Molecular mechanisms of cell adehsion

The Gullberg laboratory has characterized the integrin α11β1, which is expressed on subsets of normal fibroblasts and on carcinoma-associated fibroblasts. Cells lacking α11β1 display disturbed cell-collagen interactions, altered metalloproteinase synthesis and reduced cell proliferation. Major projects within the group aim to further understand the role of this collagen receptor and other fibroblast integrins during health and in disease.

MEDOD1

MEDOD2

BMED320

BMED325

BMED330

FARM260

1996

• Kristofer Rubin; Donald Gullberg; Bianca Tomasini-Johansson et al. (1996). Molecular Recognition of the Extracellular Matrix by Cell Surface Receptors. (external link)

2012

• Cecilia M. Österholm; Ning Lu; Åsa Liden et al. (2012). Fibroblast EXT1-levels influence tumor cell proliferation and migration in composite spheroids. (external link)
• Samir W. Hamaia; Nicholas Pugh; Nicolas Raynal et al. (2012). Mapping of potent and specific binding motifs, GLOGEN and GVOGEA, for integrin alpha 1 beta 1 using collagen toolkits II and III. (external link)

2014

• Ning Lu; Tine Veronica Karlsen; Rolf K. Reed et al. (2014). Fibroblast α11β1 integrin regulates tensional homeostasis in fibroblast/A549 carcinoma heterospheroids. (external link)

2009

• R Hallinger; K Blumbach; Donald Gullberg et al. (2009). Collagen-binding integrins alpha2beta1 and alpha11beta1-key determinants of scar matrix remodeling?. (external link)

2021

• Nazia Islam Disha; Elon Donald Gullberg (2021). Role of evolutionary conserved residues in integrin α11 cytoplasmic tail. (external link)

2019

• Hilde Ytre-Hauge Smeland; Cecilie Askeland; Elisabeth Wik et al. (2019). Integrin α11β1 is expressed in breast cancer stroma and associates with aggressive tumor phenotypes.. (external link)

2017

• Cedric Zeltz; Roya Navab; Marion Kusche-Gullberg et al. (2017). Role of the Extracellular Matrix in Tumor Stroma: Barrier or Support?. (external link)

See a complete overview of publications in Cristin.