- agnete.engelsen@uib.no
- Visitor address
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Haukeland Universitetssykehus Laboratoriebygget, 7. etg. Heis øst
5009 Bergen - Postal address
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P.O. Box 7804NO-5020 BergenNorway
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Research
Immunforsvarets frontliner
A field report from Engelsen's research stay at the French Research Institute Gustave Roussy (Paris, France) in the norwegian journal Forskerforum explains how we aim to engage the immune system in the eradication of cancers. (Article by Kjerstin Gjengedal).
On a quest to cure cancer
'The premature death from cancer of a close friend and colleague, made Agnete Engelsen even more determined to find a way to cure this devastating disease.'
The PhD interview/ cancer research. Article in the UiB Magazine by Jens Helleland Ådnanes.
Read more about my opportunity to participate in the High-Impact Cancer Research (HICR): Cancer, Biology and Therapeutics Program at Harvard Medical School -a truly inspirational postgraduate medical education program!
Translational Cancer Research requires a wide range of standaard and advanced methodologies. Read more about the excitement and international participation at the first fully web-based version of CCBIO 905 Methods in Cancer Biomarker Research. This course is part of The CCBIO Research School for Cancer Studies.
Outreach
Great excitement at the Research fair in Bergen
Excited children and adults crowded the Research Fair when researchers at the Center for Cancer Biomarkers (CCBIO) displayed living cancer cells in the microscope and performed a play about the cancer cell Greedy Frieda.
Read more about the research communication in the newspaper Studvest
Teaching
Online teaching/ courses: Read more about the first fully web-based version of CCBIO905: Methods in Cancer Biomarker Research
Academic responsibility:
CCBIO901 Junior Scientist Symposium, PhD course, The CCBIO Research School for Cancer Studies, UiB (RSCS)
MED1BIOMED Biomedisinske Tema, Mandatory MD course, Department of Biomedicine, UiB
CCBIO905 Methods in Cancer Biomarker Research, PhD course, The CCBIO Research School for Cancer Studies, UiB (RSCS)
HUCEL 320 Cell culture and cellular techniques: Flow Cytometry, Master course, Department of Biomedicine, UiB
Individual lectures:
BMED331 Tumor biology, Master course, Department of Biomedicine, UiB
MED1BIOMED Biomedisinske Tema, Mandatory MD course, Department of Biomedicine, UiB
CCBIO905 Methods in Cancer Biomarker Research, PhD course, The CCBIO Research School for Cancer Studies, UiB (RSCS)
BZL 256 Embryology, Department of Zoology, UiB
MED1BAS, FARM 260/NUTR, ODONT, Histology Mandatory preclinical MD lab courses, Department of Biomedicine, UiB
Publications
Academic article
- Camilla Tvedt Ekanger; Maria Ramnefjell; Maren Sofie Faldalen Guttormsen et al. (2025). An Organoid Model for Translational Cancer Research Recapitulates Histoarchitecture and Molecular Hallmarks of Non-Small-Cell Lung Cancer. (external link)
- Gro Vatne Røsland; Agnete Svendsen; Anja Torsvik et al. (2009). Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. (external link)
- Agnete Svendsen; Joost JC Verhoeff; Heike Immervoll et al. (2011). Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. (external link)
- Austin James Rayford; Fabian Gärtner; Maria Paula Ramnefjell et al. (2024). AXL expression reflects tumor-immune cell dynamics impacting outcome in non-small cell lung cancer patients treated with immune checkpoint inhibitor monotherapy. (external link)
- Olivera Bozickovic; Linn Skartveit; Agnete Svendsen et al. (2018). A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells. (external link)
- Sissel Elisabeth Dyrstad; Maria Lie Lotsberg; Tuan Zea Tan et al. (2021). Blocking aerobic glycolysis by targeting pyruvate dehydrogenase kinase in combination with EGFR TKI and ionizing radiation increases therapeutic effect in non-small cell lung cancer cells. (external link)
- Martha Chekenya; Camilla Krakstad; Agnete Svendsen et al. (2008). The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling. (external link)
- Maria Lie Lotsberg; Katarzyna Wnuk-Lipinska; Stéphane Terry et al. (2020). AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells. (external link)
- Jian Wang; Per Øystein Sakariassen; Oleg Tsinkalovsky et al. (2008). CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. (external link)
- Agnete Svendsen Tenfjord Engelsen; Maria Lie Lotsberg; Raefa Abou Khouzam et al. (2022). Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition. (external link)
- Anja Torsvik; Daniel Stieber; Per Øyvind Enger et al. (2014). U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells. (external link)
- Camilla Tvedt Ekanger; Nilima Dinesh Kumar; Rosanne W. Koutstaal et al. (2025). Comparison of air-liquid interface transwell and airway organoid models for human respiratory virus infection studies. (external link)
- Agnete Engelsen; Katarzyna Wnuk-Lipinska; Sébastien Bougnaud et al. (2020). AXL is a driver of stemness in normal mammary gland and breast cancer. (external link)
- Kristine Yttersian Sletta; Maria Kathrine Tveitarås; Ning Lu et al. (2017). Oxygen-dependent regulation of tumor growth and metastasis in human breast cancer xenografts. (external link)
- Maria Lie Lotsberg; Gro Vatne Røsland; Austin James Rayford et al. (2022). Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models. (external link)
- Laurence Hoareau; Agnete Engelsen; Marianne Aanerud et al. (2021). Induction of alveolar and bronchiolar phenotypes in human lung organoids. (external link)
- Camilla Tvedt Ekanger; Fan Zhou; Dana Bohan et al. (2022). Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 respiratory virus. (external link)
- Gro Vatne Røsland; Sissel Elisabeth Dyrstad; Deusdedit Tusubira et al. (2019). Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC.. (external link)
- Stéphane Terry; Abderemane Abdou; Agnete Svendsen et al. (2019). AXL targeting overcomes human lung cancer cell resistance to NK- And CTL-mediated cytotoxicity. (external link)
- Jian Wang; Agnete Svendsen; Justyna Kmiecik et al. (2011). Targeting the NG2/CSPG4 Proteoglycan Retards Tumour Growth and Angiogenesis in Preclinical Models of GBM and Melanoma. (external link)
- Simone P Niclou; Claude Danzeisen; Hans Petter Eikesdal et al. (2008). A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. (external link)
- Andrea Gras Navarro; Justyna Kmiecik; Lina Wik Leiss et al. (2014). NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival. (external link)
- Elyes Chouaieb; Stéphane Terry; Stephanie Corgnac et al. (2018). Cancer Immunotherapy 2017 (Paris, France). Progress and challenges. (external link)
- Mohummad Aminur Rahman; Agnete Engelsen; Shahin Sarowar et al. (2022). Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway. (external link)
- Mohummad Aminur Rahman; Andrea Gras Navarro; Jorunn Brekke et al. (2019). Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival. (external link)
- Lars Prestegarden; Agnete Svendsen; Jian Wang et al. (2010). Glioma cell populations grouped by different cell type markers drive brain tumor growth. (external link)
- Frits Alan Thorsen; Sandra Afione; Peter Csaba Huszthy et al. (2006). Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma. (external link)
- Tiina Jokela; Agnete Svendsen; Agata Rybicka et al. (2018). Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance. (external link)
Master’s thesis
- Joakim Hekland; Linda Elin Birkhaug Stuhr; Agnete Engelsen et al. (2021). Development and Characterization of an ex vivo Organotypic Non-Small Cell Lung Cancer Model to Study the Effect of Elevated Oxygen Treatment. (external link)
- Austin James Rayford; James Lorens; Agnete Svendsen (2019). The Role of Axl in Cancer and Stem Cell Plasticity: in vivo Lineage Tracing and Imaging Mass Cytometry Analysis. (external link)
- Hekland Joakim; Agnete Engelsen; Linda Elin Birkhaug Stuhr (2021). Development and Characterization of an ex vivo Organotypic Non-Small Cell Lung Cancer Model to Study the Effect of Elevated Oxygen Treatment. (external link)
- Camilla Tvedt Ekanger; Agnete Engelsen; Linda Elin Birkhaug Stuhr (2021). Human organotypic airway and lung organoids for the study of SARS-CoV-2 infectivity and cytopathology. (external link)
- Emmanuelle Lucie Arnal; Agnete Engelsen; Linda Elin Birkhaug Stuhr et al. (2023). Disrupting the metabolic homeostasis of lung cancer to increase the efficacy of immune checkpoint inhibition. (external link)
- Maren Sofie Faldalen Guttormsen; Agnete Engelsen; James Lorens et al. (2023). Predictive Biomarkers Beyond Next Generation Sequencing: Functional Testing of Homologous Recombination Repair Deficiency Status in Patient-Derived Tissue Cultures. (external link)
Academic literature review
- Daniel J. Klionsky; Amal Kamal Abdel-Aziz; Sara Abdelfatah et al. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). (external link)
- Bibiana I. Ferreira; Maria Kolnes Lie; Agnete Svendsen et al. (2017). Adaptive mechanisms of resistance to anti-neoplastic agents. (external link)
- Stéphane Terry; Agnete Engelsen; Stéphanie Buart et al. (2020). Hypoxia-driven intratumor heterogeneity and immune evasion. (external link)
- Maria Lie Lotsberg; Austin James Rayford; Jean Paul Thiery et al. (2020). Decoding cancer’s camouflage: epithelial-mesenchymal plasticity in resistance to immune checkpoint blockade. (external link)
- Rania F. Zaarour; Bilal Azakir; Edries Y. Hajam et al. (2021). Role of Hypoxia-Mediated Autophagy in Tumor Cell Death and Survival. (external link)
Academic book chapter
- Maria Lie Lotsberg; Ying Yi Chen; Sushil Dhakal et al. (2020). Autophagy mediated danger signaling regulates tumor immunosurveillance and may potentiate the effects of anti-cancer immunotherapy through increased adjuvanticity. (external link)
- Kjersti Davidsen; Gry Sandvik Haaland; Maria Kolnes Lie et al. (2017). The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance. (external link)
Conference abstract
- Jian Wang; Oleg Tsinkalovsky; Agnete Svendsen et al. (2009). Targeting the tumor stroma: a novel therapeutic strategy based on separate analysis of the malignant and stromal cell compartments in brain tumors. (external link)
- Martha Chekenya; Inger Anne Netland; Joost JC Verhoeff et al. (2010). NG2 PROMOTES RESISTANCE TO IONIZING RADIATION BY ELEVATED PEROXIREDOXIN-1 AND DNA DAMAGE RESPONSE IN GLIOBLASTOMA MULTIFORME. (external link)
- Lars Prestegarden; Agnete Svendsen; Jian Wang et al. (2009). CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORIGENICITY IN VIVO. (external link)
- Lars Prestegarden; Agnete Svendsen; Jian Wang et al. (2008). CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORGENICITY IN VIVO. (external link)