The main research aim is to characterize metabolic phenotypes of human leukemia cells, and investigate how metabolic pathways may be implicated in the development of cancer cells`drug resistance.
Additional research interests include the contribution of the microenvironment in acute myeloid leukemia (AML); in particular how leukemia cells are influenced by stromal cells and chemokines, and how leukemia cells adapt to changes in oxygen levels and nutrient availability.

2007

• Elisabeth Ersvær; Peter Hampson; Kimberley Joanne Hatfield et al. (2007). T cells remaining after intensive chemotherapy for acute myelogenous leukemia show a broad cytokine release profile including high levels of interferon-gamma that can be further increased by a novel protein kinase C agonist PEP005. (external link)
• Camilla I Stapnes; Anne Paulus Døskeland; Kimberley Joanne Hatfield et al. (2007). The proteasome inhibitors bortezomib and PR-171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells. (external link)
• Camilla I Stapnes; Anita Ryningen; Kimberley Joanne Hatfield et al. (2007). Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in the susceptibility to histone deacetylase inhibitors. (external link)

2009

• Håkon Reikvam; Kimberley Joanne Hatfield; Astrid Marta Olsnes et al. (2009). PRIMARY HUMAN ACUTE MYELOGENOUS LEUKEMIA CELLS SHOW CONSTITUTIVE RELEASE OF SEVERAL MATRIX METALLOPROTEASES AND THEIR INHIBITORS. (external link)
• Astrid Marta Olsnes; Kimberley Joanne Hatfield; Øystein Bruserud (2009). The chemokine system and its contribution to leukemogenesis and treatment responsiveness in patients with acute myeloid leukemia. (external link)
• Kimberley Joanne Hatfield; Anne Margrete Øyan; Elisabeth Ersvær et al. (2009). Phase II study of subcutaneous alemtuzumab without dose escalation in patients with advanced-stage, relapsed chronic lymphocytic leukaemia. (external link)

2022

• Marte Karen Brattås; Anette Lodvir Hemsing; Kristin Paulsen Rye et al. (2022). Heterogeneity of patient-derived acute myeloid leukemia cells subjected to SYK in vitro inhibition. (external link)

2017

• Kimberley Joanne Hatfield; Guro Kristin Melve; Øystein Bruserud (2017). Granulocyte colony-stimulating factor alters the systemic metabolomic profile in healthy donors. (external link)

2015

• Håkon Reikvam; Ida Sofie Grønningsæter; Aymen B Ahmed et al. (2015). Metabolic serum profiles for patients receiving allogeneic stem cell transplantation: the pretransplant profile differs for patients with and without posttransplant capillary leak syndrome. (external link)

2014

• Roald Lindås; Tor Henrik Anderson Tvedt; Kimberley Joanne Hatfield et al. (2014). Preconditioning serum levels of endothelial cell-derived molecules and the risk of posttransplant complications in patients treated with allogeneic stem cell transplantation.. (external link)

See a complete overview of publications in Cristin.

Bergen Research Foundation funded project: Characterization of metabolic phenotypes and signaling pathways in acute myeloid leukemia and their role in anti-leukemia treatment.