Molecular mechanisms of cell adehsion

The Gullberg laboratory has characterized the integrin α11β1, which is expressed on subsets of normal fibroblasts and on carcinoma-associated fibroblasts. Cells lacking α11β1 display disturbed cell-collagen interactions, altered metalloproteinase synthesis and reduced cell proliferation. Major projects within the group aim to further understand the role of this collagen receptor and other fibroblast integrins during health and in disease.

MEDOD1

MEDOD2

BMED320

BMED325

BMED330

FARM260

2025

• Anna De Giuseppe; Adrian Deichsel; Alina Reese et al. (2025). Collagen-binding integrin α11β1 contributes to joint destruction in arthritic hTNFtg mice. (external link)
• Joan Chang; Adam Pickard; Jeremy Herrera et al. (2025). Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis. (external link)

2024

• Daniel C. Stewart; Becky K. Brisson; William K. Yen et al. (2024). Type III Collagen Regulates Matrix Architecture and Mechanosensing during Wound Healing. (external link)
• Moses Musiime; Pugazendhi Murugan Erusappan; Edna Cukierman et al. (2024). Fibroblast integrin α11β1 is a collagen assembly receptor in mechanoregulated fibrillar adhesions. (external link)

2023

• Katja Bieber; Siegfried Bezdek; Yask Gupta et al. (2023). Forward genetics and functional analysis highlight Itga11 as a modulator of murine psoriasiform dermatitis. (external link)
• Mugdha Sawant; Fang Wang; Janis Koester et al. (2023). Ablation of integrin-mediated cell-collagen communication alleviates fibrosis. (external link)
• Andre Grigorian; Elon Donald Gullberg; Moses Musiime (2023). Matrix Stiffness-dependent Regulation of Integrin α11β1 Expression. (external link)
• Cedric Zeltz; Marion Kusche Gullberg; Ritva Leena Heljasvaara et al. (2023). Novel roles for cooperating collagen receptor families in fibrotic niches. (external link)

See a complete overview of publications in NVA.

1990 Phd Medical Chemistry, Uppsala University

1990-1992 Post Doc, Molecular Biology Institute, University of California Los Angeles

1993-2003 Researcher, Uppsala University

2004- today Professor, Department of Biomedicine, UoB