Simona Chera fullførte sin PhD ved the Department of Genetics and Evolution, at the Faculty of Science, University of Geneva, i 2008, hvor hun studerte mekanismer som er involvert i regnerasjon. Etterfølgende, arbeidet hun som postdoktor i i Prof. Pedro Herreras lab i Geneve, hvor arbeidet dreide seg om identifisering av mekanisme involvert i spontan regenerering av insulin produserende β-celler. (Thorel et al. 2010, Nature and Chera et al. 2014, Nature). 

I mars 2015 flyttet Chera til bergen, hvor hun fortsatte arbeidet som postdoktor i labgruppen til Prof. Helge Ræder. Her forsket hun på differensiering av β-celler fra pluripotente stam-celler fra patienter med Mature Onset Diabetes of the Young (MODY). Nå er hun Førsteamanuensis ved Klinisk institutt, UiB og NCMM Young associate Investigator. 

 

Hovedfokuset gjennom hennes karriere har vært å karakterisere cellulære og molekylære signaler som regulerer balansen mellom regeneration og homeostase i vev. Dette arbeidet har resultert i flere publikasjoner

Poster

• Unger, Lucas; Mathisen, Andreas Frøslev; Legøy, Thomas Aga et al. (2024). Deciphering the HNF1A and Hedgehog Signaling Crosstalk during Stem Cell Islet differentiation. (ekstern lenke)
• Sharmine, Shayla; Ghila, Luiza Mihaela; Chera, Simona (2024). Short-term effect of Somatostatin Modulators on Glycemic Control in MODY mice. (ekstern lenke)
• Unger, Lucas; Legøy, Thomas Aga; Ghila, Luiza Mihaela et al. (2024). Exploring hedgehog signaling and HNF1A Crosstalk in HNF1A-MODY stem cell islets. (ekstern lenke)
• Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Paulo, Joao et al. (2023). Human induced pluripotent stem cells as a model for environmental impact on diabetes. (ekstern lenke)
• Sharmine, Shayla; Legøy, Thomas Aga; Mathisen, Andreas Frøslev et al. (2023). Mapping islet architecture changes upon high fat diet challenge in a HNF1A-MODY mouse model. (ekstern lenke)
• Unger, Lucas; Legøy, Thomas Aga; Mathisen, Andreas Frøslev et al. (2023). Investigating the developmental role of HNF1A, HNF1B and HNF4A in human pancreatic islet cell differentiation. (ekstern lenke)
• Hossain, Md Kaykobad; Altankhuyag, Altanchimeg; Legøy, Thomas Aga et al. (2023). Mapping predictive bladder cancer signatures in a mouse model. (ekstern lenke)
• Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Scholz, Hanne et al. (2022). Molecular mechanisms affecting islet like cell fate acquisition in differentiating iPSC derived β-like cells”. (ekstern lenke)
• Mathisen, Andreas Frøslev; Legøy, Thomas Aga; Ghila, Luiza Mihaela et al. (2022). Hnf1a is a key regulator of β-cell identity and function. (ekstern lenke)
• Mathisen, Andreas Frøslev; Legøy, Thomas Aga; Ghila, Luiza Mihaela et al. (2022). Know your background, know your data. (ekstern lenke)
• Mathisen, Andreas Frøslev; Legøy, Thomas Aga; Ghila, Luiza Mihaela et al. (2022). Mind your background!. (ekstern lenke)
• Unger, Lucas; Ghila, Luiza Mihaela; Chera, Simona (2022). Investigating the developmental role of HNF1A, HNF1B and HNF4A in human pancreatic islet cell differentiation. (ekstern lenke)
• Unger, Lucas; Legøy, Thomas Aga; Ghila, Luiza Mihaela et al. (2022). Investigating the developmental role of HNF1A in human pancreatic islet cell differentiation. (ekstern lenke)
• Wang, Chencheng; Abadpour, Shadab; Aizenshtadt, Alexandra et al. (2021). Glucose during in vitro pancreatic beta cells regeneration: friends or for?. (ekstern lenke)

Faglig foredrag

• Chera, Simona (2024). Supply or Instruct: A luxury problem in mammalian adult regeneration. (ekstern lenke)
• Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Paulo, Joao et al. (2024). Impact of diabetogenic signals from endocrine disrupting chemicals on a HNF1A cell model. (ekstern lenke)
• Mathisen, Andreas Frøslev; Chera, Simona (2024). The landscape of islet maturation and ageing is regulated by a signalling loop between Hnf1a and the immune system. (ekstern lenke)
• Chera, Simona (2024). Regeneration: Death is Only the Beginning. (ekstern lenke)
• Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Paulo, Joao et al. (2024). Impact of endocrine disruptors on MODY3 iPSCs differentiation toward SC-islets – potential diabetogens. (ekstern lenke)
• Unger, Lucas; Legøy, Thomas Aga; Chera, Simona et al. (2023). Exploring the role of transcription factors HNF1A, HNF1B, and HNF4A in human pancreatic islet cell differentiation. (ekstern lenke)
• Chera, Simona (2023). Mapping master regulators of regeneration rhythms in the pancreatic islet. (ekstern lenke)
• Chera, Simona (2023). The beta cell in ageing. (ekstern lenke)
• Mathisen, Andreas Frøslev; Legøy, Thomas Aga; Larsen, Ulrik et al. (2023). Hnf1a Is An Important Regulator in Ageing And Maturation Of Pancreatic Islets. (ekstern lenke)
• Unger, Lucas; Legøy, Thomas Aga; Ghila, Luiza Mihaela et al. (2023). Exploring the role of transcription factors HNF1A, HNF1B, and HNF4A in human induced pluripotent stem cell-derived pancreatic islet cell differentiation. (ekstern lenke)
• Chera, Simona (2022). Investigating islet cell plasticity dynamics by exploiting monogenic diabetes contexts. (ekstern lenke)
• Chera, Simona (2022). Using patient-derived iPSC multi-omics to demultiplex pancreatic islet cell fate confinement. (ekstern lenke)
• Chera, Simona (2022). Investigating islet cell-fate dynamic during in vitro differentiation. (ekstern lenke)
• Chera, Simona (2022). And some that die deserve life: in vivo mechanisms regulating cell identity during beta-cell decay and regeneration. (ekstern lenke)
• Chera, Simona (2022). Regeneration, Rhythms, Regulators. (ekstern lenke)
• Chera, Simona (2022). Mammalian Regeneration Rhythms. (ekstern lenke)
• Chera, Simona (2022). Beta to alpha cells and back. (ekstern lenke)
• Chera, Simona (2021). Using patient-derived iPSC to demultiplex cell fate confinement. (ekstern lenke)

Vitenskapelig foredrag

• Chera, Simona (2024). How to harness human induced pluripotent stem cells for beta cell generation. (ekstern lenke)
• Chera, Simona (2023). Regeneration Strategies in Mammals . (ekstern lenke)
• Mathisen, Andreas Frøslev; Legøy, Thomas Aga; Larsen, Ulrik et al. (2023). Islet maturation and ageing is governed by the Hnf1a transcription factor. (ekstern lenke)
• Chera, Simona (2022). Mapping Master Regulators of Regeneration Rhythms. (ekstern lenke)
• Chera, Simona (2021). Islet cell identity and diabetes development. (ekstern lenke)
• Chera, Simona (2021). Mapping cell identity shifts in the adult pancreatic islet . (ekstern lenke)

Vitenskapelig artikkel

• Wang, Chencheng; Abadpour, Shadab; Olsen, Petter Angell et al. (2024). Glucose Concentration in Regulating Induced Pluripotent Stem Cells Differentiation Toward Insulin-Producing Cells. (ekstern lenke)
• Unger, Lucas; Ghila, Luiza Mihaela; Chera, Simona (2024). Targeted Gene Silencing by Using GapmeRs in Differentiating Human-Induced Pluripotent Stem Cells (hiPSC) Toward Pancreatic Progenitors. (ekstern lenke)
• Vasicek, Jakub; Kuznetsova, Ksenia; Skiadopoulou, Dafni et al. (2024). ProHap enables human proteomic database generation accounting for population diversity. (ekstern lenke)
• Mathisen, Andreas Frøslev; Larsen, Ulrik; Kavli, Natalie Aasen et al. (2024). Moderate beta-cell ablation triggers synergic compensatory mechanisms even in the absence of overt metabolic disruption. (ekstern lenke)
• Unger, Lucas; Mathisen, Andreas Frøslev; Chera, Simona et al. (2024). The GLI code controls HNF1A levels during foregut differentiation. (ekstern lenke)
• Sinturel, Flore; Chera, Simona; Brulhart-Meynet, Marie-Claude et al. (2024). Alterations of lipid homeostasis in morbid obese patients are partly reversed by bariatric surgery. (ekstern lenke)
• Wang, Chencheng; Abadpour, Shadab; Aizenshtadt, Aleksandra et al. (2024). Cell identity dynamics and insight into insulin secretagogues when employing stem cell-derived islets for disease modeling. (ekstern lenke)
• Mathisen, Andreas Frøslev; Legøy, Thomas Aga; Larsen, Ulrik et al. (2024). The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop. (ekstern lenke)
• Mathisen, Andreas Frøslev; Vacaru, Andrei Mircea; Unger, Lucas et al. (2024). Molecular profiling of NOD mouse islets reveals a novel regulator of insulitis onset. (ekstern lenke)
• Sinturel, Flore; Chera, Simona; Brulhart-Meynet, Marie-Claude et al. (2023). Circadian organization of lipid landscape is perturbed in type 2 diabetic patients. (ekstern lenke)
• Sinturel, Flore; Chera, Simona; Brulhart-Meynet, Marie-Claude et al. (2023). Circadian organization of lipid landscape is perturbed in type 2 diabetic patients. (ekstern lenke)
• Daian, Laura Maria; Tanko, Gabriela; Vacaru, Andrei Mircea et al. (2023). Modulation of Unfolded Protein Response Restores Survival and Function of β-Cells Exposed to the Endocrine Disruptor Bisphenol A. (ekstern lenke)
• Mathisen, Andreas Frøslev; Abadpour, Shadab; Legøy, Thomas Aga et al. (2023). Global proteomics reveals insulin abundance as a marker of human islet homeostasis alterations. (ekstern lenke)
• Fernandez, Manuel Carrasco; Wang, Chencheng; Søviknes, Anne Mette et al. (2022). Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells. (ekstern lenke)
• Petrenko, Volodymyr; Sinturel, Flore; Loizides-Mangold, Ursula et al. (2022). Type 2 diabetes disrupts circadian orchestration of lipid metabolism and membrane fluidity in human pancreatic islets. (ekstern lenke)
• Bhagchandani, Preksha; Chang, Charles A.; Zhao, Weichen et al. (2022). Islet cell replacement and transplantation immunology in a mouse strain with inducible diabetes. (ekstern lenke)
• Berle, Magnus; Hestetun, Kjersti Elvestad; Vethe, Heidrun et al. (2022). Mapping Proteome Changes in Microsatellite Stable, Recurrent Colon Cancer Reveals a Significant Immune System Signature. (ekstern lenke)
• Ghila, Luiza; Legøy, Thomas Aga; Chera, Simona (2021). A Method for Encapsulation and Transplantation into Diabetic Mice of Human Induced Pluripotent Stem Cells (hiPSC)-Derived Pancreatic Progenitors. (ekstern lenke)
• Oropeza, Daniel; Cigliola, Valentina; Romero, Agustín et al. (2021). Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss. (ekstern lenke)
• Ghila, Luiza; Legøy, Thomas Aga; Mathisen, Andreas Frøslev et al. (2021). Chronically elevated exogenous glucose elicits antipodal effects on the proteome signature of differentiating human ipsc-derived pancreatic progenitors. (ekstern lenke)
• Petrenko, Volodymyr; Stolovich-Rain, Miri; Vandereycken, Bart et al. (2020). The core clock transcription factor BMAL1 drives circadian β-cell proliferation during compensatory regeneration of the endocrine pancreas. (ekstern lenke)
• Legøy, Thomas Aga; Vethe, Heidrun; Abadpour, Shadab et al. (2020). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling . (ekstern lenke)
• Ghila, Luiza; Bjørlykke, Yngvild; Legøy, Thomas Aga et al. (2020). Bioinformatic analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4α mutation. (ekstern lenke)
• Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Salim, Zaidon et al. (2020). In vivo environment swiftly restricts human pancreatic progenitors toward mono-hormonal identity via a HNF1A/HNF4A mechanism. (ekstern lenke)
• Bjørlykke, Yngvild; Søviknes, Anne Mette; Hoareau, Laurence et al. (2019). Reprogrammed cells display distinct proteomic signaturesAssociated with colony morphology variability. (ekstern lenke)
• Legøy, Thomas Aga; Ghila, Luiza; Vethe, Heidrun et al. (2019). In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. (ekstern lenke)
• Furuyama, Kenichiro; Chera, Simona; van Gurp, Leon et al. (2019). Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. (ekstern lenke)
• Vethe, Heidrun; Ghila, Luiza; Berle, Magnus et al. (2019). The effect of WnT pathway modulators on human iPSC-derived pancreatic beta cell maturation. (ekstern lenke)
• Vethe, Heidrun; Legøy, Thomas Aga; Abadpour, Shadab et al. (2019). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. (ekstern lenke)
• Berle, Magnus; Ghila, Luiza; Vethe, Heidrun et al. (2018). Novel protein signatures suggest progression to muscular invasiveness in bladder cancer. (ekstern lenke)
• Cigliola, Valentina; Ghila, Luiza; Thorel, Fabrizio et al. (2018). Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells. (ekstern lenke)
• Vethe, Heidrun; Bjørlykke, Yngvild; Ghila, Luiza et al. (2017). Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells. (ekstern lenke)
• Chakravarthy, Harini; Gu, Xueying; Enge, Martin et al. (2017). Converting adult pancreatic islet α cells into β cells by targeting both Dnmt1 and Arx. (ekstern lenke)

Leder

• Chera, Simona; Rentzsch, Fabian (2023). Stem cells: The cell that does it all. (ekstern lenke)
• Ghila, Luiza Mihaela; Furuyama, Kenichiro; Grey, Shane T. et al. (2022). Editorial: Beta-Cell Fate: From Gene Circuits to Disease Mechanisms. (ekstern lenke)

Sammendrag/abstract

• Wang, Chencheng; Abadpour, Shadab; Aizenshtadt, Alexandra et al. (2021). 402.2: High Glucose Concentration Increases KATP Channel Activity but Suppresses Mitochondrial Respiration Ability in Insulin-producing Cells Regenerated From Stem Cells. (ekstern lenke)

Populærvitenskapelig artikkel

• Bhagchandani, Preksha; Chang, Charles; Zhao, Weichen et al. (2021). Islet transplantation tolerance in animals with defined histocompatibility and diabetes. (ekstern lenke)

Vitenskapelig oversiktsartikkel/review

• Cigliola, Valentina; Ghila, Luiza; Chera, Simona et al. (2019). Tissue repair brakes: A common paradigm in the biology of regeneration: Concise review. (ekstern lenke)
• Cigliola, Valentina; Thorel, Fabrizio; Chera, Simona et al. (2016). Stress-induced adaptive islet cell identity changes. (ekstern lenke)
• Chera, Simona; Herrera, Pedro L. (2016). Regeneration of pancreatic insulin-producing cells by in situ adaptive cell conversion. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

Selected publications:

1. Legøy TA*, Vethe H*, Abadpour S, Strand BL, Scholz H, Paulo JA, Ræder H, Ghila L, Chera S. Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signaling. Scientific Reports 2020 Jan 15;10(1):414. doi: 10.1038/s41598-019-57305-x [BioRxiv 2019 Oct 04, preprint doi: 10.1101/791442]
2. Legøy TA, Mathisen AF, Salim Z, Vethe H, Bjørlykke Y, Abadpour S, Paulo JA, Scholz H, Raeder H, Ghila L, Chera S. In vivo Environment Swiftly Restricts Human Pancreatic Progenitors Toward Mono-Hormonal Identity via a HNF1A/HNF4A Mechanism. Frontiers in Cell and Developmental Biology 2020 Feb 25;8:109. eCollection 2020. doi: 10.3389/fcell.2020.00109
3. Legøy TA, Ghila L, Vethe H, Abadpour S, Mathisen AF, Paulo JA, Scholz H, Raeder H, Chera S. In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. Acta Physiologica (Oxf) 2020 Apr;228(4):e13433. Epub 2020 Jan 8. doi: 10.1111/apha.13433. PMID:31872528