The main research aim is to characterize metabolic phenotypes of human leukemia cells, and investigate how metabolic pathways may be implicated in the development of cancer cells`drug resistance.
Additional research interests include the contribution of the microenvironment in acute myeloid leukemia (AML); in particular how leukemia cells are influenced by stromal cells and chemokines, and how leukemia cells adapt to changes in oxygen levels and nutrient availability.

2025

• Brattås, Marte Karen; Görtler, Franziska Stilla Maria; Johansen, Silje et al. (2025). Gene Expression Profiling in Acute Myeloid Leukemia Patient Subgroups With High and Low Sensitivity Toward SYK Inhibitors. (external link)
• Dyrstad, Sissel; Hatfield, Kimberley Joanne; Stigen, Endre et al. (2025). Mapping of Functional Metabolic Phenotypes in Acute Myeloid Leukemia. (external link)

2024

• Reikvam, Håkon; Hatfield, Kimberley Joanne; Sandnes, Miriam et al. (2024). Future biomarkers for acute graft-versus-host disease: potential roles of nucleic acids, metabolites, and immune cell markers. (external link)

2023

• Reikvam, Håkon; Bruserud, Øystein; Hatfield, Kimberley Joanne (2023). Pretransplant systemic metabolic profiles in allogeneic hematopoietic stem cell transplant recipients - identification of patient subsets with increased transplant-related mortality. (external link)

2022

• Hatfield, Kimberley Joanne; Bruserud, Øystein; Reikvam, Håkon (2022). Pretransplant Systemic Lipidomic Profiles in Allogeneic Stem Cell Transplant Recipients. (external link)
• Brattås, Marte Karen; Hemsing, Anette Lodvir; Rye, Kristin Paulsen et al. (2022). Heterogeneity of patient-derived acute myeloid leukemia cells subjected to SYK in vitro inhibition. (external link)
• Reikvam, Håkon; Hatfield, Kimberley Joanne; Wendelbo, Øystein et al. (2022). Endocan in Acute Leukemia: Current Knowledge and Future Perspectives. (external link)
• Hemsing, Anette Lodvir; Rye, Kristin Paulsen; Hatfield, Kimberley Joanne et al. (2022). NPM1-mutated patient-derived AML cells are more vulnerable to rac1 inhibition. (external link)
• Reikvam, Håkon; Vo, Anh Khoi; Johansen, Silje et al. (2022). MicroRNA serum profiles and chronic graft-versus-host disease. (external link)

2021

• Grønningsæter, Ida Sofie; Reikvam, Håkon; Aasebø, Elise et al. (2021). Effects of the autophagy‐inhibiting agent chloroquine on acute myeloid leukemia cells; characterization of patient heterogeneity. (external link)

See a complete overview of publications in Cristin.

Bergen Research Foundation funded project: Characterization of metabolic phenotypes and signaling pathways in acute myeloid leukemia and their role in anti-leukemia treatment.