Endocrinology, steroid profiling 

Vitenskapelig artikkel

• Røys, Eirik Åsen; Viste, Kristin; Farrell, Christopher John et al. (2025). A Parametric Empirical Bayes Approach to Personalized Reference Intervals and Reference Change Values. (ekstern lenke)
• Røys, Eirik Åsen; Viste, Kristin; Kellmann, Ralf et al. (2025). Estimating Reference Change Values Using Routine Patient Data: A Novel Pathology Database Approach. (ekstern lenke)
• Røys, Eirik Åsen; Guldhaug, Nora Alicia; Viste, kristin et al. (2023). Sex Hormones and Adrenal Steroids: Biological Variation Estimated Using Direct and Indirect Methods. (ekstern lenke)
• Ueland, Grethe Åstrøm; Kellmann, Ralf; Jørstad, Melissa Davidsen et al. (2021). Bedtime Salivary Cortisol as a Screening Test for Cushing Syndrome in Children. (ekstern lenke)
• Soeriyadi, Angela H.; Mazmouz, Rabia; Pickford, Russell et al. (2020). Heterologous expression of an unusual ketosynthase, SxtA, leads to production of saxitoxin intermediates in Escherichia coli. (ekstern lenke)
• Bertelsen, Bjørn-Erik; Kellmann, Ralf; Viste, Kristin et al. (2020). An ultrasensitive routine LC-MS/MS method for estradiol and estrone in the clinically relevant sub-picomolar range. (ekstern lenke)
• Ueland, Grethe Åstrøm; Methlie, Paal; Øksnes, Marianne et al. (2018). The short cosyntropin test revisited: new normal reference range using LC-MS/MS. (ekstern lenke)
• Ahmed, Kareem Eldin Mohammed; Frøysa, Håvard G; Karlsen, Odd Andre et al. (2018). Effects of defined mixtures of POPs and endocrine disruptors on the steroid metabolome of the human H295R adrenocortical cell line. (ekstern lenke)
• Eldin, Mohammed Adhmed Abdel Ghafar Kareem; Frøysa, Håvard G; Karlsen, Odd Andre et al. (2018). LC-MS/MS based profiling and dynamic modelling of the steroidogenesis pathway in adrenocarcinoma H295R cells. (ekstern lenke)
• Ueland, Grethe Åstrøm; Methlie, Paal; Kellmann, Ralf et al. (2017). Simultaneous assay of cortisol and dexamethasone improved diagnostic accuracy of the dexamethasone suppression test. (ekstern lenke)
• Braadland, Peder; Grytli, Helene Hartvedt; Ramberg, Håkon Andre et al. (2016). Low β2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism. (ekstern lenke)
• Stüken, Anke Corinna; Orr, Russell; Kellmann, Ralf et al. (2011). Discovery of Nuclear-Encoded Genes for the Neurotoxin Saxitoxin in Dinoflagellates. (ekstern lenke)
• Murray, Shauna A.; Wiese, Maria; Stüken, Anke et al. (2011). sxtA-Based Quantitative Molecular Assay To Identify Saxitoxin-Producing Harmful Algal Blooms in Marine Waters. (ekstern lenke)
• Pearson, Leanne; Mihali, Troco K.; Moffitt, Michelle et al. (2010). On the chemistry, toxicology and genetics of the cyanobacterial toxins, microcystin, nodularin, saxitoxin and cylindrospermopsin. (ekstern lenke)
• Kellmann, Ralf; Schaffner, Carlos António Markus; Grønset, Toril Anne et al. (2009). Proteomic response of human neuroblastoma cells to azaspiracid-1. (ekstern lenke)
• Mihali, Troco Kaan; Kellmann, Ralf; Neilan, Brett A. (2009). Characterisation of the paralytic shellfish toxin biosynthesis gene clusters in Anabaena circinalis AWQC131C and Aphanizomenon sp. NH-5. (ekstern lenke)
• Kellmann, Ralf; Mihali, Troco Kaan; Neilan, Brett A. (2008). Identification of a Saxitoxin Biosynthesis Gene with a History of Frequent Horizontal Gene Transfers. (ekstern lenke)
• Kellmann, Ralf; Mihali, Troco Kaan; Jeon, Young Jae et al. (2008). Biosynthetic intermediate analysis and functional homology reveal a saxitoxin gene cluster in cyanobacteria. (ekstern lenke)
• Mihali, Troco Kaan; Kellmann, Ralf; Muenchhoff, Julia et al. (2008). Characterization of the Gene Cluster responsible for Cylindrospermopsin Biosynthesis. (ekstern lenke)
• Kellmann, Ralf; Neilan, Brett A. (2007). Biochemical characterisation of paralytic shellfish toxin biosynthesis in vitro. (ekstern lenke)

Leserinnlegg

• Røys, Eirik Åsen; Viste, kristin; Farrell, Christopher-John et al. (2024). Refining within-subject biological variation estimation using routine laboratory data: Practical applications of the refineR algorithm. (ekstern lenke)

Vitenskapelig foredrag

• Stüken, Anke; Orr, Russell; Kellmann, Ralf et al. (2011). Discovery of nucelar-encoded genes for the neurotoxin saxitoxin in dinoflagellates. (ekstern lenke)
• Stüken, Anke; Orr, Russell; Kellmann, Ralf et al. (2011). Discovery of nucelar-encoded genes for the neurotoxin saxitoxin in dinoflagellates. (ekstern lenke)
• Kellmann, Ralf; Neilan, Brett A.; Fladmark, Kari Espolin et al. (2009). Saxitoxin biosynthesis in organisms from two kingdoms - horizontal gene transfer or parallel evolution?. (ekstern lenke)
• Orr, Russell; Espelund, Mari; Kellmann, Ralf et al. (2008). Evolution witihin the genus Alexandrium focusing on toxicity. (ekstern lenke)
• Kellmann, Ralf (2007). Alkaloid toxin production by cyanobacteria. (ekstern lenke)

Poster

• Stüken, Anke; Orr, Russell; Kellmann, Ralf et al. (2010). Saxitoxin gene identified in dinoflagellates. (ekstern lenke)
• Kellmann, Ralf; Grønset, Toril A; Schaffner, Carlos a.m. et al. (2008). Protein expression changes in human neuroblastoma cells treated with azaspiracid-1. (ekstern lenke)

Vitenskapelig oversiktsartikkel/review

• Kellmann, Ralf; Stüken, Anke; Orr, Russell J. S. et al. (2010). Biosynthesis and Molecular Genetics of Polyketides in Marine Dinoflagellates. (ekstern lenke)

Errata

• Kellmann, Ralf; Mihali, Troco Kaan; Neilan, Brett Adam (2009). Identification of a Saxitoxin Biosynthesis Gene with a History of Frequent Horizontal Gene Transfers (vol 67, pg 526, 2008). (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

 

 

Kellmann R, Mihali TK, Jeon YJ, Pickford R, Pomati F, Neilan BA  (2008)  Biosynthetic intermediate analysis and functional homology reveal a saxitoxin gene cluster in cyanobacteria. Applied & Environmental Microbiology 74:4044-53

Kellmann R, Michali TK, Neilan BA  (2008)  Identification of a saxitoxin biosynthesis gene with a history of frequent horizontal gene transfers. J Mol Evol 67:526-38

Kellmann R, Mihali TK, Neilan BA  (2008)  Identification of a saxitoxin biosynthesis gene that has an evolutionary history with frequent horizontal gene transfer events. Journal of Molecular Evolution 67:526-38

Kellmann R, Mills T, Neilan BA  (2006)  Functional modelling and phylogenetic distribution of putative cylindrospermopsin biosynthesis enzymes. Journal of Molecular Evolution 62:267-280

Kellmann R, Neilan BA  (2007)  Biochemical characterisation of paralytic shellfish toxin biosynthesis in vitro. Journal of Phycology 43:497-508

Mihali TK, Kellmann R, Muenchhoff J, Barrow KD, Neilan BA  (2008)  Characterization of the gene cluster responsible for cylindrospermopsin biosynthesis. Appl Environ Microbiol 74:716-22

Neilan BA, Moffitt MC, Mills T, Kellmann R, Burns BP  (2002)  Novel options for strategic management of water bodies afflicted by harmful algal blooms: the molecular genetics of cyanobacteria. Water Quality Technology, p 1-17

Neilan BA, Pearson LA, Moffitt MC, Kaebernick M, Mihali TK, Kellmann R, Pomati F  (2005)  A brief history of the molecular biology and genetics of cyanobacterial toxicity and its future in the age of OMICS Advances in Experimental Medicine and Biology. Springer, p 120-148

Neilan BA, Pearson LA, Moffitt MC, Mihali KT, Kaebernick M, Kellmann R, Pomati F  (2008)  The genetics and genomics of cyanobacterial toxicity. Adv Exp Med Biol 619:417-52

Pomati F, Kellmann R, Burns BP, Cavaliere R, Neilan BA  (2006)  Comparative gene expression studies of PSP-toxins producing and non-toxic Anabaena circinalis strains and effects of lidocaine hydrochloride. Environment International 32:734-748

 

 

1. The molecular mode of action of azaspiracid

2. Saxitoxin biosynthesis and genomics in organisms from two kingdoms - horizontal gene transfer or parallel evolution?