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- thomas.legoy@uib.no
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Haukelandsbakken 15 Glasblokkene, blokk 1, 6 etg
5021 Bergen - Postadresse
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Postboks 7804
5020 Bergen
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Forskergrupper
Kort info
Ved å bruke induserte pluripotente stamceller (iPSCs) som eg differensierer til insulin produserande celler som modeller ynskjer eg å forstå korleis farlege kjemikal som menneskjer er eksponert for påverkar utvikling og funksjon til dei hormonproduserande cellene i bukspyttkjertelen.
Publikasjoner
Vitenskapelig artikkel
- Gudmestad, June Helen; Unger, Lucas; Paulo, Joao A et al. (2025). Endocrine-disrupting chemical exposure during differentiation alters the proliferation–maturation balance in stem-cell islets. (ekstern lenke)
- Sharmine, Shayla; Legøy, Thomas Aga; Unger, Lucas et al. (2025). Caloric Restriction Substantially Improves Glucose Regulation in Mice With Hnf1a‐Deficient Beta‐Cells. (ekstern lenke)
- Unger, Lucas; Larsen, Ulrik; Sharmine, Shayla et al. (2025). Efficient cytoplasmic cell quantification using a semi-automated FIJI-based tool. (ekstern lenke)
- Mathisen, Andreas Frøslev; Legøy, Thomas Aga; Larsen, Ulrik et al. (2024). The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop. (ekstern lenke)
- Unger, Lucas; Mathisen, Andreas Frøslev; Chera, Simona et al. (2024). The GLI code controls HNF1A levels during foregut differentiation. (ekstern lenke)
- Mathisen, Andreas Frøslev; Abadpour, Shadab; Legøy, Thomas Aga et al. (2023). Global proteomics reveals insulin abundance as a marker of human islet homeostasis alterations. (ekstern lenke)
- Ghila, Luiza; Legøy, Thomas Aga; Mathisen, Andreas Frøslev et al. (2021). Chronically elevated exogenous glucose elicits antipodal effects on the proteome signature of differentiating human ipsc-derived pancreatic progenitors. (ekstern lenke)
- Ghila, Luiza; Legøy, Thomas Aga; Chera, Simona (2021). A Method for Encapsulation and Transplantation into Diabetic Mice of Human Induced Pluripotent Stem Cells (hiPSC)-Derived Pancreatic Progenitors. (ekstern lenke)
- Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Salim, Zaidon et al. (2020). In vivo environment swiftly restricts human pancreatic progenitors toward mono-hormonal identity via a HNF1A/HNF4A mechanism. (ekstern lenke)
- Ghila, Luiza; Bjørlykke, Yngvild; Legøy, Thomas Aga et al. (2020). Bioinformatic analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4α mutation. (ekstern lenke)
- Legøy, Thomas Aga; Vethe, Heidrun; Abadpour, Shadab et al. (2020). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. (ekstern lenke)
- Legøy, Thomas Aga; Ghila, Luiza; Vethe, Heidrun et al. (2019). In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. (ekstern lenke)
- Vethe, Heidrun; Legøy, Thomas Aga; Abadpour, Shadab et al. (2019). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. (ekstern lenke)
- Kvifte, Gunnar Mikalsen; Legøy, Thomas Aga; Soule, Jonathan (2017). The plesiobiontic association of formica lemani bondroit with lasius flavus (Fabricius) (Hymenoptera, Formicidae) in Norway. (ekstern lenke)
Faglig foredrag
- Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Paulo, Joao et al. (2024). Impact of diabetogenic signals from endocrine disrupting chemicals on a HNF1A cell model. (ekstern lenke)
- Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Paulo, Joao et al. (2024). Impact of endocrine disruptors on MODY3 iPSCs differentiation toward SC-islets – potential diabetogens. (ekstern lenke)
- Unger, Lucas; Legøy, Thomas Aga; Ghila, Luiza Mihaela et al. (2023). Exploring the role of transcription factors HNF1A, HNF1B, and HNF4A in human induced pluripotent stem cell-derived pancreatic islet cell differentiation. (ekstern lenke)
- Mathisen, Andreas Frøslev; Legøy, Thomas Aga; Larsen, Ulrik et al. (2023). Hnf1a Is An Important Regulator in Ageing And Maturation Of Pancreatic Islets. (ekstern lenke)
- Unger, Lucas; Legøy, Thomas Aga; Chera, Simona et al. (2023). Exploring the role of transcription factors HNF1A, HNF1B, and HNF4A in human pancreatic islet cell differentiation. (ekstern lenke)
Poster
- Unger, Lucas; Mathisen, Andreas Frøslev; Legøy, Thomas Aga et al. (2024). Deciphering the HNF1A and Hedgehog Signaling Crosstalk during Stem Cell Islet differentiation. (ekstern lenke)
- Unger, Lucas; Legøy, Thomas Aga; Ghila, Luiza Mihaela et al. (2024). Exploring hedgehog signaling and HNF1A Crosstalk in HNF1A-MODY stem cell islets. (ekstern lenke)
- Hossain, Md Kaykobad; Altankhuyag, Altanchimeg; Legøy, Thomas Aga et al. (2024). Dynamic proteome profiling detects progressive alterations induced by BBN in the mouse bladder. (ekstern lenke)
- Hossain, Md Kaykobad; Altankhuyag, Altanchimeg; Legøy, Thomas Aga et al. (2024). Short-term BBN treatment alters the proteomic profile of mouse bladder. (ekstern lenke)
- Legøy, Thomas Aga; Unger, Lucas; Paulo, Joao A. et al. (2024). Exposure to Endocrine Disrupting Chemicals During Differentiation of HNF1A-MODY SC-islets has an Adverse Effect on Cell Fitness. (ekstern lenke)
- Unger, Lucas; Legøy, Thomas Aga; Mathisen, Andreas Frøslev et al. (2023). Investigating the developmental role of HNF1A, HNF1B and HNF4A in human pancreatic islet cell differentiation. (ekstern lenke)
- Hossain, Md Kaykobad; Altankhuyag, Altanchimeg; Legøy, Thomas Aga et al. (2023). Mapping predictive bladder cancer signatures in a mouse model. (ekstern lenke)
- Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Paulo, Joao et al. (2023). Human induced pluripotent stem cells as a model for environmental impact on diabetes. (ekstern lenke)
- Sharmine, Shayla; Legøy, Thomas Aga; Mathisen, Andreas Frøslev et al. (2023). Mapping islet architecture changes upon high fat diet challenge in a HNF1A-MODY mouse model. (ekstern lenke)
- Mathisen, Andreas Frøslev; Legøy, Thomas Aga; Ghila, Luiza Mihaela et al. (2022). Know your background, know your data. (ekstern lenke)
- Unger, Lucas; Legøy, Thomas Aga; Ghila, Luiza Mihaela et al. (2022). Investigating the developmental role of HNF1A in human pancreatic islet cell differentiation. (ekstern lenke)
- Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Scholz, Hanne et al. (2022). Molecular mechanisms affecting islet like cell fate acquisition in differentiating iPSC derived β-like cells”. (ekstern lenke)
- Mathisen, Andreas Frøslev; Legøy, Thomas Aga; Ghila, Luiza Mihaela et al. (2022). Hnf1a is a key regulator of β-cell identity and function. (ekstern lenke)
- Mathisen, Andreas Frøslev; Legøy, Thomas Aga; Ghila, Luiza Mihaela et al. (2022). Mind your background!. (ekstern lenke)
Vitenskapelig foredrag
- Legøy, Thomas Aga; Unger, Lucas; Paulo, Joao A. et al. (2024). Environmental neglect: endocrine disruptors as underappreciated but important diabetogens in HNF1A-MODY cell model. (ekstern lenke)
- Mathisen, Andreas Frøslev; Legøy, Thomas Aga; Larsen, Ulrik et al. (2023). Islet maturation and ageing is governed by the Hnf1a transcription factor. (ekstern lenke)