Dendrittiske celler, særlig deres bruk i immunterapi mot kreft og autoimmune sykdommer.

Enkeltcelle analyser for stratifisering av pasienter og for å utvikle nye behandingsstrategier.

Medlem av organisasjonskommitteen for den årlige "Immunologiens dag" (29.4.)

 

Emneansvarlig for

• FARM270 (Farmasøytisk mikrobiologi og immunologi)
• Immunologi MED3 (tredje semester medisin)
• HUIMM320 (Basal immunologi)

Underviser i

• HUIMM307 Basic course in flow cytometry
• HUIMM901 Project seminars
• HUIMM903 Cellular and molecular immunology

Brev til redaktøren

• Petrovic, Aleksandra; Ten Bergen, Lisa Lynn; Solberg, Silje Michelsen et al. (2023). Biological treatment in severe psoriasis: Influence on peripheral blood dendritic cells. (ekstern lenke)

Poster

• Meeren, Aina van der; Appel, Silke; Lied, Gülen Arslan et al. (2023). Diagnostic gut biomarkers with imaging mass cytometry in irritable bowel syndrome. (ekstern lenke)
• Van Der Meeren, Aina; Appel, Silke; Lied, Gülen Arslan et al. (2023). Bergen BrainGut study: diagnostic gut biomarkers in irritable bowel syndrome with imaging mass cytometry. (ekstern lenke)
• Haldorsen, Karstein; Appel, Silke; Bruland, Ove et al. (2009). Fc receptor IIA, IIIA and IIIB single nucleotide polymorphisms and Fc receptor IIIB copy number variation: No association with primary Sjögren’s syndrome. (ekstern lenke)
• Vogelsang, Petra; Brun, Johan G; Jonsson, Roland et al. (2009). Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjögren's syndrome. (ekstern lenke)
• Vogelsang, Petra; Lier, GS; Brun, Johan G et al. (2009). Dendritic cells from patients with primary Sjögren's syndrome have slightly enhanced endocytic capacity. (ekstern lenke)
• Nordmark, Gunnel; Kristjansdottir, Gudlaug; Appel, Silke et al. (2009). Association of C8orf13-BLK and TNFSF4 Gene Variants with Primary Sjögren's Syndrome. (ekstern lenke)

Vitenskapelig artikkel

• Petrovic, Aleksandra; Bueide, Ingvild Øye; Tveit, Kåre Steinar et al. (2023). Herring roe oil in treatment of psoriasis – influence on immune cells and cytokine network. (ekstern lenke)
• Lundtoft, Christian; Pucholt, Pascal; Martin, Myriam et al. (2022). Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases. (ekstern lenke)
• Sarkar, Irene; Davies, Richard Allan; Aarebrot, Anders Krogh et al. (2022). Aberrant signaling of immune cells in Sjögren's syndrome patient subgroups upon interferon stimulation. (ekstern lenke)
• Trutschel, Diana; Bost, Pierre; Mariette, Xavier et al. (2022). Variability of Primary Sjögren's Syndrome Is Driven by Interferon α and Interferon α Blood Levels Are Associated With the Class II HLA–DQ Locus. (ekstern lenke)
• Keindl, Magdalena; Davies, Richard Allan; Bergum, Brith et al. (2022). Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome. (ekstern lenke)
• Azeem, Waqas; Bakke, Ragnhild Maukon; Gabriel, Benjamin et al. (2021). Evaluation of β-catenin inhibition of axitinib and nitazoxanide in human monocyte-derived dendritic cells. (ekstern lenke)
• Bharaj, Tamandeep Kaur; Aqrawi, Lara A.; Fromreide, Siren et al. (2021). Inflammatory Stratification in Primary Sjögren’s Syndrome Reveals Novel Immune Cell Alterations in Patients’ Minor Salivary Glands. (ekstern lenke)
• Keindl, Magdalena; Fedotkina, Olena; du Plessis, Elsa et al. (2020). Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms. (ekstern lenke)
• Solberg, Silje Michelsen; Aarebrot, Anders K.; Sarkar, Irene et al. (2020). Mass cytometry analysis of blood immune cells from psoriasis patients on biological therapy. (ekstern lenke)
• Azeem, Waqas; Bakke, Ragnhild Maukon; Appel, Silke et al. (2020). Dual pro- and anti-inflammatory features of monocyte-derived dendritic cells. (ekstern lenke)
• Davies, Richard Allan; Sarkar, Irene; Hammenfors, Daniel et al. (2019). Single cell based phosphorylation profiling identifies alterations in toll-like receptor 7 and 9 signaling in patients with primary sjogren's syndrome. (ekstern lenke)
• Sauter, Alexander; Yi, Dag Heiro; Li, Yayan et al. (2019). The Culture Dish Surface Influences the Phenotype and Cytokine Production of Human Monocyte-Derived Dendritic Cells. (ekstern lenke)
• Aarebrot, Anders Krogh; Solberg, Silje Michelsen; Davies, Richard Allan et al. (2018). Phosphorylation of intracellular signaling molecules in peripheral blood cells from psoriasis patients on originator or biosimilar infliximab. (ekstern lenke)
• Davies, Richard Allan; Hammenfors, Daniel; Bergum, Brith et al. (2018). Aberrant cell signalling in PBMCs upon IFN-? stimulation in primary Sjogren's syndrome patients associates with type I interferon signature. (ekstern lenke)
• Yi, Dag Heiro; Stetter, Nadine; Jakobsen, Kjerstin et al. (2018). 3-Day monocyte-derived dendritic cells stimulated with a combination of OK432, TLR7/8 ligand, and prostaglandin E2 are a promising alternative for cancer immunotherapy. (ekstern lenke)
• Fuchs, Anke; Gliwiński, Mateusz; Grageda, Nathali et al. (2018). Minimum information about T regulatory cells: A step toward reproducibility and standardization. (ekstern lenke)
• Solberg, Silje Michelsen; Sandvik, Lene Frøyen; Eidsheim, Marianne et al. (2018). Serum cytokine measurements and biological therapy of psoriasis - Prospects for personalized treatment?. (ekstern lenke)
• Davies, Richard Allan; Hammenfors, Daniel; Bergum, Brith et al. (2017). Patients with primary Sjögren's syndrome have alterations in absolute quantities of specific peripheral leucocyte populations. (ekstern lenke)
• Karlsen, Marie; Jakobsen, Kjerstin; Jonsson, Roland et al. (2017). Expression of Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Patients with Primary Sjogren's Syndrome. (ekstern lenke)
• Lord, Phillip; Spiering, Rachel; Aguillon, Juan C. et al. (2016). Minimum information about tolerogenic antigen-presenting cells (MITAP): A first step towards reproducibility and standardisation of cellular therapies. (ekstern lenke)
• Davies, Richard Allan; Vogelsang, Petra; Jonsson, Roland et al. (2016). An optimized multiplex flow cytometry protocol for the analysis of intracellular signaling in peripheral blood mononuclear cells. (ekstern lenke)
• Sauter, Alexander; Mc Duffie, Yvonne; Böhm, Heike et al. (2015). Surface-mediated priming during in vitro generation of monocyte-derived dendritic cells. (ekstern lenke)
• Karlsen, Marie; Hansen, Torbjørn; Nordal, Hilde Haugedal et al. (2015). Expression of toll-like receptor -7 and -9 in B cell subsets from patients with primary Sjögren's syndrome. (ekstern lenke)
• Karlsen, Marie; Jonsson, Roland; Brun, Johan G et al. (2015). TLR-7 and -9 Stimulation of Peripheral Blood B Cells Indicate Altered TLR Signalling in Primary Sjögren's Syndrome Patients by Increased Secretion of Cytokines. (ekstern lenke)
• Sandvik, Lene Frøyen; Skarstein, Kathrine; Krynitz, Britta et al. (2015). Peritumoral dermis of squamous cell carcinomas in renal transplant recipients contains less CD11c+ myeloid dendritic cells and FoxP3+ T cells compared to immunocompetent controls. (ekstern lenke)
• Sprater, Florian; Azeem, Waqas; Appel, Silke (2014). Activation of peroxisome proliferator-activated receptor gamma leads to upregulation of ESE-3 expression in human monocyte-derived dendritic cells. (ekstern lenke)
• Sandvik, Lene Frøyen; Skarstein, Kathrine; Sviland, Lisbeth et al. (2014). CD11c+ dendritic cells rather than Langerhans cells are reduced in normal skin of immunosuppressed renal transplant recipients. (ekstern lenke)
• Vogelsang, Petra; Karlsen, Marie; Brun, Johan G et al. (2014). Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren's syndrome. (ekstern lenke)
• Sauter, Alexander; Richter, Gunther; Micoulet, Alexandre et al. (2013). Effective polyethylene glycol passivation for the inhibition of surface interactions of peripheral blood mononuclear cells and platelets. (ekstern lenke)
• Volchenkov, Roman; Brun, Johan G; Jonsson, Roland et al. (2013). In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome. (ekstern lenke)
• Sandvik, Lene Frøyen; Volchenkov, Roman; Jonsson, Roland et al. (2013). Characterization of monocyte-derived dendritic cells from immunosuppressed renal transplant recipients with and without squamous cell carcinomas. (ekstern lenke)
• Haldorsen, Karstein; Appel, Silke; Le Hellard, Stephanie et al. (2013). No association of primary Sjögren's syndrome with Fcγ receptor gene variants. (ekstern lenke)
• Volchenkov, Roman; Karlsen, Marie; Jonsson, Roland et al. (2013). Type 1 regulatory T cells and regulatory B cells induced by tolerogenic dendritic cells. (ekstern lenke)
• Landsverk, Ole J. B.; Ottesen, Anett Hellebø; Berg-Larsen, Axel et al. (2012). Differential regulation of MHC II and invariant chain expression during maturation of monocyte-derived dendritic cells. (ekstern lenke)
• Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland et al. (2012). The bacterial preparation OK432 induces IL-12p70 secretion in human dendritic cells in a TLR3 dependent manner. (ekstern lenke)
• Sprater, Florian; Hovden, Arnt-Ove; Appel, Silke (2012). Expression of ESE-3 isoforms in immunogenic and tolerogenic human monocyte-derived dendritic cells. (ekstern lenke)
• Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland et al. (2011). Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses. (ekstern lenke)
• Lied, Gülen Arsland; Vogelsang, Petra; Berstad, Arnold et al. (2011). Dendritic cell populations in patients with self-reported food hypersensitivity. (ekstern lenke)
• Karlsen, Marie; Hovden, Arnt-Ove; Vogelsang, Petra et al. (2011). Bromelain Treatment Leads to Maturation of Monocyte-derived Dendritic Cells but Cannot Replace PGE(2) in a Cocktail of IL-1 beta, IL-6, TNF-alpha and PGE(2). (ekstern lenke)
• Appel, Silke; Le Hellard, Stephanie; Bruland, Ove et al. (2011). Potential association of muscarinic receptor 3 gene variants with primary Sjögren's syndrome. (ekstern lenke)
• Nordmark, Gunnel; Kristjansdottir, Gudlaug; Theander, Elke et al. (2011). Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome. (ekstern lenke)
• Vogelsang, Petra; Brun, Johan G; Øijordsbakken, Gunnvor et al. (2010). Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjögren's syndrome. (ekstern lenke)
• Vogelsang, Petra; Hovden, Arnt-Ove; Jonsson, Roland et al. (2009). Levels of dendritic cell populations and regulatory T cells vary significantly between two commonly used mouse strains. (ekstern lenke)
• Delaleu, Nicolas; Jonsson, Malin V; Appel, Silke et al. (2008). New Concepts in the Pathogenesis of Sjogren's Syndrome. (ekstern lenke)
• Appel, Silke; Brossart, P. (2007). Development of novel compounds to treat autoimmune and inflammatory diseases and graft versus host reactions. (ekstern lenke)
• Appel, Silke; Bringmann, Anita; Grünebach, Frank et al. (2006). Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs. (ekstern lenke)

Vitenskapelig foredrag

• Osmani, Dorentina; Hans, Manpret Kour; Jakobsen, Kjerstin et al. (2023). Planter vs. dødelig virus. (ekstern lenke)

Intervju

• Riise, Ivar Lid; Kleiveland, Mathias; Andersen, Heidi Lie et al. (2023). Dreper kreftceller med hageplanter. (ekstern lenke)

Vitenskapelig oversiktsartikkel/review

• Ten Bergen, Lisa Lynn; Petrovic, Aleksandra; Aarebrot, Anders K. et al. (2020). Current knowledge on autoantigens and autoantibodies in psoriasis. (ekstern lenke)
• Ten Bergen, Lisa Lynn; Petrovic, Aleksandra; Aarebrot, Anders K. et al. (2020). The TNF/IL-23/IL-17 axis-Head-to-head trials comparing different biologics in psoriasis treatment. (ekstern lenke)
• Yi, Dag Heiro; Appel, Silke (2013). Current status and future perspectives of dendritic cell-based cancer immunotherapy. (ekstern lenke)
• Volchenkov, Roman; Sprater, Florian; Vogelsang, Petra et al. (2012). The 2011 Nobel Prize in physiology or medicine. (ekstern lenke)
• Jonsson, Roland; Vogelsang, Petra; Volchenkov, Roman et al. (2011). The complexity of Sjögren's syndrome: Novel aspects on pathogenesis. (ekstern lenke)
• Vogelsang, Petra; Jonsson, Malin V; Dalvin, Sussie Trine et al. (2006). Role of dendritic cells in Sjögren´s syndrome. (ekstern lenke)

Doktorgradsavhandling

• Solberg, Silje Michelsen; Appel, Silke; Bryceson, Yenan et al. (2019). Systemic inflammation in psoriasis: Circulating immune cells and cytokines. (ekstern lenke)
• Davies, Richard Allan; Appel, Silke; Vogelsang, Petra et al. (2017). Flow cytometry based analyses as a tool in biomarker discovery for patient stratification in primary Sjögren’s syndrome. (ekstern lenke)
• Karlsen, Marie; Appel, Silke; Hansen, Torbjørn (2015). Toll-like receptors in primary Sjögren’s syndrome. Special emphasis on B cells. (ekstern lenke)
• Haldorsen, Karstein; Bolstad, Anne Isine; Brun, Johan G et al. (2011). Epidemiological, clinical, and immunogenetic aspects of primary Sjögren's syndrome. (ekstern lenke)

Leserinnlegg

• Haldorsen, Karstein; Bruland, Ove; Appel, Silke et al. (2013). Reply to 'Comment on No association of primary Sjogren's syndrome with Fc gamma receptor gene variants'. (ekstern lenke)
• Sandvik, Lene Frøyen; Vogelsang, Petra; Leivestad, Torbjørn et al. (2012). Quantification of Plasmacytoid Dendritic Cells and Type 1 Myeloid Dendritic Cells in Peripheral Blood of Renal Transplant Recipients With and Without Squamous Cell Carcinoma. (ekstern lenke)
• Volchenkov, Roman; Jonsson, Roland; Appel, Silke (2012). Anti-Ro and anti-La autoantibody profiling in Norwegian patients with primary Sjogren's syndrome using luciferase immunoprecipitation systems (LIPS). (ekstern lenke)
• Hovden, Arnt-Ove; Appel, Silke (2010). The First Dendritic Cell-Based Therapeutic Cancer Vaccine is Approved by the FDA. (ekstern lenke)

Sammendrag/abstract

• Volchenkov, Roman; Karlsen, Marie; Jonsson, Roland et al. (2013). Type 1 Regulatory T cells and Regulatory B Cells Induced by Dexamethasone and 1,25-Dihydroxyvitamin D3 Treated Monocyte-Derived Dendritic Cells. (ekstern lenke)
• Volchenkov, Roman; Karlsen, Marie; Jonsson, Roland et al. (2012). Comparison of different protocols for the generation of monocytes-derived tolerogenic dendritic cells for immunotherapy. (ekstern lenke)
• Karlsen, Marie; Hansen, Torbjørn; Jonsson, Roland et al. (2012). Expression of Toll-like receptors 7 and 9 in B cell populations of patients with Sjogren's syndrome. (ekstern lenke)
• Haldorsen, Karstein; Appel, Silke; Le Hellard, Stephanie et al. (2012). No association of primary Sjögren's Syndrome with Fc gamma? Receptor gene variants. (ekstern lenke)
• Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland et al. (2011). Maturation of Dendritic Cells with the Bacterial Compound OK432 Induces High Secretion of IL-12p70 in a TLR3 Dependent Manner. (ekstern lenke)
• Sandvik, Lene Frøyen; Leivestad, Torbjørn; Sandnes, Dagny Ann et al. (2011). Can Levels of Blood Plasmacytoid Dendritic Cells be used as a Prognostic Factor for Development of Squamous Cell Carcinomas in Organ Transplant Recipients?. (ekstern lenke)
• Volchenkov, Roman; Hovden, Arnt-Ove; Karlsen, Marie et al. (2011). Generation of Tolerogenic Monocyte-Derived Dendritic Cells. (ekstern lenke)
• Sprater, Florian; Hovden, Arnt-Ove; Niere, Marc et al. (2011). The Epithelial Specific Transcription Factor ESE-3 is Expressed in Immature Dendritic Cells and Occurs Primarily as the ESE-3b Isoform. (ekstern lenke)
• Hovden, Arnt-Ove; Karlsen, Marie; Sandnes, Dagny Ann et al. (2010). Maturation of Monocyte Derived Dendritic Cells With OK432 Leads to Altered Expression of Surface Markers. (ekstern lenke)
• Appel, Silke; Vogelsang, Petra; Brun, Johan G et al. (2010). Patients with Primary Sjogren's Syndrome have Significantly Reduced Amounts of Plasmacytoid and Type 2 Myeloid Dendritic Cells in Peripheral Blood. (ekstern lenke)
• Nordmark, Gunnel; Kristjansdotti, Gudlaug; Theander, Elke et al. (2010). Gene Variants in Fam167A-Blk and Tnfsf4 are associated with Primary Sjogren's Syndrome. (ekstern lenke)
• Haldorsen, Karstein; Appel, Silke; Bruland, Ove et al. (2010). Fc gamma receptor IIA, IIIA and IIIB single nucleotide polymorphisms and Fc gamma receptor IIIB copy number variation: No association with primary Sjögren's syndrome. (ekstern lenke)
• Karlsen, Marie; Hovden, Arnt-Ove; Vogelsang, Petra et al. (2010). Bromelain Treatment Leads to Maturation of Monocyte Derived Dendritic Cells. (ekstern lenke)
• Lied, Gülen Arsland; Vogelsang, Petra; Berstad, Arnold et al. (2010). Dendritic cell populations in patients with self-reported food hypersensitivity. (ekstern lenke)
• Vogelsang, Petra; Deswaerte, Virginie; Jonsson, Malin V et al. (2008). Age-related distribution of cDC and pDC in salivary glands of NOD mice. (ekstern lenke)
• Hovden, Arnt-Ove; Sandnes, Dagny Ann; Jonsson, Roland et al. (2008). Maturation of monocyte derived dendritic cells with OK432 leads to altered expression of surface markers. (ekstern lenke)
• Bringmann, Anita; Hilgendorf, Ingo; Appel, Silke et al. (2008). Characterization of Gene p306 Expressed in Monocyte Derived Dendritic Cells. (ekstern lenke)

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