Jeg har en PhD fra Universitetet i Bergen (2017) der jeg undersøkte molekylære endringer i uterine svulster. Jeg er for tiden forsker i Bergen Gynekologiske Krefforskningsgruppe der mitt hovedfokus er å karakterisere kreftdrivere som man kan målrette behandling mot - med fokus på de mest aggressive uterine svulstene. jeg ser på genomiske, molekylære, radiologiske, og kliniskpatologiske drivere i disse kreftsvulstene og prøver å finne gode biomarkører for forbedret diagnostikk og prediksjon av behandlingsrespons. 

Vitenskapelig artikkel

• Halle, Mari Kyllesø; Bozickovic, Olivera; Forsse, David Erik et al. (2024). Clinicopathological and radiological stratification within FIGO 2018 stages improves risk-prediction in cervical cancer. (ekstern lenke)
• Halle, Mari Kyllesø; Hodneland, Erlend; Wagner-Larsen, Kari Strøno et al. (2024). Radiomic profiles improve prognostication and reveal targets for therapy in cervical cancer. (ekstern lenke)
• Krakstad, Camilla; Berg, Hege Fredriksen; Lindemann, Kristina Yvonne Kathe et al. (2024). Frequency of ERBB2-Low Expression in Endometrial Cancer. (ekstern lenke)
• Hodneland, Erlend; Andersen, Erling; Wagner-Larsen, Kari Strøno et al. (2024). Impact of MRI radiomic feature normalization for prognostic modelling in uterine endometrial and cervical cancers. (ekstern lenke)
• Bellone, Stefania; Jeong, Kyungjo; Halle, Mari Kyllesø et al. (2024). Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix. (ekstern lenke)
• van den Berg, Madeleine Charlotte; Berg, Hege Fredriksen; Stokowy, Tomasz et al. (2024). Expression patterns of mismatch repair proteins in cervical cancer uncover independent prognostic value of MSH-2. (ekstern lenke)
• Wagner-Larsen, Kari Strøno; Hodneland, Erlend; Fasmer, Kristine Eldevik et al. (2023). MRI-based radiomic signatures for pretreatment prognostication in cervical cancer. (ekstern lenke)
• Lien, Hilde Eide; Berg, Hege Fredriksen; Halle, Mari Kyllesø et al. (2023). Single-cell profiling of low-stage endometrial cancers identifies low epithelial vimentin expression as a marker of recurrent disease. (ekstern lenke)
• Eide, Agnes Jørgensen; Halle, Mari Kyllesø; Lura, Njål et al. (2023). Visceral fat percentage for prediction of outcome in uterine cervical cancer. (ekstern lenke)
• Hodneland, Erlend; Kaliyugarasan, Sathiesh Kumar; Wagner-Larsen, Kari Strøno et al. (2022). Fully Automatic Whole-Volume Tumor Segmentation in Cervical Cancer. (ekstern lenke)
• Wagner-Larsen, Kari Strøno; Lura, Njål Gjærde; Salvesen, Øyvind et al. (2022). Interobserver agreement and prognostic impact for MRI–based 2018 FIGO staging parameters in uterine cervical cancer. (ekstern lenke)
• Sofiyeva, Nigar; Krakstad, Camilla; Halle, Mari Kyllesø et al. (2022). APOBEC3A/B deletion polymorphism and endometrial cancer risk. (ekstern lenke)
• Lura, Njål Gjærde; Wagner-Larsen, Kari Strøno; Forsse, David Erik et al. (2022). What MRI-based tumor size measurement is best for predicting long-term survival in uterine cervical cancer?. (ekstern lenke)
• Chakravarthy, Ankur; Reddin, Ian; Henderson, Stephen et al. (2022). Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance. (ekstern lenke)
• Berg, Hege Fredriksen; Engerud, Hilde Renate; Myrvold, Madeleine et al. (2022). Mismatch repair markers in preoperative and operative endometrial cancer samples; expression concordance and prognostic value. (ekstern lenke)
• Halle, Mari Kyllesø; Sødal, Marte; Forsse, David Erik et al. (2021). A 10-gene prognostic signature points to LIMCH1 and HLA-DQB1 as important players in aggressive cervical cancer disease. (ekstern lenke)
• Halle, Mari Kyllesø; Munk, Ane Cecilie Dæhli; Engesæter, Birgit Øvstebø et al. (2021). A gene signature identifying CIN3 regression and cervical cancer survival. (ekstern lenke)
• Øvestad, Irene Tveiterås; Engesæter, Birgit Øvstebø; Halle, Mari Kyllesø et al. (2021). High-Grade Cervical Intraepithelial Neoplasia (CIN) Associates with Increased Proliferation and Attenuated Immune Signaling. (ekstern lenke)
• Høivik, Erling Andre; Hodneland, Erlend; Dybvik, Julie Andrea et al. (2021). A radiogenomics application for prognostic profiling of endometrial cancer. (ekstern lenke)
• Ruiz, Fiona J.; Sundaresan, Aishwarya; Zhang, Jin et al. (2021). Genomic characterization and therapeutic targeting of HPV undetected cervical carcinomas. (ekstern lenke)
• Helwa, Reham; Gansmo, Liv Beathe; Bjørnslett, Merete Pauline et al. (2021). Impact of MDM2 promoter SNP55 (rs2870820) on risk of endometrial and ovarian cancer. (ekstern lenke)
• Halle, Mari Kyllesø; Sundaresan, Aishwarya; Zhang, Jianqing et al. (2021). Genomic alterations associated with mutational signatures, DNA damage repair and chromatin remodeling pathways in cervical carcinoma.. (ekstern lenke)
• Engerud, Hilde Renate; Berg, Hege Fredriksen; Myrvold, Madeleine et al. (2020). High degree of heterogeneity of PD-L1 and PD-1 from primary to metastatic endometrial cancer. (ekstern lenke)
• Berg, Hege Fredriksen; Ju, Zhenlin; Myrvold, Madeleine et al. (2020). Development of prediction models for lymph node metastasis in endometrioid endometrial carcinoma. (ekstern lenke)
• Forsse, David Erik; Berg, Hege Fredriksen; Bozickovic, Olivera et al. (2020). Maintained survival outcome after reducing lymphadenectomy rates and optimizing adjuvant treatment in endometrial cancer. (ekstern lenke)
• Holst, Frederik; Werner, Henrica Maria Johanna; Mjøs, Siv et al. (2019). PIK3CA amplification associates with aggressive phenotype but not markers of AKT-mTOR signaling in endometrial carcinoma. (ekstern lenke)
• Forsse, David Erik; Tangen, Ingvild Løberg; Fasmer, Kristine Eldevik et al. (2019). Blood steroid levels predict survival in endometrial cancer and reflect tumor estrogen signaling. (ekstern lenke)
• Strand, Elin; Tangen, Ingvild Løberg; Fasmer, Kristine Eldevik et al. (2019). Blood metabolites associate with prognosis in endometrial cancer. (ekstern lenke)
• Kusonmano, Kanthida; Halle, Mari Kyllesø; Wik, Elisabeth et al. (2018). Identification of highly connected and differentially expressed gene subnetworks in metastasizing endometrial cancer. (ekstern lenke)
• Bollineni, Vikram Rao; Ytre-Hauge, Sigmund; Gulati, Ankush et al. (2018). The prognostic value of preoperative FDG-PET/CT metabolic parameters in cervical cancer patients. (ekstern lenke)
• Halle, Mari Kyllesø; Ojesina, Akinyemi I; Engerud, Hilde Renate et al. (2017). Clinicopathologic and molecular markers in cervical carcinoma: a prospective cohort study. (ekstern lenke)
• Mjøs, Siv; Werner, Henrica Maria Johanna; Birkeland, Even et al. (2017). PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer. (ekstern lenke)
• Gansmo, Liv Beathe; Bjørnslett, Merete Pauline; Halle, Mari Kyllesø et al. (2017). MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk. (ekstern lenke)
• Halle, Mari Kyllesø; Tangen, Ingvild Løberg; Berg, Hege Fredriksen et al. (2017). HER2 expression patterns in paired primary and metastatic endometrial cancer lesions. (ekstern lenke)
• Tangen, Ingvild Løberg; Venereis, Jennifer Taylor; Halle, Mari Kyllesø et al. (2017). Expression of glucocorticoid receptor is associated with aggressive primary endometrial cancer and increases from primary to metastatic lesions. (ekstern lenke)
• Berg, Anna; Gulati, Ankush; Ytre-Hauge, Sigmund et al. (2017). Preoperative imaging markers and PDZ-binding kinase tissue expression predict low-risk disease in endometrial hyperplasias and low grade cancers. (ekstern lenke)
• Tangen, Ingvild Løberg; Onyango, Therese Bredholt; Kopperud, Reidun Kristin et al. (2016). Androgen receptor as potential therapeutic target in metastatic endometrial cancer. (ekstern lenke)
• Gibson, William J.; Høivik, Erling Andre; Halle, Mari Kyllesø et al. (2016). The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis. (ekstern lenke)
• Gansmo, Liv Beathe; Bjørnslett, Merete Pauline; Halle, Mari Kyllesø et al. (2016). The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian—but not endometrial cancer. (ekstern lenke)
• Mauland, Karen Klepsland; Wik, Elisabeth; Høivik, Erling Andre et al. (2016). Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival. (ekstern lenke)
• Berg, Anna; Fasmer, Kristine Eldevik; Mauland, Karen Klepsland et al. (2016). Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer. (ekstern lenke)
• Yang, Ji-Yeon; Werner, Henrica Maria Johanna; Li, Jie et al. (2016). Integrative protein-based prognostic model for early-stage endometrioid endometrial cancer. (ekstern lenke)
• Berg, Anna; Høivik, Erling Andre; Mjøs, Siv et al. (2015). Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients. (ekstern lenke)
• Krakstad, Camilla; Tangen, Ingvild Løberg; Høivik, Erling Andre et al. (2015). ATAD2 overexpression links to enrichment of B-MYBtranslational signatures and development of aggressive endometrial carcinoma. (ekstern lenke)
• Earp, Magdalene A; Kelemen, Linda E.; Magliocco, Anthony M. et al. (2014). Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA. (ekstern lenke)
• Ojesina, Akinyemi; Lichtenstein, Lee; Freeman, Samuel S. et al. (2014). Landscape of genomic alterations in cervical carcinomas. (ekstern lenke)
• Wik, Elisabeth; Trovik, Jone; Kusonmano, Kanthida et al. (2014). Endometrial Carcinoma Recurrence Score (ECARS) validates to identify aggressive disease and associates with markers of epithelial-mesenchymal transition and PI3K alterations. (ekstern lenke)
• Werner, Henrica Maria Johanna; Trovik, Jone; Halle, Mari Kyllesø et al. (2014). Stathmin Protein Level, a Potential Peredictive Marker for Taxane Treatment Response in Endometrial Cancer. (ekstern lenke)
• Charbonneau, Bridget; Block, MS; Bamlet, WR et al. (2014). Risk of ovarian cancer and the NF-kB pathway: Genetic association with IL1A and TNFSF10. (ekstern lenke)
• Tangen, Ingvild Løberg; Werner, Henrica Maria Johanna; Berg, Anna et al. (2014). Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial cancer lesions. (ekstern lenke)
• Halle, Mari Kyllesø; Krakstad, Camilla; Engerud, Hilde Renate Haugen et al. (2014). Molecular profiling in fresh tissue with high tumor cell content promotes enrichment for aggressive adenocarcinomas in cervix. (ekstern lenke)
• Engerud, Hilde Renate Haugen; Tangen, Ingvild Løberg; Berg, Ansgar et al. (2014). High level of HSF1 associates with aggressive endometrial carcinoma and suggests potential for HSP90 inhibitors. (ekstern lenke)
• Tangen, Ingvild Løberg; Krakstad, Camilla; Halle, Mari Kyllesø et al. (2014). Switch in FOXA1 status associates with endometrial cancer progression. (ekstern lenke)
• Høivik, Erling Andre; Kusonmano, Kanthida; Halle, Mari Kyllesø et al. (2014). Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene. (ekstern lenke)
• Helgeland, Hanna; Sandve, Simen Rød; Torgersen, Jacob et al. (2014). The evolution and functional divergence of the beta-carotene oxygenase gene family in teleost fish-Exemplified by Atlantic salmon. (ekstern lenke)
• Delahanty, Ryan J.; Xiang, Yong-Bing; Spurdle, Amanda et al. (2013). Polymorphisms in inflammation pathway genes and endometrial cancer risk. (ekstern lenke)
• Pharoah, Paul D.P.; Halle, Mari Kyllesø; Krakstad, Camilla et al. (2013). GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (ekstern lenke)
• Permuth-Wey, Jennifer; Lawrenson, K; Shen, HC et al. (2013). Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. (ekstern lenke)
• Long, Jirong; Zheng, Wei; Xiang, Yong-Bing et al. (2012). Genome-wide association study identifies a possible susceptibility locus for endometrial cancer. (ekstern lenke)
• Krakstad, Camilla; Birkeland, Even; Seidel, Danila et al. (2012). High-throughput mutation profiling of primary and metastatic endometrial cancers identifies KRAS, FGFR2 and PIK3CA to be frequently mutated. (ekstern lenke)

Errata

• Lien, Hilde Eide; Berg, Hege Fredriksen; Halle, Mari Kyllesø et al. (2023). Corrigendum to “Single-cell profiling of low-stage endometrial cancers identifies low epithelial vimentin expression as a marker of recurrent disease” [EBioMedicine 92 (2023) 104595] (eBioMedicine (2023) 92, (S2352396423001603), (10.1016/j.ebiom.2023.104595)). (ekstern lenke)

Doktorgradsavhandling

• Halle, Mari Kyllesø; Salvesen, Helga; Krakstad, Camilla (2017). Molecular alterations suggesting new treatment strategies in uterine carcinomas. (ekstern lenke)

Leserinnlegg

• Halle, Mari Kyllesø; Werner, Henrica Maria Johanna; Krakstad, Camilla et al. (2012). Stratification based on high tumour cell content in fresh frozen tissue promotes selection of aggressive endometrial carcinomas. (ekstern lenke)

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