Bakgrunn

Omtrent 1/3 av alle kreftpasienter får spredning av kreften til hjernen (hjernemetastaser), og metastaser til hjernen er 10 ganger mer vanlig enn kreft som oppstår i hjernen. De mest vanlige krefttypene som sprer seg til hjernen, er lungekreft (50-60%), brystkreft (15-20%), hudkreft (5-10%), og kreft i mage/tarm (4-6%).

Kreftpasienter med hjernemetastaser har en dårlig prognose, og dagens kreftbehandling øker ikke pasientoverlevelsen nevneverdig. Det er derfor nødvendig med forskning for å kunne finne nye behandlingsmetoder, og i denne sammenheng er det behov for gode modeller for å kunne forstå metastaseringsprosessen bedre. 

Utvikling av nye dyremodeller for å studere kreftspredning til hjernen

Vi injiserer kreftceller fra humane hjernemetastaser direkte inn i blodstrømmen på immundefekte mus. Vi ser da at cellene sprer seg til dyrehjernen, på samme måte som man observerer i pasienten. Disse modellene rekapitulerer de ulike stegene i kreftspredningsprosessen, og gjør oss i stand til å effektivt kunne teste ut nye behandlingsalternativer.

Pågående forskningsaktiviteter

Vår forskning fokuserer på 3 ulike angrepsmåter:

Vi har utført genetiske studier av kreftspredningen i våre dyremodeller, og bestemt en gensignatur for hjernemetastaser fra hudkreft. På bakgrunn av disse dataene har vi funnet flere ulike medikamenter, idag i bruk på andre sykdommer enn kreft, som viser seg å hemme veksten av hudkreft i hjernen.

Vi studerer blod-hjerne barrieren (BBB), som blokkerer medikamenter fra å trenge inn i hjernen, og dermed hindrer effektiv behandling. I et forskningsprosjekt har vi vært istand til å åpne BBB på forsøksdyr, og dermed oppnå god effekt av behandlingen.

For tiden studerer vi betydningen av såkalte exosomer i spredningen av hjernekreft. Vi har lovende data som viser at mikro-RNA levert til hjernen av exosomene, øker kreftspredningen. Vi har greidd å hemme denne spredningen ved å genetisk blokkere enkelte mikro-RNA til hjernen.  Dette er et pågående samarbeide med partnere ved Shandong University, Kina, og University of Luxembourg.

POPULÆRVITENSKAPELIGE ARTIKLER

1.   Mottok kinesiske forskningsmidler. Medical Faculty web site, University of Bergen, October 2, 2020 (In Norwegian). https://www.uib.no/med/139047/mottok-kinesiske-forskningsmidler

2.   Fikk kinesisk æresprofessorat. På Høyden, October 31, 2018 (In Norwegian). http://pahoyden.no/2018/10/fikk-kinesisk-aeresprofessorat

3.   Slik jobber 100 forskere i Bergen hver dag for å løse kreftgåten. Bergens Tidende, July 22, 2017 (In Norwegian). https://www.bt.no/btmagasinet/i/voqmV/Bruker-designermus-for-a-lose-kreftgaten?utm_campaign=Echobox&utm_medium=Social&utm_source=Facebook#link_time=1500704688

4.   30 millioner til kreftforskning. University of Bergen web site, Nov 1, 2016 (In Norwegian). http://www.uib.no/mofa/102056/30-millioner-til-kreftforskning

5.   207 millioner til kreftforskning. Kreftforeningen (blog), Oct 27, 2015 (In Norwegian). (http://www.kreftforeningens-blogg.no/2015/10/207-millioner-til-kreftforskning/ )

6.     Nøttestoff reduserte kreft i musehjerner. Forskning.no, July 25, 2015 (In Norwegian). https://forskning.no/2015/07/nottestoff-reduserte-kreft-i-musehjerner

7.   Forsker: Jeg trodde det var for godt til å være sant. Bergens Tidende, July 2, 2015 (In Norwegian). (http://www.bt.no/nyheter/lokalt/--Jeg-har-ikke-sett-lignende-i-mine-20-ar-som-forsker-3393563.html ).

8.   Nøtter kan redusere kreft med spredning til hjernen. Kreftforeningen.no, July 1, 2015 (In Norwegian). (https://kreftforeningen.no/forskning/forskningsprosjekter-vi-stotter/notter-kan-redusere-kreft-med-spredning-til-hjernen/?utm_source=apsis-anp-3&utm_medium=email&utm_content=unspecified&utm_campaign=01.%20juli ).

9.   Nøtter kan redusere kreft med spredning til hjernen. University of Bergen web site, July 1, 2015 (In Norwegian). (http://www.uib.no/aktuelt/89958/n%C3%B8tter-kan-redusere-kreft-med-spredning-til-hjernen ).

10.   Frits Thorsen in Bergens Tidende: Exciting findings in preventing metastatic spreading. http://www.uib.no/en/rg/mic/90150/frits-thorsen-bergens-tidende-exciting-findings-preventing-metastatic-spreading   

1989-2002 Underviser i strålingsfysikk, Haukeland Universitetssykehus, Bergen.

1991-1994 Timelærer i Apparatlære, ved Radiografhøgskolen i Bergen.

1993-2006 Klinisk konsulent, Elekta Instrument AB, Stockholm, Sverige.

2004-2023 Foreleser i histologi og anatomi, Institutt for biomedisin, UiB.

2008-2022 Invitert foredragsholder ved 18 internasjonale kreftkonferanser.

 

Vitenskapelig artikkel

• Thorsen, Frits (2024). Fluspirilene exerts an anti-glioblastoma effect through suppression of the FOXM1-KIF20A/BIRC5 axis. . (ekstern lenke)
• Bhoopathi, Praveen; Mannangatti, Padmanabhan; Pradhan, Anjan K. et al. (2024). Noninvasive therapy of brain cancer using a unique systemic delivery methodology with a cancer terminator virus. (ekstern lenke)
• Spitzer, Daniel; Khel, Maryam I.; Pütz, Tim et al. (2023). A flow cytometry-based protocol for syngenic isolation of neurovascular unit cells from mouse and human tissues. (ekstern lenke)
• Rigg, Emma Kayleigh; Wang, Jiwei; Xue, Zhiwei et al. (2023). Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes. (ekstern lenke)
• Reigstad, Agathe; Herdlevær, Christina Frantzen; Rigg, Emma Kayleigh et al. (2022). CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells. (ekstern lenke)
• Zhang, Yulin; Kong, Yang; Ma, Yuan et al. (2021). Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines. (ekstern lenke)
• Aasen, Synnøve Nymark; Espedal, Heidi; Keunen, Olivier et al. (2021). Current landscape and future perspectives in preclinical MR and PET imaging of brain metastasis. (ekstern lenke)
• Mannsåker, Trond Are; Hoang, Tuyen; Aasen, Synnøve Nymark et al. (2021). Cabozantinib is effective in melanoma brain metastasis cell lines and affects key signaling pathways. (ekstern lenke)
• Zhang, Xin; Ding, Kaikai; Ji, Jianxiong et al. (2020). Trifluoperazine prolongs the survival of experimental brain metastases by STAT3-dependent lysosome membrane permeabilization. . (ekstern lenke)
• Kong, Yang; Feng, Zichao; Zhang, Yulin et al. (2020). Identification of immune-related genes contributing to the development of glioblastoma using weighted gene co-expression network analysis. . (ekstern lenke)
• Zhang, Yulin; Fu, Xiao; Jia, Junsheng et al. (2020). Glioblastoma Therapy Using Codelivery of Cisplatin and Glutathione Peroxidase Targeting siRNA from Iron Oxide Nanoparticles. (ekstern lenke)
• Ji, Jianxiong; Ding, Kaikai; Luo, Tao et al. (2020). TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα. . (ekstern lenke)
• Han, Mingzhi; Wang, Shuai; Yang, Ning et al. (2019). Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma.. (ekstern lenke)
• Feng, Zichao; Zhou, Wenjing; Wang, Jiwei et al. (2019). Reduced expression of proteolipid protein 2 increases ER stress-induced apoptosis and autophagy in glioblastoma.. (ekstern lenke)
• Bernatz, Simon; Ilina, Elena I.; Devraj, Kavi et al. (2019). Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases. (ekstern lenke)
• Han, Mingzhi; Wang, Shuai; Fritah, Sabrina et al. (2019). Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/β-catenin signalling. (ekstern lenke)
• Aasen, Synnøve Nymark; Parajuli, Himalaya; Hoang, Tuyen et al. (2019). Effective treatment of metastatic melanoma by combining mapk and pi3k signaling pathway inhibitors. (ekstern lenke)
• Aasen, Synnøve Nymark; Espedal, Heidi; Holte, Christopher Florian et al. (2019). Improved drug delivery to brain metastases by peptide-mediated permeabilization of the blood-brain barrier. (ekstern lenke)
• Ji, Jianxiong; Xu, Ran; Ding, Kaikai et al. (2019). Long Noncoding RNA SChLAP1 Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-kappa B Signaling. (ekstern lenke)
• Ji, Jianxiong; Ding, Kaikai; Luo, Tao et al. (2019). PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1. (ekstern lenke)
• Sundstrøm, Terje; Prestegarden, Lars; Azuaje, Francisco et al. (2019). Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. (ekstern lenke)
• Baghirov, Habib; Snipstad, Sofie; Sulheim, Einar et al. (2018). Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model. (ekstern lenke)
• Zeiner, PS; Zinke, Jens; Kowalewski, DJ et al. (2018). CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival. (ekstern lenke)
• Wang, Jiwei; Qi, Qichao; Zhou, Wenjing et al. (2018). Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. (ekstern lenke)
• Zhang, Xin; Xu, Ran; Zhang, Chao et al. (2017). Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination. (ekstern lenke)
• Talasila, Krishna Mukharji; Røsland, Gro Vatne; Hagland, Hanne Røland et al. (2017). The angiogenic switch leads to a metabolic shift in human glioblastoma. (ekstern lenke)
• Ilhan-Mutlu, Aysegül; Osswald, Matthias; Liao, Yunxiang et al. (2016). Bevacizumab prevents brain metastases formation in lung adenocarcinoma. (ekstern lenke)
• Aasen, Synnøve Nymark; Pospíšilová, Aneta; Eichler, Tilo Wolf et al. (2015). A novel nanoprobe for multimodal imaging is effectively incorporated into human melanoma metastatic cell lines. (ekstern lenke)
• Sundstrøm, Terje; Espedal, Heidi; Harter, Patrick N. et al. (2015). Melanoma brain metastasis is independent of lactate dehydrogenase A expression. (ekstern lenke)
• Daphu, Inderjit Kaur; Horn, Sindre August; Stieber, Daniel et al. (2014). In vitro treatment of melanoma brain metastasis by simultaneously targeting the MAPK and PI3K signaling pathways. (ekstern lenke)
• Brekke, Cecilie; Wang, Jian; Thuen, Marte et al. (2014). Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma. (ekstern lenke)
• Rygh, Cecilie Brekke; Wang, Jian; Thuen, Marte et al. (2014). Dynamic Contrast Enhanced MRI Detects Early Response to Adoptive NK Cellular Immunotherapy Targeting the NG2 Proteoglycan in a Rat Model of Glioblastoma. (ekstern lenke)
• Keunen, Olivier; Taxt, Torfinn; Grüner, Ragna Elisabeth et al. (2014). Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies. (ekstern lenke)
• Lillefosse, Haldis Haukås; Tastesen, Hanne Sørup; Du, Zhen-yu et al. (2013). Hydrolyzed casein reduces diet-induced obesity in male C57BL/6J mice. (ekstern lenke)
• Thorsen, Frits Alan; Fite, Brett; Mahakian, Lisa M. et al. (2013). Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases. (ekstern lenke)
• Poli, Aurélie; Wang, Jian; Domingues, Olivia et al. (2013). Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival. (ekstern lenke)
• Sundstrøm, Terje; Daphu, Inderjit Kaur; Wendelbo, Ingvild Haukaas et al. (2013). Automated tracking of nanoparticle-labeled melanoma cells improves the predictive power of a brain metastasis model. (ekstern lenke)
• Viel, Thomas; Talasila, Krishna Mukharji; Monfared, Parisa et al. (2012). Analysis of the growth dynamics of angiogenesis-dependent and -independent experimental glioblastomas by multimodal small-animal PET and MRI. (ekstern lenke)
• Skeie, Bente; Enger, Per Øyvind; Brøgger, Jan C et al. (2012). Gamma knife surgery versus reoperation for recurrent glioblastoma multiforme. (ekstern lenke)
• Thorsen, Frits Alan (2011). MRI of experimental gliomas. (ekstern lenke)
• Ke, Xisong; Li, Wencheng; Hovland, Randi et al. (2011). Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model. (ekstern lenke)
• Keunen, Olivier; Johansson, Mikael; Oudin, Anaîs et al. (2011). Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. (ekstern lenke)
• Wang, Jian; Daphu, Inderjit Kaur; Pedersen, Paal-Henning et al. (2011). A novel brain metastases model developed in immunodeficient rats closely mimics the growth of metastatic brain tumours in patients. (ekstern lenke)
• Enger, Per Øyvind; Skeie, Geir Olve; Thorsen, Frits Alan et al. (2010). Gamma knife surgery of meningiomas involving the cavernous sinus: long-term follow-up of 100 patients. (ekstern lenke)
• Curry, Fitz-Roy E.; Brekke, Cecilie; Karlsen, Tine Veronica et al. (2010). Atrial natriuretic peptide modulation of albumin clearance and contrast agent permeability in mouse skeletal muscle and skin: role in regulation of plasma volume. (ekstern lenke)
• Torkildsen, Øivind Fredvik; Brunborg, Linn Anne; Thorsen, Frits Alan et al. (2009). Effects of dietary intervention on MRI activity, de- and remyelination in the cuprizone model for demyelination. (ekstern lenke)
• Vik-Mo, Einar Osland; Øksnes, Marianne; Pedersen, Paal-Henning et al. (2009). Gamma knife stereotactic radiosurgery of Nelson syndrome. (ekstern lenke)
• Wang, Jian; Sakariassen, Per Øystein; Tsinkalovsky, Oleg et al. (2008). CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. (ekstern lenke)
• Thorsen, Frits Alan; Jirak, Daniel; Wang, Jian et al. (2008). Two distinct tumor phenotypes isolated from glioblastomas show different MRS characteristics. (ekstern lenke)
• Huszthy, Peter Csaba; Goplen, Dorota; Thorsen, Frits Alan et al. (2008). Oncolytic herpes simplex virus type-1 therapy in a highly infiltrative animal model of human glioblastoma. (ekstern lenke)
• Brekke, Cecilie; Williams, SC; Price, J et al. (2007). Cellular multiparametric MRI of neural stem cell therapy in a rat glioma model. (ekstern lenke)
• Thorsen, Frits Alan; Enger, Per Øyvind; Wang, Jian et al. (2007). Human glioblastoma biopsy spheroids xenografted into the nude rat brain show growth inhibition after stereotactic radiosurgery. (ekstern lenke)
• Eikefjord, Eli N.; Thorsen, Frits Alan; Rørvik, Jarle (2007). Comparison of effective radiation doses in patients undergoing unenhanced MDCT and excretory urography for acute flank pain. (ekstern lenke)
• Vik-Mo, Einar O; Øksnes, Marianne; Pedersen, Paal-Henning et al. (2007). Gamma knife stereotactic radiosurgery for acromegaly. (ekstern lenke)
• Thorsen, Frits Alan; Afione, Sandra; Huszthy, Peter Csaba et al. (2006). Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma. (ekstern lenke)
• Huszthy, Peter Csaba; Brekken, Christian; Pedersen, Tina Bugge et al. (2006). Antitumor efficacy improved by local delivery of species-specific endostatin. (ekstern lenke)

Mastergradsoppgave

• Berle, Birgitte Feginn; Rigg, Emma Kayleigh; Thorsen, Frits (2023). 3D Modelling of Brain Metastasis Microenvironment for Evaluation of Tumour-Stromal Interactions. (ekstern lenke)
• Moreino, Shannon; Thorsen, Frits; Wang, Jian (2021). Development of 3D in vitro Interaction Models for the Evaluation and Treatment of Brain Metastases. (ekstern lenke)
• Rigg, Emma; Thorsen, Frits (2020). In vitro study of a selective PI3K inhibitor on brain metastases. (ekstern lenke)
• Bjørnstad, Ole Vidhammer; Thorsen, Frits (2019). Characterization of Melanoma Brain Metastasis Cell Lines. (ekstern lenke)
• Singam, Caroline Sørensen; Thorsen, Frits (2017). In vitro study of the effect of cabozantinib (XL184) on canine oral melanoma cell lines. (ekstern lenke)
• Hårklau, Runar Oddvarson; Thorsen, Frits (2017). An In vitro Drug Study of Cabozantinib on Glioblastoma Cell Lines. (ekstern lenke)
• Holte, Christopher Florian; Thorsen, Frits (2016). In vitro and in vivo studies of a novel blood brain barrier permeabilizing peptide K16ApoE. And novel in vivo treatment of melanoma brain metastases. (ekstern lenke)
• Mola, Nazanin; Thorsen, Frits Alan (2015). In vitro effects of BEZ-235 on human melanoma metastatic cell lines. (ekstern lenke)
• Aasen, Synnøve Nymark; Thorsen, Frits Alan; Skaftnesmo, Kai Ove (2014). Visualization of metastatic melanoma cells by fluorescence microscopy and MRI using a novel glycogen nanoprobe. (ekstern lenke)
• Wendelbo, Ingvild Haukaas; Thorsen, Frits Alan (2010). IN VITRO EFFECTS OF NANOPARTICLE CONTRAST AGENTS ON CELLULAR FUNCTIONS AND RELAXOMETRY. (ekstern lenke)

Leder

• Sibson, Nicola R.; Thorsen, Frits; Soto, Manuel Sarmiento (2022). Editorial: The Role of the Immune Response in Brain Metastasis. (ekstern lenke)
• Bjerkvig, Rolf; Thorsen, Frits (2019). Glioblastoma: A prognostic value of AMT-PET?. (ekstern lenke)

Fagartikkel

• Taule, Erlend Moen; Schipmann-Miletic, Stephanie; Thorsen, Frits et al. (2022). Hjernemetastasar – diagnostikk og behandling. (ekstern lenke)

Vitenskapelig oversiktsartikkel/review

• Valiente, Manuel; Van Swearingen, Amanda E D; Anders, Carey K et al. (2020). Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines. . (ekstern lenke)
• Qin, SP; Fite, BZ; Gagnon, KG et al. (2014). A physiological perspective on the use of imaging to assess the in vivo delivery of therapeutics. (ekstern lenke)
• Daphu, Inderjit Kaur; Sundstrøm, Terje; Horn, Sindre August et al. (2013). In vivo animal models for studying brain metastasis: value and limitations. (ekstern lenke)
• Huszthy, Peter Csaba; Daphu, Inderjit Kaur; Niclou, Simone P et al. (2012). In vivo models of primary brain tumors: pitfalls and perspectives. (ekstern lenke)

Poster

• Aasen, Synnøve Nymark; Parajuli, Himalaya; Roy, Kislay et al. (2019). Effective Treatment Of Metastatic Melanomas Using Combined MAPK And PI3K Pathways Inhibitors. (ekstern lenke)
• Kim, Jana; Kim, Eugene; Hill, Deborah Katherine et al. (2017). Multiparametric MRI for optimal prostate cancer detection in TRAMP mice. (ekstern lenke)
• Baghirov, Habib; Åslund, Andreas; Snipstad, Sofie et al. (2016). Focused ultrasound-mediated transport of poly(alkyl) cyanoacrylate nanoparticles across the blood-brain barrier in a melanoma brain metastasis model. (ekstern lenke)
• Thuen, Marte; Wang, Jien; Enger, Per Øyvind et al. (2011). Therapeutic Targeting of NG2 Proteoglycan with MAb & Pre-Armed NK Cells in Human GMB Evaluated with Dynamic Enhanced & Diffusion Weighted MRI in Rats. (ekstern lenke)

Doktorgradsavhandling

• Aasen, Synnøve Nymark; Thorsen, Frits (2019). Treatment strategies for experimental melanoma brain metastases. (ekstern lenke)

Vitenskapelig foredrag

• Baghirov, Habib; Snipstad, Sofie; Sulheim, Einar et al. (2016). Focused ultrasound-mediated transport of poly(alkyl) cyanoacrylate nanoparticles across the blood-brain barrier in a melanoma brain metastasis model. (ekstern lenke)
• Baghirov, Habib; Åslund, Andreas; Snipstad, Sofie et al. (2016). Focused ultrasound-mediated transport of poly(alkyl) cyanoacrylate nanoparticles across the blood-brain barrier in a melanoma brain metastasis model. (ekstern lenke)
• Ke, Xisong; Li, Wencheng; Qu, Yi et al. (2009). EMT Promotes Malignant Transformation of Prostate Epithelial Cells in Culture. (ekstern lenke)
• Skeie, Bente Sandvei; Enger, Per Øyvind; Skeie, Geir Olve et al. (2001). Gamma Knife Radiosurgery of meningiomas involving the cavernous sinus. (ekstern lenke)

Faglig foredrag

• Baghirov, Habib; Snipstad, Sofie; Sulheim, Einar et al. (2016). Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma and melanoma metastases. (ekstern lenke)

Forskerlinjeoppgave

• Horn, Sindre August; Thorsen, Frits (2014). In Vitro Treatment of Melanoma Brain Metastasis by Simultaneously Targeting the MAPK and PI3K Signaling Pathways. (ekstern lenke)

Sammendrag/abstract

• Thorsen, Frits Alan; Fite, B; Mahakian, Lisa M. et al. (2013). EARLY TUMOR DETECTION AND CHARACTERIZATION OF CHANGES IN TUMOR PERMEABILITY OF BRAINMETASTASES USING MULTIMODAL IMAGING. (ekstern lenke)
• Sundstrøm, Terje; Varughese, Jobin K.; Harter, Patrick et al. (2013). BRAIN-SPECIFIC GENE SIGNATURE OF MELANOMA METASTASIS. (ekstern lenke)
• Brekke, Cecilie; Thuen, Marte; Poli, Aurélie et al. (2012). Early MRI findings of targeting the NG2 proteoglycan in GBM. (ekstern lenke)
• Szczepanski, C; Bjerkvig, Rolf; Tenstad, Olav et al. (2011). Treatment of Solid Cancers Using a New Cationic Cytolytic Peptide. (ekstern lenke)
• Daphu, Inderjit Kaur; Immervoll, Heike ; Bjerkvig, Rolf et al. (2011). A novel and clinically relevant mouse model reflecting the disease progression in melanoma brain metastasis in patients. (ekstern lenke)
• Jacobsen, Hege; Dicko, Aly; Wang, Jian et al. (2011). Separate analysis of the cancer and stroma cell populations from orthotopically implanted tumor biopsies in eGFP scid mice. (ekstern lenke)
• Daphu, Inderjit Kaur; Immervoll, Heike ; Wendelbo, Ingvild Haukaas et al. (2011). Molecular imaging and genetic studies reveal selective homing of human brain metastatic cells to various organs in NOD/SCID mice. (ekstern lenke)
• Chekenya, Martha; Wang, Jian; Poli, A et al. (2010). THERAPEUTIC TARGETING OF THE NG2 PROTEOGLYCAN WITH MAB 9.2.27 AND ADOPTIVELY TRANSFERRED NK CELLS LYSES HUMAN GLIOBLASTOMA MULTIFORME IN VIVO. (ekstern lenke)
• Daphu, Inderjit Kaur; Immervoll, Heike ; Bjerkvig, Rolf et al. (2010). A NOVEL PATIENT MELANOMA BRAIN METASTASIS MODEL DEVELOPED IN NOD-SCID MICE REFLECTS THE CLINICAL METASTATIC DISEASE PROGRESSION IN PATIENTS. (ekstern lenke)
• Niclou, SP; Johansson, Mikael; Keunen, O et al. (2009). PHENOTYPIC AND PHYSIOLOGIC EFFECTS OF BEVACIZUMAB IN A HIGHLY INFILTRATIVE AND ANGIOGENIC HUMAN GLIOBLASTOMA MODEL. (ekstern lenke)
• Thorsen, Frits Alan; Daphu, Inderjit Kaur; Pedersen, Paal-Henning et al. (2008). DEVELOPMENT OF A NEW BRAIN METASTASES MODEL IN IMMUNODEFICIENT ANIMALS. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

Publikasjonsliste 2013-2023

* = delt siste forfatterskap

1. Rigg E, Wang J, Xue Z, Lunavat T, Liu G, Hoang T, Parajuli H, Han M, Bjerkvig R, Nazarov P, Nicot N, Kreis S, Margue CW, Nomigni MT, Utikal J, Miletic H, Sundstrøm T, Li X, Thorsen F. Inhibition of extracellular vesicle derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes. J Extracell Ves 2023, Oct; 12(10):e12363. doi: 10.1002/jev2.12363.
2. Spitzer D, Guérit S, Khel M, Pütz T, Zinke J, Jia X, Sommer K, Filipski K, Thorsen F, Freiman T, Harter P, Reiss Y, Liebner S, Di Tacchio M, Devraj K. A flow cytometry based protocol for syngenic isolation of neurovascular unit cells from mouse and human tissues. Nat Protoc 2023 May, 18(5):1510-1542. doi:10.1038/s41596-023-00805-y.
3. Taule EM, Schipmann-Miletic S, Thorsen F, Johannessen TA, Miletic H, Storstein A, Oltedal L, Sundstrøm T. Hjernemetastasar – diagnostikk og behandling. Tidsskr Nor Laegeforen 2022, Oct 10;142(14). doi: 10.4045/tidsskr.21.0809. Review, in Norwegian.
4. Reigstad A, Herdlevær CF, Rigg E, Hoang T, Bjørnstad OV, Aasen SN, Preiss J, Haan C, Sundstrøm T, Thorsen F. CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells. PLoS One 2022 Sep 9, 17(9):e0273711. doi: 10.1371/journal.pone.0273711. [IF 3.24]
5. Sibson NR, Thorsen F, Sarmiente Soto M. The role of the immune response in brain metastasis. Front Oncol 10 May 2022. doi: 10.3389/fonc.2022.922700. Editorial.
6. Aasen SN, Espedal H, Keunen O, Adamsen TCH, Bjerkvig R*, Thorsen F*. Current landscape and future perspectives in preclinical MR and PET imaging of brain metastasis. Neuro-Oncol Adv, 3(1):1-14, 2021. https://doi.org/10.1093/noajnl/vdab151. Review.
7. Mannsåker TA, Hoang T, Aasen SN, Bjørnstad OV, Parajuli H, Sundstrøm T, Thorsen F. Cabozantinib is effective in melanoma brain metastasis cell lines and affects key signaling pathways. Int J Mol Sci 2021 Nov 14, 22(22):12296. https://doi.org/10.3390/ijms222212296. [IF 5.923].
8. Zhang Y, Kong Y, Ma Y, Ni S, Wikerholmen T, Xi K, Zhao F, Zhao Z, Wang J, Huang B, Chen A, Yao Z, Han M, Feng Z, Hu Y, Thorsen F*, Wang J*, Li X*. Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines. Oncogene 2021 Jan 8, 40(8):1425-1439. doi: 10.1038/s41388-020-01622-3.
9. Zhang Y, Fu X, Jia J, Wikerholmen T, Xi K, Kong Y, Wang J, Chen H, Ma Y, Li Z, Wang C, Qi Q, Thorsen F, Wang J, Cui J, Li X, Ni S. Glioblastoma therapy using codelivery of cisplatin and gluthathione peroxidase targeting siRNA from iron oxide particles. ACS Appl Mater Interfaces 2020 Sep 4. 
10. Ji J, Ding K, Luo T, Zhang X, Chen A, Zhang D, Li G, Thorsen F, Huang B, Li X, Wang J. TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα. Cell Death & Diff 2020 Aug 19, 18:6938-15. 
11. Kong Y, Feng Z, Zhang Y, Liu X, Yuan M, Zhao Z, Huang B, Chen A, Zhang D, Thorsen F, Wang J, Yang N, Li X. Identification of immune-related genes contributing to the development of glioblastoma using weighted gene co-expression network analysis. Front Immunol 2020 July 16, 11:1281. 
12. Valiente M, Van Swearingen AED, Anders C, Bairoch A, Boire A, Bos P, Cittelly D, Erez N, Ferraro G, Fukumura D, Gril BM, Herlyn M, Holmen SL, Jain RK, Joyce JA, Lorger M, Massagué J, Neman J, Sibson N, Steeg P, Thorsen F, Young L, Vareslija D, Vultur A, Weis-García F, Winkler F. Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines. Cancer Res 2020 July 8. 
13. Feng Z, Zhou W, Wang J, Qi Q, Han M, Kong Y, Zhang Y, Chen A, Huang B, Chen A, Zhang D, Li W, Zhang Q, Bjerkvig R, Wang J*, Thorsen F*, Li X*. Reduced expression of proteolipid 2 increases ER-stress-induced apoptosis and autophagy in glioblastoma. J Cell Mol Med 2020 Mar 17, 24(5):2847-2856.
14. Zhang X, Ding K, Ji J, Parajuli H, Aasen SN, Espedal H, Huang B, Chen A, Wang J*, Li X*, Thorsen F*. Trifluoperazine prolongs the survival of experimental brain metastases by STAT3-dependent lysosome membrane permeabilization. Am J Cancer Res 2020 Feb 1, 10(2):545-563. 
15. Han M, Wang S, Fritah S, Zhou W, Yang N, Huang B, Chen A, Li G, Miletic H, Thorsen F, Bjerkvig R, Li X, Wang J. Interfering with long non-coding RNA MIR22HG processing inhibits glioma progression through suppression of Wnt/b-catenin signalling. Brain 2020 Feb 1, 143(2):512-530.  
16. Ji J, Ding K, LuoT, Xu R, Zhang X, Huang B, Chen A, Zhang D, Miletic H, Bjerkvig R*, Thorsen F*, Wang J*, Li X*. PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1. Oncogene 2020 Jan 11, 39(5):1125-1139. 
17. Han M, Wang S, Zhao W, Kong Y, Huang B, Chen A, Saed HS, Li G, Miletic H, Thorsen F, Bjerkvig R, Li X, Wang J. Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma. EMBO Mol Med, 2020 Jan 9;12(1):e10924. 
18. Bernatz S, Ilina E, Devraj K, Harter PN, Mueller K, Kleber S, Braun Y, Penski C, Renner C, Halder R, Jennewein L, Solbach C, Thorsen F, Pestalozzi BC, Mischo A, Mittelbronn M. Impact of docetaxel on blood-brain barrier function and formation of breast cancer brain metastases. J Exp & Clin Cancer Res 2019 Oct 29;38(1):434. 
19. Ji J, Xu R, Ding K, Bao G, Zhang X, Huang B, Wang X, Martinez A, Wang X, Li G, Miletic H, Thorsen F, Bjerkvig R, Xiang L, Han B, Chen A, Li X, Wang J. Long noncoding RNA SChLAP1 forms a growth promoting complex with HNRNPL in human glioblastoma through stabilization and activation of NF-kB signalling. Clin Cancer Res 2019 Sep. 6.
20. Aasen SN, Espedal H, Holte CF, Keunen O, Karlsen TV, Tenstad O, Maherally Z, Miletic H, Hoang T, Eikeland AV, Baghirov H, Olberg DE, Pilkington GJ, Sarkar G, Jenkins R, Sundstrøm T, Bjerkvig R, Thorsen F. Improved drug delivery to experimental melanoma brain metastasis by peptide-mediated permeabilization of the blood-brain barrier. Mol Cancer Ther 2019 Aug 29. 
21. Aasen SN, Parajuli H, Roy K, Hoang T, Stokke K, Wang J, Feng Z, Bjerkvig R, Thorsen F. Effective treatment of metastatic melanoma by combining MAPK and PI3K signaling pathway inhibitors. Int J Mol Sci 20(17):4235, Aug 29, 2019. 
22. Sundstrøm T, Prestegarden L, Azuaje F, Røsland GV, Varughese JK, Aasen SN, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Inghem ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Bjerkvig R*, Thorsen F*. Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathol Comm 7:55, Apr 10, 2019. doi: 10.1186/s40478-019-0712-8.
23. Bjerkvig R, Thorsen F. Glioblastoma: a prognostic value of AMT-PET? Neuro-Oncol 21(2):146-147, Feb 14, 2019. 
24. Wang J, Qi Q, Zhou W, Feng Z, Huang B, Chen A, Zhang D, Li W, Zhang Q, Bjerkvig R, Prestegarden L, Thorsen F, Li X, Wang J. Inhibition of glioma growth by flavokawain B is mediated through endoplasmatic reticulum stress induced autophagy. Autophagy 2018 Jul 19.
25. Zeiner PS, Zinke J, Kowalewski DJ, Bernatz S, Tichy J, Ronellenfitsch MW, Thorsen F, Berger A, Forster MT, Muller A, Steinbach JP, Beschorner R, Wischhusen J, Kvasnicka HM, Plate KH, Stefanovic S, Weide B, Mittelbronn M, Harter PN. CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival. Acta Neuropathol Comm 6:18, 2018. 
26. Baghirov H, Snipstad S, Sulheim E, Berg S, Hansen R, Thorsen F, Mørch Y, de Lange Davies C, Åslund ÅKO. Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model. PLoS ONE, 13(1):e0191102, 2018. 
27. Zhang X, Xu R, Zhang C, Xu Y, Han M, Huang B, Chen A, Qiu C, Thorsen F, Prestegarden L, Bjerkvig R, Wang J, Li XG. Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination. J Exp Clin Cancer Res 36(1):118, 2017. doi:10.1186/s13046-017-0588-z. 
28. Talasila KM, Røsland G, Hagland H, Eskilsson E, Tran GT, Fritah S, Azuaje F, Atai N, Harter P, Mittelbronn M, Anderson M, van Noorden R, Niclou SP, Thorsen F, Tronstad KJ, Tzoulis C, Bjerkvig R, Miletic H. The angiogenic switch leads to a metabolic switch in human glioblastoma. Neuro-Oncol Sep 19(3):383-393, 2017. 
29. Ilhan-Mutlu A, Osswald M, Liao Y, Gömmel M, Reck M, Miles D, Mariani P, Gianni L, Lutiger B, Nendel V, Srock S, Perez-Moreno P, Thorsen F, von Baumgarten L, Preusser M, Wick W, Winkler F. Bevacizumab prevents brain metastases formation in lung adenocarcinoma. Mol Cancer Ther Jan 25, 15(4):702-710, 2016. 
30. Aasen SN, Pospisilova A, Eichler T, Panek J, Hruby M, Stepanek P, Spriet E, Jirak D, Skaftnesmo KO, Thorsen F. A novel nanoprobe for visualisation of melanoma metastatic cells by fluorescence and MRI. Int J Mol Sci 16:21658-21680, 2015.
31. Sundstrøm T, Espedal H, Harter P, Fasmer KE, Skaftnesmo KO, Horn S, Hodneland E, Mittelbronn M, Weide B, Beschorner R, Bendner B, Rygh CB, Lund-Johansen M, Bjerkvig R, Thorsen F. Melanoma brain metastasis is independent on LDHA expression. Neuro-Oncol 17:1374-1385, 2015. 
32. Keunen O, Taxt T, Tonn JC, Grüner R, Lund-Johansen M, Pavlin T, Bjerkvig R, Niclou S, Thorsen F. Multimodal imaging of gliomas in the context of cellular and molecular therapies. Adv Drug Deliv Rev 76:98-115, 2014. 
33. Rygh, CB, Wang J, Thuen M, Gras-Navarro A, Huuse EM, Thorsen F, Poli A, Zimmer J, Haraldseth O, Lie SA, Enger PØ, Chekenya M. Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma. PLoS ONE 2014 9(9):e108414.
34. Daphu I, Horn S, Stieber D, Varughese J, Skaftnesmo KO, Bjerkvig R, Thorsen F. In vitro treatment of melanoma brain metastasis by simultaneously targeting the MAPK and PI3K signaling pathways. Int J Mol Sci 15:8773-8794, 2014.
35. Qin SP, Fite BZ, Gagnon KG, Seo JW, Curry F, Thorsen F, Ferrara KW. A physiological perspective on the use of imaging to assess the in vivo delivery of therapeutics. Ann Biomed Eng 42(2):280-298, 2014.
36. Thorsen F, Fite B, Mahakian L, Seo JW, Qin SP, Harrison V, Johnson S, Ingham E, Meade T, Caskey C, Sundstrøm T, Meade T, Harter PN, Skaftnesmo KO, Ferrara KW. Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases. J Control Rel 172:812-822, 2013. 
37. Poli A, Wang J, Domingues O, Planagumá J, Yan T, Rygh CB, Skaftnesmo KO, Thorsen F, McCormack E, Hentges F, Pedersen PH, Zimmer J, Enger PO, Chekenya M. Targeting glioblastoma with NK-cells and mAb against NG2/CSPG4 prolongs animal survival. Oncotarget 4(9):1527-1546, 2013. 
38. Lillefosse HH, Tastesen HS, Du ZY, Ditlev DB, Thorsen F, Madsen L, Kristiansen K, Liaset B. Hydrolyzed casein reduces diet-induced obesity in male C57BL/6J mice. J Nutr 143(9):1367-1375, 2013.
39. Sundstrøm T,  Daphu I, Wendelbo I, Hodneland E, Lundervoll A, Immervoll H, Skaftnesmo KO, Babic M, Jendelova P, Sykova E, Lund-Johansen M, Bjerkvig R, Thorsen F. Quantitative tracking of nanoparticle labeled melanoma cells improves the predictive power of an experimental brain metastasis model. Cancer Res 73(8):2445-2456, 2013. 
40. Daphu I, Sundstrøm T, Huszthy PC, Niclou SP, Sakariassen P, Immervoll H, Miletic H, Bjerkvig R, Thorsen F. In vivo animal models for studying brain metastasis: value and limitations. Clin Exp Metastasis 30:695-710, 2013.

Forskningsveiledning:

2016-2021 Hovedveileder for 3 Post Docs.

2014-2021 Hovedveileder for 9 studenter i Forskerlinjeprogrammet, UiB.

2005-2021 Veileder for 13 PhD studenter (7 som hovedveileder).

1996-2021 Veileder for 16 Master studenter (hovedveileder).

Arbeidserfaring:

1989-1995 Haukeland Sykehus. Medisinsk Fysiker, Overingeniør.

1991-1994 Timelærer i Apparatlære, Radiografhøgskolen i Bergen.

1993-2006 Elekta Instrument AB. Medisinsk konsulent.

1995- 1998 Universitetet i Bergen. Stipendiat.

1998-2004 Haukeland Universitetssykehus. Medisinsk Fysiker, Sjefingeniør.    

2000-2002 Institutt for Anatomi og Cellebiologi. Forsker (Post. doc.).                    

2004-2008 UNIFOB AS. Vitenskapelig Prosjektleder. 

2008-2010 Institutt for Biomedisin, UiB. Førsteamanuensis.

2010-2023 Institutt for Biomedisin, UiB. Professor.

2019-2021 Shandong University, Jinan, Kina. Professor.                             

Utdannelse:

1989 Cand Mag i fysikk, matematikk og data, Universitetet i Trondheim.

1989 Cand Scient i biofysikk, Universitetet i Trondheim.

1998 Dr Scient, Institutt for Anatomi og Cellebiologi, Universitetet i Bergen.

Kurs:

1990 Bedriftspedagogisk senter. Presentasjonsteknikk og kommunikasjon.  

1994 Elektrisitetstilsynet. Godkjenning for å reparere elektromedisinsk utstyr.

1998 Hewlett Packard, Oslo. Sluttbrukerkurs i Unix operativsystem.

1998 Universitetet i Bergen. Påbyggingsseminarer i forsøksdyrlære.

1999 Haukeland Sykehus. Prosjektledelse.

2000 Advanced Visualization System. Introduksjon i AVS programmering.

2004 Hyperion Ltd (Ressurssenteret,Bergen). How to negotiate, manage, administer and finish an EU Contract.

2006 Psykologisk Fakultet, UiB. Basismodul i universitetespedagogikk.

2007 Psykologisk Fakultet, UiB. Forskningsveiledning.

2007-09 UNIFOB AS, Bergen. Utviklingsprogram for Forskningsledere.

2018 UiB PhD-veileder kurs bestått 31.07.2018.

2018  Begynnerkurs i Kinesisk-Mandarin (Mandarin nivå A1, del 1 og 2).