Academic literature review

• Bruserud, Øystein; Selheim, Frode; Valladares, Maria del Carmen Hernandez et al. (2025). XPO1/Exportin-1 in Acute Myelogenous Leukemia; Biology and Therapeutic Targeting. (external link)
• Bruserud, Øystein; Selheim, Frode; Valladares, Maria del Carmen Hernandez et al. (2024). Monocytic Differentiation in Acute Myeloid Leukemia Cells: Diagnostic Criteria, Biological Heterogeneity, Mitochondrial Metabolism, Resistance to and Induction by Targeted Therapies. (external link)
• Rodriguez, Paula Carrillo; Selheim, Frode; Valladares, Maria del Carmen Hernandez (2023). Mass Spectrometry-Based Proteomics Workflows in Cancer Research: The Relevance of Choosing the Right Steps. (external link)
• Hernandez-Valladares, Maria; Bruserud, Øystein; Selheim, Frode (2020). The implementation of mass spectrometry-based proteomics workflows in clinical routines of acute myeloid leukemia: Applicability and perspectives. (external link)
• Selheim, Frode; Aasebø, Elise; Ribas, Catalina et al. (2019). An overview on G protein-coupled receptor-induced signal transduction in acute myeloid leukemia. (external link)
• Hernandez-Valladares, Maria; Vaudel, Marc; Selheim, Frode et al. (2017). Proteogenomics approaches for studying cancer biology and their potential in the identification of acute myeloid leukemia biomarkers. (external link)
• Hernandez-Valladares, Maria; Aasebø, Elise; Selheim, Frode et al. (2016). Selecting Sample Preparation Workflows for Mass Spectrometry-Based Proteomic and Phosphoproteomic Analysis of Patient Samples with Acute Myeloid Leukemia. (external link)
• Kleppe, Rune; Krakstad, Camilla; Selheim, Frode et al. (2011). The cAMP-dependent protein kinase pathway as therapeutic target - possibilities and pitfalls. (external link)
• Kleppe, Rune; Kjærland, Endre; Selheim, Frode (2006). Proteomic and computational methods in systems modeling of cellular signaling. (external link)
• Herfindal, Lars; Selheim, Frode (2006). Microcystin produces disparate effects on liver cells in a dose dependent manner. (external link)

Academic article

• Selheim, Frode; Aasebø, Elise; Reikvam, Håkon et al. (2024). Monocytic Differentiation of Human Acute Myeloid Leukemia Cells: A Proteomic and Phosphoproteomic Comparison of FAB-M4/M5 Patients with and without Nucleophosmin 1 Mutations. (external link)
• Selheim, Frode; Aasebø, Elise; Bruserud, Øystein et al. (2024). High Mitochondrial Protein Expression as a Potential Predictor of Relapse Risk in Acute Myeloid Leukemia Patients with the Monocytic FAB Subtypes M4 and M5. (external link)
• Bartaula-Brevik, Sushma; Leitch, Calum; Valladares, Maria del Carmen Hernandez et al. (2023). Vacuolar ATPase Is a Possible Therapeutic Target in Acute Myeloid Leukemia: Focus on Patient Heterogeneity and Treatment Toxicity. (external link)
• Sarowar, Shahin; Cirillo, Davide; Játiva, Pablo et al. (2022). The styryl benzoic acid derivative DC10 potentiates radiotherapy by targeting the xCT-glutathione axis. (external link)
• Grønningsæter, Ida Sofie; Reikvam, Håkon; Aasebø, Elise et al. (2021). Effects of the autophagy‐inhibiting agent chloroquine on acute myeloid leukemia cells; characterization of patient heterogeneity. (external link)
• Aasebø, Elise; Brenner, Annette; Hernandez-Valladares, Maria et al. (2021). Patient Heterogeneity in Acute Myeloid Leukemia: Leukemic Cell Communication by Release of Soluble Mediators and Its Effects on Mesenchymal Stem Cells. (external link)
• Aasebø, Elise; Brenner, Annette; Hernandez-Valladares, Maria et al. (2021). Proteomic Characterization of Spontaneous Stress-Induced In Vitro Apoptosis of Human Acute Myeloid Leukemia Cells; Focus on Patient Heterogeneity and Endoplasmic Reticulum Stress. (external link)
• Aasebø, Elise; Brenner, Annette; Hernandez-Valladares, Maria et al. (2021). Proteomic comparison of bone marrow derived osteoblasts and mesenchymal stem cells. (external link)
• Aasebø, Elise; Brenner, Annette; Birkeland, Even et al. (2021). The constitutive extracellular protein release by acute myeloid leukemia cells—A proteomic study of patient heterogeneity and its modulation by mesenchymal stromal cells. (external link)
• Hernandez-Valladares, Maria; Wangen, Rebecca; Aasebø, Elise et al. (2021). Proteomic studies of primary acute myeloid leukemia cells derived from patients before and during disease-stabilizing treatment based on all-trans retinoic acid and valproic acid. (external link)
• Aasebø, Elise; Berven, Frode; Bartaula-Brevik, Sushma et al. (2020). Proteome and Phosphoproteome Changes Associated with Prognosis in Acute Myeloid Leukemia. (external link)
• Hernandez-Valladares, Maria; Aasebø, Elise; Berven, Frode et al. (2020). Biological characteristics of aging in human acute myeloid leukemia cells: the possible importance of aldehyde dehydrogenase, the cytoskeleton and altered transcriptional regulation. (external link)
• Aasebø, Elise; Birkeland, Even; Selheim, Frode et al. (2020). The extracellular bone marrow microenvironment — a proteomic comparison of constitutive protein release by in vitro cultured osteoblasts and mesenchymal stem cells. (external link)
• Aasebø, Elise; Berven, Frode; Hovland, Randi et al. (2020). The progression of acute myeloid leukemia from first diagnosis to chemoresistant relapse: A comparison of proteomic and phosphoproteomic profiles. (external link)
• Åsrud, Kathrine Sivertsen; Pedersen, Line; Aesoy, Reidun et al. (2019). Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy. (external link)
• Brenner, Annette; Aasebø, Elise; Hernandez-Valladares, Maria et al. (2019). The capacity of long-term in vitro proliferation of acute myeloid leukemia cells supported only by exogenous cytokines is associated with a patient subset with adverse outcome. (external link)
• Aasebø, Elise; Hernandez-Valladares, Maria; Selheim, Frode et al. (2019). Proteomic profiling of primary human acute myeloid leukemia cells does not reflect their constitutive release of soluble mediators. (external link)
• Tveitarås, Maria Kathrine; Selheim, Frode; Sortland, Kristina et al. (2019). Protein expression profiling of plasma and lungs at different stages of metastatic development in a human triple negative breast cancer xenograft model.. (external link)
• Rahman, Mohummad Aminur; Navarro, Andrea Gras; Brekke, Jorunn et al. (2019). Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival. (external link)
• Aasebø, Elise; Berven, Frode; Bartaula-Brevik, Sushma et al. (2019). Proteome and phosphoproteome changes associated with prognosis in acute myeloid leukemia. (external link)
• Nepstad, Ina; Hatfield, Kimberley Joanne; Grønningsæter, Ida Sofie et al. (2019). Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells.. (external link)
• Reis, Luiza C.; Ramos-Sanchez, Eduardo Milton; Petitto-Assis, Fabricio et al. (2018). Insulin-Like Growth Factor-I as an Effector Element of the Cytokine IL-4 in the Development of a Leishmania major Infection. (external link)
• Nepstad, Ina; Hatfield, Kimberley Joanne; Aasebø, Elise et al. (2018). Two acute myeloid leukemia patient subsets are identified based on the constitutive PI3K-Akt-mTOR signaling of their leukemic cells; a functional, proteomic and transcriptomic comparison. (external link)
• Kleppe, Rune; Jonassen, Inge; Doskeland, Stein Ove et al. (2018). Mathematical modelling of nitric oxide/cyclic GMP/cyclic AMP signalling in platelets. (external link)
• Wangen, Rebecca; Aasebø, Elise; Trentani, Andrea et al. (2018). Preservation Method and Phosphate Buffered Saline Washing Affect the Acute Myeloid Leukemia Proteome. (external link)
• Forthun, Rakel Brendsdal; Aasebø, Elise; Rasinger, Josef Daiel et al. (2017). Phosphoprotein DIGE profiles reflect blast differentiation, cytogenetic risk stratification, FLT3/NPM1 mutations and therapy response in acute myeloid leukaemia. (external link)
• Kopperud, Reidun Kristin; Rygh, Cecilie Brekke; Karlsen, Tine Veronica et al. (2017). Increased microvascular permeability in mice lacking Epac1 (Rapgef3). (external link)
• Nygaard, Gyrid; Herfindal, Lars; Åsrud, Kathrine Sivertsen et al. (2017). Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. (external link)
• Hernandez-Valladares, Maria; Aasebø, Elise; Mjaavatten, Olav et al. (2016). Reliable FASP-based procedures for optimal quantitative proteomic and phosphoproteomic analysis on samples from acute myeloid leukemia patients. (external link)
• Forthun, Rakel Brendsdal; Hinrichs, Carina; Dowling, Tara Helen et al. (2016). The past, present and future subclassification of patients with acute Myeloid Leukemia. (external link)
• Aasebø, Elise; Mjaavatten, Olav; Vaudel, Marc et al. (2016). Freezing effects on the acute myeloid leukemia cell proteome and phosphoproteome revealed using optimal quantitative workflows. (external link)
• Aasebø, Elise; Forthun, Rakel Brendsdal; Berven, Frode et al. (2016). Global cell proteome profiling, phospho-signaling and quantitative proteomics for identification of new biomarkers in acute myeloid leukemia patients. (external link)
• Vaudel, Marc; Barsnes, Harald; Bjerkvig, Rolf et al. (2016). Practical considerations for omics experiments in biomedical sciences. (external link)
• Sanchez, Luis Francisco Hernandez; Aasebø, Elise; Selheim, Frode et al. (2016). Systemic Analysis of Regulated Functional Networks. (external link)
• Sleire, Linda; Skeie, Bente Sandvei; Netland, Inger Anne et al. (2015). Drug repurposing: Sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc<sup>-</sup>, leading to glutathione depletion. (external link)
• Aasebø, Elise; Vaudel, Marc; Mjaavatten, Olav et al. (2014). Performance of super-SILAC based quantitative proteomics for comparison of different acute myeloid leukemia (AML) cell lines. (external link)
• Nygaard, Gyrid; Herfindal, Lars; Kopperud, Reidun Kristin et al. (2014). Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. (external link)
• Nilsson, Carol L.; Berven, Frode; Selheim, Frode et al. (2013). Chromosome 19 annotations with disease speciation: a first report from the Global Research Consortium. (external link)
• Myhren, Lene Elisabeth; Nygaard, Gyrid; Gausdal, Gro et al. (2013). Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. (external link)
• Herfindal, Lars; Nygaard, Gyrid; Kopperud, Reidun Kristin et al. (2013). Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. (external link)
• Mjaavatten, Olav; Nygaard, Gyrid; Berven, Frode et al. (2012). Minimization of side reactions during Lys Tag derivatization of C-terminal lysine peptides. (external link)
• Jensen, Baard Olav; Kleppe, Rune; Kopperud, Reidun Kristin et al. (2011). Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. (external link)
• Herfindal, Lars; Myhren, Lene Elisabeth; Kleppe, Rune et al. (2011). Nostocyclopeptide-M1: A potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and 1B1. (external link)
• Jensen, Baard Olav; Kleppe, Rune; Kopperud, Reidun Kristin et al. (2010). Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. (external link)
• Jokela, Jouni; Herfindal, Lars; Wahlsten, Matti et al. (2010). A novel cyanobacterial nostocyclopeptide is a potent antitoxin against microcystins. (external link)
• Oftedal, Linn Silje Wathne; Selheim, Frode; Wahlsten, Matti et al. (2010). Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes. (external link)
• Oveland, Eystein; Gjertsen, Bjørn Tore; Wergeland, Line et al. (2009). Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells. (external link)
• Birkeland, Even; Nygaard, G; Oveland, Eystein et al. (2009). Epac-induced Alterations in the Proteome of Human SH-SY5Y Neuroblastoma Cells. (external link)
• Chekenya, Martha; Krakstad, Camilla; Svendsen, Agnete et al. (2008). The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling. (external link)
• Herfindal, Lars; Selheim, Frode; Oftedal, Linn Silje Wathne et al. (2005). A high proportion of Baltic Sea benthic cyanobacterial isolates contain apoptogens able to induce rapid death of isolated rat hepatocytes. (external link)
• Selheim, Frode; Herfindal, Lars; Martins, Rosario et al. (2005). Neuro-apoptogenic and blood platelet targeting toxins in benthic marine cyanobacteria from the Portuguese coast. (external link)
• Jensen, BO; Selheim, Frode; Døskeland, Stein Ove et al. (2004). Protein kinase A mediates inhibition of the thrombin-induced platelet shape change by nitric oxide. (external link)
• Christensen, Anne Elisabeth; Selheim, Frode; Rooij, Johan de et al. (2003). cAMP analog mapping of Epac1 and camp kinase: discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. (external link)
• Kopperud, Reidun; Krakstad, Camilla; Selheim, Frode et al. (2003). cAMP effector mechanisms. Novel twists for an "old" signaling system. (external link)
• Selheim, Frode; Holmsen, Holm; Vassbotn, Flemming S (2002). Identification of functional VEGF receptors on human platelets. (external link)
• Selheim, Frode; Herfindal, Lars; Knutsen, Gjert et al. (2001). Alterations in platelet phospholipid metabolism by substances from a marine microalgae. (external link)
• Selheim, Frode; Frøyset, Ann Kristin; Strand, Ingrid et al. (2000). Adrenaline potentiates PI 3-kinase in platelets stimulated with thrombin and SFRLLN: role of secreted ADP. (external link)
• Selheim, Frode; Holmsen, Holm A; Vassbotn, Flemming S (2000). PI 3-kinase signalling in platelets: the significance of synergistic, autocrine stimulation. (external link)
• Selheim, Frode; Fukami, Miriam; Holmsen, Holm A et al. (2000). Platelet-derived-growth-factor-induced signalling in human platelets: phosphoinositide-3-kinase-dependent inhibition of platelet activation. (external link)
• Selheim, Frode; Frøyset, Ann Kristin; Strand, Ingrid et al. (2000). Adrenaline potentiates PI 3-kinase in platelets stimulated with thrombin and SFRLLN: role of secreted ADP. (external link)
• Selheim, Frode; Holmsen, Holm A; Vassbotn, Flemming (2000). PI 3-kinase signalling in platelets: the significance of synergistic, autocrine stimulation. (external link)
• Selheim, Frode; Fukami, Miriam; Holmsen, Holm A et al. (2000). Platelet-derived-growth-factor-induced signalling in human platelets: phosphoinositide-3-kinase-dependent inhibition of platelet activation. (external link)
• Selheim, Frode; Holmsen, Holm A; Vassbotn, Flemming (1999). Platelet-Derived Growth Factor Inhibits Platelet Activation in Heparinized Whole Blood. (external link)
• Selheim, Frode; Idsøe, Randi Norunn; Fukami, Miriam et al. (1999). Formation of PI 3-Kinase Products in Platelets by Thrombin, but Not Collagen, is Dependent on Synergistic Autocrine Stimulation, Particularly through Secreted ADP. (external link)
• Selheim, Frode; Holmsen, Holm A; Vassbotn, Flemming S (1999). S:Platelet-derived growth factor (PDGF) inhibits platelet activation in whole blood. (external link)
• Selheim, Frode; Idsøe, Randi N.; Fukami, Miriam et al. (1999). Formation of PI 3-kinase products in platelets by thrombin, but not by collagen, is dependent on synergistic autocrine activation stimulation, particularly through secreted ADP. (external link)
• Selheim, Frode; Vassbotn, Flemming; Holmsen, Holm A (1996). Effect of platelet derived growth factor on platelets, an example of autocrine inhibition. (external link)

Editorial

• Selheim, Frode (2019). Targeted and Immune-Based Therapies for Acute Myeloid Leukemia: Inflammatory Signaling and Multiple Post-Translational Modifications. (external link)
• Selheim, Frode; Herfindal, Lars (2016). Editorial: Toward Personalized Treatment for Acute Myeloid Leukemia. (external link)
• Selheim, Frode; Herfindal, Lars (2016). Toward personalized treatment for acute myeloid leukemia. (external link)
• Selheim, Frode (2006). Proteomic Technologies in Translational Medicine. (external link)

Reader opinion piece

• Brenner, Annette; Aasebø, Elise; Hernandez-Valladares, Maria et al. (2017). Rethinking the role of osteopontin in human acute myeloid leukemia. (external link)

Masters thesis

• Wangen, Rebecca; Selheim, Frode (2017). Optimization of Sample Preparation for Mass Spectrometry-Based Quantitative Analysis of All-Trans Retinoic Acid and Valproic Acid Treated Acute Myeloid Leukemia Patients. (external link)
• Berven, Frode; Vethe, Heidrun; Selheim, Frode (2012). Mass spectrometry-based proteomics of human cerebrospinal fluid. Biomarker discovery and verification in multiple sclerosis. (external link)
• Guldbransen, Astrid; Berven, Frode; Selheim, Frode (2012). Glycoproteomics in Human Cerebrospinal Fluid Mapping the CSF Proteome, and Biomarker Discovery and Qualification in Multiple Sclerosis. (external link)
• Kleppe, Anne Cecilie; Selheim, Frode (2012). Inhibition of platelet surface expression of P-selectin by site-selective synergistic pairs of cAMP Analogs. (external link)
• Aasebø, Elise; Berven, Frode; Selheim, Frode (2011). A proteomics study of Cerebrospinal fluid in relation to biomarker discovery and verification in Multiple Sclerosis, with emphasis on the effect of pre-analytical factors. (external link)
• Bjørlykke, Yngvild; Berven, Frode; Selheim, Frode (2011). Proteomics in Cerebrospinal fluid: Finding proteins highly enriched in CSF, proteins influenced by the rostro-caudal gradient, and biomarker verification in Multiple Sclerosis. (external link)
• Selheim, Frode; Krakstad, Camilla; Birkeland, Even (2008). Quantitative proteomics of Epac signaling in differentiating human SH-SY5Y neuroblastoma cells. (external link)
• Larsen, Maria Helen Kurki; Selheim, Frode; Herfindal, Lars (2008). Platelet inhibitory compounds from marine microorganisms. (external link)
• Ljones, Marie Louise; Krakstad, Camilla; Selheim, Frode (2008). Epac-induced neuronal differentiation of Human SH-SY5Y neuroblastoma cells. (external link)
• Hashmi, Awais Muzammal; Holmsen, Holm A; Selheim, Frode et al. (2005). The functional quality of INTERCEPT – treated platelets during storage. (external link)
• Hagland, Hanne; Selheim, Frode; Doskeland, Stein Ove (2005). Cyclic AMP dependent protein kinase (cAPK) and exchange protein directly activated by cAMP (Epac) signaling in Rat pheochromocytoma PC12 and Human Neuroblastma SH-SY5Y cell line. (external link)
• Selheim, Frode (1995). c-fos mRNA prosessing i nomale og tumorigne C3H/10T1/2 celler. Hovedoppgave (cand.scient.). (external link)

Academic chapter/article/Conference paper

• Aasebø, Elise; Berven, Frode; Selheim, Frode et al. (2016). Interpretation of Quantitative Shotgun Proteomic Data. (external link)

Poster

• Mjaavatten, Olav; Nygård, Gyrid; Selheim, Frode (2010). Peptide Side-Products of Lys Tag Derivatization reaction. (external link)
• Herfindal, Lars; Myhren, Lene Elisabeth; Kleppe, Rune et al. (2010). Liver specific transporters of microcystins as a tool to find novel inhibitors of OATP1B1 and OATP1B3. (external link)
• Garberg, Hilde Kristin; Opsahl, Jill Anette; Arntzen, Magnus et al. (2009). Proteomic Unit at UoB (PROBE) The Norwegian Proteomics centre. (external link)
• Birkeland, Even; Nygård, Gyrid; Selheim, Frode (2009). Epac-induced changes in the proteome of human SH-SY5Y neuroblastoma cells. (external link)
• Mjaavatten, Olav; Selheim, Frode (2009). Possible side-chemistries with guanidino labeling strategies of C-terminal lysine‐peptides: Effect of different derivatization conditions. (external link)
• Kleppe, Rune; Selheim, Frode; Doskeland, Stein Ove (2007). Compartment modeling of nitric-oxide mediated activation of the cAMP-dependent protein kinase in platelets. (external link)
• Fladmark, Kari; Selheim, Frode (2006). PROBE – nasjonal platform for proteomikk. NBS – Nytt 3/2006: 32-35. (external link)
• Prestegard, S; Hatfield, Kimberley Joanne; Knutsen, G. et al. (2005). Searching cyanobacteria and microalgae from Norwegian waters for drug candidates. (external link)
• Herfindal, Lars; Selheim, Frode; Aursland, Kjetil et al. (2002). Effects of a new bioactive substance from a marine microalga on mammalian cells. (external link)
• Herfindal, Lars; Selheim, Frode; Knutsen, Gjert et al. (2001). New apoptosis-modulating substances from marine microalgae. (external link)
• Herfindal, Lars; Krakstad, Camilla; Selheim, Frode et al. (2001). TWO NOVEL APOPTOSIS-MODULATION SUBSTANCES ISOLATED FROM MARINE MICRO-ALGAE. (external link)

Academic lecture

• Selheim, Frode (2009). Proteomikk nettverket. Hvordan er det organisert og hva kan vi tilby. (external link)
• Selheim, Frode (2009). Proteomic-plattformen - PROBE. (external link)
• Kopperud, Reidun; Krakstad, Camilla; Selheim, Frode et al. (2003). cAMP effector mechanisms. Novel twists for an "old" signalling system. (external link)
• Herfindal, Lars; Selheim, Frode; Knutsen, Gjert et al. (2002). New apoptosis-modulating substances from marine microalgae. (external link)

Report

• Hagland, Hanne; Selheim, Frode; Keen, TJ et al. (2005). The cAMP Receptors Epac and PKA synergize to induce PC12 cell neuritogenesis and to protect against apoptosis. (external link)
• Tharmapathy, Pasupathy; Selheim, Frode; Ødegaard, Ketil Joachim et al. (2000). Venlafaxine Treatment Stimulates Blood Platelet Activity. (external link)

Doctoral dissertation

• Selheim, Frode (1999). Autocrine signalling and PDGF-induced inhibition of human platelet activation. (external link)

See a complete overview of publications in Cristin.