Prosjektet undersøker effekten av ulike medikamenter som blokkerer sentrale metabolske signalveier i akutt myeloid leukemi (AML). Prosjektet har som mål å karakterisere ulike metabolske signalveier i leukemiceller, samt autofagi, og studere hvordan dette bidrar til kjemoresistens i AML. Prosjektet er støttet av midler fra Bergens forskningsstiftelse.

2007

• Elisabeth Ersvær; Peter Hampson; Kimberley Joanne Hatfield et al. (2007). T cells remaining after intensive chemotherapy for acute myelogenous leukemia show a broad cytokine release profile including high levels of interferon-gamma that can be further increased by a novel protein kinase C agonist PEP005. (ekstern lenke)
• Camilla I Stapnes; Anne Paulus Døskeland; Kimberley Joanne Hatfield et al. (2007). The proteasome inhibitors bortezomib and PR-171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells. (ekstern lenke)
• Camilla I Stapnes; Anita Ryningen; Kimberley Joanne Hatfield et al. (2007). Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in the susceptibility to histone deacetylase inhibitors. (ekstern lenke)

2009

• Håkon Reikvam; Kimberley Joanne Hatfield; Astrid Marta Olsnes et al. (2009). PRIMARY HUMAN ACUTE MYELOGENOUS LEUKEMIA CELLS SHOW CONSTITUTIVE RELEASE OF SEVERAL MATRIX METALLOPROTEASES AND THEIR INHIBITORS. (ekstern lenke)
• Astrid Marta Olsnes; Kimberley Joanne Hatfield; Øystein Bruserud (2009). The chemokine system and its contribution to leukemogenesis and treatment responsiveness in patients with acute myeloid leukemia. (ekstern lenke)
• Kimberley Joanne Hatfield; Anne Margrete Øyan; Elisabeth Ersvær et al. (2009). Phase II study of subcutaneous alemtuzumab without dose escalation in patients with advanced-stage, relapsed chronic lymphocytic leukaemia. (ekstern lenke)

2022

• Marte Karen Brattås; Anette Lodvir Hemsing; Kristin Paulsen Rye et al. (2022). Heterogeneity of patient-derived acute myeloid leukemia cells subjected to SYK in vitro inhibition. (ekstern lenke)

2017

• Kimberley Joanne Hatfield; Guro Kristin Melve; Øystein Bruserud (2017). Granulocyte colony-stimulating factor alters the systemic metabolomic profile in healthy donors. (ekstern lenke)

2015

• Håkon Reikvam; Ida Sofie Grønningsæter; Aymen B Ahmed et al. (2015). Metabolic serum profiles for patients receiving allogeneic stem cell transplantation: the pretransplant profile differs for patients with and without posttransplant capillary leak syndrome. (ekstern lenke)

2014

• Roald Lindås; Tor Henrik Anderson Tvedt; Kimberley Joanne Hatfield et al. (2014). Preconditioning serum levels of endothelial cell-derived molecules and the risk of posttransplant complications in patients treated with allogeneic stem cell transplantation.. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

2016-2020: Metabolic phenotypes of leukemia cells.