Eystein Sverre Husebye

Stilling

Professor

Tilhørighet

Klinisk institutt 2

Forskning

Addison's sykdom (binyrebarksvikt)

Autoimmune polyendokrine syndromer

Hypoparathyroidisme

Undervisning

Hormonsykdommer

Publikasjoner

Ten papers of special significance

1. Ueland GÅ, Methlie P, Jøssang DE, Sagen JV, Viste K, Thordarson HB, Heie A, Grytaas M, Løvås K, Biermann M, Husebye ES. Adrenal Venous Sampling for Assessment of Autonomous Cortisol Secretion. J Clin Endocrinol Metab. 2018 Dec 1;103(12):4553-4560. First major study showing the importance of adrenal venous sampling in the evaluation of adrenal Cushing’s syndrome.

2. Ueland GÅ, Methlie P, Øksnes M, Thordarson HB, Sagen J, Kellmann R, Mellgren G, Ræder M, Dahlqvist P, Dahl SR, Thorsby PM, Løvås K, Husebye ES. The short cosyntropintest revisited - new normal reference range using LCMSMS. J Clin Endocrinol Metab. 2018 Feb 14. doi: 10.1210/jc.2017-02602. [Epub ahead of print]. First major re-evaluation of the short synacthen test using LCMSMS.

3. Husebye ES, Anderson MS, Kämpe O. Autoimmune polyendocrine syndromes. New Engl.J Med, 378, 1132-41, 2018 (IF 72.4). Invited review that summarizes the current status on polyendocrine syndromes.

4. Orlova EM, Sozaeva LS, Kareva MA, Oftedal BE, Wolff ASB, Breivik L, Zakharova EY, Ivanova ON, Kämpe O, Dedov II, Knappskog PM, Peterkova VA, and Husebye ES. Expanding the phenotypic and genotypic landscape of autoimmune polyendocrine syndrome type-1. J Clin Endocrinol Metabol 102, 3546-56, 2017 (IF 5.5). Clinical and immunological characterization of the hitherto largest cohort of patients with autoimmune polyendocrine syndrome type 1 in the world.

5. Landegren N, Sharon D, Shum AK, Khan IS, Fasano K, Hallgren Å, Kampf C, Freyhult E, Ardesjö-Lundgren B, Alimohammadi M, Rathsman S, Ludvigsson JF, Hedelin H, Lundh D, Motrich R, Rivero V, Fong L, Giwercman A, Gustafsson J, Perheentupa J, Husebye ES, Anderson MS, Snyder M, Kämpe O. Prostatic transglutaminase 4 as a male-specific autoantigen. Science Trans Med 2015 7(292):292ra101. (IF 16.8). Identification of transglutaminase 4 as the first geneder-specific autoantigen assosiated with autoimmune prostatitis. Transglutaminase 4 is an autoantigen in both humans and in autoimmune regulator knockout mice. Furthermore it was demonstrated that transglutaminase 4 belows to the family of aire-regulated genes.

6. Chuprin C, Avin A, Goldfarb Y, Herzig Y, Levi B, Jacob A, Sela A, Katz S1, Grossman M, Guyon C, Rathaus M, Cohen H, Sagi I, Giraud M, McBurney M, Husebye ES, Abramson J. Sirt1 is essential for Aire-mediated induction of central immunological tolerance. Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance. Nature Immunology 16,737-45, 2015, (IF 21.5). Demonstration of Sirtuin-1 as a key regulator of AIRE by deacetylation using mouse models. Sirt1-mutations have been described in monogenic autoimmune diabetes mellitus type 1

7. Oftedal BE, Hellesen A, Erichsen MM, Bratland B, Vardi A, Perheentupa J, Kemp EH, Fiskerstrand T, Viken MK, Weetman AP, Fleishman SJ, Banka S, Newman WG, Sewell WAC, Sozaeva LG, Zayats T, Haugarvoll K, Orlova EM, Haavik J Johansson S, Knappskog PM, Løvås L, Wolff ASB, Abramson J, Husebye ES. Dominant Autoimmune Regulator mutations associated with common organ-specific autoimmune diseases. Immunity 42,1185-96, 2015. (IF 22.8). Identification of a new mechanism for familial autoimmunity by identification of several dominant negative mutations in the autoimmune regulator gene. The study includes clinical and immunological characterization of patients as well as functional studies of the mutants demonstrating the dominant negative effect. The paper was accompanied by an editorial and front page cover illustration (June issue).

8. Dawoodji A, Chen JL, Shepherd D, Dalin F, Tarlton A, Alimohammadi M, Penna-Martinez M, Meyer G, Mitchell AL, Gan EH, Bratland E, Bensing S, Husebye ES, Pearce SH, Badenhoop K, Kämpe O, Cerundolo V. High Frequency of Cytolytic 21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison's Disease Patients. J Immunol 193, 2118-26, 2014 (IF 4.8). Demonstration of both CD8 and CD4 T cell reativity against 21-hydroxylase and identification of distinct epitopes, building on previous observation by us Bratland et al JCEM, 2009 and Husebye et al, Endocrinology, 2005.

9. Mitchell AL, Macarthur KD, Gan EH, Baggott LE, Wolff AS, Skinningsrud B, Platt H, Short A, Lobell A, Kämpe O, Bensing S, Betterle C, Kasperlik-Zaluska A, Zurawek M, Fichna M, Kockum I, Nordling Eriksson G, Ekwall O, Wahlberg J, Dahlqvist P, Hulting AL, Penna-Martinez M, Meyer G, Kahles H, Badenhoop K, Hahner S, Quinkler M, Falorni A, Phipps-Green A, Merriman TR, Ollier W, Cordell HJ, Undlien D, Czarnocka B, Husebye ES, Pearce SH. Association of autoimmune Addison's disease with alleles of STAT4 and GATA3 in European cohorts. Plos One, 9(3):e88991. doi: 10.1371/journal.pone.0088991. eCollection 2014. (IF 3.5). Results of a FP7-Euradrenal (coordinator Husebye) to find novel disease associations in autoimmune Addison’s disease involving Addison cohorts from 6 European countries totalling over 2000 patients with autoimmune Addison’s disease. Several novel associations were found including GATA3 and STAT4

10. Oksnes M, Björnsdottir S, Isaksson M, Methlie P, Carlsen S, Nilsen RM, Broman JE, Triebner K, Kämpe O, Hulting AL, Bensing S, Husebye ES, Løvås K. Continuous Subcutaneous Hydrocortisone Infusion versus Oral Hydrocortisone Replacement for Treatment of Addison's Disease: A Randomized Clinical Trial. J Clin Endocrinol Metabol 99,1665-74, 2014. (IF 5.5). Clinical study of circadian cortisol treatment first introduced by us. Using subcutaneous cintinous infusion of cortisol by an insulin pump we were able to restore circadian levels of cortisol. The preatment was safe and patients reported improved quality of life.

Prosjekter

Leder K.G. Jebsen-senter for autoimmune sykdommer

Koordinator av H2020 Ultradian

Kompetanse

Spesialist i endokrinologi og indremedisin