Mette Vesterhus er ansatt som professor ved UiB (100%) og er undervisningsgruppeleder for propedeutikk ved K2. Hun er spesialist i fordøyelsessykdommer med spesiell interesse for leversykdommer og har en bistilling som overlege ved Haraldsplass diakonale sykehus. Forskningen hennes fokuserer på autoimmune leversykdommer, med særlig vekt på leverelastografi og biomarkører for sykdomsaktivitet og prognose ved primær skleroserende cholangitt. Hun leder Forskningsgruppe for leversykdommer ved Haraldsplass, NoPSC Bergen Clinical Research Group, og er prosjektleder for ScandPSC - Strategic Prospective Scandinavian PSC Biobank & Cohort og Nasjonalt nettverk for autoimmune leversykdommer.

Vi trenger en ny strategi for leversykdom | Tidsskrift for Den norske legeforening

– Forventer en dobling av sykdomsbyrden for alvorlig leversykdom

Leveren har et image-problem

• Leversykdommer (MED6, MED11; masterstudiet i ernæringsfysiologi)
• Propedeutikk (MED5)

Vitenskapelig artikkel

• Fossdal, Guri; Braadland, Peder Rustøen; Hov, Johannes Espolin Roksund et al. (2025). Mitochondrial dysfunction and lipid alterations in primary sclerosing cholangitis. (ekstern lenke)
• Braadland, Peder Rustøen; Bergquist, Annika; Kummen, Martin et al. (2023). Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation. (ekstern lenke)
• Lapitz, Ainhoa; Azkargorta, Mikel; Milkiewicz, Piotr et al. (2023). Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma. (ekstern lenke)
• Lazarus, Jeffrey V.; Mark, Henry E.; Allen, Alina M. et al. (2023). A global action agenda for turning the tide on fatty liver disease. (ekstern lenke)
• Wacker, Eike Matthias; Uellendahl-Werth, Florian; Bej, Saptarshi et al. (2023). Whole blood RNA sequencing identifies transcriptional differences between primary sclerosing cholangitis and ulcerative colitis. (ekstern lenke)
• Muynck, Kevin De; Heyerick, Lander; Ponti, Federico F. De et al. (2023). Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis. (ekstern lenke)
• Bergquist, Annika; Weismüller, Tobias J.; Levy, Cynthia et al. (2022). Impact on follow-up strategies in patients with primary sclerosing cholangitis. (ekstern lenke)
• Braadland, Peder Rustøen; Schneider, Kai Markus; Bergquist, Annika et al. (2022). Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis. (ekstern lenke)
• Singh, Yashbir; Jons, William A.; Eaton, John E. et al. (2022). Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis. (ekstern lenke)
• Helgadottir, Holmfridur; Folvik, Geir; Vesterhus, Mette Nåmdal (2022). Improvement of cholestatic episodes in patients with benign recurrent intrahepatic cholestasis (BRIC) treated with rifampicin. A long-term follow-up. (ekstern lenke)
• Laursen, Tea Lund; Bossen, Lars; Pihl, Rasmus et al. (2022). Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4 (ITIH4) in Autoimmune Cholestatic Liver Diseases. (ekstern lenke)
• Dhillon, Amandeep Kaur; Rupp, Christian; Bergquist, Annika et al. (2021). Associations of neopterin and kynurenine–tryptophan ratio with survival in primary sclerosing cholangitis. (ekstern lenke)
• Vesterhus, Mette; Nielsen, Mette Juul; Hov, Johannes Roksund et al. (2021). Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease. (ekstern lenke)
• Fossdal, Guri; Mjelle, Anders Batman; Wiencke, Kristine et al. (2021). Fluctuating biomarkers in primary sclerosing cholangitis: A longitudinal comparison of alkaline phosphatase, liver stiffness, and ELF. (ekstern lenke)
• Bossen, Lars; Vesterhus, Mette Nåmdal; Hov, Johannes Espolin Roksund et al. (2021). Circulating Macrophage Activation Markers Predict Transplant-Free Survival in Patients With Primary Sclerosing Cholangitis. (ekstern lenke)
• Mjelle, Anders Batman; Mulabecirovic, Anesa; Olafsdottir, Edda Jonina et al. (2021). Controlled Attenuation Parameter in Healthy Individuals Aged 8-70 Years. (ekstern lenke)
• Mjelle, Anders Batman; Mulabecirovic, Anesa; Havre, Roald Flesland et al. (2020). Liver elastography in healthy children using three different systems - how many measurements are necessary?. (ekstern lenke)
• Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C. et al. (2020). Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis. (ekstern lenke)
• Mousa, Omar Y; Juran, Brian D; McCauley, Bryan M. et al. (2020). Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation. (ekstern lenke)
• Taraldsen, Victoria Resvik; Tomasgard, Sunneva; Rudlang, Margrethe Thune et al. (2020). Point shear wave elastography and the effect of physical exercise, alcohol consumption, and respiration in healthy adults. (ekstern lenke)
• Hedin, Charlotte Rose Hawkey; Sado, Gina; Ndegwa, Nelson et al. (2020). Effects of Tumor Necrosis Factor Antagonists in Patients With Primary Sclerosing Cholangitis. (ekstern lenke)
• Mjelle, Anders Batman; Fossdal, Guri; Gilja, Odd Helge et al. (2020). Liver Elastography in Primary Sclerosing Cholangitis Patients Using Three Different Scanner Systems. (ekstern lenke)
• Saffioti, Francesca; Roccarina, Davide; Vesterhus, Mette et al. (2019). Cholangiocarcinoma is associated with a raised enhanced liver fibrosis score independent of primary sclerosing cholangitis. (ekstern lenke)
• Dhillon, Amandeep Kaur; Kremer, Andreas E.; Kummen, Martin et al. (2019). Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis. (ekstern lenke)
• Mjelle, Anders Batman; Mulabecirovic, Anesa; Havre, Roald Flesland et al. (2019). Normal Liver Stiffness Values in Children: A Comparison of Three Different Elastography Methods. (ekstern lenke)
• Dhillon, Amandeep Kaur; Kummen, Martin; Trøseid, Marius et al. (2019). Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis. (ekstern lenke)
• Zenouzi, Roman; Liwinski, T; Yamamura, J et al. (2018). Follow-up magnetic resonance imaging/3D-magnetic resonance cholangiopancreatography in patients with primary sclerosing cholangitis: challenging for experts to interpret. (ekstern lenke)
• Eaton, JE; Vesterhus, Mette; McCauley, Bryan M. et al. (2018). Primary sclerosing cholangitis risk estimate tool (PREsTo) predicts outcomes of the disease: A derivation and validation study using machine learning. (ekstern lenke)
• Mulabecirovic, Anesa; Mjelle, Anders Batman; Gilja, Odd Helge et al. (2018). Liver elasticity in healthy individuals by two novel shear-wave elastography systems-Comparison by age, gender, BMI and number of measurements. (ekstern lenke)
• Nielsen, MJ; Thorburn, Douglas; Leeming, DJ et al. (2018). Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis. (ekstern lenke)
• Goode, EC; Clark, AB; Melis, GM et al. (2018). Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System. (ekstern lenke)
• Bende, Felix; Mulabecirovic, Anesa; Popescu, Alina et al. (2017). Assessing liver stiffness by 2-D shear wave elastography in a healthy cohort. (ekstern lenke)
• Mulabecirovic, Anesa; Mjelle, Anders Batman; Gilja, Odd Helge et al. (2017). Repeatability of shear wave elastography in liver fibrosis phantoms—Evaluation of five different systems. (ekstern lenke)
• Trivedi, PJ; Tickle, J; Vesterhus, Mette et al. (2017). Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner. (ekstern lenke)
• Vries, Elisabeth M.G. de; Färkkilä, Martti; Milkiewicz, Piotr et al. (2017). Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study. (ekstern lenke)
• Vesterhus, Mette; Holm, Anders; Hov, Johannes Espolin Roksund et al. (2017). Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. (ekstern lenke)
• Hov, Johannes Espolin Roksund; Boberg, Kirsten Muri; Taraldsrud, Eli et al. (2017). Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis. (ekstern lenke)
• Jendrek, Sebastian Torben; Gotthardt, Daniel; Nitzsche, Thomas et al. (2017). Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis. (ekstern lenke)
• Jørgensen, Silje Fjellgård; Trøseid, Marius; Kummen, Martin et al. (2016). Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation. (ekstern lenke)
• Kummen, Martin; Vesterhus, Mette; Trøseid, Marius et al. (2016). Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function. (ekstern lenke)
• Mulabecirovic, Anesa; Mjelle, Anders Batman; Vesterhus, Mette et al. (2016). In Vitro Comparison of Five Different Elastography Systems for Clinical Applications, Using Strain and Shear Wave Technology. (ekstern lenke)
• Mjelle, Anders Batman; Mulabecirovic, Anesa; Hausken, Trygve et al. (2016). Ultrasound and point shear wave elastography in livers of patients with primary sclerosing cholangitis. (ekstern lenke)
• Mulabecirovic, Anesa; Vesterhus, Mette; Gilja, Odd Helge et al. (2016). In vitro comparison of five different elastography systems for clinical applications, using strain and shear wave technology. (ekstern lenke)
• Kummen, Martin; Holm, Kristian; Anmarkrud, Jarl Andreas et al. (2016). The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls. (ekstern lenke)
• Vesterhus, Mette; Melum, Espen (2016). Prognostic biomarkers and surrogate end points in PSC.. (ekstern lenke)
• Zweers, Serge J.; Shiryaev, Alexey; Komuta, Mina et al. (2016). Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis. (ekstern lenke)
• Vesterhus, Mette; Hov, Johannes Espolin Roksund; Holm, Anders et al. (2015). Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis. (ekstern lenke)
• Ræder, Helge; McAllister, Fiona E.; Tjora, Erling et al. (2014). Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid. (ekstern lenke)
• Karlsen, Tom Hemming; Vesterhus, Mette; Boberg, Kirsten Muri (2014). Review article: Controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis. (ekstern lenke)
• Ræder, Helge; Vesterhus, Mette; Ouaamari, Abdelfattah El et al. (2013). Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (Maturity-Onset Diabetes of the young). (ekstern lenke)
• Johansson, Bente Berg; Torsvik, Janniche; Bjørkhaug, Lise et al. (2011). Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE. (ekstern lenke)
• Haldorsen, Ingfrid S.; Ræder, Helge; Vesterhus, Mette et al. (2011). The role of pancreatic imaging in monogenic diabetes. (ekstern lenke)
• Vesterhus, Mette; Ræder, Helge; Kurpad, Amarnath J et al. (2010). Pancreatic Function in Carboxyl-Ester Lipase Knockout Mice. (ekstern lenke)
• Vesterhus, Mette; Haldorsen, Ingfrid Salvesen; Ræder, Helge et al. (2008). Reduced pancreatic volume in hepatocyte nuclear factor 1A-maturity-onset diabetes of the young. (ekstern lenke)
• Vesterhus, Mette; Ræder, Helge; Johansson, Stefan et al. (2008). Pancreatic Exocrine Dysfunction in Maturity-Onset Diabetes of the Young Type 3. (ekstern lenke)
• Haldorsen, Ingfrid Salvesen; Vesterhus, Mette; Ræder, Helge et al. (2008). Lack of pancreatic body and tail in HNF1B mutation carriers. (ekstern lenke)
• Vesterhus, Mette; Ræder, Helge; Aurlien, Harald et al. (2008). Neurological features and enzyme therapy in patients with endocrine and exocrine pancreas dysfunction due to CEL mutations. (ekstern lenke)

Fagartikkel

• Hussain, Nasir; Ma, Christopher; Hirschfield, Gideon et al. (2024). Protocol for the development of a core outcome set for clinical trials in primary sclerosing cholangitis. (ekstern lenke)
• Helgadottir, Holmfridur; Folseraas, Trine; Kemmerich, Gunter et al. (2023). Primær skleroserende kolangitt. (ekstern lenke)
• Ness-Jensen, Eivind; Seip, Birgitte Karen Berggreen; Vesterhus, Mette (2020). Prioriteringsråd for fordøyelsessykdommer under korona-pandemien. (ekstern lenke)

Vitenskapelig oversiktsartikkel/review

• Helgadottir, Holmfridur; Vesterhus, Mette Nåmdal (2023). Noninvasive evaluation of fibrosis in adult biliary diseases. (ekstern lenke)
• Lazarus, Jeffrey V.; Mark, Henry E.; Anstee, Quentin M. et al. (2021). Advancing the global public health agenda for NAFLD: a consensus statement. (ekstern lenke)
• Vesterhus, Mette Nåmdal; Wiencke, Kristine; Haukeland, John Willy et al. (2021). Klinisk oversiktsartikkel: Diagnostikk og behandling av autoimmun hepatitt. (ekstern lenke)
• Lohse, Ansgar W.; Sebode, Marcial; Jørgensen, Marianne H. et al. (2020). Second-line and third-line therapy for autoimmune hepatitis: A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group. (ekstern lenke)
• Vesterhus, Mette; Karlsen, Tom Hemming (2020). Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities. (ekstern lenke)
• Karlsen, Tom Hemming; Folseraas, Trine; Thorburn, Douglas et al. (2017). Primary sclerosing cholangitis - a comprehensive review. (ekstern lenke)
• Haldorsen, Ingfrid S.; Ræder, Helge; Vesterhus, Mette et al. (2012). The role of pancreatic imaging in monogenic diabetes mellitus. (ekstern lenke)

Kronikk

• Vesterhus, Mette Nåmdal; Jørgensen, Kristin Kaasen; Frigstad, Svein Oskar et al. (2022). Vi trenger en ny strategi for leversykdom. (ekstern lenke)

Leder

• Vesterhus, Mette Nåmdal (2022). Gode TIPS ved alvorlig leversykdom. (ekstern lenke)

Faglig foredrag

• Vesterhus, Mette Nåmdal (2021). ELF Test in PSC - should we start using it?. (ekstern lenke)
• Vesterhus, Mette Nåmdal (2021). 2.linjebehandling ved PBC og AIH. (ekstern lenke)
• Vesterhus, Mette Nåmdal (2021). Juvenile PSC/ASC: The adult side.. (ekstern lenke)
• Vesterhus, Mette Nåmdal (2021). ULTRASOUND EVALUATION OF PSC. (ekstern lenke)
• Vesterhus, Mette Nåmdal (2021). PSC - What is that disease exactly?. (ekstern lenke)
• Mulabecirovic, Anesa; Vesterhus, Mette; Gilja, Odd Helge et al. (2017). Ultralyd Elastografi. (ekstern lenke)
• Mulabecirovic, Anesa; Mjelle, Anders Batman; Gilja, Odd Helge et al. (2017). Måling av vevsstivhet på fantomer med fire ulike «shear wave» elastografisystemer. (ekstern lenke)

Poster

• Mortensen, Joachim Høg; Lunder, Aida Kapic; Manon-Jensen, Tina et al. (2020). P117 Biomarkers of extracellular matrix remodelling are associated with intestinal fibrosis assessed by magnetic resonance enterography and accumulated intestinal damage (Lémann index): the IBSEN study. (ekstern lenke)
• Mulabecirovic, Anesa; Bende, Felix; Sporea, I et al. (2017). ASSESSING LIVER STIFFNESS USING 2D-SHEAR WAVE ELASTOGRAPHY IN A HEALTHY COHORT. (ekstern lenke)
• Mjelde, Anders Batman; Hausken, Trygve; Karlsen, Tom Hemming et al. (2015). Point shear wave elastography of the liver in primary sclerosing cholangitis.. (ekstern lenke)
• Kummen, Martin; Vesterhus, Mette; Trøseid, Marius et al. (2015). P1174: Microbiota-dependent marker trimethylamine-N-oxide (TMAO) is associated with the severity of primary sclerosing cholangitis.. (ekstern lenke)
• Mulabecirovic, Anesa; Vesterhus, Mette; Gilja, Odd Helge et al. (2015). In vitro quantification and reproducibility of elasticity measurements using four different ultrasound scanners. (ekstern lenke)
• Kummen, Martin; Vesterhus, Mette; Trøseid, Marius et al. (2015). MICROBIOTA-DEPENDENT MARKER TRIMETHYLAMINE-N-OXIDE (TMAO) IS ASSOCIATED WITH THE SEVERITY OF PRIMARY SCLEROSING CHOLANGITIS. (ekstern lenke)

Vitenskapelig foredrag

• Mulabecirovic, Anesa; Mjelle, Anders Batman; Havre, Roald Flesland et al. (2016). Quantification of tissue elasticity in vitro using three clinical shear wave elastography platforms on liver fibrosis phantoms. (ekstern lenke)
• Mjelle, Anders Batman; Mulabecirovic, Anesa; Hausken, Trygve et al. (2016). Elastography of the Liver in Primary Sclerosing Cholangitis. (ekstern lenke)
• Kummen, Martin; Holm, Kristian; Anmarkrud, Jarl Andreas et al. (2015). O082 : THE GUT MICROBIOTA IN PRIMARY SCLEROSING CHOLANGITIS DIFFERS FROM THAT OF HEALTHY CONTROLS AND ULCERATIVE COLITIS PATIENTS WITHOUT BILIARY DISEASE. (ekstern lenke)
• Mulabecirovic, Anesa; Vesterhus, Mette; Gilja, Odd Helge et al. (2015). In vitro quantification and reproducibility of elasticity measurements using five different elastography systems. (ekstern lenke)

Vitenskapelig Kapittel/Artikkel/Konferanseartikkel

• Mjelde, Anders Batman; Hausken, Trygve; Karlsen, Tom Hemming et al. (2015). Point shear wave elastography of the liver in primary sclerosing cholangitis.. (ekstern lenke)

Doktorgradsavhandling

• Vesterhus, Mette (2009). Monogenic diabetes and pancreatic exocrine dysfunction in mouse and man. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

• Strategic Prospective Scandinavian PSC Biobank (National PI)
• Nasjonalt nettverk for autoimmune leversykdommer (PI)
• Biomarkers of prognosis and disease activity in primary sclerosing cholangitis