Helge Ræder
Position
Professor, Vice Dean for Innovation at Faculty of Medicine, Consultant Pediatrician
Affiliation
Research groups
Research
My research aim is to characterize and better understand the major signaling pathways involved in endocrine disease, specifically diabetes development and adreno-gonadal development, by studying developing cells differentiated from induced pluripotent stem cells (iPSCs) generated from families with monogenic disease or other patients with adreno-gonadal conditions.
https://raederlab.w.uib.no/
http://www.uib.no/diabetes/80059/node-6-stamcelleforskning
Outreach
https://raederlab.wordpress.com/
https://www.facebook.com/raederlab/
Teaching
I teach pediatric topics to medical students, including lectures and bedside teaching. My lectures include Growth and Puberty Disorders (MED12) and Intoxication and Fluid Therapy (MED9) (Department of Clinical Science).
I also teach metabolic diseases for Nutrition students (NUC352, Department of Clinical Medicine).
I also contribute to teaching in Master Courses (BMED330; Department of Biomedicine).
I also lead two Elective Courses at the Medical Faculty (Department of Clinical Science):
ELMED303 (Future Medicine)
ELMED223 (Innovation and Entrepeneurship)
I also organize and teach pediatric residents at the Course in Pediatric Endocrinology with topics including Calcium metabolism and case demonstrations.
Publications
2024
- Seljeseth, Ingvild Müller; Sørlie, Henrik; Grønli, Janne et al. (2024). Nightly Sleep and Daily Job Task Performance: An Experience Sampling Study. (external link)
- Wang, Chencheng; Abadpour, Shadab; Olsen, Petter Angell et al. (2024). Glucose Concentration in Regulating Induced Pluripotent Stem Cells Differentiation Toward Insulin-Producing Cells. (external link)
- Wang, Chencheng; Abadpour, Shadab; Aizenshtadt, Aleksandra et al. (2024). Cell identity dynamics and insight into insulin secretagogues when employing stem cell-derived islets for disease modeling. (external link)
2023
- Ali, Hassan Abdel-Raouf Abdel-Wahab; Suliman, Salwa; Osman, Tarig Al-Hadi et al. (2023). Xeno-free generation of human induced pluripotent stem cells from donor-matched fibroblasts isolated from dermal and oral tissues. (external link)
- Scholz, Hanne; Ræder, Helge (2023). Response to Comment on Carrasco et al. Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells. Diabetes 2022;71:862-869. (external link)
2022
- Fernandez, Manuel Carrasco; Wang, Chencheng; Søviknes, Anne Mette et al. (2022). Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells. (external link)
- Kahraman, Sevim; Dirice, Ercument; Basile, Giorgio et al. (2022). Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8. (external link)
- Ekanger, Camilla Tvedt; Zhou, Fan; Bohan, Dana et al. (2022). Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 respiratory virus. (external link)
- Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Scholz, Hanne et al. (2022). Molecular mechanisms affecting islet like cell fate acquisition in differentiating iPSC derived β-like cells”. (external link)
- Sandvei, Marie Søfteland; Jacobsen, Geir Wenberg; Stien, Marianne Heldal et al. (2022). A national intercalated medical student research program –student perceptions, satisfaction, and factors associated with pursuing a PhD. (external link)
- Myklebust, Mette Pernille; Søviknes, Anne Mette; Halvorsen, Ole Johan et al. (2022). MicroRNAs in Differentiation of Embryoid Bodies and the Teratoma Subtype of Testicular Cancer. (external link)
2021
- Wang, Chencheng; Abadpour, Shadab; Aizenshtadt, Alexandra et al. (2021). Glucose during in vitro pancreatic beta cells regeneration: friends or for?. (external link)
- Wang, Chencheng; Abadpour, Shadab; Aizenshtadt, Alexandra et al. (2021). 402.2: High Glucose Concentration Increases KATP Channel Activity but Suppresses Mitochondrial Respiration Ability in Insulin-producing Cells Regenerated From Stem Cells. (external link)
- Choi, Man Hung; Tjora, Erling; Forthun, Rakel Brendsdal et al. (2021). KRAS mutation analysis by droplet digital PCR of duodenal juice from patients with MODY8 and other pancreatic diseases. (external link)
- Hoareau, Laurence; Engelsen, Agnete ; Aanerud, Marianne et al. (2021). Induction of alveolar and bronchiolar phenotypes in human lung organoids. (external link)
- Ghila, Luiza; Legøy, Thomas Aga; Mathisen, Andreas Frøslev et al. (2021). Chronically elevated exogenous glucose elicits antipodal effects on the proteome signature of differentiating human ipsc-derived pancreatic progenitors. (external link)
2020
- Gupta, Manoj K.; Vethe, Heidrun; Softic, Samir et al. (2020). Leptin receptor signaling regulates protein synthesis pathways and neuronal differentiation in pluripotent stem cells. (external link)
- Legøy, Thomas Aga; Vethe, Heidrun; Abadpour, Shadab et al. (2020). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling . (external link)
- Ghila, Luiza; Bjørlykke, Yngvild; Legøy, Thomas Aga et al. (2020). Bioinformatic analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4α mutation. (external link)
2019
- Bjørlykke, Yngvild; Søviknes, Anne Mette; Hoareau, Laurence et al. (2019). Reprogrammed cells display distinct proteomic signaturesAssociated with colony morphology variability. (external link)
- Loo, Larry Sai Weng; Vethe, Heidrun; Soetedjo, Andreas Alvin Purnomo et al. (2019). Dynamic proteome profiling of human pluripotent stem cell-derived pancreatic progenitors. (external link)
- Ng, Natasha Hui Jin; Jasmen, Joanita Binte; Lim, Chang Siang et al. (2019). HNF4A haploinsufficiency in MODY1 abrogates liver and pancreas differentiation from patient-derived induced pluripotent stem cells. (external link)
- Legøy, Thomas Aga; Ghila, Luiza; Vethe, Heidrun et al. (2019). In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. (external link)
- Furuyama, Kenichiro; Chera, Simona; van Gurp, Leon et al. (2019). Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. (external link)
- Vethe, Heidrun; Ghila, Luiza; Berle, Magnus et al. (2019). The effect of WnT pathway modulators on human iPSC-derived pancreatic beta cell maturation. (external link)
- Vethe, Heidrun; Legøy, Thomas Aga; Abadpour, Shadab et al. (2019). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. (external link)
2018
- Johansson, Bente Berg; Fjeld, Karianne; el Jellas, Khadija et al. (2018). The role of the carboxyl ester lipase (CEL) gene in pancreatic disease. (external link)
- Jacobsen, Geir Wenberg; Ræder, Helge; Stien, Marianne Heldal et al. (2018). Springboard to an academic career - A national medical student research program. (external link)
2017
- Vethe, Heidrun; Bjørlykke, Yngvild; Ghila, Luiza et al. (2017). Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells. (external link)
- Verheggen, Kenneth; Ræder, Helge; Berven, Frode et al. (2017). Anatomy and evolution of database search engines—a central component of mass spectrometry based proteomic workflows. (external link)
2016
- Rafaelsen, Silje Hjorth; Johansson, Stefan; Ræder, Helge et al. (2016). Hereditary hypophosphatemia in Norway: A retrospective population-based study of genotypes, phenotypes, and treatment complications. (external link)
- Hernandez Sanchez, Luis Francisco; Aasebø, Elise; Selheim, Frode et al. (2016). Systemic Analysis of Regulated Functional Networks. (external link)
- Vaudel, Marc; Barsnes, Harald; Ræder, Helge et al. (2016). Using Proteomics Bioinformatics Tools and Resources in Proteogenomic Studies. (external link)
- Teo, Adrian Kee Keong; Lau, Hwee Hui; Valdez, Ivan Achel et al. (2016). Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia. (external link)
- Vaudel, Marc; Verheggen, Kenneth; Csordas, Attila et al. (2016). Exploring the potential of public proteomics data. (external link)
2014
- Bjørlykke, Yngvild; Vethe, Heidrun; Vaudel, Marc et al. (2014). Carboxyl-ester lipase maturity-onset diabetes of the young disease protein biomarkers in secretin-stimulated duodenal juice. (external link)
- Rafaelsen, Silje Hjorth; Johansson, Stefan; Ræder, Helge et al. (2014). Long-term clinical outcome and phenotypic variability in hyperphosphatemic familial tumoral calcinosis and hyperphosphatemic hyperostosis syndrome caused by a novel GALNT3 mutation; case report and review of the literature. (external link)
- Ræder, Helge; McAllister, Fiona E.; Tjora, Erling et al. (2014). Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid. (external link)
2013
- Teo, Adrian K.K.; Windmueller, Rebecca; Johansson, Bente Berg et al. (2013). Derivation of Human Induced Pluripotent Stem Cells from Patients with Maturity Onset Diabetes of the Young. (external link)
- Søvik, Oddmund; Irgens, Henrik Underthun; Molnes, Janne et al. (2013). Monogenetic diabetes mellitus in Norway :. (external link)
- Ræder, Helge; Vesterhus, Mette; El Ouaamari, Abdelfattah et al. (2013). Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (Maturity-Onset Diabetes of the young). (external link)
- Rafaelsen, Silje Hjorth; Ræder, Helge; Fagerheim, Anne Kristine et al. (2013). Exome sequencing reveals FAM20c mutations associated with fibroblast growth factor 23-related hypophosphatemia, dental anomalies, and ectopic calcification. (external link)
- Tjora, Erling; Wathle, Gaute K; Erchinger, Friedemann et al. (2013). Exocrine pancreatic function in hepatocyte nuclear factor 1 beta-maturity-onset diabetes of the young (HNF1B-MODY) is only moderately reduced: compensatory hypersecretion from a hypoplastic pancreas. (external link)
- Tjora, Erling; Wathle, Gaute K; Engjom, Trond et al. (2013). Severe pancreatic dysfunction but compensated nutritional status in monogenic pancreatic disease caused by carboxyl-ester lipase mutations. (external link)
2012
- Gonc, E. Nazli; Ozturk, Burcu Bulum; Haldorsen, Ingfrid S. et al. (2012). HNF1B mutation in a Turkish child with renal and exocrine pancreas insufficiency, diabetes and liver disease. (external link)
- Haldorsen, Ingfrid S.; Ræder, Helge; Vesterhus, Mette et al. (2012). The role of pancreatic imaging in monogenic diabetes mellitus. (external link)
- Ræder, Helge; Molven, Anders; Njølstad, Pål Rasmus (2012). Skreddersydd medisin eller narsissomikk?. (external link)
2011
- Hertel, Jens Kristoffer; Johansson, Stefan; Ræder, Helge et al. (2011). Evaluation of four novel genetic variants affecting hemoglobin A1c levels in a population-based type 2 diabetes cohort (the HUNT2 study). (external link)
- Thanabalasingham, Gaya; Shah, Nabi; Vaxillaire, Martine et al. (2011). A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes. (external link)
- Haldorsen, Ingfrid S.; Ræder, Helge; Vesterhus, Mette et al. (2011). The role of pancreatic imaging in monogenic diabetes. (external link)
- Johansson, Bente Berg; Torsvik, Janniche; Bjørkhaug, Lise et al. (2011). Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE. (external link)
2010
- Vesterhus, Mette; Ræder, Helge; Kurpad, Amarnath J et al. (2010). Pancreatic Function in Carboxyl-Ester Lipase Knockout Mice. (external link)
- Njølstad, Pål Rasmus; Hertel, Jens Kristoffer; Søvik, Oddmund et al. (2010). Fremskritt innen diabetesgenetikk. (external link)
- Torsvik, Janniche; Johansson, Stefan; Johansen, Anders et al. (2010). Mutations in the VNTR of the carboxyl-ester lipase gene (CEL) are a rare cause of monogenic diabetes. (external link)
- Allen, Hana Lango; Johansson, Stefan; Ellard, Sian et al. (2010). Polygenic risk variants for Type 2 Diabetes susceptibility modify age at diagnosis in Monogenic HNF1A Diabetes. (external link)
2008
- Fjeld, Karianne; Torsvik, Janniche; Johansson, Stefan et al. (2008). Structural changes in the repeated region of the carboxyl-ester lipase (CEL) gene and the development of diabetes. (external link)
- Vesterhus, Mette; Haldorsen, Ingfrid Salvesen; Ræder, Helge et al. (2008). Reduced pancreatic volume in hepatocyte nuclear factor 1A-maturity-onset diabetes of the young. (external link)
- Sagen, Jørn V.; Bjørkhaug, Lise; Molnes, Janne et al. (2008). Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry. (external link)
- Vesterhus, Mette; Ræder, Helge; Aurlien, Harald et al. (2008). Neurological features and enzyme therapy in patients with endocrine and exocrine pancreas dysfunction due to CEL mutations. (external link)
- Vesterhus, Mette; Ræder, Helge; Johansson, Stefan et al. (2008). Pancreatic Exocrine Dysfunction in Maturity-Onset Diabetes of the Young Type 3. (external link)
- Ræder, Helge; Bjerknes, Robert (2008). X-bundet hypofosfatemisk rakitt: Ny kunnskap om patofysiologi, behandling og oppfølging. (external link)
- Ræder, Helge; Shaw, Nick; Netelenbos, C. et al. (2008). A case of X-linked hypophosphatemic rickets: complications and the therapeutic use of cinacalcet. (external link)
- Eide, Stig Åge; Ræder, H; Ræder, Helge et al. (2008). Prevalence of HNF1A (MODY3) mutations in a Norwegian population (the HUNT2 Study). (external link)
- Haldorsen, Ingfrid Salvesen; Vesterhus, Mette; Ræder, Helge et al. (2008). Lack of pancreatic body and tail in HNF1B mutation carriers. (external link)
- Hertel, Jens Kristoffer; Johansson, Stefan; Ræder, H et al. (2008). Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study). (external link)
- Molven, Anders; Ringdal, Monika; Nordbø, Anita-Merete et al. (2008). Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes. (external link)
2007
- Vesterhus, Mette; Johansson, Stefan; Ræder, Helge et al. (2007). Pancreatic exocrine deficiency is common in MODY 3. (external link)
- Johansson, Stefan; Ræder, Helge; Eide, Stig Åge et al. (2007). Studies in 3,523 Norwegians and meta-analysis in 11,571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (HNF4A) P2 region are associated with type 2 diabetes in Scandinavians. (external link)
- Ræder, Helge; Haldorsen, Ingfrid Salvesen; Ersland, Lars et al. (2007). Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-Ester lipase. (external link)
2006
- Ræder, Helge; Njølstad, Pål Rasmus (2006). Ny type diabetes. (external link)
- Raeder, Helge; Ræder, Helge; Bjorkhaug, Lise et al. (2006). A hepatocyte nuclear factor-4 alpha gene (HNF4A) P2 promoter haplotype linked with late-onset diabetes - Studies of HNF4A variants in the Norwegian MODY registry. (external link)
- Ræder, Helge; Johansson, Stefan; Holm, Pål I. et al. (2006). Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. (external link)
- Ræder, Helge (2006). Novel monogenic causes of diabetes and pancreatic exocrine dysfunction. (external link)
See a complete overview of publications in Cristin.
https://scholar.google.com/citations?user=ecPm_OoAAAAJ&hl=en