Espen Hartveit
Position
Professor, Group Leader Neural Networks Research Group
Affiliation
- espen.hartveit@uib.no
- Phone number
- +47 55586350
- Visitor address
-
Jonas Lies vei 91
5009 Bergen - Postal address
-
P.O. Box 7804NO-5020 BergenNorway
Espen Hartveit
Position
Professor, Group Leader Neural Networks Research Group
Affiliation
Research groups
Research
Synaptic interactions in the retina: receptors, mechanisms, circuits and networks
Our lab is interested in the cellular and molecular basis of synaptic transmission and synaptic integration in the central nervous system. Our main goal is to understand the synaptic and cellular mechanisms employed by identified neurons and specific microcircuits for signal processing. The primary techniques we use are targeted patch-clamp recording of visually-identified neurons, multiphoton (2-photon) imaging, immunocytochemistry, confocal imaging and computational modeling.
Teaching
BMED340
MED3
Publications
2024
- Opdahl, Alexander; Hartveit, Espen; Veruki, Margaret Lin et al. (2024). Compartmental modeling of AII amacrine cells. (external link)
- Hartveit, Espen; Veruki, Margaret Lin (2024). Developing kinetic models of hyperpolarization-activated cation channels in bipolar cells of rat retina. (external link)
- Veruki, Margaret Lin; Hartveit, Espen (2024). Modulating excitability of the AII amacrine cell. (external link)
2022
- Beltran Matas, Pablo; Castilho, Aurea; Tencer, Barbora et al. (2022). Inhibitory inputs to an inhibitory interneuron: Spontaneous postsynaptic currents and GABA<inf>A</inf> receptors of A17 amacrine cells in the rat retina. (external link)
- Liu, Jian Hao; Peter, David Olukoya; Guttormsen, Maren Sofie Faldalen et al. (2022). The mosaic of AII amacrine cell bodies in rat retina is indistinguishable from a random distribution. (external link)
- Fournel, Rémi; Veruki, Margaret Lin; Hartveit, Espen (2022). Digital reconstruction and quantitative morphometric analysis of bipolar cells in live rat retinal slices. (external link)
- Hartveit, Espen; Veruki, Margaret Lin; Zandt, Bas-Jan (2022). Dendritic morphology of an inhibitory retinal interneuron enables simultaneous local and global synaptic integration. (external link)
2021
- Liu, Jian Hao; Singh, Jeet Bahadur; Veruki, Margaret Lin et al. (2021). Morphological properties of the axon initial segment-like process of AII amacrine cells in the rat retina. (external link)
- Beltran Matas, Pablo; Hartveit, Espen; Veruki, Margaret Lin (2021). Different glutamate sources and endogenous co-agonists activate extrasynaptic NMDA receptors on amacrine cells of the rod pathway microcircuit. (external link)
2020
- Fournel, Rémi; Hartveit, Espen; Veruki, Margaret Lin (2020). Differential contribution of gap junctions to the membrane properties of ON- and OFF-bipolar cells of the rat retina. (external link)
- Beltran Matas, Pablo; Hartveit, Espen; Veruki, Margaret Lin (2020). Different mechanisms of activation of extrasynaptic NMDA receptors in a retinal microcircuit . (external link)
2019
- Beltran Matas, Pablo; Hartveit, Espen; Veruki, Margaret Lin (2019). Different sources of glutamate activate extrasynaptic NMDA receptors in the rod pathway microcircuit of the mammalian retina. (external link)
- Liu, Jian Hao; Singh, Jeet Bahadur; Veruki, Margaret Lin et al. (2019). Why does an axon-less interneuron in the retina fire action potentials?. (external link)
- Hartveit, Espen; Zandt, Bas-Jan; Veruki, Margaret Lin (2019). The AII amacrine cell: dendritic morphology optimized for simultaneous local and global synaptic integration. (external link)
- Fournel, Rémi; Hartveit, Espen; Veruki, Margaret Lin (2019). Compartmental models of bipolar cells in rat retina developed from quantitative morphological reconstructions. (external link)
- Hartveit, Espen (2019). Multiphoton Microscopy. (external link)
- Hartveit, Espen; Zandt, Bas-Jan; Veruki, Margaret Lin (2019). Multiphoton excitation microscopy for the reconstruction and analysis of single neuron morphology . (external link)
- Hartveit, Espen; Veruki, Margaret Lin (2019). Combining Multiphoton Excitation Microscopy with Fast Microiontophoresis to Investigate Neuronal Signaling. (external link)
- Hartveit, Espen; Veruki, Margaret Lin; Zandt, Bas-Jan (2019). Capacitance measurement of dendritic exocytosis in an electrically coupled inhibitory retinal interneuron: an experimental and computational study. (external link)
- Beltran Matas, Pablo; Castilho, Aurea; Hartveit, Espen et al. (2019). Pharmacological characterization of synaptic and extrasynaptic GABAA receptors on retinal amacrine cells . (external link)
- Veruki, Margaret Lin; Beltran Matas, Pablo; Hartveit, Espen (2019). Activating extrasynaptic NMDA receptors on interneurons of the rod pathway microcircuit in the mammalian retina. (external link)
- Liu, Jian Hao; Veruki, Margaret Lin; Hartveit, Espen (2019). Why does an axon-less interneuron in the retina fire action potentials?. (external link)
- Veruki, Margaret Lin; Zhou, Yifan; Castilho, Aurea et al. (2019). Extrasynaptic NMDA receptors on rod pathway amacrine cells: molecular composition, activation, and signaling. (external link)
2018
- Meadows, Marc; Veruki, Margaret Lin; Hartveit, Espen et al. (2018). Exo- and endocytosis at a retinal inhibititory synapse during crossover inhibition. (external link)
- Meadows, Marc; Veruki, Margaret Lin; Hartveit, Espen et al. (2018). Exo- and endocytosis at a retinal inhibitory synapse during crossover inhibition. (external link)
- Zandt, Bas-Jan; Veruki, Margaret Lin; Hartveit, Espen (2018). Electrotonic signal processing in AII amacrine cells: compartmental models and passive membrane properties for a gap junction-coupled retinal neuron. (external link)
- Beltran Matas, Pablo; Castilho, Aurea; Hartveit, Espen et al. (2018). Functional properties of GABAA receptors on rod amacrine (AII and A17) cells of the rat retina. (external link)
2017
- Zandt, Bas-Jan; Losnegård, Are; Hodneland, Erlend et al. (2017). Semi-automatic 3D morphological reconstruction of neurons with densely branching morphology: Application to retinal AII amacrine cells imaged with multi-photon excitation microscopy. (external link)
- Meadows, Marc; Veruki, Margaret Lin; Hartveit, Espen et al. (2017). Exo- and endocytosis in an inhibitory neuron of the retina. (external link)
- Hartveit, Espen (2017). Morphological reconstruction and passive cable modeling: getting it all right!. (external link)
- Fournel, Rémi; Hartveit, Espen; SwitchBoard, ITN H2020 et al. (2017). Netthinnen / Retina. (external link)
- Hartveit, Espen (2017). Fast and dynamic regulation of electrical synapses in the mammalian retina. (external link)
- Hartveit, Espen; Zandt, Bas-Jan; Veruki, Margaret Lin (2017). AMPA receptors at ribbon synapses of AII amacrine cells in the mammalian retina: kinetic models and molecular identity. (external link)
- Hartveit, Espen; Zandt, Bas-Jan; Madsen, Eirik et al. (2017). AMPA receptors at ribbon synapses in the mammalian retina: kinetic models and molecular identity. (external link)
- Zandt, Bas-Jan; Liu, Jian Hao; Veruki, Margaret Lin et al. (2017). AII amacrine cells: quantitative reconstruction and morphometric analysis of electrophysiologically identified cells in live rat retinal slices imaged with multi-photon excitation microscopy. (external link)
2016
- Zhou, Yifan; Tencerova, Barbora; Hartveit, Espen et al. (2016). Functional NMDA receptors are expressed by both AII and A17 amacrine cells in the rod pathway of the mammalian retina. (external link)
- Liu, Jian Hao; Zandt, Bas-Jan; Veruki, Margaret Lin et al. (2016). Quantitative morphological reconstruction and analysis of dye-filled AII amacrine cells in retinal slices imaged with multi-photon excitation (MPE) microscopy. (external link)
- Fournel, Rémi; Hartveit, Espen; Veruki, Margaret Lin (2016). Dynamic and integrative properties of bipolar cells in the mammalian retina. (external link)
- Hartveit, Espen; Veruki, Margaret Lin (2016). NMDA receptors and regulation of electrical synapses between retinal amacrine cells. (external link)
- Hartveit, Espen; Zandt, Bas-Jan; Veruki, Margaret Lin (2016). Developing passive compartmental models of AII amacrine cells by combined multi-photon excitation microscopy and electrophysiogical recording. (external link)
- Zandt, Bas-Jan; Veruki, Margaret Lin; Hartveit, Espen (2016). Detailed passive models of retinal AII amacrine cells based on simultaneous electrophysiology and multiphoton excitation microscopy. (external link)
- Veruki, Margaret Lin; Zhou, Yifan; Castilho, Aurea et al. (2016). Extrasynaptic NMDA receptors on rod pathway amacrine cells. (external link)
- Hartveit, Espen (2016). Patch-clamp measurements and data analysis. (external link)
2015
- Castilho, Aurea; Ambrósio, António F.; Hartveit, Espen et al. (2015). Disruption of a neural microcircuit in the rod pathway of the mammalian retina by diabetes mellitus. (external link)
- Veruki, Margaret Lin; Zhou, Yifan; Castilho, Aurea et al. (2015). Expression, activation and subunit composition of NMDA receptors on rod pathway amacrine cells. (external link)
- Hartveit, Espen; Zandt, Bas-Jan; Liu, Jian Hao et al. (2015). Quantitative morphological reconstruction and analysis of dye-filled AII amacrine cells in retinal slices imaged with multi-photon excitation (MPE) microscopy. (external link)
- Tencerova, Barbora; Veruki, Margaret Lin; Hartveit, Espen (2015). Fast and dynamic regulation of electrical synapses between AII amacrine cells. (external link)
- Hartveit, Espen (2015). Modulation of electrical synapses between AII amacrine cells. (external link)
- Castilho, Aurea; Madsen, Eirik; Ambrósio, António F. et al. (2015). Diabetic hyperglycemia reduces Ca2+ permeability of extrasynaptic AMPA receptors. (external link)
- Zhou, Yifan; Castilho, Aurea; Hartveit, Espen et al. (2015). NMDA receptors in rod pathway amacrine cells in the mammalian retina. (external link)
- Castilho, Aurea; Hartveit, Espen; Veruki, Margaret Lin (2015). Inhibitory inputs to A17 amacrine cells in the rat retina. (external link)
- Madsen, Eirik; Hartveit, Espen (2015). Diabetic hyperglycemia reduces Ca2+ permeability of AMPA receptors expressed by AII amacrine cells. (external link)
2014
- Zhou, Yifan; Castilho, Aurea; Hartveit, Espen et al. (2014). Activation and functional consequences of extrasynaptic NMDA receptors on AII amacrine cells of the rat retina. (external link)
- Castilho, Aurea; Ambrosio, Antonio F; Hartveit, Espen et al. (2014). Functional consequences of diabetic hyperglycemia in the rat retina. (external link)
- Zhou, Yifan; Castilho, Aurea; Hartveit, Espen et al. (2014). Functional properties of NMDA receptors on AII amacrine cells. (external link)
- Liu, Jian Hao; Riisdal, John Georg; Veruki, Margaret Lin et al. (2014). AII amacrine cells: Quantitative reconstruction and morphometric analysis. (external link)
- Veruki, Margaret Lin; Castilho, Aurea; Ambrosio, Antonio F et al. (2014). Diabetes disrupts an inhibitory microcircuit in the rod pathway of the mammalian retina. (external link)
- Hartveit, Espen (2014). A Retinal Microcircuit in Health and Disease. (external link)
- Liu, Jian Hao; Riisdal, John Georg; Veruki, Margaret Lin et al. (2014). Using multi-photon excitation microscopy for neural reconstruction and morphometric analysis. (external link)
2013
- Riisdal, John Georg; Veruki, Margaret Lin; Hartveit, Espen (2013). Quantitative reconstruction and morphological analysis of AII amacrine cells. (external link)
- Hartveit, Espen; Castilho, Aurea; Madsen, Eirik et al. (2013). Feedback mechanisms of rod bipolar cells in the healthy and diseased retina. (external link)
- Riisdal, John Georg; Veruki, Margaret Lin; Hartveit, Espen (2013). Databasing the retina: Quantitative reconstruction and morphological analysis of AII amacrine cells. (external link)
2012
2011
- Veruki, Margaret Lin; Hartveit, Espen (2011). Combining multi-photon excitation (MPE) microscopy and electrophysiological recording to develop computational models of electrically-coupled AII amacrine cells. (external link)
- Veruki, Margaret Lin; Hartveit, Espen (2011). Combining multi-photon excitation (MPE) microscopy and electrophysiological recording to develop computational models of electrically coupled AII amacrine cells. (external link)
- Hartveit, Espen; Veruki, Margaret Lin (2011). Developing computational models of neurons with electrical synapses using multi-photon excitation (MPE) microscopy and electrophysiological recording. (external link)
- Losnegård, Are; Munthe-Kaas, Antonella Zanna; Hartveit, Espen et al. (2011). Segmentation and reconstruction of neurons for simulation of signal transmission. (external link)
- Freeman, Daniel K; Jeng, Jed S; Kelly, Shawn K et al. (2011). Calcium channel dynamics limit synaptic release in response to prosthetic stimulation with sinusoidal waveforms. (external link)
2010
- Wang, Xiang; Veruki, Margaret Lin; Bukoreshtliev, Nickolay V et al. (2010). Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channels. (external link)
- Hartveit, Espen; Veruki, Margaret Lin (2010). Accurate measurement of junctional conductance between electrically coupled cells with dual whole-cell voltage-clamp under conditions of high series resistance. (external link)
- Veruki, Margaret Lin; Oltedal, Leif; Hartveit, Espen (2010). Electrical coupling and passive membrane properties of AII amacrine cells. (external link)
- Oltedal, Leif; Hartveit, Espen (2010). Transient release kinetics of rod bipolar cells revealed by capacitance measurement of exocytosis from axon terminals in rat retinal slices. (external link)
2009
- Veruki, Margaret Lin; Hartveit, Espen (2009). Meclofenamic acid blocks electrical synapses of retinal AII amacrine and ON-cone bipolar cells. (external link)
- Oltedal, Leif; Veruki, Margaret Lin; Hartveit, Espen (2009). Passive membrane properties and electrotonic signal processing in retinal rod bipolar cells. (external link)
- Veruki, Margaret Lin; Oltedal, Leif; Hartveit, Espen (2009). Passive membrane properties of AII amacrine cells. (external link)
- Mørkve, Svein Harald; Hartveit, Espen (2009). Properties of glycine receptors underlying synaptic currents in presynaptic axon terminals of rod bipolar cells in the rat retina. (external link)
2008
- Øyra, Harald Nils; Hartveit, Espen; Veruki, Margaret Lin (2008). GABA receptors on AII amacrine cells in rat retina. (external link)
- Veruki, Margaret Lin; Oltedal, Leif; Hartveit, Espen (2008). Electrical Synapses Between AII Amacrine Cells: Dynamic Range and Functional Consequences of Variation in Junctional Conductance. (external link)
2007
- Hartveit, Espen (2007). Regulation of synaptic transmission through presynaptic glutamate transporters. (external link)
- Oltedal, Leif; Mørkve, Svein Harald; Veruki, Margaret Lin et al. (2007). Patch clamp investigations and compartmental modeling of rod bipolar axon terminals in an in vitro thin slice preparation of the mammalian retina. (external link)
- Hartveit, Espen; Veruki, Margaret Lin (2007). Studying properties of neurotransmitter receptors by non-stationary noise analysis of spontaneous postsynaptic currents and agonist-evoked responses in outside-out patches. (external link)
- Veruki, Margaret Lin; Gill, Silje Bakken; Hartveit, Espen (2007). Spontaneous IPSCs and glycine receptors with slow kinetics in wide-field amacrine cells in the mature rat retina. (external link)
- Veruki, Margaret Lin; Gill, Silje Bakken; Hartveit, Espen (2007). Unique glycine receptor properties differentially shape glycinergic input to interneurons in the rat retina. (external link)
2006
- Veruki, Margaret Lin; Mørkve, Svein Harald; Hartveit, Espen (2006). Activation of a presynaptic glutamate transporter regulates synaptic transmission through electrical signaling. (external link)
- Gill, Silje Bakken; Veruki, Margaret Lin; Hartveit, Espen (2006). Functional properties of spontaneous IPSCs and glycine receptors in rod amacrine (AII) cells in the rat retina. (external link)
- Hartveit, Espen; Veruki, Margaret Lin (2006). Studying properties of neurotransmitter receptors by non-stationary noise analysis of spontaneous synaptic currents. (external link)
- Veruki, Margaret Lin; Hartveit, Espen (2006). Artificial electrical synapses in networks of AII (rod) amacrine cells in rat retina. (external link)
2002
- Veruki, Margaret; Hartveit, Espen (2002). AII (rod) amacrine cells form a network of electrically coupled interneurons in the mammalian retina. (external link)
- Veruki, Margaret; Hartveit, Espen (2002). Electrical synapses mediate signal transmission in the rod pathway of the mammalian retina. (external link)
- Mørkve, Svein Harald; Veruki, Margaret; Hartveit, Espen (2002). Functional characteristics of non-NMDA-type ionotropic glutamate receptor channels in AII amacrine cells in rat retina. (external link)
- Veruki, Margaret; Hartveit, Espen (2002). AII amacrine cells form a network of electrically coupled interneurons. (external link)
- Hartveit, Espen; Veruki, Margaret (2002). Functional properties of electrical synapses between AII(rod) amacrine cells in the mammalian retina. (external link)
2001
1998
1993
- Hartveit, Espen; Heggelund, Paul (1993). Brain stem influence on visual response of lagged and nonlagged cells in the cat lateral geniculate nucleus. (external link)
- Hartveit, Espen; Heggelund, Paul (1993). The effect of acetylcholine on the visual response of lagged cells in the cat dorsal lateral geniculate nucleus. (external link)
- Hartveit, Espen; Heggelund, Paul; Ramberg, SI (1993). Brainstem modulation of spatial receptive field properties of single cells in the dorsal lateral geniculate nucleus of the cat. (external link)
1992
- Hartveit, Espen; Heggelund, Paul (1992). The effect of contrast on the visual response of lagged and nonlagged cells in the cat lateral geniculate nucleus. (external link)
- Hartveit, Espen; Heggelund, Paul (1992). Effects of acetylcholine on the visual response of lagged and nonlagged cells in the lateral geniculate nucleus of the cat. (external link)
- Heggelund, Paul; Hartveit, Espen; Ramberg, Stein (1992). Brainstem peribrachial influence on the receptive field structure of cells in the lateral geniculate nucleus of the cat. (external link)
1990
- Heggelund, Paul; Hartveit, Espen (1990). Neurotransmitter receptors mediating excitatory input to cells in the cat lateral geniculate nucleus. I. Lagged cells. (external link)
- Hartveit, Espen; Heggelund, Paul (1990). Brainstem modulation of lagged and nonlagged cells in the cat lateral geniculate nucleus. (external link)
- Hartveit, Espen; Heggelund, Paul (1990). Neurotransmitter receptors mediating excitatory input to cells in the cat lateral geniculate nucleus. II. Non-lagged cells. (external link)
1989
- Kasamatsu, Takuji; Imamura, Kazuyuki; Hartveit, Espen et al. (1989). Do NMDA receptors account for cortical plasticity in kittens?. (external link)
- Heggelund, Paul; Hartveit, Espen (1989). Lagged and non-lagged cells in the cat lateral geniculate nucleus receive retinal input through different glutamate receptors. (external link)