A recent and important international practice guideline on PBC (Luo et al. 2025) (external link) was put on the agenda by Morten Horn (PhD, specialist in neurology and senior consultant at the Department of Neurology at UOS). This article sets new recomendations for nomenclature, diagnosis, evaluation and management. PBC being a very heterogeneous condition, in both clinical penetrance and symptoms, there is a need for clear guidelines on how to define and diagnose it, and how to manage PBC symptoms. The new international consensus article provides a major leap forward in this regard.

Multiple senior physicians gave talks on how to diagnose and meet this disease, including Alexander Balck, who is one of the many international experts behind the new guideline article.

The seminar will be available on replay here (external link).

Primary Brain Calcification (PBC, previously Fahr's disease)

The genetic disease PBC (previously called Fahr's) has been historically underestimated with new population genomics estimates ranging from 2.1/1000 (European estimate, Nicolas et al 2018) to 6.6/1000 (Chinese estimate, Chen et al 2019).