DynAMoND - Dynamics of Affect Modulation in Neurodevelopmental Disorders

The classification of psychiatric disorders is largely shaped by clinical observations and long-standing scientific traditions. These traditions have led to diagnostic systems in which conditions with overlapping symptoms and risk factors are categorized as distinct disorders. The DynAMoND project challenges this separation by examining ADHD, bipolar disorder, and borderline personality disorder—three conditions traditionally studied within different psychiatric domains.

Despite their differences, all three disorders involve pronounced mood fluctuations that can last from hours to months, causing distress and complicating treatment. However, it remains unclear whether these mood swings share a common underlying mechanism or represent distinct phenomena. To address this question, DynAMoND is conducting an international collaborative study across Germany, Spain, Switzerland, Norway, and Italy.

The study will include 120 participants per group, comprising individuals with ADHD, bipolar disorder, borderline personality disorder, and healthy controls, aged 14 to 30 years. Researchers will gather data on mood, activity, and stress using smartphone sensors and online surveys, alongside genetic analyses from saliva samples. Initial assessments will be conducted through questionnaires, and participants will receive a summary of key findings and recommendations at the study’s conclusion.

If successful, the project could pave the way for more effective treatments, reducing the burden of disease and improving the quality of life for many patients.