- rune.nielsen@uib.no
- Visitor address
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Haukeland universitetssykehus, Laboratoriebygget
5009 Bergen - Postal address
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P.O. Box 7804NO-5020 BergenNorway
Research groups
Research
2011: PhD in epidemiology and health economics of chronic obstructive pulmonary disease (COPD)
2012-2018: Postdoc on the MicroCOPD study working on data collection and bioinformatic analysis on the microbiota of the airways in COPD.
2018: Associate professor in respiratory medicine, supervision on projects on the microbiome and epidemiology in COPD.
Publications
2025
- Abozid, Hazim; Wouters, Emiel F.M.; Cherkaski, Hamid Hacene et al. (2025). Quality of life associated with chronic cough in the multinational Burden of Obstructive Lung Disease study: a cross-sectional study. (external link)
- Cestelli, Lucia; Amaral, Andre F. S.; Benediktsdottir, Bryndis et al. (2025). The association between systemic inflammation, lung function and respiratory symptoms in the BOLD study in Northern Europe. (external link)
- Knudsen, Kristel Svalland; Husebø, Gunnar Reksten; Nielsen, Rune et al. (2025). Whole genome sequencing of the pulmonary microbiome in interstitial lung disease subtypes. (external link)
- Rotevatn, Anders Ørskov; Eagan, Tomas Mikal Lind; Tangedal, Solveig et al. (2025). Gut microbiota in chronic obstructive pulmonary disease varies by CT-verified emphysema status. (external link)
- Müller, Alexander; Wouters, Emiel F. M.; Burney, Peter et al. (2025). Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study: A cross-sectional analysis. (external link)
- Knox-Brown, Ben; Algharbi, Fahad; Mulhern, Octavia et al. (2025). Bronchodilator responsiveness and future chronic airflow obstruction: a multinational longitudinal study. (external link)
- Burney, Peter G J; Potts, James; Knox-Brown, Ben et al. (2025). Geographical variation in lung function: Results from the multicentric cross-sectional BOLD study. (external link)
- Burney, Peter G.J.; Nguyen, Tracey; Agarwal, Dhiraj et al. (2025). Fibular length and vital capacity in the multinational Burden of Obstructive Lung Disease follow-up study. (external link)
- Cestelli, Lucia; Johannessen, Ane; Gulsvik, Amund et al. (2025). Risk Factors, Morbidity, and Mortality in Association With Preserved Ratio Impaired Spirometry and Restrictive Spirometric Pattern: Clinical Relevance of Preserved Ratio Impaired Spirometry and Restrictive Spirometric Pattern. (external link)
2024
- Cestelli, Lucia; Stavem, Knut; Johannessen, Ane et al. (2024). Outcome-based Definition of the Lower Limit of Normal in Spirometry: A Study of 26,000 Young Adult Men. (external link)
- Tangedal, Solveig; Nielsen, Rune; Aanerud, Marianne et al. (2024). Lower airway microbiota in COPD and healthy controls. (external link)
2023
- Knox-Brown, Ben; Potts, James; Santofimio, Valentina Quintero et al. (2023). Isolated small airways obstruction predicts future chronic airflow obstruction: a multinational longitudinal study. (external link)
- Knox-Brown, Ben; Patel, Jaymini; Potts, James et al. (2023). Small airways obstruction and its risk factors in the Burden of Obstructive Lung Disease (BOLD) study: a multinational cross-sectional study. (external link)
- Rastoder, Ema; Sivapalan, Pradeesh; Eklöf, Josefin et al. (2023). Calcium Channel Blockers and the Risk of Exacerbation in Patients with Chronic Obstructive Pulmonary Disease: A Nationwide Study of 48,488 Outpatients. (external link)
- Cestelli, Lucia; Gulsvik, Amund; Johannessen, Ane et al. (2023). Reduced lung function and cause-specific mortality: A population-based study of Norwegian men followed for 26 years. (external link)
- Ratanachina, Jate; Amaral, Andre F.S.; Matteis, Sara De et al. (2023). Association of respiratory symptoms and lung function with occupation in the multinational Burden of Obstructive Lung Disease (BOLD) study. (external link)
2022
- Mathioudakis, Alexander G.; Abroug, Fekri; Agusti, Alvar et al. (2022). ERS statement: A core outcome set for clinical trials evaluating the management of COPD exacerbations. (external link)
- Martinsen, Einar Marius Hjellestad; Eagan, Tomas Mikal Lind; Wiker, Harald Gotten et al. (2022). A longitudinal study of the pulmonary mycobiome in subjects with and without chronic obstructive pulmonary disease. (external link)
- Knudsen, Kristel Svalland; Lehmann, Sverre; Nielsen, Rune et al. (2022). The lower airways microbiome and antimicrobial peptides in idiopathic pulmonary fibrosis differ from chronic obstructive pulmonary disease. (external link)
- Svendsen, Christina Due; Kuiper, Karel Kier-Jan; Ostridge, Kristoffer et al. (2022). Factors associated with coronary heart disease in COPD patients and controls. (external link)
- Knudsen, Kristel Svalland; Lehmann, Sverre; Nielsen, Rune et al. (2022). The lower airways microbiota and antimicrobial peptides indicate dysbiosis in sarcoidosis. (external link)
- Cestelli, Lucia; Johannessen, Ane; Stavem, Knut et al. (2022). Period and cohort effects: consequences on spirometric lung function in Norway during the 20th century. (external link)
2021
- Stavem, Knut; Johannessen, Ane; Nielsen, Rune et al. (2021). Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time. (external link)
- Nielsen, Rune; Xue, Yaxin; Jonassen, Inge et al. (2021). Repeated bronchoscopy in health and obstructive lung disease: is the airway microbiome stable?. (external link)
- Martinsen, Einar Marius Hjellestad; Eagan, Tomas Mikal Lind; Leiten, Elise Orvedal et al. (2021). The pulmonary mycobiome—A study of subjects with and without chronic obstructive pulmonary disease. (external link)
- Burney, Peter; Patel, Jaymini; Minelli, Cosetta et al. (2021). Prevalence and Population-Attributable Risk for Chronic Airflow Obstruction in a Large Multinational Study. (external link)
- Nerpin, Elisabet; Ferreira, Diogenes Seraphim; Weyler, Joost et al. (2021). Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status. (external link)
- Amaral, André F.S.; Burney, Peter G.J.; Patel, Jaymini et al. (2021). Chronic airflow obstruction and ambient particulate air pollution. (external link)
- Drengenes, Christine; Eagan, Tomas Mikal; Haaland, Ingvild et al. (2021). Exploring protocol bias in airway microbiome studies: one versus two PCR steps and 16S rRNA gene region V3 V4 versus V4. (external link)
2020
- Gagnat, Ane Aamli; Gjerdevik, Miriam; Lie, Stein Atle et al. (2020). Acute exacerbations of COPD and risk of lung cancer in COPD patients with and without a history of asthma. (external link)
- Husebø, Gunnar; Gabazza, Esteban; D'Alessandro-Gabazza, Corina et al. (2020). Coagulation markers as predictors for clinical events in COPD. (external link)
- Leiten, Elise Orvedal; Eagan, Tomas Mikal; Martinsen, Einar Marius Hjellestad et al. (2020). Complications and discomfort after research bronchoscopy in the MicroCOPD study. (external link)
- Erdal, Marta; Johannessen, Ane; Bakke, Per S. et al. (2020). Incremental costs of COPD exacerbations in GOLD stage 2+ COPD in ever-smokers of a general population. (external link)
- Mathioudakis, Alexander G.; Abroug, Fekri; Agusti, Alvar et al. (2020). Core outcome set for the management of acute exacerbations of chronic obstructive pulmonary disease: The cosaecopd ers task force study protocol. (external link)
- Leiten, Elise Orvedal; Nielsen, Rune; Wiker, Harald Gotten et al. (2020). The airway microbiota and exacerbations of COPD. (external link)
- Gulsvik, Amund; Bakke, Per; Brøgger, Jan et al. (2020). Respiratory symptoms and mortality in four general population cohorts over 45 years. (external link)
2019
- Janson, Christer; Accordini, Simone; Cazzoletti, Lucia et al. (2019). Pharmacological treatment of asthma in a cohort of adults during a 20-year period: Results from the european community respiratory health survey I, II and III. (external link)
- Nerpin, Elisabet; Olivieri, Mario; Gislason, Thorainn et al. (2019). Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III. (external link)
- Tangedal, Solveig; Nielsen, Rune; Aanerud, Marianne et al. (2019). Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients. (external link)
- Martinsen, Einar Marius Hjellestad; Eagan, Tomas Mikal; Leiten, Elise Orvedal et al. (2019). Motivation and response rates in bronchoscopy studies. (external link)
- Husebø, Gunnar; Nielsen, Rune; Hardie, Jon Andrew et al. (2019). Risk factors for lung cancer in COPD - results from the Bergen COPD cohort study. (external link)
- Drengenes, Christine; Wiker, Harald G; Kalananthan, Tharmini et al. (2019). Laboratory contamination in airway microbiome studies. (external link)
2017
- Husebø, Gunnar; Grønseth, Rune; Lerner, Lorena et al. (2017). Growth differentiation factor-15 is a predictor of important disease outcomes in patients with COPD. (external link)
- Grønseth, Rune; Erdal, Marta; Tan, Wan C. et al. (2017). Unemployment in chronic airflow obstruction around the world: Results from the BOLD study. (external link)
- Tangedal, Solveig; Aanerud, Marianne; Grønseth, Rune et al. (2017). Comparing microbiota profiles in induced and spontaneous sputum samples in COPD patients. (external link)
2016
- Erdal, Marta; Johannessen, Ane; Eagan, Tomas Mikal et al. (2016). Incidence of utilization- and symptom-defined COPD exacerbations in hospital- and population-recruited patients. (external link)
- Martinsen, Einar Marius Hjellestad; Leiten, Elise Orvedal; Bakke, Per S. et al. (2016). Participation in research bronchoscopy: a literature review. (external link)
- Leiten, Elise Orvedal; Martinsen, Einar Marius Hjellestad; Eagan, Tomas Mikal et al. (2016). Complications and discomfort of bronchoscopy: a systematic review. (external link)
- Husebø, Gunnar; Bakke, Per S.; Grønseth, Rune et al. (2016). Macrophage migration inhibitory factor, a role in COPD. (external link)
2014
- Husebø, Gunnar Reksten; Bakke, Per S.; Aanerud, Marianne et al. (2014). Predictors of exacerbations in chronic obstructive pulmonary disease - results from the Bergen COPD Cohort Study. (external link)
- Grønseth, Rune; Vollmer, William M.; Hardie, Jon Andrew et al. (2014). Predictors of dyspnoea prevalence: Results from the BOLD study. (external link)
- Erdal, Marta; Johannessen, Ane; Askildsen, Jan Erik et al. (2014). Productivity losses in chronic obstructive pulmonary disease: a population-based survey.. (external link)
2013
- Lamprecht, Bernd; Vanfleteren, Lowie E.; Studnicka, Michael et al. (2013). Sex-related differences in respiratory symptoms: results from the BOLD Study. (external link)
- Nielsen, Rune; Kankaanranta, Hannu; Bjermer, Leif et al. (2013). Cost effectiveness of adding budesonide/formoterol to tiotropium in COPD in four Nordic countries. (external link)
- Janson, Christer; Marks, Guy; Buist, Sonia et al. (2013). The impact of COPD on health status: findings from the BOLD study. (external link)
2011
- Nielsen, Rune; Johannessen, Ane; Omenaas, Ernst et al. (2011). Excessive costs of COPD in ever-smokers. A longitudinal community study. (external link)
- Nielsen, Rune (2011). Costs of chronic obstructive pulmonary disease in a general population. (external link)
- Rebordosa, Cristina; Kogevinas, Manolis; Guerra, Sandra et al. (2011). ADRB2 Gly16Arg polymorphism, asthma control and lung function decline. (external link)
2009
- Nielsen, Rune; Johannessen, Ane; Benediktsdottir, Bryndis et al. (2009). Present and future costs of COPD in Iceland and Norway: results from the BOLD study. (external link)
- Nielsen, Rune; Johannessen, Ane; Bakke, Per S. et al. (2009). Aspects of healthcare utilisation in self-reported obstructive lung disease. (external link)