Research
Immunforsvarets frontliner
A field report from Engelsen's research stay at the French Research Institute Gustave Roussy (Paris, France) in the norwegian journal Forskerforum explains how we aim to engage the immune system in the eradication of cancers. (Article by Kjerstin Gjengedal).
On a quest to cure cancer
'The premature death from cancer of a close friend and colleague, made Agnete Engelsen even more determined to find a way to cure this devastating disease.'
The PhD interview/ cancer research. Article in the UiB Magazine by Jens Helleland Ådnanes.
Read more about my opportunity to participate in the High-Impact Cancer Research (HICR): Cancer, Biology and Therapeutics Program at Harvard Medical School -a truly inspirational postgraduate medical education program!
Translational Cancer Research requires a wide range of standaard and advanced methodologies. Read more about the excitement and international participation at the first fully web-based version of CCBIO 905 Methods in Cancer Biomarker Research. This course is part of The CCBIO Research School for Cancer Studies.
Outreach
Great excitement at the Research fair in Bergen
Excited children and adults crowded the Research Fair when researchers at the Center for Cancer Biomarkers (CCBIO) displayed living cancer cells in the microscope and performed a play about the cancer cell Greedy Frieda.
Read more about the research communication in the newspaper Studvest
Teaching
Online teaching/ courses: Read more about the first fully web-based version of CCBIO905: Methods in Cancer Biomarker Research
Academic responsibility:
CCBIO901 Junior Scientist Symposium, PhD course, The CCBIO Research School for Cancer Studies, UiB (RSCS)
MED1BIOMED Biomedisinske Tema, Mandatory MD course, Department of Biomedicine, UiB
CCBIO905 Methods in Cancer Biomarker Research, PhD course, The CCBIO Research School for Cancer Studies, UiB (RSCS)
HUCEL 320 Cell culture and cellular techniques: Flow Cytometry, Master course, Department of Biomedicine, UiB
Individual lectures:
BMED331 Tumor biology, Master course, Department of Biomedicine, UiB
MED1BIOMED Biomedisinske Tema, Mandatory MD course, Department of Biomedicine, UiB
CCBIO905 Methods in Cancer Biomarker Research, PhD course, The CCBIO Research School for Cancer Studies, UiB (RSCS)
BZL 256 Embryology, Department of Zoology, UiB
MED1BAS, FARM 260/NUTR, ODONT, Histology Mandatory preclinical MD lab courses, Department of Biomedicine, UiB
Publications
Academic article
- Rayford, Austin James; Gärtner, Fabian; Ramnefjell, Maria Paula et al. (2024). AXL expression reflects tumor-immune cell dynamics impacting outcome in non-small cell lung cancer patients treated with immune checkpoint inhibitor monotherapy. (external link)
- Ekanger, Camilla Tvedt; Zhou, Fan; Bohan, Dana et al. (2022). Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 respiratory virus. (external link)
- Lotsberg, Maria Lie; Røsland, Gro Vatne; Rayford, Austin James et al. (2022). Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models. (external link)
- Engelsen, Agnete Svendsen Tenfjord; Lotsberg, Maria Lie; Khouzam, Raefa Abou et al. (2022). Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition. (external link)
- Rahman, Mohummad Aminur; Engelsen, Agnete ; Sarowar, Shahin et al. (2022). Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway. (external link)
- Dyrstad, Sissel Elisabeth; Lotsberg, Maria Lie; Tan, Tuan Zea et al. (2021). Blocking aerobic glycolysis by targeting pyruvate dehydrogenase kinase in combination with EGFR TKI and ionizing radiation increases therapeutic effect in non-small cell lung cancer cells. (external link)
- Hoareau, Laurence; Engelsen, Agnete ; Aanerud, Marianne et al. (2021). Induction of alveolar and bronchiolar phenotypes in human lung organoids. (external link)
- Engelsen, Agnete ; Wnuk-Lipinska, Katarzyna; Bougnaud, Sébastien et al. (2020). AXL is a driver of stemness in normal mammary gland and breast cancer. (external link)
- Lotsberg, Maria Lie; Wnuk-Lipinska, Katarzyna; Terry, Stéphane et al. (2020). AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells. (external link)
- Røsland, Gro Vatne; Dyrstad, Sissel Elisabeth; Tusubira, Deusdedit et al. (2019). Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC.. (external link)
- Terry, Stéphane; Abdou, Abderemane; Svendsen, Agnete et al. (2019). AXL targeting overcomes human lung cancer cell resistance to NK- And CTL-mediated cytotoxicity. (external link)
- Rahman, Mohummad Aminur; Gras Navarro, Andrea; Brekke, Jorunn et al. (2019). Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival. (external link)
- Chouaieb, Elyes; Terry, Stéphane; Corgnac, Stephanie et al. (2018). Cancer Immunotherapy 2017 (Paris, France). Progress and challenges. (external link)
- Jokela, Tiina; Svendsen, Agnete; Rybicka, Agata et al. (2018). Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance. (external link)
- Bozickovic, Olivera; Skartveit, Linn; Svendsen, Agnete et al. (2018). A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells. (external link)
- Sletta, Kristine Yttersian; Tveitarås, Maria Kathrine; Lu, Ning et al. (2017). Oxygen-dependent regulation of tumor growth and metastasis in human breast cancer xenografts. (external link)
- Torsvik, Anja; Stieber, Daniel; Enger, Per Øyvind et al. (2014). U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells . (external link)
- Gras Navarro, Andrea; Kmiecik, Justyna; Leiss, Lina Wik et al. (2014). NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival. (external link)
- Svendsen, Agnete; Verhoeff, Joost JC; Immervoll, Heike et al. (2011). Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. (external link)
- Wang, Jian; Svendsen, Agnete; Kmiecik, Justyna et al. (2011). Targeting the NG2/CSPG4 Proteoglycan Retards Tumour Growth and Angiogenesis in Preclinical Models of GBM and Melanoma. (external link)
- Prestegarden, Lars; Svendsen, Agnete; Wang, Jian et al. (2010). Glioma cell populations grouped by different cell type markers drive brain tumor growth. (external link)
- Røsland, Gro Vatne; Svendsen, Agnete; Torsvik, Anja et al. (2009). Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. (external link)
- Chekenya, Martha; Krakstad, Camilla; Svendsen, Agnete et al. (2008). The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling. (external link)
- Niclou, Simone P; Danzeisen, Claude; Eikesdal, Hans Petter et al. (2008). A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. (external link)
- Wang, Jian; Sakariassen, Per Øystein; Tsinkalovsky, Oleg et al. (2008). CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. (external link)
- Thorsen, Frits Alan; Afione, Sandra; Huszthy, Peter Csaba et al. (2006). Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma. (external link)
Masters thesis
- Guttormsen, Maren Sofie Faldalen; Engelsen, Agnete ; Lorens, James et al. (2023). Predictive Biomarkers Beyond Next Generation Sequencing: Functional Testing of Homologous Recombination Repair Deficiency Status in Patient-Derived Tissue Cultures. (external link)
- Arnal, Emmanuelle Lucie; Engelsen, Agnete ; Stuhr, Linda Elin Birkhaug et al. (2023). Disrupting the metabolic homeostasis of lung cancer to increase the efficacy of immune checkpoint inhibition. (external link)
- Ekanger, Camilla Tvedt; Engelsen, Agnete ; Stuhr, Linda Elin Birkhaug (2021). Human organotypic airway and lung organoids for the study of SARS-CoV-2 infectivity and cytopathology. (external link)
- Joakim, Hekland; Engelsen, Agnete ; Stuhr, Linda Elin Birkhaug (2021). Development and Characterization of an ex vivo Organotypic Non-Small Cell Lung Cancer Model to Study the Effect of Elevated Oxygen Treatment. (external link)
- Hekland, Joakim; Stuhr, Linda Elin Birkhaug; Engelsen, Agnete et al. (2021). Development and Characterization of an ex vivo Organotypic Non-Small Cell Lung Cancer Model to Study the Effect of Elevated Oxygen Treatment. (external link)
- Rayford, Austin James; Lorens, James; Svendsen, Agnete (2019). The Role of Axl in Cancer and Stem Cell Plasticity: in vivo Lineage Tracing and Imaging Mass Cytometry Analysis. (external link)
Academic literature review
- Zaarour, Rania F.; Azakir, Bilal; Hajam, Edries Y. et al. (2021). Role of Hypoxia-Mediated Autophagy in Tumor Cell Death and Survival. (external link)
- Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara et al. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) . (external link)
- Lotsberg, Maria Lie; Rayford, Austin James; Thiery, Jean Paul et al. (2020). Decoding cancer’s camouflage: epithelial-mesenchymal plasticity in resistance to immune checkpoint blockade. (external link)
- Terry, Stéphane; Engelsen, Agnete ; Buart, Stéphanie et al. (2020). Hypoxia-driven intratumor heterogeneity and immune evasion. (external link)
- Ferreira, Bibiana I.; Lie, Maria Kolnes; Svendsen, Agnete et al. (2017). Adaptive mechanisms of resistance to anti-neoplastic agents. (external link)
Academic chapter/article/Conference paper
- Lotsberg, Maria Lie; Chen, Ying Yi; Dhakal, Sushil et al. (2020). Autophagy mediated danger signaling regulates tumor immunosurveillance and may potentiate the effects of anti-cancer immunotherapy through increased adjuvanticity. (external link)
- Davidsen, Kjersti; Haaland, Gry Sandvik; Lie, Maria Kolnes et al. (2017). The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance. (external link)
Doctoral dissertation
Abstract
- Chekenya, Martha; Netland, Inger Anne; Verhoeff, Joost JC et al. (2010). NG2 PROMOTES RESISTANCE TO IONIZING RADIATION BY ELEVATED PEROXIREDOXIN-1 AND DNA DAMAGE RESPONSE IN GLIOBLASTOMA MULTIFORME. (external link)
- Wang, Jian; Tsinkalovsky, Oleg; Svendsen, Agnete et al. (2009). Targeting the tumor stroma: a novel therapeutic strategy based on separate analysis of the malignant and stromal cell compartments in brain tumors. (external link)
- Prestegarden, Lars; Svendsen, Agnete; Wang, Jian et al. (2009). CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORIGENICITY IN VIVO. (external link)
- Prestegarden, Lars; Svendsen, Agnete; Wang, Jian et al. (2008). CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORGENICITY IN VIVO. (external link)