My research activities focus on biomaterials, i.e. artificial materials used in reconstructive surgery, which may have huge clinical impact in terms of usage and diversity. The associated research topics span from applied research to basic. The activities are designed to involve biomechanical, biological and chemical effects of artificial materials used on humans. The activity is based on clinical aspects, and is therefore translational; from clinic to laboratory. The biomaterial laboratory (Biomatlab) has since 2009 been situated in the laboratory facilities at Haukeland University Hospital and Department of Clinical Medicine, UiB, which provides a unique opportunity to connect basic research with clinical activities in the field of biomaterials.
There is a strong collaboration with the Norwegian Arthroplasty Register in Bergen, which represents an important body for identifying longevity of joint replacements. 
I have extensive experience in clinical and biological issues, which started with the analysis of trace metals in lung tissue in the Master thesis and continued with my PhD work on the chemical analysis of a large clinical material taken from patients with dental amalgam fillings.
The activities that were started in the postdoctoral period, was further developed under my stipend from Bergen Medical Research Foundation (2010-2013). My project deals with the clinical and biological effects of implants that remain in the body. This is performed by characterize the degradation products in tissue and blood from patients with different types of implants, and correlate with clinical analysis, such as effects on bone cells and immune system.
The ongoing and planned activities will broaden the knowledge of biological and clinical consequences of artificial biomaterials, which can be used in developing new and safer materials.

2024

• Sellin, Marie-Luise; Seyfarth-Sehlke, Anika; Aziz, Mahammad et al. (2024). Isolation of TiNbN wear particles from a coated metal-on-metal bearing: Morphological characterization and in vitro evaluation of cytotoxicity in human osteoblasts. (external link)
• Silva, Maya Maya Barbosa; Gjertsen, Jan-Erik; Moldestad, Irene Ohlen et al. (2024). Effects of implant precoating and fat contamination on the stability of the tibial baseplate. (external link)
• Johannessen, Håkon Greve; Hallan, Geir; Kadar, Thomas Istvan Edelsvärd et al. (2024). Polyethylene wear and cup migration of cemented total hip arthroplasty with femoral heads made of oxidized zirconium, steel, or cobalt chromium: a 10-year secondary analysis from a randomized trial using radiostereometry. (external link)

2023

• Khan, Michelle; Lygre, Stein Håkon Låstad; Høl, Paul Johan et al. (2023). Does precoating of the NexGen Option tibial component lower the risk of loosening? 10 years follow up from the Norwegian Arthroplasty Register 2012-2021. (external link)
• Khan, Michelle; Lygre, Stein Håkon Låstad; Hallan, Geir et al. (2023). Bruk av blodtomhet ved totalprotese i kne- 3 års oppfølging (2018-2021) med data fra Nasjonalt register for leddproteser. (external link)
• Khan, Michelle; Gjertsen, Jan-Erik; Fenstad, Anne Marie et al. (2023). Cementing techniques for total ktnee arthroplasty in Norwegian hospitals; a questionnaire-based study. (external link)

2022

• Wolf, Susann; Johannessen, Anne Christine; Ellison, Peter et al. (2022). Inflammatory tissue reactions around aseptically loose cemented hip prostheses: A retrieval study of the Spectron EF stem with Reflection All‐Poly acetabular cup. (external link)
• Zalieckas, Justas; Rios Mondragon, Ivan; Pobedinskas, Paulius et al. (2022). Polycrystalline diamond coating on orthopedic implants: Realization and role of surface topology and chemistry in adsorption of proteins and cell proliferation. (external link)
• Høl, Paul Johan; Hallan, Geir; Furnes, Ove Nord et al. (2022). Similarly low-blood metal ion levels at 10-years follow-up of total hip arthroplasties with Oxinium, CoCrMo, and stainless steel femoral heads. Data from a randomized clinical trial. (external link)
• Khan, Michelle; Moldestad, Irene Ohlen; Ellison, Peter et al. (2022). Initial Stability Of Surface vs Full Cemented Tibial Components Under Cyclic Loading. (external link)
• Greve Johannessen, Håkon; Kadar, Thomas; Hallan, Geir et al. (2022). Polyethylene Wear In Total Hip Arthroplasty; Comparing Oxinium And CoCr Femoral Heads Using Radiostereometry With 10 Years Follow-Up. (external link)

2021

• Greve Johannessen, Håkon; Kadar, Thomas; Hallan, Geir et al. (2021). Polyethylene wear in total hip arthroplasty; comparing Oxinium and CoCr femoral heads using radiostereometry with 10 years follow-up. (external link)
• Høl, Paul Johan; Hallan, Geir; Indrekvam, Kari (2021). Metallionenivåer i blod fra pasienter med metall-mot-metall-hofteprotese. (external link)

2020

• Khan, Michelle; Gjertsen, Jan-Erik; Refsum, Anders Myhre et al. (2020). En spørreundersøkelse om sementeringsteknikker som brukes ved total kneprotesekirurgi ved norske sykehus. (external link)
• Høl, Paul Johan; Hallan, Geir; Furnes, Ove Nord et al. (2020). Metallionenivåer i blod etter 10 år med hofteproteser med ulike hodematerialer. (external link)
• Strandenes, Eivind; Ellison, Peter; Mølster, Anders et al. (2020). Strength of side-to-side and step-cut repairs in tendon transfers: biomechanical testing of porcine flexor tendons. (external link)

2019

• Strandenes, Eivind; Ellison, Peter; Mølster, Anders et al. (2019). Strength of Pulvertaft modifications: tensile testing of porcine flexor tendons. (external link)
• Høl, Paul Johan; Furnes, Ove; Hallan, Geir et al. (2019). Kontrollen av medisinske implantater kan bli bedre. (external link)
• Jonitz-Heincke, Anika; Seyfarth, Anika; Fabry, Christian et al. (2019). Impact of TiNbN wear particles on osteoblastic differentiation capacity and induction of inflammatory reactions. (external link)
• Høl, Paul Johan; Ellison, Peter John; Wolf, Susann et al. (2019). Mekanismer for aseptisk løsning av sementert Spectron EF hoftestamme med Reflection kopp - en retrievalstudie. (external link)
• Høl, Paul Johan (2019). Metals in orthopaedic implants: Mechanical, chemical and biological properties of titanium and stainless steel implants . (external link)
• Refsum, Anders Myhre; Nguyen, Uy Viet; Gjertsen, Jan Erik et al. (2019). Cementing technique for primary knee arthroplasty: a scoping review. (external link)
• Høl, Paul Johan; Gjerdet, Nils Roar; Jonung, Torbjörn (2019). Corrosion and metal release from overlapping arterial stents under mechanical and electrochemical stress - An experimental study. (external link)

2018

• Høl, Paul Johan (2018). Metallnivå i blod hos pasienter med hofteprotese. (external link)
• Høl, Paul Johan; Kristoffersen, Einar Klæboe; Vindenes, Hilde Kristin et al. (2018). Novel titanium antigens and assessment of immune activation. (external link)
• Jonitz-Heincke, Anika; Tillmann, Jenny; Ostermann, Melanie et al. (2018). Label-free monitoring of uptake and toxicity of endoprosthetic wear particles in human cell cultures. (external link)
• Ellison, Peter; Høl, Paul Johan; Babic, Ankica (2018). An individual patient outcome tool for joint replacement patients. (external link)
• Høl, Paul Johan; Kristoffersen, Einar Klæboe; Gjerdet, Nils Roar et al. (2018). Novel nanoparticulate and ionic titanium antigens for hypersensitivity testing. (external link)
• Ellison, Peter; Høl, Paul Johan; Babic, Ankica (2018). An individual patient outcome tool for joint replacement patients. (external link)

2017

• Varsi, Kristin; Bolann, Bjørn Johan; Torsvik, Ingrid Kristin et al. (2017). Impact of maternal selenium status on infant outcome during the first 6 months of life. (external link)

See a complete overview of publications in Cristin.

Bergen Implant Retrieval center for Implants

My on-going project is about improving performance and safety of clinical biomaterials. 

Bergen retrieval center for implants is collecting and analyzing joint prostheses that have failed due to aseptic loosening, often in combination with osteolysis or other immunological reactions.

I have specialised in trace element analysis, mainly on clinically related samples. Main elements of interest are Co, Cr, Zr, Mo, Ni and Ti measured by ICP-MS.

Read more: https://www.researchgate.net/project/Bergen-Retrieval-Center-for-Implants