Dendritic cell biology with special emphasis on aspects that enable their use in immunotherapeutic strategies, both for cancer and autoimmune diseases.

Single cell network profiling to stratify patients and develop new treatment strategies.

 

Member of the organizing committee for the annual "Day of Immunology" (29.4.)

• Immunology MED3 (third semester medical studies)
• FARM270 (Pharmaceutical microbiology and immunology)
• MEDMET901 Ethics and health research

 

 

Academic article

• Albin Björk; Johannes Mofors; Lauro Meneghel et al. (2025). A proteomic profile correlates with salivary gland inflammation and disease-associated antibodies in Sjögren’s disease. (external link)
• Waqas Azeem; Ragnhild Maukon Bakke; Silke Appel et al. (2020). Dual pro- and anti-inflammatory features of monocyte-derived dendritic cells. (external link)
• Alexander Sauter; Yvonne Mc Duffie; Heike Böhm et al. (2015). Surface-mediated priming during in vitro generation of monocyte-derived dendritic cells. (external link)
• Waqas Azeem; Ragnhild Maukon Bakke; Benjamin Gabriel et al. (2021). Evaluation of β-catenin inhibition of axitinib and nitazoxanide in human monocyte-derived dendritic cells. (external link)
• Anke Fuchs; Mateusz Gliwiński; Nathali Grageda et al. (2018). Minimum information about T regulatory cells: A step toward reproducibility and standardization. (external link)
• Aleksandra Petrovic; Ingvild Øye Bueide; Kåre Steinar Tveit et al. (2023). Herring roe oil in treatment of psoriasis – influence on immune cells and cytokine network. (external link)
• Petra Vogelsang; Johan G Brun; Gunnvor Øijordsbakken et al. (2010). Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjögren's syndrome. (external link)
• Richard Allan Davies; Daniel Hammenfors; Brith Bergum et al. (2017). Patients with primary Sjögren's syndrome have alterations in absolute quantities of specific peripheral leucocyte populations. (external link)
• Arnt-Ove Hovden; Marie Karlsen; Roland Jonsson et al. (2012). The bacterial preparation OK432 induces IL-12p70 secretion in human dendritic cells in a TLR3 dependent manner. (external link)
• Irene Sarkar; Richard Allan Davies; Anders Krogh Aarebrot et al. (2022). Aberrant signaling of immune cells in Sjögren's syndrome patient subgroups upon interferon stimulation. (external link)
• Silke Appel; P. Brossart (2007). Development of novel compounds to treat autoimmune and inflammatory diseases and graft versus host reactions. (external link)
• Arnt-Ove Hovden; Marie Karlsen; Roland Jonsson et al. (2011). Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses. (external link)
• Aleksandra Petrovic; Victoria Marie Samuelsen-Fossen; Richard Allan Davies et al. (2024). Immune cell activity during anti-TNF treatment in patients with psoriasis and psoriatic arthritis. (external link)
• Silje Michelsen Solberg; Anders K. Aarebrot; Irene Sarkar et al. (2020). Mass cytometry analysis of blood immune cells from psoriasis patients on biological therapy. (external link)
• Florian Sprater; Arnt-Ove Hovden; Silke Appel (2012). Expression of ESE-3 isoforms in immunogenic and tolerogenic human monocyte-derived dendritic cells. (external link)
• Silke Appel; Stephanie Le Hellard; Ove Bruland et al. (2011). Potential association of muscarinic receptor 3 gene variants with primary Sjögren's syndrome. (external link)
• Marie Karlsen; Arnt-Ove Hovden; Petra Vogelsang et al. (2011). Bromelain Treatment Leads to Maturation of Monocyte-derived Dendritic Cells but Cannot Replace PGE(2) in a Cocktail of IL-1 beta, IL-6, TNF-alpha and PGE(2). (external link)
• Diana Trutschel; Pierre Bost; Xavier Mariette et al. (2022). Variability of Primary Sjögren's Syndrome Is Driven by Interferon α and Interferon α Blood Levels Are Associated With the Class II HLA–DQ Locus. (external link)
• Gülen Arsland Lied; Petra Vogelsang; Arnold Berstad et al. (2011). Dendritic cell populations in patients with self-reported food hypersensitivity. (external link)
• Christian Lundtoft; Pascal Pucholt; Myriam Martin et al. (2022). Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases. (external link)
• Anders Krogh Aarebrot; Silje Michelsen Solberg; Richard Allan Davies et al. (2018). Phosphorylation of intracellular signaling molecules in peripheral blood cells from psoriasis patients on originator or biosimilar infliximab. (external link)
• Richard Allan Davies; Petra Vogelsang; Roland Jonsson et al. (2016). An optimized multiplex flow cytometry protocol for the analysis of intracellular signaling in peripheral blood mononuclear cells. (external link)
• Cecilia Fugmann; Sarah Reid; Pascal Pucholt et al. (2024). A high polygenic risk score is associated with SSA/SSB antibody positivity and early onset in primary Sjögren’s disease. (external link)
• Alexander Sauter; Gunther Richter; Alexandre Micoulet et al. (2013). Effective polyethylene glycol passivation for the inhibition of surface interactions of peripheral blood mononuclear cells and platelets. (external link)
• Ole J. B. Landsverk; Anett Hellebø Ottesen; Axel Berg-Larsen et al. (2012). Differential regulation of MHC II and invariant chain expression during maturation of monocyte-derived dendritic cells. (external link)
• Marie Karlsen; Torbjørn Hansen; Hilde Haugedal Nordal et al. (2015). Expression of toll-like receptor -7 and -9 in B cell subsets from patients with primary Sjögren's syndrome. (external link)
• Silje Michelsen Solberg; Lene Frøyen Sandvik; Marianne Eidsheim et al. (2018). Serum cytokine measurements and biological therapy of psoriasis - Prospects for personalized treatment?. (external link)
• Silke Appel; Anita Bringmann; Frank Grünebach et al. (2006). Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs. (external link)
• Tamandeep Kaur Bharaj; Lara A. Aqrawi; Siren Fromreide et al. (2021). Inflammatory Stratification in Primary Sjögren’s Syndrome Reveals Novel Immune Cell Alterations in Patients’ Minor Salivary Glands. (external link)
• Lene Frøyen Sandvik; Kathrine Skarstein; Lisbeth Sviland et al. (2013). CD11c+ dendritic cells rather than Langerhans cells are reduced in normal skin of immunosuppressed renal transplant recipients. (external link)
• Mandi M. Wiley; Marcin Radziszewski; Bhuwan Khatri et al. (2025). Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland. (external link)
• Alexander Sauter; Dag Heiro Yi; Yayan Li et al. (2019). The Culture Dish Surface Influences the Phenotype and Cytokine Production of Human Monocyte-Derived Dendritic Cells. (external link)
• Petra Vogelsang; Marie Karlsen; Johan G Brun et al. (2014). Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren's syndrome. (external link)
• Richard Allan Davies; Daniel Hammenfors; Brith Bergum et al. (2018). Aberrant cell signalling in PBMCs upon IFN-? stimulation in primary Sjogren's syndrome patients associates with type I interferon signature. (external link)
• Dag Heiro Yi; Nadine Stetter; Kjerstin Jakobsen et al. (2018). 3-Day monocyte-derived dendritic cells stimulated with a combination of OK432, TLR7/8 ligand, and prostaglandin E2 are a promising alternative for cancer immunotherapy. (external link)
• Muhammad Rahman; André Sulen; Lars Ertesvåg Breivik et al. (2025). Anti-perilipin-1 autoantibodies in autoimmune Addison’s disease and related endocrine disorders. (external link)
• Lene Frøyen Sandvik; Kathrine Skarstein; Britta Krynitz et al. (2015). Peritumoral dermis of squamous cell carcinomas in renal transplant recipients contains less CD11c+ myeloid dendritic cells and FoxP3+ T cells compared to immunocompetent controls. (external link)
• Roman Volchenkov; Johan G Brun; Roland Jonsson et al. (2013). In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome. (external link)
• Marie Karlsen; Roland Jonsson; Johan G Brun et al. (2015). TLR-7 and -9 Stimulation of Peripheral Blood B Cells Indicate Altered TLR Signalling in Primary Sjögren's Syndrome Patients by Increased Secretion of Cytokines. (external link)
• Richard Allan Davies; Irene Sarkar; Daniel Hammenfors et al. (2019). Single cell based phosphorylation profiling identifies alterations in toll-like receptor 7 and 9 signaling in patients with primary sjogren's syndrome. (external link)
• Roman Volchenkov; Marie Karlsen; Roland Jonsson et al. (2013). Type 1 regulatory T cells and regulatory B cells induced by tolerogenic dendritic cells. (external link)
• Florian Sprater; Waqas Azeem; Silke Appel (2014). Activation of peroxisome proliferator-activated receptor gamma leads to upregulation of ESE-3 expression in human monocyte-derived dendritic cells. (external link)
• Phillip Lord; Rachel Spiering; Juan C. Aguillon et al. (2016). Minimum information about tolerogenic antigen-presenting cells (MITAP): A first step towards reproducibility and standardisation of cellular therapies. (external link)
• Nicolas Delaleu; Malin V Jonsson; Silke Appel et al. (2008). New Concepts in the Pathogenesis of Sjogren's Syndrome. (external link)
• Magdalena Keindl; Richard Allan Davies; Brith Bergum et al. (2022). Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome. (external link)
• Marie Karlsen; Kjerstin Jakobsen; Roland Jonsson et al. (2017). Expression of Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Patients with Primary Sjogren's Syndrome. (external link)
• Magdalena Keindl; Olena Fedotkina; Elsa du Plessis et al. (2020). Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms. (external link)
• Karstein Haldorsen; Silke Appel; Stephanie Le Hellard et al. (2013). No association of primary Sjögren's syndrome with Fcγ receptor gene variants. (external link)
• Gunnel Nordmark; Gudlaug Kristjansdottir; Elke Theander et al. (2011). Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome. (external link)
• Lene Frøyen Sandvik; Roman Volchenkov; Roland Jonsson et al. (2013). Characterization of monocyte-derived dendritic cells from immunosuppressed renal transplant recipients with and without squamous cell carcinomas. (external link)
• Petra Vogelsang; Arnt-Ove Hovden; Roland Jonsson et al. (2009). Levels of dendritic cell populations and regulatory T cells vary significantly between two commonly used mouse strains. (external link)

Academic literature review

• Lisa Lynn Ten Bergen; Aleksandra Petrovic; Anders K. Aarebrot et al. (2020). The TNF/IL-23/IL-17 axis-Head-to-head trials comparing different biologics in psoriasis treatment. (external link)
• Roman Volchenkov; Florian Sprater; Petra Vogelsang et al. (2012). The 2011 Nobel Prize in physiology or medicine. (external link)
• Petra Vogelsang; Malin V Jonsson; Sussie Trine Dalvin et al. (2006). Role of dendritic cells in Sjögren´s syndrome. (external link)
• Dag Heiro Yi; Silke Appel (2013). Current status and future perspectives of dendritic cell-based cancer immunotherapy. (external link)
• Lisa Lynn Ten Bergen; Aleksandra Petrovic; Anders K. Aarebrot et al. (2020). Current knowledge on autoantigens and autoantibodies in psoriasis. (external link)
• Roland Jonsson; Petra Vogelsang; Roman Volchenkov et al. (2011). The complexity of Sjögren's syndrome: Novel aspects on pathogenesis. (external link)

Conference poster

• Gunnel Nordmark; Gudlaug Kristjansdottir; Silke Appel et al. (2009). Association of C8orf13-BLK and TNFSF4 Gene Variants with Primary Sjögren's Syndrome. (external link)
• Aina van der Meeren; Silke Appel; Gülen Arslan Lied et al. (2023). Diagnostic gut biomarkers with imaging mass cytometry in irritable bowel syndrome. (external link)
• Petra Vogelsang; GS Lier; Johan G Brun et al. (2009). Dendritic cells from patients with primary Sjögren's syndrome have slightly enhanced endocytic capacity. (external link)
• Aina van der Meeren; Silke Appel; Gülen Arslan Lied et al. (2024). Mapping of the duodenal mucosal microenvironment in iriitabel bowel syndrome with imaging mass cytometry. (external link)
• Karstein Haldorsen; Silke Appel; Ove Bruland et al. (2009). Fc receptor IIA, IIIA and IIIB single nucleotide polymorphisms and Fc receptor IIIB copy number variation: No association with primary Sjögren’s syndrome. (external link)
• Petra Vogelsang; Johan G Brun; Roland Jonsson et al. (2009). Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjögren's syndrome. (external link)
• Aina Van Der Meeren; Silke Appel; Gülen Arslan Lied et al. (2023). Bergen BrainGut study: diagnostic gut biomarkers in irritable bowel syndrome with imaging mass cytometry. (external link)

Conference abstract

• Karstein Haldorsen; Silke Appel; Ove Bruland et al. (2010). Fc gamma receptor IIA, IIIA and IIIB single nucleotide polymorphisms and Fc gamma receptor IIIB copy number variation: No association with primary Sjögren's syndrome. (external link)
• Marie Karlsen; Arnt-Ove Hovden; Petra Vogelsang et al. (2010). Bromelain Treatment Leads to Maturation of Monocyte Derived Dendritic Cells. (external link)
• Roman Volchenkov; Arnt-Ove Hovden; Marie Karlsen et al. (2011). Generation of Tolerogenic Monocyte-Derived Dendritic Cells. (external link)
• Silke Appel; Petra Vogelsang; Johan G Brun et al. (2010). Patients with Primary Sjogren's Syndrome have Significantly Reduced Amounts of Plasmacytoid and Type 2 Myeloid Dendritic Cells in Peripheral Blood. (external link)
• Arnt-Ove Hovden; Marie Karlsen; Dagny Ann Sandnes et al. (2010). Maturation of Monocyte Derived Dendritic Cells With OK432 Leads to Altered Expression of Surface Markers. (external link)
• Marie Karlsen; Torbjørn Hansen; Roland Jonsson et al. (2012). Expression of Toll-like receptors 7 and 9 in B cell populations of patients with Sjogren's syndrome. (external link)
• Petra Vogelsang; Virginie Deswaerte; Malin V Jonsson et al. (2008). Age-related distribution of cDC and pDC in salivary glands of NOD mice. (external link)
• Karstein Haldorsen; Silke Appel; Stephanie Le Hellard et al. (2012). No association of primary Sjögren's Syndrome with Fc gamma? Receptor gene variants. (external link)
• Lene Frøyen Sandvik; Torbjørn Leivestad; Dagny Ann Sandnes et al. (2011). Can Levels of Blood Plasmacytoid Dendritic Cells be used as a Prognostic Factor for Development of Squamous Cell Carcinomas in Organ Transplant Recipients?. (external link)
• Anita Bringmann; Ingo Hilgendorf; Silke Appel et al. (2008). Characterization of Gene p306 Expressed in Monocyte Derived Dendritic Cells. (external link)
• Florian Sprater; Arnt-Ove Hovden; Marc Niere et al. (2011). The Epithelial Specific Transcription Factor ESE-3 is Expressed in Immature Dendritic Cells and Occurs Primarily as the ESE-3b Isoform. (external link)
• Roman Volchenkov; Marie Karlsen; Roland Jonsson et al. (2013). Type 1 Regulatory T cells and Regulatory B Cells Induced by Dexamethasone and 1,25-Dihydroxyvitamin D3 Treated Monocyte-Derived Dendritic Cells. (external link)
• Roman Volchenkov; Marie Karlsen; Roland Jonsson et al. (2012). Comparison of different protocols for the generation of monocytes-derived tolerogenic dendritic cells for immunotherapy. (external link)
• Gunnel Nordmark; Gudlaug Kristjansdotti; Elke Theander et al. (2010). Gene Variants in Fam167A-Blk and Tnfsf4 are associated with Primary Sjogren's Syndrome. (external link)
• Gülen Arsland Lied; Petra Vogelsang; Arnold Berstad et al. (2010). Dendritic cell populations in patients with self-reported food hypersensitivity. (external link)
• Arnt-Ove Hovden; Dagny Ann Sandnes; Roland Jonsson et al. (2008). Maturation of monocyte derived dendritic cells with OK432 leads to altered expression of surface markers. (external link)
• Arnt-Ove Hovden; Marie Karlsen; Roland Jonsson et al. (2011). Maturation of Dendritic Cells with the Bacterial Compound OK432 Induces High Secretion of IL-12p70 in a TLR3 Dependent Manner. (external link)

Letter to the editor

• Karstein Haldorsen; Ove Bruland; Silke Appel et al. (2013). Reply to 'Comment on No association of primary Sjogren's syndrome with Fc gamma receptor gene variants'. (external link)
• Arnt-Ove Hovden; Silke Appel (2010). The First Dendritic Cell-Based Therapeutic Cancer Vaccine is Approved by the FDA. (external link)
• Lene Frøyen Sandvik; Petra Vogelsang; Torbjørn Leivestad et al. (2012). Quantification of Plasmacytoid Dendritic Cells and Type 1 Myeloid Dendritic Cells in Peripheral Blood of Renal Transplant Recipients With and Without Squamous Cell Carcinoma. (external link)
• Aleksandra Petrovic; Lisa Lynn Ten Bergen; Silje Michelsen Solberg et al. (2023). Biological treatment in severe psoriasis: Influence on peripheral blood dendritic cells. (external link)
• Roman Volchenkov; Roland Jonsson; Silke Appel (2012). Anti-Ro and anti-La autoantibody profiling in Norwegian patients with primary Sjogren's syndrome using luciferase immunoprecipitation systems (LIPS). (external link)

Doctoral thesis (PhD)

• Silje Michelsen Solberg; Silke Appel; Yenan Bryceson et al. (2019). Systemic inflammation in psoriasis: Circulating immune cells and cytokines. (external link)
• Marie Karlsen; Silke Appel; Torbjørn Hansen (2015). Toll-like receptors in primary Sjögren’s syndrome. Special emphasis on B cells. (external link)
• Karstein Haldorsen; Anne Isine Bolstad; Johan G Brun et al. (2011). Epidemiological, clinical, and immunogenetic aspects of primary Sjögren's syndrome. (external link)
• Richard Allan Davies; Silke Appel; Petra Vogelsang et al. (2017). Flow cytometry based analyses as a tool in biomarker discovery for patient stratification in primary Sjögren’s syndrome. (external link)

Media interview

• Ivar Lid Riise; Mathias Kleiveland; Heidi Lie Andersen et al. (2023). Dreper kreftceller med hageplanter. (external link)

Conference lecture

• Dorentina Osmani; Manpret Kour Hans; Kjerstin Jakobsen et al. (2023). Planter vs. dødelig virus. (external link)

See a complete overview of publications in Cristin.