Ivar Hordvik
Position
Emeritus
Research
The research of Ivar Hordvik is focused on components of the adaptive immune system in fish. A long term goal is to broaden the spectrum of well characterized molecules and develop molecular tools that can be used to study immune responses during experiments with vaccines and pathogens in fish.
After teleost fish made a separate branch on the phylogenetic tree significant differences have been introduced between fish and mammals, both with respect to primary sequence of corresponding molecules, and the introduction of new molecules by gene duplications. An example of this is the evolution of the immunoglobulins: Whereas IgM has been evolutionarily stable and maintained the primordial structure in all jawed vertebrates the IgD gene has been evolutionarily labile and has been subjected to many internal duplications and deletions. A newly discovered gene, encoding an isotype named IgT/IgZ appears to be specific for teleost fish. On the other hand, IgG, IgE, and IgA are isotypes present in mammals, but not in fish.
Several findings the last years have shown that studies of the immune system in fish still offers surprises. It is plausible to assume that improved knowledge on the function and ontogeny of immune components in fish will aid experimental design of future vaccination trials and interpretation of results. Delivery of vaccines across mucosal surfaces of fish would obviously be an advantage and boost the profitability of the aquaculture industry. Development of new reagents for identification of immune cells and for monitoring immune responses is also an issue which has been addressed by vaccine companies as well as many researchers.
Publications
Cloning and expression analysis of Atlantic halibut (Hippoglossus hippoglossus) CD3 genes
Author(s): Overgard, AC; Hordvik, I; Nerland, AH, et al.
Source: FISH & SHELLFISH IMMUNOLOGY Volume: 27 Issue: 6 Pages: 707-713 Published: 2009
CD4 homologues in Atlantic salmon
Author(s): Moore, LJ; Dijkstra, JM; Koppang, EO, et al.
Source: FISH & SHELLFISH IMMUNOLOGY Volume: 26 Issue: 1 Pages: 10-18 Published: 2009
Identification and characterization of a novel intraepithelial lymphoid tissue in the gills of Atlantic salmon
Author(s): Haugarvoll, E; Bjerkas, I; Nowak, BF, et al.
Source: JOURNAL OF ANATOMY Volume: 213 Issue: 2 Pages: 202-209 Published: 2008
Characterization of the CD3 zeta, CD3 gamma delta and CD3 epsilon subunits of the T cell receptor complex in Atlantic salmon
Author(s): Liu, Y; Moore, L; Koppang, EO, et al.
Source: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY Volume: 32 Issue: 1 Pages: 26-35 Published: 2008
FABP3 and FABP10 in Atlantic salmon (Salmo salar L.) - General effects of dietary fatty acid composition and life cycle variations
Author(s): Jordal, AEO; Hordvik, I; Pelsers, M, et al.
Source: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY Volume: 145 Issue: 2 Pages: 147-158 Published: OCT 2006
Myosin heavy chain mRNA expression correlates higher with muscle protein accretion than growth in Atlantic salmon, Salmo salar
Author(s): Hevroy, EM; Jordal, AEO; Hordvik, I, et al.
Source: AQUACULTURE Volume: 252 Issue: 2-4 Pages: 453-461 Published: MAR 10 2006
Identification and characterization of a second CD4-like gene in teleost fish
Author(s): Dijkstra, JM; Somamoto, T; Moore, L, et al.
Source: MOLECULAR IMMUNOLOGY Volume: 43 Issue: 5 Pages: 410-419 Published: FEB 2006
MHC class II+ cells in the gills of Atlantic salmon (Salmo salar L.) affected by amoebic gill disease
Author(s): Morrison, RN; Koppang, EO; Hordvik, I, et al.
Source: VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY Volume: 109 Issue: 3-4 Pages: 297-303 Published: FEB 15 2006
Allergy to fish parvalbumins: Studies on the cross-reactivity of allergens from 9 commonly consumed fish
Author(s): Van Do, T; Elsayed, S; Florvaag, E, et al.
Source: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Volume: 116 Issue: 6 Pages: 1314-1320 Published: DEC 2005
Evaluation of potential reference genes in real-time RT-PCR studies of Atlantic salmon
Author(s): Olsvik, PA; Lie, KK; Jordal, AEO, et al.
Source: BMC MOLECULAR BIOLOGY Volume: 6 Article Number: 21 Published: NOV 17 2005
Characterisation of salmon and trout CD8 alpha and CD8 beta
Author(s): Moore, LJ; Somamoto, T; Lie, KK, et al.
Source: MOLECULAR IMMUNOLOGY Volume: 42 Issue: 10 Pages: 1225-1234 Published: JUN 2005
Characterization of parvalbumin, the major allergen in Alaska pollack, and comparison with codfish Allergen M
Author(s): Van Do, T; Hordvik, I; Endresen, C, et al.
Source: MOLECULAR IMMUNOLOGY Volume: 42 Issue: 3 Pages: 345-353 Published: FEB 2005
The ontogeny of MHC class I expression in rainbow trout (Oncorhynchus mykiss)
Author(s): Fischer, U; Dijkstra, JM; Kollner, B, et al.
Source: FISH & SHELLFISH IMMUNOLOGY Volume: 18 Issue: 1 Pages: 49-60 Published: JAN 2005
Vaccine-associated granulomatous inflammation and melanin accumulation in Atlantic salmon, Salmo salar L., white muscle
Author(s): Koppang, EO; Haugarvoll, E; Hordvik, I, et al.
Source: JOURNAL OF FISH DISEASES Volume: 28 Issue: 1 Pages: 13-22 Published: JAN 2005
Structure and organization of the T cell receptor alpha chain genes in Atlantic salmon
Author(s): Hordvik, I; Torvund, J; Moore, L, et al.
Source: MOLECULAR IMMUNOLOGY Volume: 41 Issue: 5 Pages: 553-559 Published: JUL 2004
Granulomatous uveitis associated with vaccination in the Atlantic salmon
Author(s): Koppang, EO; Haugarvoll, E; Hordvik, I, et al.
Source: VETERINARY PATHOLOGY Volume: 41 Issue: 2 Pages: 122-130 Published: MAR 2004
Vaccination induces major histocompatibility complex class II expression in the Atlantic salmon eye
Author(s): Koppang, EO; Bjerkas, E; Bjerkas, I, et al.
Source: SCANDINAVIAN JOURNAL OF IMMUNOLOGY Volume: 58 Issue: 1 Pages: 9-14 Published: JUL 2003
The major allergen (parvalbumin) of codfish is encoded by at least two isotypic genes: cDNA cloning, expression and antibody binding of the recombinant allergens
Author(s): Van Do, T; Hordvik, I; Endresen, C, et al.
Source: MOLECULAR IMMUNOLOGY Volume: 39 Issue: 10 Pages: 595-602 Published: JAN 2003
Analysis of two IgM isotypes in Atlantic salmon and brown trout
Author(s): Hordvik, I; Berven, FS; Solem, ST, et al.
Source: MOLECULAR IMMUNOLOGY Volume: 39 Issue: 5-6 Pages: 313-321 Published: OCT 2002
Identification of a novel immunoglobulin delta transcript and comparative analysis of the genes encoding IgD in Atlantic salmon and Atlantic halibut
Author(s): Hordvik, I
Source: MOLECULAR IMMUNOLOGY Volume: 39 Issue: 1-2 Pages: 85-91 Published: SEP 2002
Diversity of the immunoglobulin heavy chain in the Atlantic salmon (Salmo salar L.) is contributed by genes from two parallel IgH isoloci.
Author(s): Solem, ST; Hordvik, I; Killie, JEA, et al.
Source: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY Volume: 25 Issue: 5-6 Pages: 403-417 Published: JUN-JUL 2001
Presence of IgM in cutaneous mucus, but not in gut mucus of Atlantic salmon, Salmo salar. Serum IgM is rapidly degraded when added to gut mucus
Author(s): Hatten, F; Fredriksen, A; Hordvik, I, et al.
Source: FISH & SHELLFISH IMMUNOLOGY Volume: 11 Issue: 3 Pages: 257-268 Published: APR 2001
Expression and analysis of recombinant salmon parvalbumin, the major allergen in atlantic salmon (Salmo salar)
Author(s): Van Do, T; Hordvik, I; Endresen, C, et al.
Source: SCANDINAVIAN JOURNAL OF IMMUNOLOGY Volume: 50 Issue: 6 Pages: 619-625 Published: 1999
Molecular cloning and phylogenetic analysis of the Atlantic salmon immunoglobulin D gene
Author(s): Hordvik, I; Thevarajan, J; Samdal, I, et al.
Source: SCANDINAVIAN JOURNAL OF IMMUNOLOGY Volume: 50 Issue: 2 Pages: 202-210 Published: AUG 1999
The putative polymerase sequence of infectious salmon anemia virus suggests a new genus within the Orthomyxoviridae
Author(s): Krossoy, B; Hordvik, I; Nilsen, F, et al.
Source: JOURNAL OF VIROLOGY Volume: 73 Issue: 3 Pages: 2136-2142 Published: MAR 1999
The impact of ancestral tetraploidy on antibody heterogeneity in salmonid fishes
Author(s): Hordvik, I
Source: IMMUNOLOGICAL REVIEWS Volume: 166 Pages: 153-157 Published: DEC 1998
Molecular phylogeny of microsporidians with particular reference to species that infect the muscles of fish
Author(s): Nilsen, F; Endresen, C; Hordvik, I
Source: JOURNAL OF EUKARYOTIC MICROBIOLOGY Volume: 45 Issue: 5 Pages: 535-543 Published: SEP-OCT 1998
Structure and organization of the immunoglobulin M heavy chain genes in Atlantic salmon, Salmo salar
Author(s): Hordvik, I; Lindstrom, CD; Voie, AM, et al.
Source: MOLECULAR IMMUNOLOGY Volume: 34 Issue: 8-9 Pages: 631-639 Published: JUN 1997
Cloning of T-cell antigen receptor beta chain cDNAs from Atlantic salmon (Salmo salar)
Author(s): Hordvik, I; Jacob, ALJ; Charlemagne, J, et al.
Source: IMMUNOGENETICS Volume: 45 Issue: 1 Pages: 9-14 Published: 1996
Cloning of two distinct cDNAs encoding parvalbumin, the major allergen of Atlantic salmon (Salmo salar)
Author(s): Lindstrom, CDV; VanDo, T; Hordvik, I, et al.
Source: SCANDINAVIAN JOURNAL OF IMMUNOLOGY Volume: 44 Issue: 4 Pages: 335-344 Published: OCT 1996
Immune genes of the Atlantic salmon, Salmo salar L.: Application of modern molecular genetic techniques to the study of antibodies and major histocompatibility complex antigens
Author(s): Hordvik, I.
Source: Aquaculture and Fisheries Management Volume: 25 Issue: 1 Pages: 47-53 Published: 1994
Haploid gynogenesis: A powerful strategy for linkage analysis in fish
Author(s): Lie, O.; Slettan, A.; Lingaas, F., et al.
Source: Animal Biotechnology Volume: 5 Issue: 1 Pages: 33-45 Published: 1994
MOLECULAR-CLONING OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I CDNAS FROM ATLANTIC SALMON (SALMO-SALAR)
Author(s): GRIMHOLT, U; HORDVIK, I; FOSSE, VM, et al.
Source: IMMUNOGENETICS Volume: 37 Issue: 6 Pages: 469-473 Published: FEB 1993
CLONING AND SEQUENCE-ANALYSIS OF CDNAS ENCODING THE MHC CLASS-II BETA-CHAIN IN ATLANTIC SALMON (SALMO-SALAR)
Author(s): HORDVIK, I; GRIMHOLT, U; FOSSE, VM, et al.
Source: IMMUNOGENETICS Volume: 37 Issue: 6 Pages: 437-441 Published: FEB 1993
CLONING AND SEQUENCE-ANALYSIS OF 2 ISOTYPIC IGM HEAVY-CHAIN GENES FROM ATLANTIC SALMON, SALMO-SALAR L
Author(s): HORDVIK, I; VOIE, AM; GLETTE, J, et al.
Source: EUROPEAN JOURNAL OF IMMUNOLOGY Volume: 22 Issue: 11 Pages: 2957-2962 Published: NOV 1992