Immunforsvarets frontliner

'I prinsippet kan immunsystemet vårt ta knekken på kreft. Men kreftcellene tyr til kamuflasje for å slippe unna'.

Les mer om forskningsprosjekt, metoder og samarbeidspartnere i denne Feltrapporten fra Institut Gustave Roussy (Paris, Frankrike) i Forskerforum. Artikkelen er skrevet av Kjerstin Gjengedal. 

On a quest to cure cancer

Intervju i the UiB Magazine om PhD arbeid og motivasjon (english only). By Jens Helleland Ådnanes. 

Les mer om min mulighet til å bli kjent med andre kreftforskere fra ulike kulturer og bli inspirert av noen av de fremste i verden gjennom deltagelse på på Harvard Medical School (HMS) prostgraduate medical education certificate program.

Kreftforskning krever et arsenal av metoder. Les mer om første heldigitale versjon av metodekurset for PhD studenter på CCBIO's Forskerskole i Kreft-studier, CCBIO905: Methods in Cancer Biomarker Research.

 

Stort engasjement på Forskningsdagene i Bergen

Begeistrede barn og voksne stod tett i tett da forskere ved Center for Cancer Biomarkers (CCBIO) viste de frammøtte levende kreftceller i mikroskopet og framførte skodespelet om kreftcella Fråtse-Frida på Forskingstorget.

Les mer om forskningsformidlingen til barn og unge i Studvest.

Digital undervisning: Les mer om første heldigitale versjon av PhD kurset CCBIO905: Methods in Cancer Biomarker Research

 

Kurs med emneansvar: 

CCBIO901 Junior Scientist Symposium, PhD kurs, The CCBIO Research School for Cancer Studies, UiB (RSCS)

MED1BIOMED Biomedisinske Tema, Obligatorisk for medisinstudenter, Institutt for Biomedisin, UiB 

CCBIO905 Methods in Cancer Biomarker Research, PhD kurs, The CCBIO Research School for Cancer Studies, UiB (RSCS)

HUCEL 320 Cell culture and cellular techniques: Flow Cytometry, Master kurs, Institutt for Biomedisin, UiB

 

Individuelle forelesninger: 

BMED331 Tumorbiologi,  Master kurs, Institutt for Biomedisin, UiB 

MED1BIOMED Biomedisinske Tema, Obligatorisk for medisinstudenter, Institutt for Biomedisin, UiB 

CCBIO905 Methods in Cancer Biomarker Research, PhD course, The CCBIO Research School for Cancer Studies, UiB (RSCS)

BZL 256 Embryologi, Institutt for Zoologi, UiB

MED1BAS, FARM 260/NUTR, ODONT, Histology, Labkurs, Institutt for Biomedisin, UiB

Vitenskapelig artikkel

• Ekanger, Camilla Tvedt; Dinesh Kumar, Nilima; Koutstaal, Rosanne W. et al. (2025). Comparison of air-liquid interface transwell and airway organoid models for human respiratory virus infection studies. (ekstern lenke)
• Rayford, Austin James; Gärtner, Fabian; Ramnefjell, Maria Paula et al. (2024). AXL expression reflects tumor-immune cell dynamics impacting outcome in non-small cell lung cancer patients treated with immune checkpoint inhibitor monotherapy. (ekstern lenke)
• Lotsberg, Maria Lie; Røsland, Gro Vatne; Rayford, Austin James et al. (2022). Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models. (ekstern lenke)
• Engelsen, Agnete Svendsen Tenfjord; Lotsberg, Maria Lie; Khouzam, Raefa Abou et al. (2022). Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition. (ekstern lenke)
• Rahman, Mohummad Aminur; Engelsen, Agnete ; Sarowar, Shahin et al. (2022). Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway. (ekstern lenke)
• Ekanger, Camilla Tvedt; Zhou, Fan; Bohan, Dana et al. (2022). Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 respiratory virus. (ekstern lenke)
• Dyrstad, Sissel Elisabeth; Lotsberg, Maria Lie; Tan, Tuan Zea et al. (2021). Blocking aerobic glycolysis by targeting pyruvate dehydrogenase kinase in combination with EGFR TKI and ionizing radiation increases therapeutic effect in non-small cell lung cancer cells. (ekstern lenke)
• Hoareau, Laurence; Engelsen, Agnete ; Aanerud, Marianne et al. (2021). Induction of alveolar and bronchiolar phenotypes in human lung organoids. (ekstern lenke)
• Engelsen, Agnete ; Wnuk-Lipinska, Katarzyna; Bougnaud, Sébastien et al. (2020). AXL is a driver of stemness in normal mammary gland and breast cancer. (ekstern lenke)
• Lotsberg, Maria Lie; Wnuk-Lipinska, Katarzyna; Terry, Stéphane et al. (2020). AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells. (ekstern lenke)
• Røsland, Gro Vatne; Dyrstad, Sissel Elisabeth; Tusubira, Deusdedit et al. (2019). Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC.. (ekstern lenke)
• Terry, Stéphane; Abdou, Abderemane; Svendsen, Agnete et al. (2019). AXL targeting overcomes human lung cancer cell resistance to NK- And CTL-mediated cytotoxicity. (ekstern lenke)
• Rahman, Mohummad Aminur; Gras Navarro, Andrea; Brekke, Jorunn et al. (2019). Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival. (ekstern lenke)
• Bozickovic, Olivera; Skartveit, Linn; Svendsen, Agnete et al. (2018). A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells. (ekstern lenke)
• Chouaieb, Elyes; Terry, Stéphane; Corgnac, Stephanie et al. (2018). Cancer Immunotherapy 2017 (Paris, France). Progress and challenges. (ekstern lenke)
• Jokela, Tiina; Svendsen, Agnete; Rybicka, Agata et al. (2018). Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance. (ekstern lenke)
• Sletta, Kristine Yttersian; Tveitarås, Maria Kathrine; Lu, Ning et al. (2017). Oxygen-dependent regulation of tumor growth and metastasis in human breast cancer xenografts. (ekstern lenke)
• Torsvik, Anja; Stieber, Daniel; Enger, Per Øyvind et al. (2014). U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells . (ekstern lenke)
• Gras Navarro, Andrea; Kmiecik, Justyna; Leiss, Lina Wik et al. (2014). NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival. (ekstern lenke)
• Svendsen, Agnete; Verhoeff, Joost JC; Immervoll, Heike et al. (2011). Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. (ekstern lenke)
• Wang, Jian; Svendsen, Agnete; Kmiecik, Justyna et al. (2011). Targeting the NG2/CSPG4 Proteoglycan Retards Tumour Growth and Angiogenesis in Preclinical Models of GBM and Melanoma. (ekstern lenke)
• Prestegarden, Lars; Svendsen, Agnete; Wang, Jian et al. (2010). Glioma cell populations grouped by different cell type markers drive brain tumor growth. (ekstern lenke)
• Røsland, Gro Vatne; Svendsen, Agnete; Torsvik, Anja et al. (2009). Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. (ekstern lenke)
• Chekenya, Martha; Krakstad, Camilla; Svendsen, Agnete et al. (2008). The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling. (ekstern lenke)
• Niclou, Simone P; Danzeisen, Claude; Eikesdal, Hans Petter et al. (2008). A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. (ekstern lenke)
• Wang, Jian; Sakariassen, Per Øystein; Tsinkalovsky, Oleg et al. (2008). CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. (ekstern lenke)
• Thorsen, Frits Alan; Afione, Sandra; Huszthy, Peter Csaba et al. (2006). Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma. (ekstern lenke)

Poster

• Ekanger, Camilla Tvedt; Zhou, Fan; Brokstad, Karl Albert et al. (2024). Comparison of Air-Liquid Interface and Organoid Airway Models for Human Respiratory Virus Infection Studies. (ekstern lenke)

Mastergradsoppgave

• Guttormsen, Maren Sofie Faldalen; Engelsen, Agnete ; Lorens, James et al. (2023). Predictive Biomarkers Beyond Next Generation Sequencing: Functional Testing of Homologous Recombination Repair Deficiency Status in Patient-Derived Tissue Cultures. (ekstern lenke)
• Arnal, Emmanuelle Lucie; Engelsen, Agnete ; Stuhr, Linda Elin Birkhaug et al. (2023). Disrupting the metabolic homeostasis of lung cancer to increase the efficacy of immune checkpoint inhibition. (ekstern lenke)
• Ekanger, Camilla Tvedt; Engelsen, Agnete ; Stuhr, Linda Elin Birkhaug (2021). Human organotypic airway and lung organoids for the study of SARS-CoV-2 infectivity and cytopathology. (ekstern lenke)
• Joakim, Hekland; Engelsen, Agnete ; Stuhr, Linda Elin Birkhaug (2021). Development and Characterization of an ex vivo Organotypic Non-Small Cell Lung Cancer Model to Study the Effect of Elevated Oxygen Treatment. (ekstern lenke)
• Hekland, Joakim; Stuhr, Linda Elin Birkhaug; Engelsen, Agnete et al. (2021). Development and Characterization of an ex vivo Organotypic Non-Small Cell Lung Cancer Model to Study the Effect of Elevated Oxygen Treatment. (ekstern lenke)
• Rayford, Austin James; Lorens, James; Svendsen, Agnete (2019). The Role of Axl in Cancer and Stem Cell Plasticity: in vivo Lineage Tracing and Imaging Mass Cytometry Analysis. (ekstern lenke)

Vitenskapelig oversiktsartikkel/review

• Zaarour, Rania F.; Azakir, Bilal; Hajam, Edries Y. et al. (2021). Role of Hypoxia-Mediated Autophagy in Tumor Cell Death and Survival. (ekstern lenke)
• Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara et al. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) . (ekstern lenke)
• Lotsberg, Maria Lie; Rayford, Austin James; Thiery, Jean Paul et al. (2020). Decoding cancer’s camouflage: epithelial-mesenchymal plasticity in resistance to immune checkpoint blockade. (ekstern lenke)
• Terry, Stéphane; Engelsen, Agnete ; Buart, Stéphanie et al. (2020). Hypoxia-driven intratumor heterogeneity and immune evasion. (ekstern lenke)
• Ferreira, Bibiana I.; Lie, Maria Kolnes; Svendsen, Agnete et al. (2017). Adaptive mechanisms of resistance to anti-neoplastic agents. (ekstern lenke)

Vitenskapelig Kapittel/Artikkel/Konferanseartikkel

• Lotsberg, Maria Lie; Chen, Ying Yi; Dhakal, Sushil et al. (2020). Autophagy mediated danger signaling regulates tumor immunosurveillance and may potentiate the effects of anti-cancer immunotherapy through increased adjuvanticity. (ekstern lenke)
• Davidsen, Kjersti; Haaland, Gry Sandvik; Lie, Maria Kolnes et al. (2017). The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance. (ekstern lenke)

Doktorgradsavhandling

• Engelsen, Agnete Svendsen Tenfjord (2013). Intratumoural Heterogeneity of Glioblastoma. Implications of Immature Phenotypes on Tumour Growth and Resistance to Treatment. (ekstern lenke)

Leserinnlegg

• Torsvik, Anja; Røsland, Gro Vatne; Svendsen, Agnete et al. (2010). Spontaneous Malignant Transformation of Human Mesenchymal Stem Cells Reflects Cross-Contamination: Putting the Research Field on Track - Letter. (ekstern lenke)

Sammendrag/abstract

• Chekenya, Martha; Netland, Inger Anne; Verhoeff, Joost JC et al. (2010). NG2 PROMOTES RESISTANCE TO IONIZING RADIATION BY ELEVATED PEROXIREDOXIN-1 AND DNA DAMAGE RESPONSE IN GLIOBLASTOMA MULTIFORME. (ekstern lenke)
• Wang, Jian; Tsinkalovsky, Oleg; Svendsen, Agnete et al. (2009). Targeting the tumor stroma: a novel therapeutic strategy based on separate analysis of the malignant and stromal cell compartments in brain tumors. (ekstern lenke)
• Prestegarden, Lars; Svendsen, Agnete; Wang, Jian et al. (2009). CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORIGENICITY IN VIVO. (ekstern lenke)
• Prestegarden, Lars; Svendsen, Agnete; Wang, Jian et al. (2008). CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORGENICITY IN VIVO. (ekstern lenke)

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