In my PhD I work with two projects.

The first project aims at studying the role of Pregnane X Receptor (PXR) in the regulation of metabolism and at identifying potential drug candidates for the management of metabolic disorders.

The second project aims at studying the effect of exposure to dietary mixtures of Persistent Organic Pollutants (POPs) on intestinal inflammation in the context of obesity. 

 

Academic article

• Flønes, Irene; Toker, Lilah; Sandnes, Dagny Ann et al. (2024). Mitochondrial complex I deficiency stratifies idiopathic Parkinson’s disease. (external link)
• Nido, Gonzalo Sanchez; Castelli, Martina Galatea; Mostafavi, Sepideh et al. (2024). Single-nucleus transcriptomics reveals disease- and pathology-specific signatures in α-synucleinopathies. (external link)
• Benoit, Berengère; Meugnier, Emmanuelle; Castelli, Martina Galatea et al. (2017). Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice. (external link)
• Castelli, Martina Galatea; Rusten, Marte; Goksøyr, Anders et al. (2014). MRNA expression of genes regulating lipid metabolism in ringed seals (Pusa hispida) from differently polluted areas. (external link)

See a complete overview of publications in Cristin.

Benoit B, Meugnier E, Castelli M, Chanon S, Vieille-Marchiset A, Durand C, Bendridi N, Pesenti S, Monternier PA, Durieux AC, Freyssenet D, Rieusset J, Lefai E, Vidal H, Ruzzin J (2017): "Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice". Nature Medicine, 2017. 23: p. 990.

M.G. Castelli, M. Rusten, A. Goksøyr, H. Routti (2014): "mRNA expression of genes regulating lipid metabolism in ringed seals (Pusa hispida) from differently polluted areas". Aquat. Toxicol., 146 (2014), pp. 239-246.