My on-going project is about improving performance and safety of clinical biomaterials. 

Bergen retrieval center for implants is collecting and analyzing joint prostheses that have failed due to aseptic loosening, often in combination with osteolysis or other immunological reactions.

I have specialised in trace element analysis, mainly on clinically related samples. Main elements of interest are Co, Cr, Zr, Mo, Ni and Ti measured by ICP-MS.

2025

• Skåden, Øystein; Furnes, Ove Nord; Lygre, Stein Håkon Låstad et al. (2025). Radiostereometric measurement of implant migration in robotically assisted vs conventional bi-cruciate stabilized cemented total knee arthroplasty: secondary analysis of a randomized controlled trial. (ekstern lenke)

2024

• Sellin, Marie-Luise; Seyfarth-Sehlke, Anika; Aziz, Mahammad et al. (2024). Isolation of TiNbN wear particles from a coated metal-on-metal bearing: Morphological characterization and in vitro evaluation of cytotoxicity in human osteoblasts. (ekstern lenke)
• Silva, Maya Maya Barbosa; Gjertsen, Jan-Erik; Moldestad, Irene Ohlen et al. (2024). Effects of implant precoating and fat contamination on the stability of the tibial baseplate. (ekstern lenke)
• Johannessen, Håkon Greve; Hallan, Geir; Kadar, Thomas Istvan Edelsvärd et al. (2024). Polyethylene wear and cup migration of cemented total hip arthroplasty with femoral heads made of oxidized zirconium, steel, or cobalt chromium: a 10-year secondary analysis from a randomized trial using radiostereometry. (ekstern lenke)

2023

• Khan, Michelle; Lygre, Stein Håkon Låstad; Høl, Paul Johan et al. (2023). Does precoating of the NexGen Option tibial component lower the risk of loosening? 10 years follow up from the Norwegian Arthroplasty Register 2012-2021. (ekstern lenke)
• Khan, Michelle; Lygre, Stein Håkon Låstad; Hallan, Geir et al. (2023). Bruk av blodtomhet ved totalprotese i kne- 3 års oppfølging (2018-2021) med data fra Nasjonalt register for leddproteser. (ekstern lenke)
• Khan, Michelle; Gjertsen, Jan-Erik; Fenstad, Anne Marie et al. (2023). Cementing techniques for total ktnee arthroplasty in Norwegian hospitals; a questionnaire-based study. (ekstern lenke)

2022

• Zalieckas, Justas; Rios Mondragon, Ivan; Pobedinskas, Paulius et al. (2022). Polycrystalline diamond coating on orthopedic implants: Realization and role of surface topology and chemistry in adsorption of proteins and cell proliferation. (ekstern lenke)
• Høl, Paul Johan; Hallan, Geir; Furnes, Ove Nord et al. (2022). Similarly low-blood metal ion levels at 10-years follow-up of total hip arthroplasties with Oxinium, CoCrMo, and stainless steel femoral heads. Data from a randomized clinical trial. (ekstern lenke)
• Khan, Michelle; Moldestad, Irene Ohlen; Ellison, Peter et al. (2022). Initial Stability Of Surface vs Full Cemented Tibial Components Under Cyclic Loading. (ekstern lenke)
• Greve Johannessen, Håkon; Kadar, Thomas; Hallan, Geir et al. (2022). Polyethylene Wear In Total Hip Arthroplasty; Comparing Oxinium And CoCr Femoral Heads Using Radiostereometry With 10 Years Follow-Up. (ekstern lenke)
• Wolf, Susann; Johannessen, Anne Christine; Ellison, Peter et al. (2022). Inflammatory tissue reactions around aseptically loose cemented hip prostheses: A retrieval study of the Spectron EF stem with Reflection All‐Poly acetabular cup. (ekstern lenke)

2021

• Greve Johannessen, Håkon; Kadar, Thomas; Hallan, Geir et al. (2021). Polyethylene wear in total hip arthroplasty; comparing Oxinium and CoCr femoral heads using radiostereometry with 10 years follow-up. (ekstern lenke)
• Høl, Paul Johan; Hallan, Geir; Indrekvam, Kari (2021). Metallionenivåer i blod fra pasienter med metall-mot-metall-hofteprotese. (ekstern lenke)

2020

• Khan, Michelle; Gjertsen, Jan-Erik; Refsum, Anders Myhre et al. (2020). En spørreundersøkelse om sementeringsteknikker som brukes ved total kneprotesekirurgi ved norske sykehus. (ekstern lenke)
• Høl, Paul Johan; Hallan, Geir; Furnes, Ove Nord et al. (2020). Metallionenivåer i blod etter 10 år med hofteproteser med ulike hodematerialer. (ekstern lenke)
• Strandenes, Eivind; Ellison, Peter; Mølster, Anders et al. (2020). Strength of side-to-side and step-cut repairs in tendon transfers: biomechanical testing of porcine flexor tendons. (ekstern lenke)

2019

• Strandenes, Eivind; Ellison, Peter; Mølster, Anders et al. (2019). Strength of Pulvertaft modifications: tensile testing of porcine flexor tendons. (ekstern lenke)
• Høl, Paul Johan; Furnes, Ove; Hallan, Geir et al. (2019). Kontrollen av medisinske implantater kan bli bedre. (ekstern lenke)
• Jonitz-Heincke, Anika; Seyfarth, Anika; Fabry, Christian et al. (2019). Impact of TiNbN wear particles on osteoblastic differentiation capacity and induction of inflammatory reactions. (ekstern lenke)
• Høl, Paul Johan; Ellison, Peter John; Wolf, Susann et al. (2019). Mekanismer for aseptisk løsning av sementert Spectron EF hoftestamme med Reflection kopp - en retrievalstudie. (ekstern lenke)
• Høl, Paul Johan (2019). Metals in orthopaedic implants: Mechanical, chemical and biological properties of titanium and stainless steel implants . (ekstern lenke)
• Refsum, Anders Myhre; Nguyen, Uy Viet; Gjertsen, Jan Erik et al. (2019). Cementing technique for primary knee arthroplasty: a scoping review. (ekstern lenke)
• Høl, Paul Johan; Gjerdet, Nils Roar; Jonung, Torbjörn (2019). Corrosion and metal release from overlapping arterial stents under mechanical and electrochemical stress - An experimental study. (ekstern lenke)

2018

• Høl, Paul Johan (2018). Metallnivå i blod hos pasienter med hofteprotese. (ekstern lenke)
• Høl, Paul Johan; Kristoffersen, Einar Klæboe; Vindenes, Hilde Kristin et al. (2018). Novel titanium antigens and assessment of immune activation. (ekstern lenke)
• Jonitz-Heincke, Anika; Tillmann, Jenny; Ostermann, Melanie et al. (2018). Label-free monitoring of uptake and toxicity of endoprosthetic wear particles in human cell cultures. (ekstern lenke)
• Ellison, Peter; Høl, Paul Johan; Babic, Ankica (2018). An individual patient outcome tool for joint replacement patients. (ekstern lenke)
• Høl, Paul Johan; Kristoffersen, Einar Klæboe; Gjerdet, Nils Roar et al. (2018). Novel nanoparticulate and ionic titanium antigens for hypersensitivity testing. (ekstern lenke)
• Ellison, Peter; Høl, Paul Johan; Babic, Ankica (2018). An individual patient outcome tool for joint replacement patients. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

Google scholar: https://scholar.google.no/citations?user=NfSE-qUAAAAJ

Bergen Implant Retrieval center for Implants

The overall goal of our projects is to improve the performance and safety of orthopaedic and other surgical implants by a clinic-laboratory interaction.

Clinical performance of artificial materials can be predicted and improved by investigation of the retrieved devices that have been in clinical use, by a translational research approach, addressing biocompatibility and assessment of physical behavior.

Read more: https://www.researchgate.net/project/Bergen-Retrieval-Center-for-Implants