecular dynamics study. (ekstern lenke)
• Skjevik, Åge Aleksander; Teigen, Knut; Gjerde, Anja Underhaug et al. (2008). INTERACTION OF A LOCAL ANAESTHETIC WITH MEMBRANE LIPIDS STUDIED COMPUTER MODELLING. (ekstern lenke)
• Pedersen, Ida Benedikte; Teigen, Knut; Gjerde, Anja Underhaug et al. (2008). BIOLOGICAL TARGETS OF LOCAL ANAESTHETICS – A MOLECULAR MODELLING STUDY. (ekstern lenke)

Doktorgradsavhandling

• Hole, Magnus; Teigen, Knut (2015). A study of Structure-Function-Stability Relationships in Tyrosine Hydroxylase. (ekstern lenke)
• Teigen, Knut (2004). Structural and Functional Aspects of Pterin-Binding Enzymes - A Nuclear Magnetic Resonance Spectroscopy and Molecular Modeling Study. (ekstern lenke)

Vitenskapelig Kapittel/Artikkel/Konferanseartikkel

• Skjærven, Lars; Teigen, Knut; Martinez, Aurora (2014). Structure–Function Relationships in the Aromatic Amino Acid Hydroxylases Enzyme Family: Evolutionary Insights. (ekstern lenke)
• Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut et al. (2010). The aromatic amino acid hydroxylase mechanism: a perspective from computational chemistry. (ekstern lenke)

Sammendrag/abstract

• Walker, Ross C.; Skjevik, Åge Aleksander; Teigen, Knut (2012). Developing a comprehensive modular phospholipid force field for AMBER. (ekstern lenke)
• Madej, Benjamin D.; Skjevik, Age; Teigen, Knut et al. (2012). AMBER-Lipid 11: A new modular lipid force field for molecular dynamics. (ekstern lenke)

Short communication

• Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut et al. (2010). Water dissociation and dioxygen binding in phenylalanine hydroxylase. (ekstern lenke)

Vitenskapelig foredrag

• Olsson, Sara Elaine; Martinez, Aurora; Teigen, Knut et al. (2009). Dioxygen in aromatic amino acid hydroxylases. (ekstern lenke)
• Teigen, Knut; Frøystein, Nils Åge; Martínez, Aurora (1998). NMR study on the conformation of L-phenylalanine and dihydrobiopterin bound to wild-type and mutant forms of recombinant human phenylalanine hydroxylase. (ekstern lenke)

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