Sigrid Aslaksen
Stilling
Postdoktor, Medical Genetics group
Tilhørighet
Forskning
Postdoc (2021-) in the Medical Genetics group focusing on functional characterization of ABCA4-variants linked to Stargardt disease and development of pharmacological chaperones.
Ph.D. fellow (2017-2020) in the Endocrine Medicine research group, led by prof. Eystein S. Husebye, at the Department of Clinical Science, University of Bergen. Main research focus: Functional characterization of genetic risk factors in autoimmune Addison's disease and immunodominant T cell responses in patients with Addison's.
Publikasjoner
Vitenskapelig artikkel
- De Bruyn, Hanna; Johnson, Megan; Moretti, Madelyn et al. (2024). The Surviving, Not Thriving, Photoreceptors in Patients with ABCA4 Stargardt Disease. (ekstern lenke)
- Aslaksen, Sigrid; Aukrust, Ingvild; Molday, Laurie et al. (2024). Functional Characterization of ABCA4 Missense Variants Aids Variant Interpretation and Phenotype Prediction in Patients With ABCA4-Retinal Dystrophies. (ekstern lenke)
- Croci, Susanna; Venneri, Mary Anna; Mantovani, Stefania et al. (2021). The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males. (ekstern lenke)
- Hellesen, Alexander; Aslaksen, Sigrid; Breivik, Lars Ertesvåg et al. (2021). 21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison’s Disease Are Restricted by HLA-A2 and HLA-C7 Molecules. (ekstern lenke)
- Aslaksen, Sigrid; Methlie, Paal; Vigeland, Magnus Dehli et al. (2019). Coexistence of congenital adrenal hyperplasia and autoimmune Addison's disease. (ekstern lenke)
- Aslaksen, Sigrid; Wolff, Anette Susanne Bøe; Vigeland, Magnus Dehli et al. (2019). Identification and characterization of rare Toll-like receptor 3 variants in patients with autoimmune Addison’s disease. (ekstern lenke)
- Vehus, Tore; Røberg-Larsen, Hanne; Waaler, Jo et al. (2016). Versatile, sensitive liquid chromatography mass spectrometry–Implementation of 10 μm OT columns suitable for small molecules, peptides and proteins. (ekstern lenke)
Se en full oversikt over publikasjoner i Cristin
Alexander Hellesen† , Sigrid Aslaksen†, Lars Breivik, Ellen Christine Røyrvik, Øyvind Bruserud, Kine Edvardsen, Karl Albert Brokstad, Anette Susanne Bøe Wolff, Eystein Sverre Husebye and Eirik Bratland (2021). †These authors have contributed equally to this work and share first authorship. 21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison’s Disease Are Restricted by HLA-A2 and HLA-C7 Molecules. Frontiers in Immunology, 12, 742848. 10.3389/fimmu.2021.742848
Sigrid Aslaksen, Anette B. Wolff, Magnus D. Vigeland, Lars Breivik, Ying Sheng, Bergithe E. Oftedal, Haydee Artaza, Beate Skinningsrud, Dag E. Undlien, Kaja K. Selmer, Eystein S. Husebye, Eirik Bratland (2019). Identification and characterization of rare Toll-like receptor 3 variants in patients with autoimmune Addison's disease. Journal of Translational Autoimmunity, 1, 100005. 10.1016/j.jtauto.2019.100005
Sigrid Aslaksen, Paal Methlie, Magnus D. Vigeland, Dag E. Jøssang, Anette B. Wolff, Ying Sheng, Bergithe E. Oftedal, Beate Skinningsrud, Dag E. Undlien, Kaja K. Selmer, Eystein S. Husebye, Eirik Bratland (2019). Coexistence of congenital adrenal hyperplasia and autoimmune Addison’s disease. Frontiers in Endocrinology, 10, 648. 10.3389/fendo.2019.00648
Tore Vehus, Hanne Røberg-Larsen, Jo Waaler, Sigrid Aslaksen, Stefan Krauss, Steven R. Wilson, Elsa Lundanes (2016). Versatile, sensitive liquid chromatography mass spectrometry – Implementation of 10 μm OT columns suitable for small molecules, peptides and proteins. Scientific Reports, 6, 37507. 10.1038/srep37507
Kompetanse
Education/academic qualifications
Postdoctoral researcher, molecular genetics of patients with ABCA4-retinal dystrophies, University of Bergen, 2021.
Philosophiae doctor (PhD), genetic risk factors in Autoimmune Addison's disease, University of Bergen, 2020.
Practical-pedagogical education, Norwegian University of Life Sciences, 2017
Master’s degree, Biotechnology and Molecular Biology, Norwegian University of Life Sciences, 2016
Bachelor's degree, Biotechnology, Norwegian University of Life Sciences, 2014
Research visits
University of Oxford, Weatherall Institute of Molecular Medicine, UK
Grants
The Scandinavian Society for Immunology travel grants, 2019
Det alminnelige medisinske forskningsfond, 2018
Dr. Nils Henrichsen og hustru Anna Henrichsens legat, 2018
Trygve Tellefsens legat, 2015