Academic article

• Frode Selheim; Elise Aasebø; Håkon Reikvam et al. (2025). Proteomic Comparison of Acute Myeloid Leukemia Cells and Normal CD34⁺Bone Marrow Cells: Studies of Leukemia Cell Differentiation and Regulation of Iron Metabolism/Ferroptosis. (external link)
• Frode Selheim; Elise Aasebø; Håkon Reikvam et al. (2024). Monocytic Differentiation of Human Acute Myeloid Leukemia Cells: A Proteomic and Phosphoproteomic Comparison of FAB-M4/M5 Patients with and without Nucleophosmin 1 Mutations. (external link)
• Frode Selheim; Elise Aasebø; Øystein Bruserud et al. (2024). High Mitochondrial Protein Expression as a Potential Predictor of Relapse Risk in Acute Myeloid Leukemia Patients with the Monocytic FAB Subtypes M4 and M5. (external link)
• Sushma Bartaula-Brevik; Calum Leitch; Maria del Carmen Hernandez Valladares et al. (2023). Vacuolar ATPase Is a Possible Therapeutic Target in Acute Myeloid Leukemia: Focus on Patient Heterogeneity and Treatment Toxicity. (external link)
• Shahin Sarowar; Davide Cirillo; Pablo Játiva et al. (2022). The styryl benzoic acid derivative DC10 potentiates radiotherapy by targeting the xCT-glutathione axis. (external link)
• Ida Sofie Grønningsæter; Håkon Reikvam; Elise Aasebø et al. (2021). Effects of the autophagy‐inhibiting agent chloroquine on acute myeloid leukemia cells; characterization of patient heterogeneity. (external link)
• Elise Aasebø; Annette Brenner; Maria Hernandez-Valladares et al. (2021). Patient Heterogeneity in Acute Myeloid Leukemia: Leukemic Cell Communication by Release of Soluble Mediators and Its Effects on Mesenchymal Stem Cells. (external link)
• Elise Aasebø; Annette Brenner; Maria Hernandez-Valladares et al. (2021). Proteomic Characterization of Spontaneous Stress-Induced In Vitro Apoptosis of Human Acute Myeloid Leukemia Cells; Focus on Patient Heterogeneity and Endoplasmic Reticulum Stress. (external link)
• Elise Aasebø; Annette Brenner; Maria Hernandez-Valladares et al. (2021). Proteomic comparison of bone marrow derived osteoblasts and mesenchymal stem cells. (external link)
• Elise Aasebø; Annette Brenner; Even Birkeland et al. (2021). The constitutive extracellular protein release by acute myeloid leukemia cells—A proteomic study of patient heterogeneity and its modulation by mesenchymal stromal cells. (external link)
• Maria Hernandez-Valladares; Rebecca Wangen; Elise Aasebø et al. (2021). Proteomic studies of primary acute myeloid leukemia cells derived from patients before and during disease-stabilizing treatment based on all-trans retinoic acid and valproic acid. (external link)
• Elise Aasebø; Frode Berven; Sushma Bartaula-Brevik et al. (2020). Proteome and Phosphoproteome Changes Associated with Prognosis in Acute Myeloid Leukemia. (external link)
• Maria Hernandez-Valladares; Elise Aasebø; Frode Berven et al. (2020). Biological characteristics of aging in human acute myeloid leukemia cells: the possible importance of aldehyde dehydrogenase, the cytoskeleton and altered transcriptional regulation. (external link)
• Elise Aasebø; Even Birkeland; Frode Selheim et al. (2020). The extracellular bone marrow microenvironment — a proteomic comparison of constitutive protein release by in vitro cultured osteoblasts and mesenchymal stem cells. (external link)
• Elise Aasebø; Frode Berven; Randi Hovland et al. (2020). The progression of acute myeloid leukemia from first diagnosis to chemoresistant relapse: A comparison of proteomic and phosphoproteomic profiles. (external link)
• Kathrine Sivertsen Åsrud; Line Pedersen; Reidun Aesoy et al. (2019). Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy. (external link)
• Annette Brenner; Elise Aasebø; Maria Hernandez-Valladares et al. (2019). The capacity of long-term in vitro proliferation of acute myeloid leukemia cells supported only by exogenous cytokines is associated with a patient subset with adverse outcome. (external link)
• Elise Aasebø; Maria Hernandez-Valladares; Frode Selheim et al. (2019). Proteomic profiling of primary human acute myeloid leukemia cells does not reflect their constitutive release of soluble mediators. (external link)
• Maria Kathrine Tveitarås; Frode Selheim; Kristina Sortland et al. (2019). Protein expression profiling of plasma and lungs at different stages of metastatic development in a human triple negative breast cancer xenograft model.. (external link)
• Mohummad Aminur Rahman; Andrea Gras Navarro; Jorunn Brekke et al. (2019). Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival. (external link)
• Elise Aasebø; Frode Berven; Sushma Bartaula-Brevik et al. (2019). Proteome and phosphoproteome changes associated with prognosis in acute myeloid leukemia. (external link)
• Ina Nepstad; Kimberley Joanne Hatfield; Ida Sofie Grønningsæter et al. (2019). Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells.. (external link)
• Luiza C. Reis; Eduardo Milton Ramos-Sanchez; Fabricio Petitto-Assis et al. (2018). Insulin-Like Growth Factor-I as an Effector Element of the Cytokine IL-4 in the Development of a Leishmania major Infection. (external link)
• Ina Nepstad; Kimberley Joanne Hatfield; Elise Aasebø et al. (2018). Two acute myeloid leukemia patient subsets are identified based on the constitutive PI3K-Akt-mTOR signaling of their leukemic cells; a functional, proteomic and transcriptomic comparison. (external link)
• Rune Kleppe; Inge Jonassen; Stein Ove Doskeland et al. (2018). Mathematical modelling of nitric oxide/cyclic GMP/cyclic AMP signalling in platelets. (external link)
• Rebecca Wangen; Elise Aasebø; Andrea Trentani et al. (2018). Preservation Method and Phosphate Buffered Saline Washing Affect the Acute Myeloid Leukemia Proteome. (external link)
• Rakel Brendsdal Forthun; Elise Aasebø; Josef Daiel Rasinger et al. (2017). Phosphoprotein DIGE profiles reflect blast differentiation, cytogenetic risk stratification, FLT3/NPM1 mutations and therapy response in acute myeloid leukaemia. (external link)
• Reidun Kristin Kopperud; Cecilie Brekke Rygh; Tine Veronica Karlsen et al. (2017). Increased microvascular permeability in mice lacking Epac1 (Rapgef3). (external link)
• Gyrid Nygaard; Lars Herfindal; Kathrine Sivertsen Åsrud et al. (2017). Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. (external link)
• Maria Hernandez-Valladares; Elise Aasebø; Olav Mjaavatten et al. (2016). Reliable FASP-based procedures for optimal quantitative proteomic and phosphoproteomic analysis on samples from acute myeloid leukemia patients. (external link)
• Rakel Brendsdal Forthun; Carina Hinrichs; Tara Helen Dowling et al. (2016). The past, present and future subclassification of patients with acute Myeloid Leukemia. (external link)
• Elise Aasebø; Olav Mjaavatten; Marc Vaudel et al. (2016). Freezing effects on the acute myeloid leukemia cell proteome and phosphoproteome revealed using optimal quantitative workflows. (external link)
• Elise Aasebø; Rakel Brendsdal Forthun; Frode Berven et al. (2016). Global cell proteome profiling, phospho-signaling and quantitative proteomics for identification of new biomarkers in acute myeloid leukemia patients. (external link)
• Marc Vaudel; Harald Barsnes; Rolf Bjerkvig et al. (2016). Practical considerations for omics experiments in biomedical sciences. (external link)
• Luis Francisco Hernandez Sanchez; Elise Aasebø; Frode Selheim et al. (2016). Systemic Analysis of Regulated Functional Networks. (external link)
• Linda Sleire; Bente Sandvei Skeie; Inger Anne Netland et al. (2015). Drug repurposing: Sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc<sup>-</sup>, leading to glutathione depletion. (external link)
• Elise Aasebø; Marc Vaudel; Olav Mjaavatten et al. (2014). Performance of super-SILAC based quantitative proteomics for comparison of different acute myeloid leukemia (AML) cell lines. (external link)
• Gyrid Nygaard; Lars Herfindal; Reidun Kristin Kopperud et al. (2014). Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. (external link)
• Carol L. Nilsson; Frode Berven; Frode Selheim et al. (2013). Chromosome 19 annotations with disease speciation: a first report from the Global Research Consortium. (external link)
• Lene Elisabeth Myhren; Gyrid Nygaard; Gro Gausdal et al. (2013). Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. (external link)
• Lars Herfindal; Gyrid Nygaard; Reidun Kristin Kopperud et al. (2013). Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. (external link)
• Olav Mjaavatten; Gyrid Nygaard; Frode Berven et al. (2012). Minimization of side reactions during Lys Tag derivatization of C-terminal lysine peptides. (external link)
• Baard Olav Jensen; Rune Kleppe; Reidun Kristin Kopperud et al. (2011). Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. (external link)
• Lars Herfindal; Lene Elisabeth Myhren; Rune Kleppe et al. (2011). Nostocyclopeptide-M1: A potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and 1B1. (external link)
• Baard Olav Jensen; Rune Kleppe; Reidun Kristin Kopperud et al. (2010). Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. (external link)
• Jouni Jokela; Lars Herfindal; Matti Wahlsten et al. (2010). A novel cyanobacterial nostocyclopeptide is a potent antitoxin against microcystins. (external link)
• Linn Silje Wathne Oftedal; Frode Selheim; Matti Wahlsten et al. (2010). Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes. (external link)
• Eystein Oveland; Bjørn Tore Gjertsen; Line Wergeland et al. (2009). Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells. (external link)
• Even Birkeland; G Nygaard; Eystein Oveland et al. (2009). Epac-induced Alterations in the Proteome of Human SH-SY5Y Neuroblastoma Cells. (external link)
• Martha Chekenya; Camilla Krakstad; Agnete Svendsen et al. (2008). The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling. (external link)
• Lars Herfindal; Frode Selheim; Linn Silje Wathne Oftedal et al. (2005). A high proportion of Baltic Sea benthic cyanobacterial isolates contain apoptogens able to induce rapid death of isolated rat hepatocytes. (external link)
• Frode Selheim; Lars Herfindal; Rosario Martins et al. (2005). Neuro-apoptogenic and blood platelet targeting toxins in benthic marine cyanobacteria from the Portuguese coast. (external link)
• BO Jensen; Frode Selheim; Stein Ove Døskeland et al. (2004). Protein kinase A mediates inhibition of the thrombin-induced platelet shape change by nitric oxide. (external link)
• Anne Elisabeth Christensen; Frode Selheim; Johan de Rooij et al. (2003). cAMP analog mapping of Epac1 and camp kinase: discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. (external link)
• Reidun Kopperud; Camilla Krakstad; Frode Selheim et al. (2003). cAMP effector mechanisms. Novel twists for an "old" signaling system. (external link)
• Frode Selheim; Holm Holmsen; Flemming S Vassbotn (2002). Identification of functional VEGF receptors on human platelets. (external link)
• Frode Selheim; Lars Herfindal; Gjert Knutsen et al. (2001). Alterations in platelet phospholipid metabolism by substances from a marine microalgae. (external link)
• Frode Selheim; Ann Kristin Frøyset; Ingrid Strand et al. (2000). Adrenaline potentiates PI 3-kinase in platelets stimulated with thrombin and SFRLLN: role of secreted ADP. (external link)
• Frode Selheim; Holm A Holmsen; Flemming S Vassbotn (2000). PI 3-kinase signalling in platelets: the significance of synergistic, autocrine stimulation. (external link)
• Frode Selheim; Miriam Fukami; Holm A Holmsen et al. (2000). Platelet-derived-growth-factor-induced signalling in human platelets: phosphoinositide-3-kinase-dependent inhibition of platelet activation. (external link)
• Frode Selheim; Ann Kristin Frøyset; Ingrid Strand et al. (2000). Adrenaline potentiates PI 3-kinase in platelets stimulated with thrombin and SFRLLN: role of secreted ADP. (external link)
• Frode Selheim; Holm A Holmsen; Flemming Vassbotn (2000). PI 3-kinase signalling in platelets: the significance of synergistic, autocrine stimulation. (external link)
• Frode Selheim; Miriam Fukami; Holm A Holmsen et al. (2000). Platelet-derived-growth-factor-induced signalling in human platelets: phosphoinositide-3-kinase-dependent inhibition of platelet activation. (external link)
• Frode Selheim; Holm A Holmsen; Flemming Vassbotn (1999). Platelet-Derived Growth Factor Inhibits Platelet Activation in Heparinized Whole Blood. (external link)
• Frode Selheim; Randi Norunn Idsøe; Miriam Fukami et al. (1999). Formation of PI 3-Kinase Products in Platelets by Thrombin, but Not Collagen, is Dependent on Synergistic Autocrine Stimulation, Particularly through Secreted ADP. (external link)
• Frode Selheim; Holm A Holmsen; Flemming S Vassbotn (1999). S:Platelet-derived growth factor (PDGF) inhibits platelet activation in whole blood. (external link)
• Frode Selheim; Randi N. Idsøe; Miriam Fukami et al. (1999). Formation of PI 3-kinase products in platelets by thrombin, but not by collagen, is dependent on synergistic autocrine activation stimulation, particularly through secreted ADP. (external link)
• Frode Selheim; Flemming Vassbotn; Holm A Holmsen (1996). Effect of platelet derived growth factor on platelets, an example of autocrine inhibition. (external link)

Academic book chapter

• Elise Aasebø; Frode Berven; Frode Selheim et al. (2016). Interpretation of Quantitative Shotgun Proteomic Data. (external link)

Academic literature review

• Øystein Bruserud; Frode Selheim; Maria del Carmen Hernandez Valladares et al. (2025). XPO1/Exportin-1 in Acute Myelogenous Leukemia; Biology and Therapeutic Targeting. (external link)
• Øystein Bruserud; Frode Selheim; Maria del Carmen Hernandez Valladares et al. (2024). Monocytic Differentiation in Acute Myeloid Leukemia Cells: Diagnostic Criteria, Biological Heterogeneity, Mitochondrial Metabolism, Resistance to and Induction by Targeted Therapies. (external link)
• Paula Carrillo Rodriguez; Frode Selheim; Maria del Carmen Hernandez Valladares (2023). Mass Spectrometry-Based Proteomics Workflows in Cancer Research: The Relevance of Choosing the Right Steps. (external link)
• Maria Hernandez-Valladares; Øystein Bruserud; Frode Selheim (2020). The implementation of mass spectrometry-based proteomics workflows in clinical routines of acute myeloid leukemia: Applicability and perspectives. (external link)
• Frode Selheim; Elise Aasebø; Catalina Ribas et al. (2019). An overview on G protein-coupled receptor-induced signal transduction in acute myeloid leukemia. (external link)
• Maria Hernandez-Valladares; Marc Vaudel; Frode Selheim et al. (2017). Proteogenomics approaches for studying cancer biology and their potential in the identification of acute myeloid leukemia biomarkers. (external link)
• Maria Hernandez-Valladares; Elise Aasebø; Frode Selheim et al. (2016). Selecting Sample Preparation Workflows for Mass Spectrometry-Based Proteomic and Phosphoproteomic Analysis of Patient Samples with Acute Myeloid Leukemia. (external link)
• Rune Kleppe; Camilla Krakstad; Frode Selheim et al. (2011). The cAMP-dependent protein kinase pathway as therapeutic target - possibilities and pitfalls. (external link)
• Rune Kleppe; Endre Kjærland; Frode Selheim (2006). Proteomic and computational methods in systems modeling of cellular signaling. (external link)
• Lars Herfindal; Frode Selheim (2006). Microcystin produces disparate effects on liver cells in a dose dependent manner. (external link)

Conference lecture

• Frode Selheim (2009). Proteomikk nettverket. Hvordan er det organisert og hva kan vi tilby. (external link)
• Frode Selheim (2009). Proteomic-plattformen - PROBE. (external link)
• Reidun Kopperud; Camilla Krakstad; Frode Selheim et al. (2003). cAMP effector mechanisms. Novel twists for an "old" signalling system. (external link)
• Lars Herfindal; Frode Selheim; Gjert Knutsen et al. (2002). New apoptosis-modulating substances from marine microalgae. (external link)

Conference poster

• Ragnhild Marie Mellingen; Christine Tewa Toffa Komano; Stian Mjelde et al. (2026). Hunting high and low - a search for blood and urine biomarkers in divers. (external link)
• Olav Mjaavatten; Gyrid Nygård; Frode Selheim (2010). Peptide Side-Products of Lys Tag Derivatization reaction. (external link)
• Lars Herfindal; Lene Elisabeth Myhren; Rune Kleppe et al. (2010). Liver specific transporters of microcystins as a tool to find novel inhibitors of OATP1B1 and OATP1B3. (external link)
• Hilde Kristin Garberg; Jill Anette Opsahl; Magnus Arntzen et al. (2009). Proteomic Unit at UoB (PROBE) The Norwegian Proteomics centre. (external link)
• Even Birkeland; Gyrid Nygård; Frode Selheim (2009). Epac-induced changes in the proteome of human SH-SY5Y neuroblastoma cells. (external link)
• Olav Mjaavatten; Frode Selheim (2009). Possible side-chemistries with guanidino labeling strategies of C-terminal lysine‐peptides: Effect of different derivatization conditions. (external link)
• Rune Kleppe; Frode Selheim; Stein Ove Doskeland (2007). Compartment modeling of nitric-oxide mediated activation of the cAMP-dependent protein kinase in platelets. (external link)
• Kari Fladmark; Frode Selheim (2006). PROBE – nasjonal platform for proteomikk. NBS – Nytt 3/2006: 32-35. (external link)
• S Prestegard; Kimberley Joanne Hatfield; G. Knutsen et al. (2005). Searching cyanobacteria and microalgae from Norwegian waters for drug candidates. (external link)
• Lars Herfindal; Frode Selheim; Kjetil Aursland et al. (2002). Effects of a new bioactive substance from a marine microalga on mammalian cells. (external link)
• Lars Herfindal; Frode Selheim; Gjert Knutsen et al. (2001). New apoptosis-modulating substances from marine microalgae. (external link)
• Lars Herfindal; Camilla Krakstad; Frode Selheim et al. (2001). TWO NOVEL APOPTOSIS-MODULATION SUBSTANCES ISOLATED FROM MARINE MICRO-ALGAE. (external link)

Doctoral thesis (PhD)

• Frode Selheim (1999). Autocrine signalling and PDGF-induced inhibition of human platelet activation. (external link)

Editorial/Leader article

• Frode Selheim (2019). Targeted and Immune-Based Therapies for Acute Myeloid Leukemia: Inflammatory Signaling and Multiple Post-Translational Modifications. (external link)
• Frode Selheim; Lars Herfindal (2016). Editorial: Toward Personalized Treatment for Acute Myeloid Leukemia. (external link)
• Frode Selheim; Lars Herfindal (2016). Toward personalized treatment for acute myeloid leukemia. (external link)
• Frode Selheim (2006). Proteomic Technologies in Translational Medicine. (external link)

Letter to the editor

• Annette Brenner; Elise Aasebø; Maria Hernandez-Valladares et al. (2017). Rethinking the role of osteopontin in human acute myeloid leukemia. (external link)

Master’s thesis

• Rebecca Wangen; Frode Selheim (2017). Optimization of Sample Preparation for Mass Spectrometry-Based Quantitative Analysis of All-Trans Retinoic Acid and Valproic Acid Treated Acute Myeloid Leukemia Patients. (external link)
• Frode Berven; Heidrun Vethe; Frode Selheim (2012). Mass spectrometry-based proteomics of human cerebrospinal fluid. Biomarker discovery and verification in multiple sclerosis. (external link)
• Astrid Guldbransen; Frode Berven; Frode Selheim (2012). Glycoproteomics in Human Cerebrospinal Fluid Mapping the CSF Proteome, and Biomarker Discovery and Qualification in Multiple Sclerosis. (external link)
• Anne Cecilie Kleppe; Frode Selheim (2012). Inhibition of platelet surface expression of P-selectin by site-selective synergistic pairs of cAMP Analogs. (external link)
• Elise Aasebø; Frode Berven; Frode Selheim (2011). A proteomics study of Cerebrospinal fluid in relation to biomarker discovery and verification in Multiple Sclerosis, with emphasis on the effect of pre-analytical factors. (external link)
• Yngvild Bjørlykke; Frode Berven; Frode Selheim (2011). Proteomics in Cerebrospinal fluid: Finding proteins highly enriched in CSF, proteins influenced by the rostro-caudal gradient, and biomarker verification in Multiple Sclerosis. (external link)
• Frode Selheim; Camilla Krakstad; Even Birkeland (2008). Quantitative proteomics of Epac signaling in differentiating human SH-SY5Y neuroblastoma cells. (external link)
• Maria Helen Kurki Larsen; Frode Selheim; Lars Herfindal (2008). Platelet inhibitory compounds from marine microorganisms. (external link)
• Marie Louise Ljones; Camilla Krakstad; Frode Selheim (2008). Epac-induced neuronal differentiation of Human SH-SY5Y neuroblastoma cells. (external link)
• Awais Muzammal Hashmi; Holm A Holmsen; Frode Selheim et al. (2005). The functional quality of INTERCEPT – treated platelets during storage. (external link)
• Hanne Hagland; Frode Selheim; Stein Ove Doskeland (2005). Cyclic AMP dependent protein kinase (cAPK) and exchange protein directly activated by cAMP (Epac) signaling in Rat pheochromocytoma PC12 and Human Neuroblastma SH-SY5Y cell line. (external link)
• Frode Selheim (1995). c-fos mRNA prosessing i nomale og tumorigne C3H/10T1/2 celler. Hovedoppgave (cand.scient.). (external link)

Research report

• Hanne Hagland; Frode Selheim; TJ Keen et al. (2005). The cAMP Receptors Epac and PKA synergize to induce PC12 cell neuritogenesis and to protect against apoptosis. (external link)
• Pasupathy Tharmapathy; Frode Selheim; Ketil Joachim Ødegaard et al. (2000). Venlafaxine Treatment Stimulates Blood Platelet Activity. (external link)

See a complete overview of publications in NVA.