Silje Skrede
Position
Professor, pharmacology; department Head of innovation,
Affiliation
- silje.skrede@uib.no
- Visitor address
-
Haukeland universitetssykehus
5009 Bergen - Postal address
-
P.O. Box 7804NO-5020 BergenNorway
Silje Skrede
Position
Professor, pharmacology; department Head of innovation,
Affiliation
Research groups
Publications
Academic article
- Vidar Martin Steen; Chirag Nepal; Kari Merete Ersland et al. (2013). Neuropsychological deficits in mice depleted of the schizophrenia susceptibility gene CSMD1. (external link)
- Kari Merete Ersland; Silje Skrede; Therese Halvorsen Røst et al. (2015). Antipsychotic-induced metabolic effects in the female rat: Direct comparison between long-acting injections of risperidone and olanzapine. (external link)
- Håkon Reikvam; Jerome Tamburini; Silje Skrede et al. (2014). Antileukaemic effect of PI3K-mTOR inhibitors in acute myeloid leukaemia-gene expression profiles reveal CDC25B expression as determinate of pharmacological effect. (external link)
- Goran Jassim; Silje Skrede; Maria Jesús Vázquez et al. (2012). Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat. (external link)
- Tone Elise Gjøtterud Henriksen; Silje Skrede; Ole Bernt Fasmer et al. (2014). Blocking blue light during mania - markedly increased regularity of sleep and rapid improvement of symptoms: A case report. (external link)
- Silje Skrede; Johan Fernø; Maria Jesús Vázquez et al. (2012). Olanzapine, but not aripiprazole, weight-independently elevates serum triglycerides and activates lipogenic gene expression in female rats. (external link)
- Silje Skrede; Luis Martins; Rolf Kristian Berge et al. (2014). Olanzapine depot formulation in rat: a step forward in modelling antipsychotic-induced metabolic adverse effects. (external link)
- Andrea Rørvik Marti; Peter Meerlo; Janne Grønli et al. (2016). Shift in food intake and changes in metabolic regulation and gene expression during simulated night-shiftwork: A rat model. (external link)
- Erik Ingmar Hallin; Trond Trætteberg Serkland; Kjell-Morten Myhr et al. (2022). Ocrelizumab quantitation by liquid chromatography-tandem mass spectrometry. (external link)
- Dimitrios Andreou; Nils Eiel Steen; Kjetil Nordbø Jørgensen et al. (2021). Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness. (external link)
- Ieva Leskauskaite; Anja Torsvik; Christoffer Bartz-Johannessen et al. (2025). Sex differences in the peripheral levels of cytokines during 12-month antipsychotic treatment in a drug-naïve schizophrenia spectrum cohort. (external link)
- Gunnhild Eldhuset Hoprekstad; Erik Johnsen; Christoffer Bartz-Johannessen et al. (2025). Prednisolone add-on in early phase schizophrenia: A randomized, double-blind, placebo-controlled pilot study. (external link)
- Ibrahim Akkouh; Silje Skrede; Asbjørn Holmgren et al. (2019). Exploring lithium's transcriptional mechanisms of action in bipolar disorder: a multi-step study. (external link)
- Silje Skrede; Ingunn Fride Tvete; Lars Tanum et al. (2015). Incident users of antipsychotic agents and future use of cholesterol-lowering drugs: An observational, pharmacoepidemiologic study. (external link)
- Tone Elise Gjøtterud Henriksen; Silje Skrede; Ole Bernt Fasmer et al. (2016). Blue-blocking glasses as additive treatment for mania: A randomized placebo-controlled trial. (external link)
- Johan Fernø; Kari Merete Ersland; Inger Hødnebø Duus et al. (2015). Olanzapine depot exposure in male rats: Dose-dependent lipogenic effects without concomitant weight gain. (external link)
- Jan-Lukas Førde; Abdelnour Alhourani; Tian Carey et al. (2024). Impact of the Graphene Production Methods Sonication and Microfluidization on In Vitro and In Vivo Toxicity, Macrophage Response, and Complement Activation. (external link)
- Katerina Horska; Jan Kucera; Eva Drazanova et al. (2024). Potent synergistic effects of dulaglutide and food restriction in prevention of olanzapine-induced metabolic adverse effects in a rodent model. (external link)
- Gunnhild Eldhuset Hoprekstad; Silje Skrede; Christoffer Bartz-Johannessen et al. (2024). Association between cytokines and suicidality in patients with psychosis: A multicentre longitudinal analysis. (external link)
- Silje Skrede; Holm A Holmsen (2003). Schizofreni og membranpatologi - har antipsykotika en rolle i "membranteorien"?. (external link)
- Johan Fernø; Silje Skrede; Audun Osland Vik-Mo et al. (2006). Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: Marked differences between various antipsychotic drugs. (external link)
- Hilde Marie Torgauten; Therese Bredholt Onyango; Sonja Ljostveit et al. (2024). Hospitalisations and humoral COVID-19 vaccine response in vaccinated rituximab-treated multiple sclerosis patients. (external link)
- Silje Skrede; Vidar Martin Steen; Johan Fernø (2013). Antipsychotic-induced increase in lipid biosynthesis: activation through inhibition?. (external link)
- Trond Trætteberg Serkland; Silje Skrede; Erik Ingmar Hallin et al. (2025). Pharmacokinetic-pharmacodynamic modelling in a clinical pilot study of rituximab in multiple sclerosis: Towards personalized dosing interval. (external link)
- Silje Skrede; Johan Fernø; Bodil Bjørndal et al. (2012). Lipid-lowering effects of tetradecylthioacetic acid in antipsychotic-exposed, female rats: challenges with long-term treatment. (external link)
- Johan Fernø; Maria Therese Barøy Ræder; Audun Osland Vik-Mo et al. (2005). Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action?. (external link)
- Håkon Reikvam; Annette Brenner; Karen Marie Hagen et al. (2015). The cytokine-mediated crosstalk between primary human acute myeloid cells and mesenchymal stem cells alters the local cytokine network and the global gene expression profile of the mesenchymal cells. (external link)
- Audun Osland Vik-Mo; Johan Fernø; Silje Skrede et al. (2009). Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells. (external link)
- Erik Johnsen; Rune Andreas Kroken; Else-Marie Løberg et al. (2020). Amisulpride, aripiprazole, and olanzapine in patients with schizophrenia-spectrum disorders (BeSt InTro): a pragmatic, rater-blind, semi-randomised trial. (external link)
- Katerina Horska; Silje Skrede; Jan Kucera et al. (2024). Olanzapine, but not haloperidol, exerts pronounced acute metabolic effects in the methylazoxymethanol rat model. (external link)
- Silje Skrede; Ismael Gonzalez-Garcia; Luis Martins et al. (2017). Lack of ovarian secretions reverts the anabolic action of olanzapine in female rats. (external link)
- Jan-Lukas Førde; Lars Herfindal; Kjell-Morten Myhr et al. (2023). Ocrelizumab and ofatumumab, but not rituximab, trigger complement induction in vitro. (external link)
- Silje Skrede; Jon Andsnes Berg; KJELL OVE FOSSAN et al. (2021). Illicit substances detected through high-resolution MS analysis in urine samples are associated with greater symptom burden in patients with psychosis. (external link)
- Andrea Rørvik Marti; Sudarshan Patil; Jelena Mrdalj et al. (2017). No escaping the rat race: simulated night shift work alters the time-of-day variation in BMAL1 translational activity in the prefrontal cortex. (external link)
- Anne Oldeide Hay; Roger Trones; Lars Herfindal et al. (2022). Determination of methotrexate and its metabolites in human plasma by electromembrane extraction in conductive vials followed by LC-MS/MS. (external link)
- Iris Mulders Steine; Tetyana Zayats; Christine Stansberg et al. (2016). Implication of NOTCH1 Gene in Susceptibility to Anxiety and Depression among Sexual Abuse Victims. (external link)
- Vidar Martin Steen; Silje Skrede; Tatiana Polushina et al. (2016). Genetic evidence for a role of the SREBP transcription system and lipid biosynthesis in schizophrenia and antipsychotic treatment. (external link)
- Erik Ingmar Hallin; Trond Trætteberg Serkland; Tormod Karlsen Bjånes et al. (2024). High-throughput, low-cost quantification of 11 therapeutic antibodies using caprylic acid precipitation and LC-MS/MS. (external link)
- Katerina Horska; Jana Ruda-Kucerova; Silje Skrede (2022). GLP-1 agonists: superior for mind and body in antipsychotic-treated patients?. (external link)
- Kari Merete Ersland; Lene Secher Myrmel; Even Fjære et al. (2019). One-Year Treatment with Olanzapine Depot in Female Rats: Metabolic Effects. (external link)
- Johan Fernø; Luis Varela; Silje Skrede et al. (2011). Olanzapine-induced hyperphagia and weight gain associate with crexigenic hypothalamic neuropeptide signaling without concomitant AMPK phosphorylation. (external link)
- Johan Fernø; Silje Skrede; Audun Osland Vik-Mo et al. (2011). Lipogenic effects of psychotropic drugs: focus on the SREBP system. (external link)
- Silje Skrede; Nataša Bogavac-Stanojević; Erwin Dreesen et al. (2024). Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe. (external link)
- Johan Fernø; Audun Osland Vik-Mo; Goran Jassim et al. (2009). Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver. (external link)
- Priyanthi Borgen Gjerde; Ingrid Dieset; Carmen Elisabeth Simonsen et al. (2018). Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis. (external link)
- Janne Grønli; Peter Meerlo; Torhild Pedersen et al. (2016). A rodent model of night-shift work induces short-term and enduring sleep and electroencephalographic disturbances. (external link)
- Gunnhild Eldhuset Hoprekstad; Eirik Kjelby; Rolf Gjestad et al. (2023). Depression trajectories and cytokines in schizophrenia spectrum disorders - A longitudinal observational study. (external link)
- Trond T. Serkland; Jan Schjøtt; Jon Andsnes Berg et al. (2019). Short communication: Distribution of psychotropic drugs into lipoproteins. (external link)
- Kari Merete Ersland; Silje Skrede; Christine Stansberg et al. (2017). Subchronic olanzapine exposure leads to increased expression of myelination-related genes in rat fronto-medial cortex. (external link)
Popular science article
Conference abstract
Doctoral thesis (PhD)
Letter to the editor
- Trond Trætteberg Serkland; Silje Skrede; Jon Andsnes Berg (2021). Therapeutic Drug Monitoring vs Standard Therapy during Infliximab Induction in Patients with Chronic Immune-Mediated Inflammatory Diseases. (external link)
- Jon Andsnes Berg; Jan Schjøtt; Kjersti Carstensen et al. (2019). Stability of antidepressants and antipsychotics in gel separator tubes. (external link)
Conference lecture
- Silje Skrede (2023). TDM for mAbs - prospects based on progress of analytical methods. (external link)
- Iris Mulders Steine; Tetyana Zayats; Christine Stansberg et al. (2016). Implication of NOTCH1 Gene in Comorbid Anxiety and Depression Symptoms in a Sample of Sexual Abuse Victims.. (external link)
- Trond Trætteberg Serkland; Erik Ingmar Hallin; Kjell-Morten Myhr et al. (2022). Rituximab in the treatment of multiple sclerosis: A pharmacokinetic-pharmacodynamic model. (external link)
- Andrea Rørvik Marti; Jelena Mrdalj; Silje Skrede et al. (2016). Simulated night work alters clock gene expression in central and peripheral tissue in rats.. (external link)
- Jelena Mrdalj; Torhild Thue Pedersen; Andrea Rørvik Marti et al. (2015). Night work - disturbances in sleep and circadian rhythm parameters. An animal model.. (external link)
Master’s thesis
- Lars Herfindal; Martina Stipic; Trond T. Serkland et al. (2020). Drug transport in blood: Lipoproteins as transporters of psychotropic drugs. (external link)
- Anne Oldeide Hay; Silje Skrede; Lars Herfindal (2021). Electromembrane extraction of methotrexate and its metabolites. (external link)
- Maren Sukke Sætrang; Lars Herfindal; Silje Skrede (2022). Electromembrane extraction of immunosuppressants. (external link)
- Silje Skrede; Vibeke Løvås Bakken; Kari Merete Ersland et al. (2018). Gene Expression Changes in Rat Brain Following Long-term Antipsychotic Drug Exposure. (external link)
- Silje Skrede; Anette Sivertsen; Lars Herfindal (2023). Zebrafish Larvae as a Model Organism to Study Biotransformation. (external link)
- Anna Kristina Fredheim Oma; Silje Skrede; Susanna Röblitz et al. (2024). Pharmacokinetic models in personalized dosing of vancomycin. (external link)
Conference poster
- Andrea Rørvik Marti; Silje Skrede; Jelena Mrdalj et al. (2018). Extending the photoperiod impacts circadian rhythmicity and gene expression in prefrontal cortex and retina- Impact of exposure to blue-enriched light.. (external link)
- Andrea Rørvik Marti; jorrit waslander; Silje Skrede et al. (2018). Extended photoperiod alters circadian rhythmicity and expression of neuroplasticity markers. The impact of blue-enriched light.. (external link)
- Trond Trætteberg Serkland; Erik Ingmar Hallin; KJELL OVE FOSSAN et al. (2021). Establishing an LC-MS/MS method as a tool in a TDM approach when treating multiple sclerosis with monoclonal antibodies. (external link)
- Janne Grønli; Andrea Rørvik Marti; jorrit waslander et al. (2018). Extended photoperiod alters sleep and expression of synaptic plasticity-associated genes. The impact of blue-enriched light.. (external link)
- Erik Ingmar Hallin; Tormod Karlsen Bjånes; Trond Trætteberg Serkland et al. (2024). A high-throughput, low-cost LC-MS/MS panel for precision analysis of therapeutic antibodies. (external link)
- Rune Andreas Kroken; Else-Marie Løberg; Rolf Gjestad et al. (2017). The influence of 3 weeks of antipsychotic treatment on cell adhesion molecules in drug naive patients with schizophrenia spectrum disorder. (external link)
- Jon Andsnes Berg; Silje Skrede; Joakim Hansen et al. (2023). "Virtual Pharma" - a digital tool for visualizing pharmacokinetics and pharmacodynamics. (external link)
- Erik Ingmar Hallin; Trond Trætteberg Serkland; KJELL OVE FOSSAN et al. (2024). A rapid, automatable multiplex LC-MS/MS protocol for concomitant analysis of therapeutic antibodies. (external link)
- Trond Trætteberg Serkland; Erik Ingmar Hallin; Kjell-Morten Myhr et al. (2022). LC-MS/MS quantification of ocrelizumab in the treatment of multiple sclerosis. (external link)
Academic literature review
- Sayani Mukherjee; Silje Skrede; Edward Milbank et al. (2021). Understanding the Effects of Antipsychotics on Appetite Control. (external link)
- Malene Kalsnes Tyssedal; Erik Johnsen; Aurora Margrethe Brønstad et al. (2023). Dog-assisted interventions for adults diagnosed with schizophrenia and related disorders: a systematic review. (external link)
- Sayani Mukherjee; Silje Skrede; Martha Haugstøyl et al. (2023). Peripheral and central macrophages in obesity. (external link)
- Sayani Mukherjee; Silje Skrede; Johan Fernø (2025). The hypothalamus as a therapeutic target: Towards novel approaches for managing antipsychotic-induced weight gain. (external link)
- Rune Kroken; Else-Marie Løberg; Tore Drønen et al. (2014). A critical review of pro-cognitive drug targets in psychosis: convergence on myelination and inflammation. (external link)