My research projects are focused on understanding cellular signaling (phosphorylation) and can be divided in four topics.

-          Basal research understanding signaling node cascade.

-          Aberrant signaling pattern in chronic and acute myeloid leukemia.

-          Phospho-signaling and hematologic pattern to immunologic response.

-          Mass Cytometry – a new instrument analyzing over 40 parameters in a single cell manner.                      

I have shown that analyzing in vivo patient whole blood, the change in the signaling pattern shortly after start a new treatment regime reflects the drug that is given. Using this methodology I’m involved in several cancer sub-studies - local and international.

 

Monitoring signaling patterns in patients starting a new treatment is likely to be of important for patient progress, early drug evaluation, as well as increased understanding of complex diseases. 

Academic article

• Tislevoll, Benedicte Sjo; Hellesøy, Monica; Fagerholt, Oda Helen Eck et al. (2023). Early response evaluation by single cell signaling profiling in acute myeloid leukemia. (external link)
• Rim, Sehee; Sakkestad, Sunniva Todnem; Zhou, Fan et al. (2023). Dynamics of circulating lymphocytes responding to human experimental enterotoxigenic Escherichia coli infection. (external link)
• Tislevoll, Benedicte Sjo; Hellesøy, Monica; Fagerholt, Oda Helen Eck et al. (2022). Early response evaluation by single cell signaling profiling in acute myeloid leukemia. (external link)
• Anandan, Shamundeeswari; Thomsen, Liv Cecilie Vestrheim; Gullaksen, Stein-Erik et al. (2021). Phenotypic Characterization by Mass Cytometry of the Microenvironment in Ovarian Cancer and Impact of Tumor Dissociation Methods. (external link)
• Tadele, Dagim Shiferaw; Robertson, Joseph; Crispin, Richard et al. (2020). A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation. (external link)
• Sakkestad, Sunniva Todnem; Skavland, Jørn; Hanevik, Kurt (2019). Whole blood preservation methods alter chemokine receptor detection in mass cytometry experiments. (external link)
• Gullaksen, Stein-Erik; Bader, Lucius; Hellesøy, Monica et al. (2019). Titrating complex mass cytometry panels. (external link)
• Nepstad, Ina; Hatfield, Kimberley Joanne; Aasebø, Elise et al. (2018). Two acute myeloid leukemia patient subsets are identified based on the constitutive PI3K-Akt-mTOR signaling of their leukemic cells; a functional, proteomic and transcriptomic comparison. (external link)
• Reikvam, Håkon; Skavland, Jørn; Gullaksen, Stein-Erik et al. (2018). Chronic Myeloid Leukemia Relapsing 25 Years after Allogenic Stem Cell Transplantation. (external link)
• Gullaksen, Stein-Erik; Skavland, Jørn; Gavasso, Sonia et al. (2017). Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib. (external link)
• Sulen, Andre; Gullaksen, Stein-Erik; Bader, Lucius et al. (2016). Signaling effects of sodium hydrosulfide in healthy donor peripheral blood mononuclear cells. (external link)
• Bruserud, Øystein; Reikvam, Håkon; Fredly, Hanne Kristin et al. (2015). Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation. (external link)
• Gausdal, Gro; Wergeland, Anita; Skavland, Jørn et al. (2013). Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. (external link)
• Skavland, Jørn; Shewry, Peter R.; Marsh, John et al. (2012). In vitro screening for putative psoriasis-specific antigens among wheat proteins and peptides. (external link)
• Reikvam, Håkon; Hatfield, Kimberley Joanne; Ersvær, Elisabeth et al. (2012). Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status - consequences and potentials for pharmacological intervention. (external link)
• Skavland, Jørn; Jørgensen, Katarina Mariann; Hadziavdic, Kenan et al. (2011). Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia. (external link)
• McCormack, Emmet Martin; Skavland, Jørn; Mujic, Maja et al. (2010). Lentinan: hematopoietic, immunological, and efficacy studies in a syngeneic model of acute myeloid leukemia. (external link)
• Ersvær, Elisabeth; Liseth, Knut; Skavland, Jørn et al. (2010). Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells. (external link)
• Semaeva, Elvira; Tenstad, Olav; Skavland, Jørn et al. (2010). Access to the spleen microenvironment through lymph shows local cytokine production, increased cell flux, and altered signaling of immune cells during lipopolysaccharide-induced acute inflammation. (external link)
• Bredholt, Therese; Dimba, Elisabeth Anne Okumu; Hagland, Hanne et al. (2009). Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. (external link)
• Irish, Jonathan C.; Ånensen, Nina; Hovland, Randi et al. (2007). Flt3 Y591 duplication and Bc1-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53. (external link)
• Ersvær, Elisabeth; Skavland, Jørn; Ulvestad, Elling et al. (2007). Effects of interferon gamma on native human acute myelogenous leukaemia cells. (external link)

Errata

• Tislevoll, Benedicte Sjo; Hellesøy, Monica; Fagerholt, Oda Helen Eck et al. (2023). Author Correction: Early response evaluation by single cell signaling profiling in acute myeloid leukemia (Nature Communications, (2023), 14, 1, (115), 10.1038/s41467-022-35624-4). (external link)

Academic lecture

• Rim, Sehee; Sakkestad, Sunniva Todnem; Zhou, Fan et al. (2022). Dynamics of circulating lymphocytes responding to human experimental enterotoxigenic Escherichia coli infection. (external link)
• Rim, Sehee; Sakkestad, Sunniva Todnem; Zhou, Fan et al. (2019). Comprehensive characterization and kinetics of circulating lymphocytes in human volunteers experimentally infected with enterotoxigenic Escherichia coli. (external link)

Poster

• Rim, Sehee; Sakkestad, Sunniva Todnem; Skavland, Jørn et al. (2018). Comprehensive characterization of circulating T follicular helper cells and plasmablasts in human volunteers experimentally infected with enterotoxigenic Escherichia coli. (external link)

Academic literature review

• Gavasso, Sonia; Gullaksen, Stein-Erik; Skavland, Jørn et al. (2016). Single-cell proteomics: Potential implications for cancer diagnostics. (external link)
• Jørgensen, Katarina Mariann; Hjelle, Sigrun Margrethe; Øye, Ola Kristoffer et al. (2011). Untangling the intracellular signalling network in cancer - a strategy for data integration in acute myeloid leukemia. (external link)

Article in business/trade/industry journal

• Engen, Caroline Benedicte Nitter; Wergeland, Line; Skavland, Jørn et al. (2014). Targeted Therapy of FLT3 in Treatment of AML-Current Status and Future Directions. (external link)

Doctoral dissertation

• Skavland, Jørn (2013). Risk stratification and therapy response monitoring by phosphoprotein profiles in acute myeloid leukaemia. (external link)

Abstract

• Skavland, Jørn; Hadziavdic, Kenan; Jonassen, Inge et al. (2010). Combined epigenetic and signal transduction therapy modulate specific signal transduction patterns in acute myeloid leukemia. (external link)
• Gavasso, Sonia; Skavland, Jørn; Gjertsen, Bjørn Tore et al. (2008). Interferon-beta signal transduction, multiple sclerosis and auto-antibodies. (external link)

See a complete overview of publications in Cristin.