Immunforsvarets frontliner

'I prinsippet kan immunsystemet vårt ta knekken på kreft. Men kreftcellene tyr til kamuflasje for å slippe unna'.

Les mer om forskningsprosjekt, metoder og samarbeidspartnere i denne Feltrapporten fra Institut Gustave Roussy (Paris, Frankrike) i Forskerforum. Artikkelen er skrevet av Kjerstin Gjengedal. 

On a quest to cure cancer

Intervju i the UiB Magazine om PhD arbeid og motivasjon (english only). By Jens Helleland Ådnanes. 

Les mer om min mulighet til å bli kjent med andre kreftforskere fra ulike kulturer og bli inspirert av noen av de fremste i verden gjennom deltagelse på på Harvard Medical School (HMS) prostgraduate medical education certificate program.

Kreftforskning krever et arsenal av metoder. Les mer om første heldigitale versjon av metodekurset for PhD studenter på CCBIO's Forskerskole i Kreft-studier, CCBIO905: Methods in Cancer Biomarker Research.

 

Stort engasjement på Forskningsdagene i Bergen

Begeistrede barn og voksne stod tett i tett da forskere ved Center for Cancer Biomarkers (CCBIO) viste de frammøtte levende kreftceller i mikroskopet og framførte skodespelet om kreftcella Fråtse-Frida på Forskingstorget.

Les mer om forskningsformidlingen til barn og unge i Studvest.

Digital undervisning: Les mer om første heldigitale versjon av PhD kurset CCBIO905: Methods in Cancer Biomarker Research

 

Kurs med emneansvar: 

CCBIO901 Junior Scientist Symposium, PhD kurs, The CCBIO Research School for Cancer Studies, UiB (RSCS)

MED1BIOMED Biomedisinske Tema, Obligatorisk for medisinstudenter, Institutt for Biomedisin, UiB 

CCBIO905 Methods in Cancer Biomarker Research, PhD kurs, The CCBIO Research School for Cancer Studies, UiB (RSCS)

HUCEL 320 Cell culture and cellular techniques: Flow Cytometry, Master kurs, Institutt for Biomedisin, UiB

 

Individuelle forelesninger: 

BMED331 Tumorbiologi,  Master kurs, Institutt for Biomedisin, UiB 

MED1BIOMED Biomedisinske Tema, Obligatorisk for medisinstudenter, Institutt for Biomedisin, UiB 

CCBIO905 Methods in Cancer Biomarker Research, PhD course, The CCBIO Research School for Cancer Studies, UiB (RSCS)

BZL 256 Embryologi, Institutt for Zoologi, UiB

MED1BAS, FARM 260/NUTR, ODONT, Histology, Labkurs, Institutt for Biomedisin, UiB

Vitenskapelig artikkel

• Camilla Tvedt Ekanger; Maria Ramnefjell; Maren Sofie Faldalen Guttormsen et al. (2025). An Organoid Model for Translational Cancer Research Recapitulates Histoarchitecture and Molecular Hallmarks of Non-Small-Cell Lung Cancer. (ekstern lenke)
• Gro Vatne Røsland; Agnete Svendsen; Anja Torsvik et al. (2009). Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. (ekstern lenke)
• Agnete Svendsen; Joost JC Verhoeff; Heike Immervoll et al. (2011). Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. (ekstern lenke)
• Austin James Rayford; Fabian Gärtner; Maria Paula Ramnefjell et al. (2024). AXL expression reflects tumor-immune cell dynamics impacting outcome in non-small cell lung cancer patients treated with immune checkpoint inhibitor monotherapy. (ekstern lenke)
• Olivera Bozickovic; Linn Skartveit; Agnete Svendsen et al. (2018). A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells. (ekstern lenke)
• Sissel Elisabeth Dyrstad; Maria Lie Lotsberg; Tuan Zea Tan et al. (2021). Blocking aerobic glycolysis by targeting pyruvate dehydrogenase kinase in combination with EGFR TKI and ionizing radiation increases therapeutic effect in non-small cell lung cancer cells. (ekstern lenke)
• Martha Chekenya; Camilla Krakstad; Agnete Svendsen et al. (2008). The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling. (ekstern lenke)
• Maria Lie Lotsberg; Katarzyna Wnuk-Lipinska; Stéphane Terry et al. (2020). AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells. (ekstern lenke)
• Jian Wang; Per Øystein Sakariassen; Oleg Tsinkalovsky et al. (2008). CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. (ekstern lenke)
• Agnete Svendsen Tenfjord Engelsen; Maria Lie Lotsberg; Raefa Abou Khouzam et al. (2022). Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition. (ekstern lenke)
• Anja Torsvik; Daniel Stieber; Per Øyvind Enger et al. (2014). U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells. (ekstern lenke)
• Camilla Tvedt Ekanger; Nilima Dinesh Kumar; Rosanne W. Koutstaal et al. (2025). Comparison of air-liquid interface transwell and airway organoid models for human respiratory virus infection studies. (ekstern lenke)
• Agnete Engelsen; Katarzyna Wnuk-Lipinska; Sébastien Bougnaud et al. (2020). AXL is a driver of stemness in normal mammary gland and breast cancer. (ekstern lenke)
• Kristine Yttersian Sletta; Maria Kathrine Tveitarås; Ning Lu et al. (2017). Oxygen-dependent regulation of tumor growth and metastasis in human breast cancer xenografts. (ekstern lenke)
• Maria Lie Lotsberg; Gro Vatne Røsland; Austin James Rayford et al. (2022). Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models. (ekstern lenke)
• Laurence Hoareau; Agnete Engelsen; Marianne Aanerud et al. (2021). Induction of alveolar and bronchiolar phenotypes in human lung organoids. (ekstern lenke)
• Camilla Tvedt Ekanger; Fan Zhou; Dana Bohan et al. (2022). Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 respiratory virus. (ekstern lenke)
• Gro Vatne Røsland; Sissel Elisabeth Dyrstad; Deusdedit Tusubira et al. (2019). Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC.. (ekstern lenke)
• Stéphane Terry; Abderemane Abdou; Agnete Svendsen et al. (2019). AXL targeting overcomes human lung cancer cell resistance to NK- And CTL-mediated cytotoxicity. (ekstern lenke)
• Jian Wang; Agnete Svendsen; Justyna Kmiecik et al. (2011). Targeting the NG2/CSPG4 Proteoglycan Retards Tumour Growth and Angiogenesis in Preclinical Models of GBM and Melanoma. (ekstern lenke)
• Simone P Niclou; Claude Danzeisen; Hans Petter Eikesdal et al. (2008). A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. (ekstern lenke)
• Andrea Gras Navarro; Justyna Kmiecik; Lina Wik Leiss et al. (2014). NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival. (ekstern lenke)
• Elyes Chouaieb; Stéphane Terry; Stephanie Corgnac et al. (2018). Cancer Immunotherapy 2017 (Paris, France). Progress and challenges. (ekstern lenke)
• Mohummad Aminur Rahman; Agnete Engelsen; Shahin Sarowar et al. (2022). Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway. (ekstern lenke)
• Mohummad Aminur Rahman; Andrea Gras Navarro; Jorunn Brekke et al. (2019). Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival. (ekstern lenke)
• Lars Prestegarden; Agnete Svendsen; Jian Wang et al. (2010). Glioma cell populations grouped by different cell type markers drive brain tumor growth. (ekstern lenke)
• Frits Alan Thorsen; Sandra Afione; Peter Csaba Huszthy et al. (2006). Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma. (ekstern lenke)
• Tiina Jokela; Agnete Svendsen; Agata Rybicka et al. (2018). Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance. (ekstern lenke)

Masteroppgave

• Joakim Hekland; Linda Elin Birkhaug Stuhr; Agnete Engelsen et al. (2021). Development and Characterization of an ex vivo Organotypic Non-Small Cell Lung Cancer Model to Study the Effect of Elevated Oxygen Treatment. (ekstern lenke)
• Austin James Rayford; James Lorens; Agnete Svendsen (2019). The Role of Axl in Cancer and Stem Cell Plasticity: in vivo Lineage Tracing and Imaging Mass Cytometry Analysis. (ekstern lenke)
• Hekland Joakim; Agnete Engelsen; Linda Elin Birkhaug Stuhr (2021). Development and Characterization of an ex vivo Organotypic Non-Small Cell Lung Cancer Model to Study the Effect of Elevated Oxygen Treatment. (ekstern lenke)
• Camilla Tvedt Ekanger; Agnete Engelsen; Linda Elin Birkhaug Stuhr (2021). Human organotypic airway and lung organoids for the study of SARS-CoV-2 infectivity and cytopathology. (ekstern lenke)
• Emmanuelle Lucie Arnal; Agnete Engelsen; Linda Elin Birkhaug Stuhr et al. (2023). Disrupting the metabolic homeostasis of lung cancer to increase the efficacy of immune checkpoint inhibition. (ekstern lenke)
• Maren Sofie Faldalen Guttormsen; Agnete Engelsen; James Lorens et al. (2023). Predictive Biomarkers Beyond Next Generation Sequencing: Functional Testing of Homologous Recombination Repair Deficiency Status in Patient-Derived Tissue Cultures. (ekstern lenke)

Vitenskapelig litteraturgjennomgang

• Daniel J. Klionsky; Amal Kamal Abdel-Aziz; Sara Abdelfatah et al. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). (ekstern lenke)
• Bibiana I. Ferreira; Maria Kolnes Lie; Agnete Svendsen et al. (2017). Adaptive mechanisms of resistance to anti-neoplastic agents. (ekstern lenke)
• Stéphane Terry; Agnete Engelsen; Stéphanie Buart et al. (2020). Hypoxia-driven intratumor heterogeneity and immune evasion. (ekstern lenke)
• Maria Lie Lotsberg; Austin James Rayford; Jean Paul Thiery et al. (2020). Decoding cancer’s camouflage: epithelial-mesenchymal plasticity in resistance to immune checkpoint blockade. (ekstern lenke)
• Rania F. Zaarour; Bilal Azakir; Edries Y. Hajam et al. (2021). Role of Hypoxia-Mediated Autophagy in Tumor Cell Death and Survival. (ekstern lenke)

Vitenskapelig bokkapittel

• Maria Lie Lotsberg; Ying Yi Chen; Sushil Dhakal et al. (2020). Autophagy mediated danger signaling regulates tumor immunosurveillance and may potentiate the effects of anti-cancer immunotherapy through increased adjuvanticity. (ekstern lenke)
• Kjersti Davidsen; Gry Sandvik Haaland; Maria Kolnes Lie et al. (2017). The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance. (ekstern lenke)

Konferanseposter

• Camilla Tvedt Ekanger; Fan Zhou; Karl Albert Brokstad et al. (2024). Comparison of Air-Liquid Interface and Organoid Airway Models for Human Respiratory Virus Infection Studies. (ekstern lenke)

Konferanseabstrakt

• Jian Wang; Oleg Tsinkalovsky; Agnete Svendsen et al. (2009). Targeting the tumor stroma: a novel therapeutic strategy based on separate analysis of the malignant and stromal cell compartments in brain tumors. (ekstern lenke)
• Martha Chekenya; Inger Anne Netland; Joost JC Verhoeff et al. (2010). NG2 PROMOTES RESISTANCE TO IONIZING RADIATION BY ELEVATED PEROXIREDOXIN-1 AND DNA DAMAGE RESPONSE IN GLIOBLASTOMA MULTIFORME. (ekstern lenke)
• Lars Prestegarden; Agnete Svendsen; Jian Wang et al. (2009). CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORIGENICITY IN VIVO. (ekstern lenke)
• Lars Prestegarden; Agnete Svendsen; Jian Wang et al. (2008). CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORGENICITY IN VIVO. (ekstern lenke)

Leserbrev

• Anja Torsvik; Gro Vatne Røsland; Agnete Svendsen et al. (2010). Spontaneous Malignant Transformation of Human Mesenchymal Stem Cells Reflects Cross-Contamination: Putting the Research Field on Track - Letter. (ekstern lenke)

Doktorgradsavhandling

• Agnete Svendsen Tenfjord Engelsen (2013). Intratumoural Heterogeneity of Glioblastoma. Implications of Immature Phenotypes on Tumour Growth and Resistance to Treatment. (ekstern lenke)

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